Antibody Information

General Information of This Antibody

Antibody ID	ANI0GJJSU
Antibody Name	Anti-IL13RA2 PF-06473811 mAb
Antibody Type	Monoclonal antibody (mAb)
Antibody Subtype	Humanized IgG
Antigen Name	Interleukin-13 receptor subunit alpha-2 (IL13RA2)	Antigen Info

Each Antibody-drug Conjugate Related to This Antibody

Full Information of The Activity Data of The ADC(s) Related to This Antibody

Anti-IL13RA2-ADC [Investigative]

ADC Info

Discovered Using Cell Line-derived Xenograft Model

Click To Hide/Show 1 Activity Data Related to This Level

Experiment 1 Reporting the Activity Date of This ADC					[1]
Efficacy Data	Tumor Growth Inhibition value (TGI)	≈ 29.60% (Day 13)	High IL13RA2 expression (IL13RA2+++)
Method Description	2 x10⁶ A375 cells in 50% Cultrex basement membrane extract were injected subcutaneously in the flank of athymic nu/nu mice for FMT imaging or in the upper right shoulder for PET/CT imaging.
In Vivo Model	A375 xenograft model
In Vitro Model	Amelanotic melanoma	A375 cells		CVCL_0132

References

Ref 1	Targeting and pharmacology of an anti-IL13R2 antibody and antibody-drug conjugate in a melanoma xenograft model. MAbs. 2021 Jan-Dec;13(1):1958662.

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