Linker Information
General Information of This Linker
| Linker ID |
LIN0NGSQO
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| Linker Name |
DIBAC-PEG4-vcPAB-Gly linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Formula |
C51H66N8O14
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| Isosmiles |
CC([C@H](NC(CCOCCOCCOCCOCCNC(CCC(N1C2=C(C#CC(C=CC=C3)=C3C1)C=CC=C2)=O)=O)=O)C(N[C@@H](CCCNC(N)=O)C(NC4=CC=C(C=C4)COC(NCC(O)=O)=O)=O)=O)C
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| InChI |
InChI=1S/C51H66N8O14/c1-35(2)47(49(66)57-41(11-7-22-54-50(52)67)48(65)56-40-17-13-36(14-18-40)34-73-51(68)55-32-46(63)64)58-44(61)21-24-69-26-28-71-30-31-72-29-27-70-25-23-53-43(60)19-20-45(62)59-33-39-10-4-3-8-37(39)15-16-38-9-5-6-12-42(38)59/h3-6,8-10,12-14,17-18,35,41,47H,7,11,19-34H2,1-2H3,(H,53,60)(H,55,68)(H,56,65)(H,57,66)(H,58,61)(H,63,64)(H3,52,54,67)/t41-,47-/m0/s1
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| InChIKey |
YGVATABKHRJNOO-VONAPMJUSA-N
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| Pharmaceutical Properties |
Molecule Weight
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1015.131
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Polar area
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304.38
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Complexity
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2286.207196
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xlogp Value
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2.3095
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Heavy Count
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73
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Rot Bonds
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32
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Hbond acc
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13
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Hbond Donor
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8
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Each Antibody-drug Conjugate Related to This Linker
Full Information of The Activity Data of The ADC(s) Related to This Linker
TRSQ-ZP3A-LP12 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) |
0.029 nM
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Positive HER2 expression (HER2+++/++) | ||
| Method Description |
The anti-proliferation test was carried out with SK-BR-3 human breast cancer cell line. Cells were grown in McCoy's 5a medium supplemented with 18% FBS,penicillin/streptomycin and L-glutamine.
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| In Vitro Model | Breast adenocarcinoma | SK-BR-3 cells | CVCL_0033 | ||