Antibody-drug Conjugate Information
General Information of This Antibody-drug Conjugate (ID: DRG0HOUOQ)
| ADC Name |
HER2 × HER3 BsADC
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| Synonyms |
HER2 × HER3 BsADC
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| Organization |
School of Pharmacy, Shanghai Jiao Tong University
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| Drug Status |
Investigative
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| Drug-to-Antibody Ratio |
2.89
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| Structure |
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| Antibody Name |
23V
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Antibody Info | ||||
| Antigen Name |
Receptor tyrosine-protein kinase erbB-2 (HER2); Receptor tyrosine-protein kinase erbB-3 (HER3)
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Antigen Info | ||||
| Payload Name |
Monomethyl auristatin E
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Payload Info | ||||
| Payload Target |
Microtubule (MT)
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Target Info | ||||
| Linker Name |
Mc-Val-Cit-PABC
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Linker Info | ||||
| Conjugate Type |
Random conjugation through reduced inter-chain cysteines.
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| Combination Type |
Vedotin
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2027 Update
General Information of The ADMET Data Related to This ADC
Absorption
| Standard Type | Value | Units | Description | Reference |
|---|---|---|---|---|
| Area Under the Concentration-Time Curve (AUC) | 18.01 | day·ug/mL |
Pharmacokinetics parameters analysis of BsADC
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[1] |
| Maximum Observed Concentration (Cmax) | 14.71 | ug/mL |
Pharmacokinetics parameters analysis of BsADC
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[1] |
Distribution
| Standard Type | Value | Units | Description | Reference |
|---|---|---|---|---|
| Volume of Distribution (Vd) | 0.33 | mL/kg |
Pharmacokinetics parameters analysis of BsADC
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[1] |
Excretion
| Standard Type | Value | Units | Description | Reference |
|---|---|---|---|---|
| Clearance (CL) | 0.08 | mL/day/kg |
Pharmacokinetics parameters analysis of BsADC
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[1] |
| Elimination Half-Life (t1/2) | 4.65 | mL/kg |
Pharmacokinetics parameters analysis of BsADC
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[1] |
References