Antibody-drug Conjugate Information
General Information of This Antibody-drug Conjugate (ADC)
| ADC ID |
DRG0ASYKZ
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| ADC Name |
Izeltabart tapatansine
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| Synonyms |
izeltabart tapatansine; IMGC936; IMGC936-0901
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| Organization |
ImmunoGen (Top20 MNC) (Originator);MacroGenics (Originator) (No Rights)
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| Drug Status |
Phase 1/2 (discontinued)
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| Drug-to-Antibody Ratio |
2
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| Structure |
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| Antibody Name |
Izeltabart
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Antibody Info | ||||
| Antigen Name |
Disintegrin and metalloproteinase domain-containing protein 9 (ADAM9)
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Antigen Info | ||||
| Payload Name |
DM21-C
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Payload Info | ||||
| Therapeutic Target |
Microtubule (MT)
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Target Info | ||||
| Linker Name |
Mc-Ala-Ala-Ala
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Linker Info | ||||
| Conjugate Type |
Reactive Cysteines
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| Combination Type |
tapatansine
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The indication landscape of This ADC(2027 Update)
The clinical trial pipeline of This ADC(2027 Update)
| Indication | Phase 1 | Phase 1/2 | Phase 2 | Phase 2/3 | Phase 3 | New Drug Application | Approved | ||
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| Breast cancer |
1 Trials
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| Colorectal cancer |
1 Trials
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| Gastroesophageal junction adenocarcinoma |
1 Trials
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| Lung cancer |
1 Trials
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| Pancreatic cancer |
1 Trials
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| Unspecific solid tumor |
1 Trials
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