Antibody Information

General Information of This Antibody

Antibody ID	ANI0UYOXH
Antibody Name	Anti-GPC1 GPC1-ADC (MMAE) mAb
Synonyms	Anti-GPC1 GPC1-ADC(MMAE) mAb; 01a033 Click to Show/Hide
Antibody Type	Monoclonal antibody (mAb)
Antibody Subtype	Humanized IgG1-kappa
Antigen Name	Glypican-1 (GPC1)	Antigen Info
Click to Show/Hide the Sequence Information of This Antibody
Heavy Chain Sequence	MKHLWFFLLLVAAPRWVLSQVQLKQSGPELVKPGASVKISCKASGYSFTGYYMHWVKQSP EKSLEWIGEINPSTGDTTYNQKFKAKATLTVDKSSSTAYMQLKSLTSEDSAVYYCAREKR DDGVFAYWGQGTLVTVSSAKTTAPSVYPLAPVCGDTTGSSVTLGCLVKGYFPEPVTLTWN SGSLSSGVHTFPAVLQSDLYTLSSSVTVTSSTWPSQSITCNVAHPASSTKVDKKIEPRGP TIKPCPPCKCPAPNLLGGPSVFIFPPKIKDVLMISLSPIVTCVVVDVSEDDPDVQISWFV NNVEVHTAQTQTHREDYNSTLRVVSALPIQHQDWMSGKEFKCKVNNKDLPAPIERTISKP KGSVRAPQVYVLPPPEEEMTKKQVTLTCMVTDFMPEDIYVEWTNNGKTELNYKNTEPVLD SDGSYFMYSKLRVEKKNWVERNSYSCSVVHEGLHNHHTTKSFSRTPGK Click to Show/Hide
Light Chain Sequence	MRLLAQLLGLLMLWVPGSSGDIVMSQSPKSMSMSVGERVALSCKASENVGTYVSWYQQKP EQSPKLLIYGASNRYTGVPDRFTGSGSATDFTLTISSVQAEDLADYYCGQSYSYPLTFGA GTKLELKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVL NSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC Click to Show/Hide

Each Antibody-drug Conjugate Related to This Antibody

Full Information of The Activity Data of The ADC(s) Related to This Antibody

GPC1-ADC-MMAE [Investigative]

ADC Info

Discovered Using Patient-derived Xenograft Model

Click To Hide/Show 2 Activity Data Related to This Level

Experiment 1 Reporting the Activity Date of This ADC				[1]
Efficacy Data	Tumor Growth Inhibition value (TGI)	≈ 88.80% (Day 35)	High GPC1 expression (GPC1+++)
In Vivo Model	Pancreatic cancer PDX model (PDX: PK645)
Experiment 2 Reporting the Activity Date of This ADC				[1]
Efficacy Data	Tumor Growth Inhibition value (TGI)	≈ 98.70% (Day 28)	High GPC1 expression (GPC1+++)
In Vivo Model	Pancreatic cancer PDX model (PDX: PK565)

Revealed Based on the Cell Line Data

Click To Hide/Show 3 Activity Data Related to This Level

Experiment 1 Reporting the Activity Date of This ADC					[1]
Efficacy Data	Half Maximal Inhibitory Concentration (IC50)	80.90 pM	High GPC1 expression (GPC1+++)
Method Description	GPC1-ADC(MMAE) induces efficient tumor cell killing in cells PDX models from a Pancreatic ductal adenocarcinoma (PDAC) patient with GPC1 expression.
In Vitro Model	Pancreatic carcinoma	KP-2 cells		CVCL_3004
Experiment 2 Reporting the Activity Date of This ADC					[1]
Efficacy Data	Half Maximal Inhibitory Concentration (IC50)	0.55 nM	High GPC1 expression (GPC1+++)
Method Description	GPC1-ADC(MMAE) induces efficient tumor cell killing in cells PDX models from a Pancreatic ductal adenocarcinoma (PDAC) patient with GPC1 expression.
In Vitro Model	Pancreatic ductal adenocarcinoma	PK-8 cells		CVCL_4718
Experiment 3 Reporting the Activity Date of This ADC					[1]
Efficacy Data	Half Maximal Inhibitory Concentration (IC50)	0.68 nM	High GPC1 expression (GPC1+++)
Method Description	GPC1-ADC(MMAE) induces efficient tumor cell killing in cells PDX models from a Pancreatic ductal adenocarcinoma (PDAC) patient with GPC1 expression.
In Vitro Model	Pancreatic ductal adenocarcinoma	BxPC-3 cells		CVCL_0186

References

Ref 1	Glypican-1 Is a Novel Target for Stroma and Tumor Cell Dual-Targeting Antibody-Drug Conjugates in Pancreatic Cancer. Mol Cancer Ther. 2021 Dec;20(12):2495-2505.