Antigen Information

General Information of This Antigen (ID: TAR0PNBPC)
Antigen Name
Neurogenic locus notch homolog protein 3 (NOTCH3)
Gene Name
NOTCH3
Gene ID
4854
Sequence
MGPGARGRRRRRRPMSPPPPPPPVRALPLLLLLAGPGAAAPPCLDGSPCANGGRCTQLPS
REAACLCPPGWVGERCQLEDPCHSGPCAGRGVCQSSVVAG.FSCRCPRGFRGPDCSLPDP
CLSSPCAHGARCSVGPDGRFLCSCPPGYQGRSCRSDVDECRVGEPCRHGGTCLNTPGSFR
CQCPAGYTGPLCENPAVPCAPSPCRNGGTCRQSGDLTYDCACLPGFEGQNCEVNVDDCPG
HRCLNGGTCVDGVNTYNCQCPPEWTGQFCTEDVDECQLQPNACHNGGTCFNTLGGHSCVC
VNGWTGESCSQNIDDCATAVCFHGATCHDRVASFYCACPMGKTGLLCHLDDACVSNPCHE
DAICDTNPVNGRAICTCPPGFTGGACDQDVDECSIGANPCEHLGRCVNTQGSFLCQCGRG
YTGPRCETDVNECLSGPCRNQATCLDRIGQFTCICMAGFTGTYCEVDIDECQSSPCVNGG
VCKDRVNGFSCTCPSGFSGSTCQLDVDECASTPCRNGAKCVDQPDGYECRCAEGFEGTLC
DRNVDDCSPDPCHHGRCVDGIASFSCACAPGYTGTRCESQVDECRSQPCRHGGKCLDLVD
KYLCRCPSGTTGVNCEVNIDDCASNPCTFGVCRDGINRYDCVCQPGFTGPLCNVEINECA
SSPCGEGGSCVDGENGFRCLCPPGSLPPLCLPPSHPCAHEPCSHGICYDAPGGFRCVCEP
GWSGPRCSQSLARDACESQPCRAGGTCSSDGMGFHCTCPPGVQGRQCELLSPCTPNPCEH
GGRCESAPGQLPVCSCPQGWQGPRCQQDVDECAGPAPCGPHGICTNLAGSFSCTCHGGYT
GPSCDQDINDCDPNPCLNGGSCQDGVGSFSCSCLPGFAGPRCARDVDECLSNPCGPGTCT
DHVASFTCTCPPGYGGFHCEQDLPDCSPSSCFNGGTCVDGVNSFSCLCRPGYTGAHCQHE
ADPCLSRPCLHGGVCSAAHPGFRCTCLESFTGPQCQTLVDWCSRQPCQNGGRCVQTGAYC
LCPPGWSGRLCDIRSLPCREAAAQIGVRLEQLCQAGGQCVDEDSSHYCVCPEGRTGSHCE
QEVDPCLAQPCQHGGTCRGYMGGYMCECLPGYNGDNCEDDVDECASQPCQHGGSCIDLVA
RYLCSCPPGTLGVLCEINEDDCGPGPPLDSGPRCLHNGTCVDLVGGFRCTCPPGYTGLRC
EADINECRSGACHAAHTRDCLQDPGGGFRCLCHAGFSGPRCQTVLSPCESQPCQHGGQCR
PSPGPGGGLTFTCHCAQPFWGPRCERVARSCRELQCPVGVPCQQTPRGPRCACPPGLSGP
SCRSFPGSPPGASNASCAAAPCLHGGSCRPAPLAPFFRCACAQGWTGPRCEAPAAAPEVS
EEPRCPRAACQAKRGDQRCDRECNSPGCGWDGGDCSLSVGDPWRQCEALQCWRLFNNSRC
DPACSSPACLYDNFDCHAGGRERTCNPVYEKYCADHFADGRCDQGCNTEECGWDGLDCAS
EVPALLARGVLVLTVLLPPEELLRSSADFLQRLSAILRTSLRFRLDAHGQAMVFPYHRPS
PGSEPRARRELAPEVIGSVVMLEIDNRLCLQSPENDHCFPDAQSAADYLGALSAVERLDF
PYPLRDVRGEPLEPPEPSVPLLPLLVAGAVLLLVILVLGVMVARRKREHSTLWFPEGFSL
HKDVASGHKGRREPVGQDALGMKNMAKGESLMGEVATDWMDTECPEAKRLKVEEPGMGAE
EAVDCRQWTQHHLVAADIRVAPAMALTPPQGDADADGMDVNVRGPDGFTPLMLASFCGGA
LEPMPTEEDEADDTSASIISDLICQGAQLGARTDRTGETALHLAARYARADAAKRLLDAG
ADTNAQDHSGRTPLHTAVTADAQGVFQILIRNRSTDLDARMADGSTALILAARLAVEGMV
EELIASHADVNAVDELGKSALHWAAAVNNVEATLALLKNGANKDMQDSKEETPLFLAARE
GSYEAAKLLLDHFANREITDHLDRLPRDVAQERLHQDIVRLLDQPSGPRSPPGPHGLGPL
