Antigen Information

General Information of This Antigen

Antigen ID	TAR0PXBRT
Antigen Name	Delta-like protein 4 (DLL4)
Gene Name	DLL4
Gene ID	54567
Synonym	Drosophila Delta homolog 4
Sequence	MAAASRSASGWALLLLVALWQQRAAGSGVFQLQLQEFINERGVLASGRPCEPGCRTFFRV CLKHFQAVVSPGPCTFGTVSTPVLGTNSFAVRDDSSGGGRNPLQLPFNFTWPGTFSLIIE AWHAPGDDLRPEALPPDALISKIAIQGSLAVGQNWLLDEQTSTLTRLRYSYRVICSDNYY GDNCSRLCKKRNDHFGHYVCQPDGNLSCLPGWTGEYCQQPICLSGCHEQNGYCSKPAECL CRPGWQGRLCNECIPHNGCRHGTCSTPWQCTCDEGWGGLFCDQDLNYCTHHSPCKNGATC SNSGQRSYTCTCRPGYTGVDCELELSECDSNPCRNGGSCKDQEDGYHCLCPPGYYGLHCE HSTLSCADSPCFNGGSCRERNQGANYACECPPNFTGSNCEKKVDRCTSNPCANGGQCLNR GPSRMCRCRPGFTGTYCELHVSDCARNPCAHGGTCHDLENGLMCTCPAGFSGRRCEVRTS IDACASSPCFNRATCYTDLSTDTFVCNCPYGFVGSRCEFPVGLPPSFPWVAVSLGVGLAV LLVLLGMVAVAVRQLRLRRPDDGSREAMNNLSDFQKDNLIPAAQLKNTNQKKELEVDCGL DKSNCGKQQNHTLDYNLAPGPLGRGTMPGKFPHSDKSLGEKAPLRLHSEKPECRISAICS PRDSMYQSVCLISEERNECVIATEV Click to Show/Hide
Function	Involved in the Notch signaling pathway as Notch ligand. Activates NOTCH1 and NOTCH4. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Essential for retinal progenitor proliferation. Required for suppressing rod fates in late retinal progenitors as well as for proper generation of other retinal cell types. During spinal cord neurogenesis, inhibits V2a interneuron fate. Click to Show/Hide
Uniprot Entry	DLL4_HUMAN
HGNC ID	HGNC:2910
KEGG ID	hsa:54567

Each Antibody-drug Conjuate AND It's Component Related to This Antigen

Full List of The ADC Related to This Antigen

Anti-DLL4 mAb H3L2

Antibody Info

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	H3L2-mpeoDM1	Mertansine DM1	Microtubule (MT)	BIMPRO	[1]

Anti-DLL4 mAb TH2 (A121C)

Antibody Info

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	TH2-mpeoDM1	Mertansine DM1	Microtubule (MT)	BIMPRO	[1]

Anti-DLL4 mAb THL4 (V207C, A121C)

Antibody Info

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	THL4-mpeoDM1	Mertansine DM1	Microtubule (MT)	BIMPRO	[1]
ADC Info	THL4-vcMMAE	Monomethyl auristatin E	Microtubule (MT)	Mc-Val-Cit-PABC	[1]

Anti-DLL4 mAb TL2 (V207C)

Antibody Info

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	TL2-mpeoDM1	Mertansine DM1	Microtubule (MT)	BIMPRO	[1]

References

Ref 1	Two engineered site-specific antibody-drug conjugates, HLmD4 and HLvM4, have potent therapeutic activity in two DLL4-positive tumour xenograft models. Am J Cancer Res. 2020 Aug 1;10(8):2387-2408. eCollection 2020.