Antigen Information

General Information of This Antigen
Antigen ID
TAR0PNBPC
Antigen Name
Neurogenic locus notch homolog protein 3 (NOTCH3)
Gene Name
NOTCH3
Sequence
MGPGARGRRRRRRPMSPPPPPPPVRALPLLLLLAGPGAAAPPCLDGSPCANGGRCTQLPS
REAACLCPPGWVGERCQLEDPCHSGPCAGRGVCQSSVVAG.FSCRCPRGFRGPDCSLPDP
CLSSPCAHGARCSVGPDGRFLCSCPPGYQGRSCRSDVDECRVGEPCRHGGTCLNTPGSFR
CQCPAGYTGPLCENPAVPCAPSPCRNGGTCRQSGDLTYDCACLPGFEGQNCEVNVDDCPG
HRCLNGGTCVDGVNTYNCQCPPEWTGQFCTEDVDECQLQPNACHNGGTCFNTLGGHSCVC
VNGWTGESCSQNIDDCATAVCFHGATCHDRVASFYCACPMGKTGLLCHLDDACVSNPCHE
DAICDTNPVNGRAICTCPPGFTGGACDQDVDECSIGANPCEHLGRCVNTQGSFLCQCGRG
YTGPRCETDVNECLSGPCRNQATCLDRIGQFTCICMAGFTGTYCEVDIDECQSSPCVNGG
VCKDRVNGFSCTCPSGFSGSTCQLDVDECASTPCRNGAKCVDQPDGYECRCAEGFEGTLC
DRNVDDCSPDPCHHGRCVDGIASFSCACAPGYTGTRCESQVDECRSQPCRHGGKCLDLVD
KYLCRCPSGTTGVNCEVNIDDCASNPCTFGVCRDGINRYDCVCQPGFTGPLCNVEINECA
SSPCGEGGSCVDGENGFRCLCPPGSLPPLCLPPSHPCAHEPCSHGICYDAPGGFRCVCEP
GWSGPRCSQSLARDACESQPCRAGGTCSSDGMGFHCTCPPGVQGRQCELLSPCTPNPCEH
GGRCESAPGQLPVCSCPQGWQGPRCQQDVDECAGPAPCGPHGICTNLAGSFSCTCHGGYT
GPSCDQDINDCDPNPCLNGGSCQDGVGSFSCSCLPGFAGPRCARDVDECLSNPCGPGTCT
DHVASFTCTCPPGYGGFHCEQDLPDCSPSSCFNGGTCVDGVNSFSCLCRPGYTGAHCQHE
ADPCLSRPCLHGGVCSAAHPGFRCTCLESFTGPQCQTLVDWCSRQPCQNGGRCVQTGAYC
LCPPGWSGRLCDIRSLPCREAAAQIGVRLEQLCQAGGQCVDEDSSHYCVCPEGRTGSHCE
QEVDPCLAQPCQHGGTCRGYMGGYMCECLPGYNGDNCEDDVDECASQPCQHGGSCIDLVA
RYLCSCPPGTLGVLCEINEDDCGPGPPLDSGPRCLHNGTCVDLVGGFRCTCPPGYTGLRC
EADINECRSGACHAAHTRDCLQDPGGGFRCLCHAGFSGPRCQTVLSPCESQPCQHGGQCR
PSPGPGGGLTFTCHCAQPFWGPRCERVARSCRELQCPVGVPCQQTPRGPRCACPPGLSGP
SCRSFPGSPPGASNASCAAAPCLHGGSCRPAPLAPFFRCACAQGWTGPRCEAPAAAPEVS
EEPRCPRAACQAKRGDQRCDRECNSPGCGWDGGDCSLSVGDPWRQCEALQCWRLFNNSRC
DPACSSPACLYDNFDCHAGGRERTCNPVYEKYCADHFADGRCDQGCNTEECGWDGLDCAS
EVPALLARGVLVLTVLLPPEELLRSSADFLQRLSAILRTSLRFRLDAHGQAMVFPYHRPS
PGSEPRARRELAPEVIGSVVMLEIDNRLCLQSPENDHCFPDAQSAADYLGALSAVERLDF
PYPLRDVRGEPLEPPEPSVPLLPLLVAGAVLLLVILVLGVMVARRKREHSTLWFPEGFSL
HKDVASGHKGRREPVGQDALGMKNMAKGESLMGEVATDWMDTECPEAKRLKVEEPGMGAE
EAVDCRQWTQHHLVAADIRVAPAMALTPPQGDADADGMDVNVRGPDGFTPLMLASFCGGA
LEPMPTEEDEADDTSASIISDLICQGAQLGARTDRTGETALHLAARYARADAAKRLLDAG
ADTNAQDHSGRTPLHTAVTADAQGVFQILIRNRSTDLDARMADGSTALILAARLAVEGMV
EELIASHADVNAVDELGKSALHWAAAVNNVEATLALLKNGANKDMQDSKEETPLFLAARE
GSYEAAKLLLDHFANREITDHLDRLPRDVAQERLHQDIVRLLDQPSGPRSPPGPHGLGPL
LCPPGAFLPGLKAAQSGSKKSRRPPGKAGLGPQGPRGRGKKLTLACPGPLADSSVTLSPV
DSLDSPRPFGGPPASPGGFPLEGPYAAATATAVSLAQLGGPGRAGLGRQPPGGCVLSLGL
LNPVAVPLDWARLPPPAPPGPSFLLPLAPGPQLLNPGTPVSPQERPPPYLAVPGHGEEYP
AAGAHSSPPKARFLRVPSEHPYLTPSPESPEHWASPSPPSLSDWSESTPSPATATGAMAT
TTGALPAQPLPLSVPSSLAQAQTQLGPQPEVTPKRQVLA

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Family
Nectin family
Function
Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs.

