Payload Information
General Information of This Payload
| Payload ID | PAY0UEBNO |
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|---|---|---|---|---|---|---|
| Name | US12209180B2 P4 |
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| Synonyms |
P4
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| Structure |
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| Formula | C36H48N4O3 |
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| Isosmiles | C[C@]12CCC[C@](C)(C(NC([C@]3(C)[C@]4([H])CCC(C=CC(N)=C5)=C5[C@]4(CCC3)C)=O)=O)[C@]1([H])CCC6=C2C=C(NC(CN)=O)C=C6 |
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| InChI |
InChI=1S/C36H48N4O3/c1-33-15-5-17-35(3,28(33)13-9-22-7-11-24(38)19-26(22)33)31(42)40-32(43)36(4)18-6-16-34(2)27-20-25(39-30(41)21-37)12-8-23(27)10-14-29(34)36/h7-8,11-12,19-20,28-29H,5-6,9-10,13-18,21,37-38H2,1-4H3,(H,39,41)(H,40,42,43)/t28-,29-,33-,34-,35+,36+/m1/s1
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| InChIKey |
NTDLYJFIHKSFEI-CTHTUJIWSA-N
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| Pharmaceutical Properties | Molecule Weight |
584.805 |
Polar area |
127.31 |
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Complexity |
1551.60574 |
xlogp Value |
5.5296 |
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Heavy Count |
43 |
Rot Bonds |
4 |
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Hbond acc |
5 |
Hbond Donor |
4 |
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Each Antibody-drug Conjugate Related to This Payload
Full Information of The Activity Data of The ADC(s) Related to This Payload
H1H21234N-N297Q-LP7 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) |
0.56 nM
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Positive MSR1 expression (MSR1+++/++) | ||
| Method Description |
Anti-MSR1-LXR Agonist Conjugate Activity in Differentiated THP-4/LXR-Luc cells
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| In Vitro Model | Acute monoblastic/monocytic leukemia, Childhood acute monocytic leukemia | THP-1/LXR-Luc cells | CVCL_5115 | ||
H1H21234N-N297Q-LP8 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) |
0.619 nM
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Positive MSR1 expression (MSR1+++/++) | ||
| Method Description |
Anti-MSR1-LXR Agonist Conjugate Activity in Differentiated THP-4/LXR-Luc cells
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| In Vitro Model | Acute monoblastic/monocytic leukemia, Childhood acute monocytic leukemia | THP-1/LXR-Luc cells | CVCL_5115 | ||
H1H21234N-N297Q-LP6 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) |
0.685 nM
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Positive MSR1 expression (MSR1+++/++) | ||
| Method Description |
Anti-MSR1-LXR Agonist Conjugate Activity in Differentiated THP-4/LXR-Luc cells
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| In Vitro Model | Acute monoblastic/monocytic leukemia, Childhood acute monocytic leukemia | THP-1/LXR-Luc cells | CVCL_5115 | ||
References