Antigen Information
General Information of This Antigen (ID: TAR0WBVOL)
| Antigen Name | Glypican-1 (GPC1) |
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|---|---|---|---|---|---|---|
| Gene Name | GPC1 |
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| Gene ID | ||||||
| Sequence |
MELRARGWWLLCAAAALVACARGDPASKSRSCGEVRQIYGAKGFSLSDVPQAEISGEHLR
ICPQGYTCCTSEMEENLANRSHAELETALRDSSRVLQAMLATQLRSFDDHFQHLLNDSER TLQATFPGAFGELYTQNARAFRDLYSELRLYYRGANLHLEETLAEFWARLLERLFKQLHP QLLLPDDYLDCLGKQAEALRPFGEAPRELRLRATRAFVAARSFVQGLGVASDVVRKVAQV PLGPECSRAVMKLVYCAHCLGVPGARPCPDYCRNVLKGCLANQADLDAEWRNLLDSMVLI TDKFWGTSGVESVIGSVHTWLAEAINALQDNRDTLTAKVIQGCGNPKVNPQGPGPEEKRR RGKLAPRERPPSGTLEKLVSEAKAQLRDVQDFWISLPGTLCSEKMALSTASDDRCWNGMA RGRYLPEVMGDGLANQINNPEVEVDITKPDMTIRQQIMQLKIMTNRLRSAYNGNDVDFQD ASDDGSGSGSGDGCLDDLCSRKVSRKSSSSRTPLTHALPGLSEQEGQKTSAASCPQPPTF LLPLLLFLALTVARPRWR Click to Show/Hide
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| Family | Glycosyltransferase 32 family |
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| Function |
Cell surface proteoglycan that bears heparan sulfate. Binds, via the heparan sulfate side chains, alpha-4 (V) collagen and participates in Schwann cell myelination. May act as a catalyst in increasing the rate of conversion of prion protein PRPN(C) to PRNP(Sc) via associating (via the heparan sulfate side chains) with both forms of PRPN, .geting them to lipid rafts and facilitating their interaction. Required for proper skeletal muscle differentiation by sequestering FGF2 in lipid rafts preventing its binding to receptors (FGFRs) and inhibiting the FGF-mediated signaling.
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Each Antibody-drug Conjugate and Its Component Related to This Antigen
Full List of The ADC Related to This Antigen
| The Numbers of ADCs, Their Three Components, Payload Targets, and Corresponding Diseases for This Antigens | ||||
|---|---|---|---|---|
Anti-GPC1 GPC1-ADC (MMAE) mAb
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
GPC1-ADC-MMAE
[1]
|
Monomethyl auristatin E |
Microtubule (MT) |
Mc-Val-Cit-PABC |
Anti-GPC1 GPC1-ADC mAb
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
GPC1-ADC-MMAF
[2]
|
Monomethyl auristatin F |
Microtubule (MT) |
Mc-Val-Cit-PABC |
Anti-GPC1 mAb 01a002
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
GPC-1 ADC 2
[3]
|
Monomethyl auristatin F |
Microtubule (MT) |
Mc-Val-Cit-PABC |
Anti-GPC1 mAb 01a007
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
GPC-1 ADC 15
[3]
|
Monomethyl auristatin F |
Microtubule (MT) |
Mc-Val-Cit-PABC |
Anti-GPC1 mAb 01a009
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
GPC-1 ADC 12
[3]
|
Monomethyl auristatin F |
Microtubule (MT) |
Mc-Val-Cit-PABC |
Anti-GPC1 mAb 01a016
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
GPC-1 ADC 8
[3]
|
Monomethyl auristatin F |
Microtubule (MT) |
Mc-Val-Cit-PABC |
Anti-GPC1 mAb 01a017
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
GPC-1 ADC 14
[3]
|
Monomethyl auristatin F |
Microtubule (MT) |
Mc-Val-Cit-PABC |
Anti-GPC1 mAb 01a021
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
GPC-1 ADC 10
[3]
|
Monomethyl auristatin F |
Microtubule (MT) |
Mc-Val-Cit-PABC |
Anti-GPC1 mAb 01a026
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
GPC-1 ADC 17
[3]
|
Monomethyl auristatin F |
Microtubule (MT) |
Mc-Val-Cit-PABC |
Anti-GPC1 mAb 01a030
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
GPC-1 ADC 13
[3]
|
Monomethyl auristatin F |
Microtubule (MT) |
Mc-Val-Cit-PABC |
Anti-GPC1 mAb 01a033
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
GPC-1 ADC 1
[3]
|
Monomethyl auristatin F |
Microtubule (MT) |
Mc-Val-Cit-PABC |
Anti-GPC1 mAb 01a042
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
GPC-1 ADC 16
[3]
|
Monomethyl auristatin F |
Microtubule (MT) |
Mc-Val-Cit-PABC |
Anti-GPC1 mAb 02a002
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
GPC-1 ADC 6
[3]
|
Monomethyl auristatin F |
Microtubule (MT) |
Mc-Val-Cit-PABC |
Anti-GPC1 mAb 02a006
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
GPC-1 ADC 18
[3]
|
Monomethyl auristatin F |
Microtubule (MT) |
Mc-Val-Cit-PABC |
Anti-GPC1 mAb 02a010
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
GPC-1 ADC 7
[3]
|
Monomethyl auristatin F |
Microtubule (MT) |
Mc-Val-Cit-PABC |
Anti-GPC1 mAb 02a014
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
GPC-1 ADC 5
[3]
|
Monomethyl auristatin F |
Microtubule (MT) |
Mc-Val-Cit-PABC |
Anti-GPC1 mAb 02a022
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
GPC-1 ADC 11
[3]
|
Monomethyl auristatin F |
Microtubule (MT) |
Mc-Val-Cit-PABC |
Anti-GPC1 mAb 02a034
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
GPC-1 ADC 4
[3]
|
Monomethyl auristatin F |
Microtubule (MT) |
Mc-Val-Cit-PABC |
Anti-GPC1 mAb 02a035
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
GPC-1 ADC 3
[3]
|
Monomethyl auristatin F |
Microtubule (MT) |
Mc-Val-Cit-PABC |
Anti-GPC1 mAb 02b006
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
GPC-1 ADC 9
[3]
|
Monomethyl auristatin F |
Microtubule (MT) |
Mc-Val-Cit-PABC |
Anti-GPC1 mAb clone 01a033
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
GPC-1-ADC
[4]
|
Monomethyl auristatin F |
Microtubule (MT) |
Mc-Val-Cit-PABC |
humanized anti-GPC1 monoclonal antibody
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
GPC1-ADC
[5]
|
Monomethyl auristatin E |
Microtubule (MT) |
Undisclosed |
References