LCPPGAFLPGLKAAQSGSKKSRRPPGKAGLGPQGPRGRGKKLTLACPGPLADSSVTLSPV
DSLDSPRPFGGPPASPGGFPLEGPYAAATATAVSLAQLGGPGRAGLGRQPPGGCVLSLGL
LNPVAVPLDWARLPPPAPPGPSFLLPLAPGPQLLNPGTPVSPQERPPPYLAVPGHGEEYP
AAGAHSSPPKARFLRVPSEHPYLTPSPESPEHWASPSPPSLSDWSESTPSPATATGAMAT
TTGALPAQPLPLSVPSSLAQAQTQLGPQPEVTPKRQVLA

    Click to Show/Hide
Family
Nectin family
Function
Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs.

    Click to Show/Hide
Uniprot Entry
NOTC3_HUMAN
HGNC ID
HGNC:7883
KEGG ID
hsa:4854
Each Antibody-drug Conjugate and Its Component Related to This Antigen
Full List of The ADC Related to This Antigen
The Numbers of ADCs, Their Three Components, Payload Targets, and Corresponding Diseases for This Antigens
Anti-NOTCH3 mAb
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Anti-N3-vc0101 [1]
Auristatin 0101
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
Anti-NOTCH3 mAb ch28
 Antibody Info 
ADC Name Payload Target Linker ADC Info
ch28-vc0101 [2]
ch28-vc0101 payload
Undisclosed
ch28-vc0101 linker
 ADC Info 
ch28-vc6780 [2]
ch28-vc6780 payload
Undisclosed
ch28-vc6780 linker
 ADC Info 
ch28-mc0101 [2]
ch28-mc0101 payload
Undisclosed
ch28-mc0101 linker
 ADC Info 
Ch28-mc0131 [2]
ch28-mc0131 payload
Undisclosed
ch28-mc0131 linker
 ADC Info 
ch28-mc3377 [2]
ch28-mc3377 payload
Undisclosed
ch28-mc3377 linker
 ADC Info 
ch28-mc8261 [2]
ch28-mc8261 payload
Undisclosed
ch28-mc8261 linker
 ADC Info 
ch28-MalPeg6C2-0131 [2]
ch28-MalPeg6C2-0131 payload
Undisclosed
ch28-MalPeg6C2-0131 linker
 ADC Info 
ch28-MalPeg6C2-8261 [2]
ch28-MalPeg6C2-8261 payload
Undisclosed
ch28-MalPeg6C2-8261 linker
 ADC Info 
Ch28-mc0131 [2]
ch28-mc0131 payload
Undisclosed
ch28-mc0131 linker
 ADC Info 
ch28-m(H20)c-0131 [2]
ch28-m(H20)c-0131 payload
Undisclosed
ch28-m(H20)c-0131 linker
 ADC Info 
Anti-NOTCH3 mAb ch2H6
 Antibody Info 
ADC Name Payload Target Linker ADC Info
ch2H6-mc8261 [2]
ch2H6-mc8261 payload
Undisclosed
ch2H6-mc8261 linker
 ADC Info 
Anti-NOTCH3 mAb ch75
 Antibody Info 
ADC Name Payload Target Linker ADC Info
ch75-vc0101 [2]
ch75-vc0101 payload
Undisclosed
ch75-vc0101 linker
 ADC Info 
ch75-vc6780 [2]
ch75-vc6780 payload
Undisclosed
ch75-vc6780 linker
 ADC Info 
ch75-me0131 [2]
ch75-me0131 payload
