Antibody-drug Conjugate Information

General Information of This Antibody-drug Conjugate (ADC)

ADC ID	DRG0NFKRP
ADC Name	Anti-gp41 mAb ricin A chain
Synonyms	Anti-gp41 mAb Deglycosylated ricin A-chain; Anti gp41 mAb Deglycosylated ricin A-chain; Click to Show/Hide
Drug Status	Investigative
Indication	In total 1 Indication(s) HIV infection [ICD11:1C60-1C62] Investigative
	3D MOL	2D MOL
Antibody Name	Anti-gp41 mAb 7B2		Antibody Info
Antigen Name	Envelope glycoprotein gp160 (env)		Antigen Info
Payload Name	Deglycosylated ricin A-chain (dgA)		Payload Info
Linker Name	Undisclosed

General Information of The Activity Data Related to This ADC

Revealed Based on the Cell Line Data

Click To Hide/Show 2 Activity Data Related to This Level

Standard Type	Value	Units	Cell Line	Disease Model
Half Maximal Inhibitory Concentration (IC50)	0.20 - 125	ng/mL	HEK293/92 ug cells	Human immunodeficiency virus type 1
Half Maximal Inhibitory Concentration (IC50)	815	ng/mL	H9/NL4-3 cells	Human immunodeficiency virus type 1

Full List of Activity Data of This Antibody-drug Conjugate

Revealed Based on the Cell Line Data

Click To Hide/Show 2 Activity Data Related to This Level

Experiment 1 Reporting the Activity Date of This ADC				[1]
Efficacy Data	Half Maximal Inhibitory Concentration (IC50)	0.20 ng/mL -125 ng/mL
Method Description	Target cells (1000-2000) were plated in triplicate in 96-well flat bottom tissue culture plates in 100 uL tissue culture medium in the presence of the indicated concentration of mAb for 1 h at 37. The secondary immunotoxin, goat anti-human IgG conjugated to ricin A chain, was then added at a final concentration of 300 ng/mL in 100 uL, and the cells were incubated for 3 days. Click to Show/Hide
In Vitro Model	Human immunodeficiency virus type 1	HEK293/92UG cells	.
Experiment 2 Reporting the Activity Date of This ADC				[1]
Efficacy Data	Half Maximal Inhibitory Concentration (IC50)	8 ng/mL - 15 ng/mL
Method Description	Target cells (1000-2000) were plated in triplicate in 96-well flat bottom tissue culture plates in 100 uL tissue culture medium in the presence of the indicated concentration of mAb for 1 h at 37. The secondary immunotoxin, goat anti-human IgG conjugated to ricin A chain, was then added at a final concentration of 300 ng/mL in 100 uL, and the cells were incubated for 3 days. Click to Show/Hide
In Vitro Model	Human immunodeficiency virus type 1	H9/NL4-3 cells	.

References

Ref 1	Identification of Anti-gp41 Monoclonal Antibodies That Effectively Target Cytotoxic Immunoconjugates to Cells Infected with Human Immunodeficiency Virus, Type 1. Vaccines (Basel). 2023 Apr 12;11(4):829. doi: 10.3390/vaccines11040829.