Antigen Information

General Information of This Antigen (ID: TAR0DMCMD)
Antigen Name
Disintegrin and metalloproteinase domain-containing protein 9 (ADAM9)
Gene Name
ADAM9
Gene ID
8754
Synonym
KIAA0021; MCMP; MDC9; MLTNG; Cellular disintegrin-related protein;Meltrin-gamma;Metalloprotease/disintegrin/cysteine-rich protein 9;Myeloma cell metalloproteinase
Sequence
MGSGARFPSGTLRVRWLLLLGLVGPVLGAARPGFQQTSHLSSYEIITPWRLTRERREAPR
PYSKQVSYVIQAEGKEHIIHLERNKDLLPEDFVVYTYNKEGTLITDHPNIQNHCHYRGYV
EGVHNSSIALSDCFGLRGLLHLENASYGIEPLQNSSHFEHIIYRMDDVYKEPLKCGVSNK
DIEKETAKDEEEEPPSMTQLLRRRRAVLPQTRYVELFIVVDKERYDMMGRNQTAVREEMI
LLANYLDSMYIMLNIRIVLVGLEIWTNGNLINIVGGAGDVLGNFVQWREKFLITRRRHDS
AQLVLKKGFGGTAGMAFVGTVCSRSHAGGINVFGQITVETFASIVAHELGHNLGMNHDDG
RDCSCGAKSCIMNSGASGSRNFSSCSAEDFEKLTLNKGGNCLLNIPKPDEAYSAPSCGNK
LVDAGEECDCGTPKECELDPCCEGSTCKLKSFAECAYGDCCKDCRFLPGGTLCRGKTSEC
DVPEYCNGSSQFCQPDVFIQNGYPCQNNKAYCYNGMCQYYDAQCQVIFGSKAKAAPKDCF
IEVNSKGDRFGNCGFSGNEYKKCATGNALCGKLQCENVQEIPVFGIVPAIIQTPSRGTKC
WGVDFQLGSDVPDPGMVNEGTKCGAGKICRNFQCVDASVLNYDCDVQKKCHGHGVCNSNK
NCHCENGWAPPNCETKGYGGSVDSGPTYNEMNTALRDGLLVFFFLIVPLIVCAIFIFIKR
DQLWRSYFRKKRSQTYESDGKNQANPSRQPGSVPRHVSPVTPPREVPIYANRFAVPTYAA
KQPQQFPSRPPPPQPKVSSQGNLIPARPAPAPPLYSSLT

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Function
Cleaves and releases a number of molecules with important roles in tumorigenesis and angiogenesis, such as TEK, KDR, EPHB4, CD40, VCAM1 and CDH5. May mediate cell-cell, cell-matrix interactions and regulate the motility of cells via interactions with integrins.

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Uniprot Entry
ADAM9_HUMAN
HGNC ID
HGNC:216
KEGG ID
hsa:8754
Each Antibody-drug Conjugate and Its Component Related to This Antigen
Full List of The ADC Related to This Antigen
The Numbers of ADCs, Their Three Components, Payload Targets, and Corresponding Diseases for This Antigens
AEX6003 (S442C)
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Anti-ADAM9 (C442)-DGN549 [1]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
Anti-ADAM9 antibody
 Antibody Info 
ADC Name Payload Target Linker ADC Info
MGC028
Exatecan
DNA topoisomerase 1 (TOP1)
Bicyclononyne carbamoyl sulfamide Val-Ala-PABC
 ADC Info 
DB-1317
TOP1 inhibitor
DNA topoisomerase 1 (TOP1)
Undisclosed
 ADC Info 
BG-C0979
TOP1 inhibitor
DNA topoisomerase 1 (TOP1)
Undisclosed
 ADC Info 
Izeltabart
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Izeltabart tapatansine [2]
DM21-C
Microtubule (MT)
Mc-Ala-Ala-Ala
 ADC Info 
ADC Name Payload Target Linker ADC Info
IMGC-936
DM21-C
Undisclosed
Mc-Ala-Ala-Ala
 ADC Info 
References
Ref 1 Introduction to basic information on ADC drug ANTI-ADAM9 ADC (ANTI-ADAM9(C442)-DGN549).
Ref 2 Izeltabart tapatansine by MacroGenics for Gastroesophageal (GE) Junction Carcinomas: Likelihood of Approval; 30 May 2023.