Antigen Information

General Information of This Antigen (ID: TAR0SJQDK)
Antigen Name
Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 (ENPP3)
Gene Name
ENPP3
Gene ID
5169
Synonym
PDNP3; Phosphodiesterase I beta;Phosphodiesterase I/nucleotide pyrophosphatase 3;CD203c
Sequence
MESTLTLATEQPVKKNTLKKYKIACIVLLALLVIMSLGLGLGLGLRKLEKQGSCRKKCFD
ASFRGLENCRCDVACKDRGDCCWDFEDTCVESTRIWMCNKFRCGETRLEASLCSCSDDCL
QRKDCCADYKSVCQGETSWLEENCDTAQQSQCPEGFDLPPVILFSMDGFRAEYLYTWDTL
MPNINKLKTCGIHSKYMRAMYPTKTFPNHYTIVTGLYPESHGIIDNNMYDVNLNKNFSLS
SKEQNNPAWWHGQPMWLTAMYQGLKAATYFWPGSEVAINGSFPSIYMPYNGSVPFEERIS
TLLKWLDLPKAERPRFYTMYFEEPDSSGHAGGPVSARVIKALQVVDHAFGMLMEGLKQRN
LHNCVNIILLADHGMDQTYCNKMEYMTDYFPRINFFYMYEGPAPRIRAHNIPHDFFSFNS
EEIVRNLSCRKPDQHFKPYLTPDLPKRLHYAKNVRIDKVHLFVDQQWLAVRSKSNTNCGG
GNHGYNNEFRSMEAIFLAHGPSFKEKTEVEPFENIEVYNLMCDLLRIQPAPNNGTHGSLN
HLLKVPFYEPSHAEEVSKFSVCGFANPLPTESLDCFCPHLQNSTQLEQVNQMLNLTQEEI
TATVKVNLPFGRPRVLQKNVDHCLLYHREYVSGFGKAMRMPMWSSYTVPQLGDTSPLPPT
VPDCLRADVRVPPSESQKCSFYLADKNITHGFLYPPASNRTSDSQYDALITSNLVPMYEE
FRKMWDYFHSVLLIKHATERNGVNVVSGPIFDYNYDGHFDAPDEITKHLANTDVPIPTHY
FVVLTSCKNKSHTPENCPGWLDVLPFIIPHRPTNVESCPEGKPEALWVEERFTAHIARVR
DVELLTGLDFYQDKVQPVSEILQLKTYLPTFETTI

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Family
NOTCH family
Function
Hydrolase that metabolizes extracellular nucleotides, including ATP, GTP, UTP and CTP. Limits mast cell and basophil responses during inflammation and during the chronic phases of allergic responses by eliminating the extracellular ATP that functions as signaling molecule and activates basophils and mast cells and induces the release of inflammatory cytokines. Metabolizes extracellular ATP in the lumen of the small intestine, and thereby prevents ATP-induced apoptosis of intestinal plasmacytoid dendritic cells. Has also alkaline phosphodiesterase activity.

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Uniprot Entry
ENPP3_HUMAN
HGNC ID
HGNC:3358
KEGG ID
hsa:5169
Each Antibody-drug Conjugate and Its Component Related to This Antigen
Full List of The ADC Related to This Antigen
The Numbers of ADCs, Their Three Components, Payload Targets, and Corresponding Diseases for This Antigens
Anti-ENPP3 AGS-16C3F mAb
 Antibody Info 
ADC Name Payload Target Linker ADC Info
AGS-16C3F
Monomethyl auristatin F
Microtubule (MT)
Maleimido-caproyl
 ADC Info 
Anti-ENPP3 antibody
 Antibody Info 
ADC Name Payload Target Linker ADC Info
JNJ-89862175
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
AGS-16M8F
Monomethyl auristatin F
Microtubule (MT)
Maleimido-caproyl
 ADC Info 
Undisclosed
 Antibody Info 
ADC Name Payload Target Linker ADC Info
SIM0680 [1]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
References
Ref 1 SIM0680, a potent antibody-drug conjugate for the treatment of solid tumors expressing ENPP3