Linker Information
General Information of This Linker
| Linker ID |
LIN0UPIHT
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| Linker Name |
H1H21234N-N297Q- LP6 lINKER
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C58H85N11O15
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| Isosmiles |
CC([C@@H](NC(O)CCOCCOCCOCCOCCNC(CCC(N1C2=C(C=CC=C2)C3=C(N(N=N3)CCCCCOCCOCCN)C4=C(C1)C=CC=C4)=O)=O)C(N[C@@H](CCCNC(N)=O)C(NC5=CC=C(C=C5)COC(O)=O)=O)=O)C
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| InChI |
InChI=1S/C58H85N11O15/c1-41(2)52(56(74)64-47(14-10-24-62-57(60)75)55(73)63-44-18-16-42(17-19-44)40-84-58(76)77)65-50(71)22-28-79-32-35-82-37-38-83-36-34-81-30-25-61-49(70)20-21-51(72)68-39-43-11-4-5-12-45(43)54-53(46-13-6-7-15-48(46)68)66-67-69(54)26-8-3-9-27-78-31-33-80-29-23-59/h4-7,11-13,15-19,41,47,50,52,65,71H,3,8-10,14,20-40,59H2,1-2H3,(H,61,70)(H,63,73)(H,64,74)(H,76,77)(H3,60,62,75)/t47-,50?,52+/m0/s1
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| InChIKey |
AUSUXLSNPVWJGD-URRGKQONSA-N
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| Pharmaceutical Properties |
Molecule Weight
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1176.38
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Polar area
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353.63
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Complexity
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2525.014769
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xlogp Value
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3.673
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Heavy Count
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84
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Rot Bonds
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42
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Hbond acc
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19
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Hbond Donor
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9
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Each Antibody-drug Conjugate Related to This Linker
Full Information of The Activity Data of The ADC(s) Related to This Linker
H1H21234N-N297Q-LP6 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) |
0.685 nM
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Positive MSR1 expression (MSR1+++/++) | ||
| Method Description |
Anti-MSR1-LXR Agonist Conjugate Activity in Differentiated THP-4/LXR-Luc cells
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| In Vitro Model | Acute monoblastic/monocytic leukemia, Childhood acute monocytic leukemia | THP-1/LXR-Luc cells | CVCL_5115 | ||
References