Antibody-drug Conjugate Information
General Information of This Antibody-drug Conjugate (ADC)
| ADC ID |
DRG0INKKH
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| ADC Name |
TRSQ-ZP3A-LP12
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| Synonyms |
TRSQ-ZP3A-LP12
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| Organization |
REGENERON PHARMACEUTICALS, INC.
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| Drug Status |
Investigative
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| Drug-to-Antibody Ratio |
3.8
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| Structure |
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| Antibody Name |
Anti-STEAP2 mAb
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Antibody Info | ||||
| Antigen Name |
Metalloreductase STEAP2 (STEAP2)
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Antigen Info | ||||
| Payload Name |
CL202203715A1 P7
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Payload Info | ||||
| Linker Name |
DIBAC-PEG4-vcPAB-Gly linker
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Linker Info | ||||
| Conjugate Type |
DBCO-Azide Click Chemistry Conjugation
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| Combination Type |
LP12
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General Information of The Activity Data Related to This ADC
Full List of Activity Data of This Antibody-drug Conjugate
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) | 0.029 nM | Positive HER2 expression (HER2+++/++) | ||
| Method Description |
The anti-proliferation test was carried out with SK-BR-3 human breast cancer cell line. Cells were grown in McCoy's 5a medium supplemented with 18% FBS,penicillin/streptomycin and L-glutamine.
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| In Vitro Model | Breast adenocarcinoma | SK-BR-3 cells | CVCL_0033 | ||