Antibody-drug Conjugate Information

General Information of This Antibody-drug Conjugate (ADC)
ADC ID
DRG0DXRSE
ADC Name
isumab01-C3
Synonyms
lsumab01-C3
   Click to Show/Hide
Organization
MURGITROYD & COMPANY
Drug Status
Investigative
Drug-to-Antibody Ratio
2.1
Antibody Name
Undisclosed
Antigen Name
Folate receptor alpha (FOLR1)
  Antigen Info 
Payload Name
WO2025015586A1, ADC23, Payload
  Payload Info 
Therapeutic Target
Toll-like receptor 7 (TLR7); Toll-like receptor 8 (TLR8)
  Target Info 
Linker Name
Undisclosed
Conjugate Type
DBCO-Azide Click Chemistry Conjugation
General Information of The Activity Data Related to This ADC
Revealed Based on the Cell Line Data
Click To Hide/Show 1 Activity Data Related to This Level
Standard Type Value Units Cell Line Disease Model
Half Maximal inhibitory Concentration (lC50) 
0.18
pM
CVCL_0363
Gestational choriocarcinoma
Full List of Activity Data of This Antibody-drug Conjugate
Revealed Based on the Cell Line Data
Click To Hide/Show 1 Activity Data Related to This Level
Experiment 1 Reporting the Activity Date of This ADC [1]
Efficacy Data Half Maximal inhibitory Concentration (lC50) 0.18 pM High FRa expression (FRa +++)
Method Description
A Cell line test on Jeg3
In Vitro Model Gestational choriocarcinoma Jeg3 cells CVCL_0363
References
Ref 1 Antibody-drug conjugate compounds, and methods of use and treatment