Payload Information
General Information of This Payload
| Payload ID | PAY0GZRCU |
|||||
|---|---|---|---|---|---|---|
| Name | CN118001423A+ADC2+payload |
|||||
| Synonyms |
CN118001423A+ADC2+payload
Click to Show/Hide
|
|||||
| Structure |
|
|||||
| Formula | C27H27N3O7 |
|||||
| Isosmiles | CC[C@@]1(C(C=C2C3=NC4=CC5=C(C=C4C(CCN[C@H]6COCC6)=C3CN2C7=O)OCO5)=C7COC1=O)O |
|||||
| InChI |
InChI=1S/C27H27N3O7/c1-2-27(33)19-8-21-24-17(10-30(21)25(31)18(19)12-35-26(27)32)15(3-5-28-14-4-6-34-11-14)16-7-22-23(37-13-36-22)9-20(16)29-24/h7-9,14,28,33H,2-6,10-13H2,1H3/t14-,27+/m1/s1
|
|||||
| InChIKey |
IRVBOVBWNRKCQX-ASHKIFAZSA-N
|
|||||
| Pharmaceutical Properties | Molecule Weight |
505.527 |
Polar area |
121.14 |
||
Complexity |
1485.177866 |
xlogp Value |
1.7293 |
|||
Heavy Count |
37 |
Rot Bonds |
5 |
|||
Hbond acc |
10 |
Hbond Donor |
2 |
|||
Each Antibody-drug Conjugate Related to This Payload
Full Information of The Activity Data of The ADC(s) Related to This Payload
CN118001423A ADC2 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) | < 50 nM | High NECTIN4 expression (NECTIN4 +++) | ||
| Method Description |
A Cell line test on MDA-MB-468
|
||||
| In Vitro Model | Breast adenocarcinoma | MDA-MB-468 cells | CVCL_0419 | ||
| Experiment 2 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) | ≈ 50≈200 nM | High NECTIN4 expression (NECTIN4 +++) | ||
| Method Description |
A Cell line test on SW-780
|
||||
| In Vitro Model | Mouse melanoma | SW-780 cells | CVCL_1728 | ||
| Experiment 3 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) | ≈ 50≈200 nM | High NECTIN4 expression (NECTIN4 +++) | ||
| Method Description |
A Cell line test on MCF-7
|
||||
| In Vitro Model | Invasive breast carcinoma | MCF-7 cells | CVCL_0031 | ||
| Experiment 4 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) | < 50 nM | High NECTIN4 expression (NECTIN4 +++) | ||
| Method Description |
A Cell line test on LNCAP
|
||||
| In Vitro Model | Prostate carcinoma | LNCaP cells | CVCL_0395 | ||
| Experiment 5 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) | < 50 nM | High NECTIN4 expression (NECTIN4 +++) | ||
| Method Description |
A Cell line test on BxPC-3
|
||||
| In Vitro Model | Pancreatic ductal adenocarcinoma | BxPC-3 cells | CVCL_0186 | ||
References