Antigen Information

General Information of This Antigen (ID: TAR0SWIMV)
Antigen Name
Envelope glycoprotein gp160 (env)
Gene Name
env
Gene ID
30816
Synonym
Env polyprotein
Sequence
MRVKEKYQHLWRWGWRWGTMLLGMLMICSATEKLWVTVYYGVPVWKEATTTLFCASDAKA
YDTEVHNVWATHACVPTDPNPQEVVLVNVTENFNMWKNDMVEQMHEDIISLWDQSLKPCV
KLTPLCVSLKCTDLKNDTNTNSSSGRMIMEKGEIKNCSFNISTSIRGKVQKEYAFFYKLD
IIPIDNDTTSYTLTSCNTSVITQACPKVSFEPIPIHYCAPAGFAILKCNNKTFNGTGPCT
NVSTVQCTHGIRPVVSTQLLLNGSLAEEEVVIRSANFTDNAKTIIVQLNQSVEINCTRPN
NNTRKSIRIQRGPGRAFVTIGKIGNMRQAHCNISRAKWNNTLKQIDSKLREQFGNNKTII
FKQSSGGDPEIVTHSFNCGGEFFYCNSTQLFNSTWFNSTWSTKGSNNTEGSDTITLPCRI
KQIINMWQEVGKAMYAPPISGQIRCSSNITGLLLTRDGGNSNNESEIFRPGGGDMRDNWR
SELYKYKVVKIEPLGVAPTKAKRRVVQREKRAVGIGALFLGFLGAAGSTMGAASMTLTVQ
ARQLLSGIVQQQNNLLRAIEAQQHLLQLTVWGIKQLQARILAVERYLKDQQLLGIWGCSG
KLICTTAVPWNASWSNKSLEQIWNNMTWMEWDREINNYTSLIHSLIEESQNQQEKNEQEL
LELDKWASLWNWFNITNWLWYIKLFIMIVGGLVGLRIVFAVLSVVNRVRQGYSPLSFQTH
LPIPRGPDRPEGIEEEGGERDRDRSIRLVNGSLALIWDDLRSLCLFSYHRLRDLLLIVTR
IVELLGRRGWEALKYWWNLLQYWSQELKNSAVSLLNATAIAVAEGTDRVIEVVQGAYRAI
RHIPRRIRQGLERILL

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Family
HIV-1 env protein family
Function
Oligomerizes in the host endoplasmic reticulum into predominantly trimers. In a second time, gp160 transits in the host Golgi, where glycosylation is completed. The precursor is then proteolytically cleaved in the trans-Golgi and thereby activated by cellular furin or furin-like proteases to produce gp120 and gp41.

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Uniprot Entry
ENV_HV1B1
Each Antibody-drug Conjugate and Its Component Related to This Antigen
Full List of The ADC Related to This Antigen
The Numbers of ADCs, Their Three Components, Payload Targets, and Corresponding Diseases for This Antigens
Anti-gp41 mAb 7B2
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Anti-gp41 mAb ricin A chain [1]
Deglycosylated ricin A-chain (dgA)
Undisclosed
Undisclosed
 ADC Info 
ADC Name Payload Target Linker ADC Info
B12-SG3249 [2]
SG3199
Human Deoxyribonucleic acid (hDNA)
Mal-PEG8-Val-Ala-PABC
 ADC Info 
B12-PEG-G2-DOX [3]
Cis-aconityl-doxorubicin
DNA topoisomerase 2-alpha (TOP2A)
B12-PEG-G2-DOX linker
 ADC Info 
B12-PEG-G4-DOX [3]
Cis-aconityl-doxorubicin
DNA topoisomerase 2-alpha (TOP2A)
B12-PEG-G4-DOX linker
 ADC Info 
B12-PEG-G5-DOX [3]
Cis-aconityl-doxorubicin
DNA topoisomerase 2-alpha (TOP2A)
B12-PEG-G5-DOX linker
 ADC Info 
ADC Name Payload Target Linker ADC Info
BAT123-PAP-S [4]
Pokeweed antiviral protein
Ribosome (RB)
Undisclosed
 ADC Info 
ADC Name Payload Target Linker ADC Info
MD1.22-DM1 [5]
Mertansine DM1
Microtubule (MT)
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
 ADC Info 
References
Ref 1 Identification of Anti-gp41 Monoclonal Antibodies That Effectively Target Cytotoxic Immunoconjugates to Cells Infected with Human Immunodeficiency Virus, Type 1. Vaccines (Basel). 2023 Apr 12;11(4):829. doi: 10.3390/vaccines11040829.
Ref 2 APOMAB Antibody-Drug Conjugates Targeting Dead Tumor Cells are Effective In Vivo. Mol Cancer Ther. 2019 Feb;18(2):335-345. doi: 10.1158/1535-7163.MCT-18-0842. Epub 2018 Nov 9.
Ref 3 Immune conjugate having dendron conjugated to antibody and use thereof.
Ref 4 Immunoconjugates that neutralize HIV virions kill T cells infected with diverse strains of HIV-1. J Immunol. 1990 Feb 15;144(4):1257-62.
Ref 5 A Toxin-Conjugated Recombinant Protein Targeting gp120 and gp41 for Inactivating HIV-1 Virions and Killing Latency-Reversing Agent-Reactivated Latent Cells. mBio. 2022 Feb 22;13(1):e0338421. doi: 10.1128/mbio.03384-21. Epub 2022 Jan 18.