Antigen Information

General Information of This Antigen (ID: TAR0PXBRT)
Antigen Name
Delta-like protein 4 (DLL4)
Gene Name
DLL4
Gene ID
54567
Synonym
Drosophila Delta homolog 4
Sequence
MAAASRSASGWALLLLVALWQQRAAGSGVFQLQLQEFINERGVLASGRPCEPGCRTFFRV
CLKHFQAVVSPGPCTFGTVSTPVLGTNSFAVRDDSSGGGRNPLQLPFNFTWPGTFSLIIE
AWHAPGDDLRPEALPPDALISKIAIQGSLAVGQNWLLDEQTSTLTRLRYSYRVICSDNYY
GDNCSRLCKKRNDHFGHYVCQPDGNLSCLPGWTGEYCQQPICLSGCHEQNGYCSKPAECL
CRPGWQGRLCNECIPHNGCRHGTCSTPWQCTCDEGWGGLFCDQDLNYCTHHSPCKNGATC
SNSGQRSYTCTCRPGYTGVDCELELSECDSNPCRNGGSCKDQEDGYHCLCPPGYYGLHCE
HSTLSCADSPCFNGGSCRERNQGANYACECPPNFTGSNCEKKVDRCTSNPCANGGQCLNR
GPSRMCRCRPGFTGTYCELHVSDCARNPCAHGGTCHDLENGLMCTCPAGFSGRRCEVRTS
IDACASSPCFNRATCYTDLSTDTFVCNCPYGFVGSRCEFPVGLPPSFPWVAVSLGVGLAV
LLVLLGMVAVAVRQLRLRRPDDGSREAMNNLSDFQKDNLIPAAQLKNTNQKKELEVDCGL
DKSNCGKQQNHTLDYNLAPGPLGRGTMPGKFPHSDKSLGEKAPLRLHSEKPECRISAICS
PRDSMYQSVCLISEERNECVIATEV

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Function
Involved in the Notch signaling pathway as Notch ligand. Activates NOTCH1 and NOTCH4. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Essential for retinal progenitor proliferation. Required for suppressing rod fates in late retinal progenitors as well as for proper generation of other retinal cell types. During spinal cord neurogenesis, inhibits V2a interneuron fate.

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Uniprot Entry
DLL4_HUMAN
HGNC ID
HGNC:2910
KEGG ID
hsa:54567
Each Antibody-drug Conjugate and Its Component Related to This Antigen
Full List of The ADC Related to This Antigen
The Numbers of ADCs, Their Three Components, Payload Targets, and Corresponding Diseases for This Antigens
Anti-DLL4 mAb H3L2
 Antibody Info 
ADC Name Payload Target Linker ADC Info
H3L2-mpeoDM1 [1]
Mertansine DM1
Microtubule (MT)
BIMPRO
 ADC Info 
Anti-DLL4 mAb TH2 (A121C)
 Antibody Info 
ADC Name Payload Target Linker ADC Info
TH2-mpeoDM1 [1]
Mertansine DM1
Microtubule (MT)
BIMPRO
 ADC Info 
Anti-DLL4 mAb THL4 (V207C, A121C)
 Antibody Info 
ADC Name Payload Target Linker ADC Info
THL4-mpeoDM1 [1]
Mertansine DM1
Microtubule (MT)
BIMPRO
 ADC Info 
THL4-vcMMAE [1]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
Anti-DLL4 mAb TL2 (V207C)
 Antibody Info 
ADC Name Payload Target Linker ADC Info
TL2-mpeoDM1 [1]
Mertansine DM1
Microtubule (MT)
BIMPRO
 ADC Info 
References
Ref 1 Two engineered site-specific antibody-drug conjugates, HLmD4 and HLvM4, have potent therapeutic activity in two DLL4-positive tumour xenograft models. Am J Cancer Res. 2020 Aug 1;10(8):2387-2408. eCollection 2020.