Payload Information
General Information of This Payload
| Payload ID | PAY0RXKZJ |
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| Name |
Diazeniumdiolate
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| Synonyms |
Diazeniumdiolate; Dea/no; M3QG4JA6WU; DEA/NO [MI]; Diethylamine nitric oxide free acid; UNII-M3QG4JA6WU; 1-Triazene, 3,3-diethyl-1-hydroxy-, 2-oxide; CHEBI:77714; 1,1-diethyl-2-hydroxy-3-oxotriazane; 1-Triazene, 3,3-diethyl-1-hydroxy-, 2-oxide, ION(1-), (1Z)-; 1223160-21-1; CHEMBL1160600; CHEMBL1620720; DTXSID50861542; N,N-Diethyl-N-hydroxynitrous hydrazide; LS-194425
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| Structure |
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| Formula | C4H11N3O2 |
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| Isosmiles | CCN(CC)/[N+]([O-])=N/O |
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| PubChem CID | ||||||
| InChI |
InChI=1S/C4H11N3O2/c1-3-6(4-2)7(9)5-8/h8H,3-4H2,1-2H3/b7-5-
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| InChIKey |
FOSISNXVGQBIAP-ALCCZGGFSA-N
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| IUPAC Name |
(Z)-diethylamino-hydroxyimino-oxidoazanium
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| Pharmaceutical Properties | Molecule Weight |
133.151 |
Polar area |
61.9 |
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Complexity |
9 |
xlogp Value |
0.5949 |
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Heavy Count |
9 |
Rot Bonds |
3 |
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Hbond acc |
2 |
Hbond Donor |
1 |
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Each Antibody-drug Conjugate Related to This Payload
Full Information of The Activity Data of The ADC(s) Related to This Payload
HN-01 [Investigative]
Discovered Using Cell Line-derived Xenograft Model
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Tumor Growth Inhibition value (TGI) | ≈ 81.30% | Positive CD24 expression (CD24 +++/++) | ||
| Method Description |
A hepatocellular carcinoma xenograft model was established by subcutaneously injecting BEL-7402 cells (1 x 107) into right flanks of BALB/c nude mice. When the average tumor volume reached 100 mm3, tumor-bearing mice were divided randomly into seven groups (six mice/group) and treated with HN-01 (10 mg/kg) every 3 days.
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| In Vivo Model | BEL-7402 CDX model | ||||
| In Vitro Model | Hepatoma | Bel-7402 cells | CVCL_5492 | ||
References