Undisclosed
ch75-me0131 linker
 ADC Info 
ch75-mc3377 [2]
ch75-mc3377 payload
Undisclosed
ch75-mc3377 linker
 ADC Info 
ch75-MalPegC2-0131 [2]
ch75-MalPegC2-0131 payload
Undisclosed
ch75-MalPegC2-0131 linker
 ADC Info 
ch75-MalPeg6C2-8261 [2]
ch75-MalPeg6C2-8261 payload
Undisclosed
ch75-MalPeg6C2-8261 linker
 ADC Info 
ch75-mc0131 [2]
ch75-mc0131 payload
Undisclosed
ch75-mc0131 linker
 ADC Info 
ch75-m(H20)c-0131 [2]
ch75-m(H20)c-0131 payload
Undisclosed
ch75-m(H20)c-0131 linker
 ADC Info 
Anti-NOTCH3 mAb hu28
 Antibody Info 
ADC Name Payload Target Linker ADC Info
hu28-vc0101 [2]
hu28-vc0101 payload
Undisclosed
hu28-vc0101 linker
 ADC Info 
hu28-vc6780 [2]
hu28-vc6780 payload
Undisclosed
hu28-vc6780 linker
 ADC Info 
Anti-NOTCH3 mAb hu75
 Antibody Info 
ADC Name Payload Target Linker ADC Info
hu75-vc0101 [2]
hu75-vc0101 payload
Undisclosed
hu75-vc0101 linker
 ADC Info 
hu75-vc6780 [2]
hu75-vc6780 payload
Undisclosed
hu75-vc6780 linker
 ADC Info 
Anti-NOTCH3 mAb huNeg8.8
 Antibody Info 
ADC Name Payload Target Linker ADC Info
huNeg8.8-vc0101 [2]
huNeg8.8-vc0101 payload
Undisclosed
huNeg8.8-vc0101 linker
 ADC Info 
huNeg8.8-vc6780 [2]
huNeg8.8-vc6780 payload
Undisclosed
huNeg8.8-vc6780 linker
 ADC Info 
HuNeg8.8-me0131 [2]
huNeg8.8-me0131 payload
Undisclosed
huNeg8.8-me0131 linker
 ADC Info 
huNeg8.8-mc3377 [2]
huNeg8.8-mc3377 payload
Undisclosed
huNeg8.8-mc3377 linker
 ADC Info 
HuNeg8.8-me0131 [2]
huNeg8.8-me0131 payload
Undisclosed
huNeg8.8-me0131 linker
 ADC Info 
huNeg8.8-MalPeg6C2-8261 [2]
huNeg8.8-MalPeg6C2-8261 payload
Undisclosed
huNeg8.8-MalPeg6C2-8261 linker
 ADC Info 
Anti-NOTCH3(i) mAb
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Anti-N3(i)-vc0101 [1]
Auristatin 0101
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
ADC Name Payload Target Linker ADC Info
PF-06650808
Auristatin 0101 (Aur0101)
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
References
Ref 1 NOTCH3-targeted antibody drug conjugates regress tumors by inducing apoptosis in receptor cells and through transendocytosis into ligand cells. Cell Rep Med. 2021 May 18;2(5):100279. doi: 10.1016/j.xcrm.2021.100279. eCollection 2021 May 18.
Ref 2 Anti-notch3 antibodies and antibody-drug conjugates.