Antigen Information
General Information of This Antigen (ID: TAR0TONKQ)
| Antigen Name | Nectin-4 (NECTIN4); Tumor-associated calcium signal transducer 2 (TACSTD2) |
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| Gene Name | NECTIN4; TACSTD2 |
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| Gene ID | ||||||
| Synonym1 | Ig superfamily receptor LNIR;Nectin cell adhesion molecule 4;Poliovirus receptor-related protein 4 |
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| Synonym2 | GA733-1; M1S1; TROP2; Cell surface glycoprotein Trop-2;Membrane component chromosome 1 surface marker 1;Pancreatic carcinoma marker protein GA733-1 |
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| Sequence1 |
MPLSLGAEMWGPEAWLLLLLLLASFTGRCPAGELETSDVVTVVLGQDAKLPCFYRGDSGE
QVGQVAWARVDAGEGAQELALLHSKYGLHVSPAYEGRVEQPPPPRNPLDGSVLLRNAVQA DEGEYECRVSTFPAGSFQARLRLRVLVPPLPSLNPGPALEEGQGLTLAASCTAEGSPAPS VTWDTEVKGTTSSRSFKHSRSAAVTSEFHLVPSRSMNGQPLTCVVSHPGLLQDQRITHIL HVSFLAEASVRGLEDQNLWHIGREGAMLKCLSEGQPPPSYNWTRLDGPLPSGVRVDGDTL GFPPLTTEHSGIYVCHVSNEFSSRDSQVTVDVLDPQEDSGKQVDLVSASVVVVGVIAALL FCLLVVVVVLMSRYHRRKAQQMTQKYEEELTLTRENSIRRLHSHHTDPRSQPEESVGLRA EGHPDSLKDNSSCSVMSEEPEGRSYSTLTTVREIETQTELLSPGSGRAEEEEDQDEGIKQ AMNHFVQENGTLRAKPTGNGIYINGRGHLV Click to Show/Hide
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| Sequence2 |
MARGPGLAPPPLRLPLLLLVLAAVTGHTAAQDNCTCPTNKMTVCSPDGPGGRCQCRALGS
GMAVDCSTLTSKCLLLKARMSAPKNARTLVRPSEHALVDNDGLYDPDCDPEGRFKARQCN QTSVCWCVNSVGVRRTDKGDLSLRCDELVRTHHILIDLRHRPTAGAFNHSDLDAELRRLF RERYRLHPKFVAAVHYEQPTIQIELRQNTSQKAAGDVDIGDAAYYFERDIKGESLFQGRG GLDLRVRGEPLQVERTLIYYLDEIPPKFSMKRLTAGLIAVIVVVVVALVAGMAVLVITNR RKSGKYKKVEIKELGELRKEPSL Click to Show/Hide
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| Family1 | Nectin family |
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| Family2 | EPCAM family |
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| Function1 |
Seems to be involved in cell adhesion through trans- homophilic and -heterophilic interactions, the latter including specifically interactions with NECTIN1. Does not act as receptor for alpha-herpesvirus entry into cells.
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| Function2 |
May function as a growth factor receptor.
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Each Antibody-drug Conjugate and Its Component Related to This Antigen
Full List of The ADC Related to This Antigen
| The Numbers of ADCs, Their Three Components, Payload Targets, and Corresponding Diseases for This Antigens | ||||
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Anti-Nectin-4/TROP2 bispecific VHH-Fc
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
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VBC103
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TOP1 inhibitor |
DNA topoisomerase 1 (TOP1) |
Undisclosed |
Anti-nectin-4/TROP2 bsAb
| ADC Name | Payload | Target | Linker | ADC Info |
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AK146D1
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DXd |
DNA topoisomerase 1 (TOP1) |
Mc-Ala-Ala-Ala |