Antigen Information

General Information of This Antigen

Antigen ID	TAR0SWIMV
Antigen Name	Envelope glycoprotein gp160 (env)
Gene Name	env
Synonym	Env polyprotein
Sequence	MRVKEKYQHLWRWGWRWGTMLLGMLMICSATEKLWVTVYYGVPVWKEATTTLFCASDAKA YDTEVHNVWATHACVPTDPNPQEVVLVNVTENFNMWKNDMVEQMHEDIISLWDQSLKPCV KLTPLCVSLKCTDLKNDTNTNSSSGRMIMEKGEIKNCSFNISTSIRGKVQKEYAFFYKLD IIPIDNDTTSYTLTSCNTSVITQACPKVSFEPIPIHYCAPAGFAILKCNNKTFNGTGPCT NVSTVQCTHGIRPVVSTQLLLNGSLAEEEVVIRSANFTDNAKTIIVQLNQSVEINCTRPN NNTRKSIRIQRGPGRAFVTIGKIGNMRQAHCNISRAKWNNTLKQIDSKLREQFGNNKTII FKQSSGGDPEIVTHSFNCGGEFFYCNSTQLFNSTWFNSTWSTKGSNNTEGSDTITLPCRI KQIINMWQEVGKAMYAPPISGQIRCSSNITGLLLTRDGGNSNNESEIFRPGGGDMRDNWR SELYKYKVVKIEPLGVAPTKAKRRVVQREKRAVGIGALFLGFLGAAGSTMGAASMTLTVQ ARQLLSGIVQQQNNLLRAIEAQQHLLQLTVWGIKQLQARILAVERYLKDQQLLGIWGCSG KLICTTAVPWNASWSNKSLEQIWNNMTWMEWDREINNYTSLIHSLIEESQNQQEKNEQEL LELDKWASLWNWFNITNWLWYIKLFIMIVGGLVGLRIVFAVLSVVNRVRQGYSPLSFQTH LPIPRGPDRPEGIEEEGGERDRDRSIRLVNGSLALIWDDLRSLCLFSYHRLRDLLLIVTR IVELLGRRGWEALKYWWNLLQYWSQELKNSAVSLLNATAIAVAEGTDRVIEVVQGAYRAI RHIPRRIRQGLERILL Click to Show/Hide
Family	HIV-1 env protein family
Function	Oligomerizes in the host endoplasmic reticulum into predominantly trimers. In a second time, gp160 transits in the host Golgi, where glycosylation is completed. The precursor is then proteolytically cleaved in the trans-Golgi and thereby activated by cellular furin or furin-like proteases to produce gp120 and gp41. Click to Show/Hide
Uniprot Entry	ENV_HV1B1

Each Antibody-drug Conjuate AND It's Component Related to This Antigen

Full List of The ADC Related to This Antigen

Anti-gp41 mAb 7B2

Antibody Info

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	Anti-gp41 mAb ricin A chain	Deglycosylated ricin A-chain (dgA)	Undisclosed	Undisclosed	[1]

B12

Antibody Info

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	B12-SG3249	SG3199	Human Deoxyribonucleic acid (hDNA)	Mal-PEG8-Val-Ala-PABC	[2]
ADC Info	B12-PEG-G2-DOX	Cis-aconityl-doxorubicin	DNA topoisomerase 2-alpha (TOP2A)	B12-PEG-G2-DOX linker	[3]
ADC Info	B12-PEG-G4-DOX	Cis-aconityl-doxorubicin	DNA topoisomerase 2-alpha (TOP2A)	B12-PEG-G4-DOX linker	[3]
ADC Info	B12-PEG-G5-DOX	Cis-aconityl-doxorubicin	DNA topoisomerase 2-alpha (TOP2A)	B12-PEG-G5-DOX linker	[3]

BAT 123

Antibody Info

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	BAT123-PAP-S	Pokeweed antiviral protein	Ribosome (RB)	Undisclosed	[4]

mD1.22

Antibody Info

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	MD1.22-DM1	Mertansine DM1	Microtubule (MT)	Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)	[5]

References

Ref 1	Identification of Anti-gp41 Monoclonal Antibodies That Effectively Target Cytotoxic Immunoconjugates to Cells Infected with Human Immunodeficiency Virus, Type 1. Vaccines (Basel). 2023 Apr 12;11(4):829. doi: 10.3390/vaccines11040829.
Ref 2	APOMAB Antibody-Drug Conjugates Targeting Dead Tumor Cells are Effective In Vivo. Mol Cancer Ther. 2019 Feb;18(2):335-345. doi: 10.1158/1535-7163.MCT-18-0842. Epub 2018 Nov 9.
Ref 3	Immune conjugate having dendron conjugated to antibody and use thereof.
Ref 4	Immunoconjugates that neutralize HIV virions kill T cells infected with diverse strains of HIV-1. J Immunol. 1990 Feb 15;144(4):1257-62.
Ref 5	A Toxin-Conjugated Recombinant Protein Targeting gp120 and gp41 for Inactivating HIV-1 Virions and Killing Latency-Reversing Agent-Reactivated Latent Cells. mBio. 2022 Feb 22;13(1):e0338421. doi: 10.1128/mbio.03384-21. Epub 2022 Jan 18.