Antibody Information

General Information of This Antibody

Antibody ID	ANI0EIQGP
Antibody Name	B12
Antibody Type	Monoclonal antibody (mAb)
Antibody Subtype	Humanized IgG1-kappa
Antigen Name	Envelope glycoprotein gp160 (env)	Antigen Info

Each Antibody-drug Conjugate Related to This Antibody

Full Information of The Activity Data of The ADC(s) Related to This Antibody

B12-PEG-G5-DOX [Investigative]

ADC Info

Discovered Using Cell Line-derived Xenograft Model

Click To Hide/Show 1 Activity Data Related to This Level

Experiment 1 Reporting the Activity Date of This ADC				[1]
Efficacy Data	Tumor Growth Inhibition value (TGI)	≈ 56.39% (Day 84)
Method Description	The OVCAR-3 ovarian cancer cell line was mixed with matrigel and injected subcutaneously into Athymic nude immunodeficient mouse to observe tumor growth. After 77 days of tumor growth, treatment with the antibody (B12 antibody) and B12-Dendrimer Conjugates was initiated Nine doses were administered intraperitoneally three times a week.
In Vivo Model	OVCAR-3 CDX model
In Vitro Model	Ovarian serous adenocarcinoma	OVCAR-3 cells	CVCL_0465

References

Ref 1	Immune conjugate having dendron conjugated to antibody and use thereof.

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