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Uniprot Entry
NOTC3_HUMAN
HGNC ID
HGNC:7883
KEGG ID
hsa:4854
Each Antibody-drug Conjuate AND It's Component Related to This Antigen
Full List of The ADC Related to This Antigen
Anti-NOTCH3 mAb
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
Anti-N3-vc0101
Auristatin 0101
Microtubule (MT)
Mc-Val-Cit-PABC
 [1]
Anti-NOTCH3 mAb ch28
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
Ch28-mc0131
ch28-mc0131 payload
Undisclosed
ch28-mc0131 linker
 [2]
 ADC Info 
Ch28-mc0131
ch28-mc0131 payload
Undisclosed
ch28-mc0131 linker
 [2]
 ADC Info 
ch28-vc0101
ch28-vc0101 payload
Undisclosed
ch28-vc0101 linker
 [2]
 ADC Info 
ch28-vc6780
ch28-vc6780 payload
Undisclosed
ch28-vc6780 linker
 [2]
 ADC Info 
ch28-mc0101
ch28-mc0101 payload
Undisclosed
ch28-mc0101 linker
 [2]
 ADC Info 
ch28-mc3377
ch28-mc3377 payload
Undisclosed
ch28-mc3377 linker
 [2]
 ADC Info 
ch28-mc8261
ch28-mc8261 payload
Undisclosed
ch28-mc8261 linker
 [2]
 ADC Info 
ch28-MalPeg6C2-0131
ch28-MalPeg6C2-0131 payload
Undisclosed
ch28-MalPeg6C2-0131 linker
 [2]
 ADC Info 
ch28-MalPeg6C2-8261
ch28-MalPeg6C2-8261 payload
Undisclosed
ch28-MalPeg6C2-8261 linker
 [2]
 ADC Info 
ch28-m(H20)c-0131
ch28-m(H20)c-0131 payload
Undisclosed
ch28-m(H20)c-0131 linker
 [2]
Anti-NOTCH3 mAb ch2H6
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
ch2H6-mc8261
ch2H6-mc8261 payload
Undisclosed
ch2H6-mc8261 linker
 [2]
Anti-NOTCH3 mAb ch75
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
ch75-vc0101
ch75-vc0101 payload
Undisclosed
ch75-vc0101 linker
 [2]
 ADC Info 
ch75-vc6780
ch75-vc6780 payload
Undisclosed
ch75-vc6780 linker
 [2]
 ADC Info 
ch75-me0131
ch75-me0131 payload
Undisclosed
ch75-me0131 linker
 [2]
 ADC Info 
ch75-mc3377
ch75-mc3377 payload
Undisclosed
ch75-mc3377 linker
 [2]
 ADC Info 
ch75-MalPegC2-0131
ch75-MalPegC2-0131 payload
Undisclosed
ch75-MalPegC2-0131 linker
 [2]
 ADC Info 
ch75-MalPeg6C2-8261
ch75-MalPeg6C2-8261 payload
Undisclosed
ch75-MalPeg6C2-8261 linker
 [2]
 ADC Info 
ch75-mc0131
ch75-mc0131 payload
Undisclosed
ch75-mc0131 linker
 [2]
 ADC Info 
ch75-m(H20)c-0131
ch75-m(H20)c-0131 payload
Undisclosed
ch75-m(H20)c-0131 linker
 [2]
Anti-NOTCH3 mAb hu28
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
hu28-vc0101
hu28-vc0101 payload
Undisclosed
hu28-vc0101 linker
 [2]
 ADC Info 
hu28-vc6780
hu28-vc6780 payload
Undisclosed
hu28-vc6780 linker
 [2]
Anti-NOTCH3 mAb hu75
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
hu75-vc0101
hu75-vc0101 payload
Undisclosed
hu75-vc0101 linker
 [2]
 ADC Info 
hu75-vc6780
hu75-vc6780 payload
Undisclosed
hu75-vc6780 linker
 [2]
Anti-NOTCH3 mAb huNeg8.8
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
HuNeg8.8-me0131
huNeg8.8-me0131 payload
Undisclosed
huNeg8.8-me0131 linker
 [2]
 ADC Info 
HuNeg8.8-me0131
huNeg8.8-me0131 payload
Undisclosed
huNeg8.8-me0131 linker
 [2]
 ADC Info 
huNeg8.8-vc0101
huNeg8.8-vc0101 payload
Undisclosed
huNeg8.8-vc0101 linker
 [2]
 ADC Info 
huNeg8.8-vc6780
huNeg8.8-vc6780 payload
Undisclosed
huNeg8.8-vc6780 linker
 [2]
 ADC Info 
huNeg8.8-mc3377
huNeg8.8-mc3377 payload
Undisclosed
huNeg8.8-mc3377 linker
 [2]
 ADC Info 
huNeg8.8-MalPeg6C2-8261
huNeg8.8-MalPeg6C2-8261 payload
Undisclosed
huNeg8.8-MalPeg6C2-8261 linker
 [2]
Anti-NOTCH3(i) mAb
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
Anti-N3(i)-vc0101
Auristatin 0101
Microtubule (MT)
Mc-Val-Cit-PABC
 [1]
References
Ref 1 NOTCH3-targeted antibody drug conjugates regress tumors by inducing apoptosis in receptor cells and through transendocytosis into ligand cells. Cell Rep Med. 2021 May 18;2(5):100279. doi: 10.1016/j.xcrm.2021.100279. eCollection 2021 May 18.
Ref 2 Anti-notch3 antibodies and antibody-drug conjugates.