Antibody-drug Conjugate Information
General Information of This Antibody-drug Conjugate (ADC)
| ADC ID |
DRG0GLJSW
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| ADC Name |
H1H21234N-N297Q-LP6
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| Synonyms |
Anti-MSR1-LXR agonist ADC
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| Organization |
REGENERON PHARMACEUTICALS, INC.
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| Drug Status |
Investigative
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| Drug-to-Antibody Ratio |
3.9
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| Structure |
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| Antibody Name |
anti-MSR1
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Antibody Info | ||||
| Antigen Name |
Protein MANNAN SYNTHESIS-RELATED 1 (MSR1)
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Antigen Info | ||||
| Payload Name |
US12209180B2 P4
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Payload Info | ||||
| Linker Name |
H1H21234N-N297Q- LP6 lINKER
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Linker Info | ||||
| Conjugate Type |
site-specific conjugation
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| Combination Type |
LP6
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General Information of The Activity Data Related to This ADC
Full List of Activity Data of This Antibody-drug Conjugate
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) | 0.685 nM | Positive MSR1 expression (MSR1+++/++) | ||
| Method Description |
Anti-MSR1-LXR Agonist Conjugate Activity in Differentiated THP-4/LXR-Luc cells
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| In Vitro Model | Acute monoblastic/monocytic leukemia, Childhood acute monocytic leukemia | THP-1/LXR-Luc cells | CVCL_5115 | ||
References