Antigen Information

General Information of This Antigen (ID: TAR0YOEAI)
Antigen Name
Neural cell adhesion molecule 1 (NCAM1)
Gene Name
NCAM1
Gene ID
4684
Synonym
NCAM; CD56
Sequence
MLQTKDLIWTLFFLGTAVSLQVDIVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGE
KLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMF
KNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIK
KTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGF
PEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATI
HLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPE
KQETLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQG
PVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDS
ENDFGNYNCTAVNRIGQESLEFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPI
LKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAA
SEFKTQPVQGEPSAPKLEGQMGEDGNSIKVNLIKQDDGGSPIRHYLVRYRALSSEWKPEI
RLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKSKAAHFVFRTSAQPTAIPANGSPTSGLS
TGAIVGILIVIFVLLLVVVDITCYFLNKCGLFMCIAVNLCGKAGPGAKGKDMEEGKAAFS
KDESKEPIVEVRTEEERTPNHDGGKHTEPNETTPLTEPEKGPVEAKPECQETETKPAPAE
VKTVPNDATQTKENESKA

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Function
This protein is a cell adhesion molecule involved in neuron- neuron adhesion, neurite fasciculation, outgrowth of neurites, etc.; (Microbial infection) Acts as a receptor for rabies virus.

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Uniprot Entry
NCAM1_HUMAN
HGNC ID
HGNC:7656
KEGG ID
hsa:4684
Each Antibody-drug Conjugate and Its Component Related to This Antigen
Full List of The ADC Related to This Antigen
The Numbers of ADCs, Their Three Components, Payload Targets, and Corresponding Diseases for This Antigens
ADC Name Payload Target Linker ADC Info
DXC006
CPT113
DNA topoisomerase 1 (TOP1)
A cleavable peptide linker
 ADC Info 
Lorvotuzumab
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Lorvotuzumab mertansine
DM1
Microtubule (MT)
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
 ADC Info 
HuN901-CC-1065 [1]
Rachelmycin
Human Deoxyribonucleic acid (hDNA)
Cleavable disulfide
 ADC Info 
Lorvotuzumab-ADC-24-1 [2]
Lorvotuzumab-ADC-24-1 payload
Undisclosed
Lorvotuzumab-ADC-24-1 linker
 ADC Info 
Lorvotuzumab-ADC-24-2 [2]
Lorvotuzumab-ADC-24-2 payload
Undisclosed
Lorvotuzumab-ADC-24-2 linker
 ADC Info 
Lorvotuzumab-ADC-24-3 [2]
Lorvotuzumab-ADC-24-3 payload
Undisclosed
Lorvotuzumab-ADC-24-3 linker
 ADC Info 
Lorvotuzumab-ADC-24-4 [2]
Lorvotuzumab-ADC-24-4 payload
Undisclosed
Lorvotuzumab-ADC-24-4 linker
 ADC Info 
Lorvotuzumab-ADC-24-5 [2]
Lorvotuzumab-ADC-24-5 payload
Undisclosed
Lorvotuzumab-ADC-24-5 linker
 ADC Info 
Lorvotuzumab-ADC-24-6 [2]
Lorvotuzumab-ADC-24-6 payload
Undisclosed
Lorvotuzumab-ADC-24-6 linker
 ADC Info 
Lorvotuzumab-ADC-24-7 [2]
Lorvotuzumab-ADC-24-7 payload
Undisclosed
Lorvotuzumab-ADC-24-7 linker
 ADC Info 
Lorvotuzumab-ADC-24-8 [2]
Lorvotuzumab-ADC-24-8 payload
Undisclosed
Lorvotuzumab-ADC-24-8 linker
 ADC Info 
Lorvotuzumab-ADC-24-9 [2]
Lorvotuzumab-ADC-24-9 payload
Undisclosed
Lorvotuzumab-ADC-24-9 linker
 ADC Info 
Lorvotuzumab-ADC-24-10 [2]
Lorvotuzumab-ADC-24-10 payload
Undisclosed
Lorvotuzumab-ADC-24-10 linker
 ADC Info 
Lorvotuzumab-ADC-24-11 [2]
Lorvotuzumab-ADC-24-11 payload
Undisclosed
Lorvotuzumab-ADC-24-11 linker
 ADC Info 
Lorvotuzumab-ADC-24-12 [2]
Lorvotuzumab-ADC-24-12 payload
Undisclosed
Lorvotuzumab-ADC-24-12 linker
 ADC Info 
Lorvotuzumab-ADC-24-13 [2]
Lorvotuzumab-ADC-24-13 payload
Undisclosed
Lorvotuzumab-ADC-24-13 linker
 ADC Info 
Promiximab
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Promiximab-DUBA [3]
Seco-DUBA
Human Deoxyribonucleic acid (hDNA)
Mal-Val-Cit-PABA-Cyclization spacer
 ADC Info 
Promiximab-MMAE [4]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
Undisclosed
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Anti-CD56 antibody-drug conjugate (Connectyx) [5]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
EDC-7 [6]
Glycosylation scillarenin
Undisclosed
CEN010-105
 ADC Info 
References
Ref 1 Enhancement of the selectivity and antitumor efficacy of a CC-1065 analogue through immunoconjugate formation. Cancer Res. 1995 Sep 15;55(18):4079-84.
Ref 2 Ligand-drug conjugate of exatecan analogue, preparation method therefor and application thereof; 2020-04-02.
Ref 3 Promiximab-duocarmycin, a new CD56 antibody-drug conjugates, is highly efficacious in small cell lung cancer xenograft models. Oncotarget. 2017 Dec 26;9(4):5197-5207. doi: 10.18632/oncotarget.23708. eCollection 2018 Jan 12.
Ref 4 Preparation and anti-cancer evaluation of promiximab-MMAE, an anti-CD56 antibody drug conjugate, in small cell lung cancer cell line xenograft models. J Drug Target. 2018 Dec;26(10):905-912. doi: 10.1080/1061186X.2018.1450413. Epub 2018 Apr 13.
Ref 5 Prospective Grant of an Exclusive Patent License: Anti-CD56 as an Antibody-Drug Conjugate (ADC) or Non-ADC To Target Glioblastoma Either Alone or in Combination With Other Potential Immuno-Oncology Drugs.
Ref 6 Introduction to basic information on ADC drug EDC-7