Antigen Information

General Information of This Antigen (ID: TAR0OYOTT)
Antigen Name
Epidermal growth factor receptor variant III (EGFRvIII)
Gene Name
EGFRvIII
Gene ID
1956
Synonym
ERBBvIII; ERBB1vIII; HER1vIII; Proto-oncogene c-ErbB-1vIII;Receptor tyrosine-protein kinase erbB-1vIII
Family
Tyr protein family
Function
EGFRvIII is a tumor-specific mutation that results from in-frame deletion of 801 base pairs spanning exons 27 of the coding sequence . This deletion removes 267 amino acids from the extracellular domain, creating a junction site between exons 1 and 8 and a new glycine residue.

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Uniprot Entry
EGFR_HUMAN
HGNC ID
HGNC:3236
KEGG ID
hsa:1956
Each Antibody-drug Conjugate and Its Component Related to This Antigen
Full List of The ADC Related to This Antigen
The Numbers of ADCs, Their Three Components, Payload Targets, and Corresponding Diseases for This Antigens
2A1-LC-Cys110ins
 Antibody Info 
ADC Name Payload Target Linker ADC Info
2A1-LC-Cys110ins-mc-vc-PAB-MMAE TDC [1]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
2A1-LC-Cys111ins
 Antibody Info 
ADC Name Payload Target Linker ADC Info
2A1-LC-Cys111ins-mc-vc-PAB-MMAE TDC [1]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
2A1-LC-Cys142ins
 Antibody Info 
ADC Name Payload Target Linker ADC Info
2A1-LC-Cys142ins-mc-vc-PAB-MMAE TDC [1]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
2A1-LC-Cys271ins
 Antibody Info 
ADC Name Payload Target Linker ADC Info
2A1-LC-Cys272ins-mc-vc-PAB-MMAE TDC (1.74) [1]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
2A1-LC-Cys272ins
 Antibody Info 
ADC Name Payload Target Linker ADC Info
2A1-LC-Cys272ins-mc-vc-PAB-MMAE TDC (1.77) [1]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
2A1-LC-Cys275ins
 Antibody Info 
ADC Name Payload Target Linker ADC Info
2A1-LC-Cys275ins-mc-vc-PAB-MMAE TDC [1]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
2A1-LC-Cys276ins
 Antibody Info 
ADC Name Payload Target Linker ADC Info
2A1-LC-Cys276ins-mc-vc-PAB-MMAE TDC [1]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
2A1-LC-Cys381ins
 Antibody Info 
ADC Name Payload Target Linker ADC Info
2A1-LC-Cys381ins-mc-vc-PAB-MMAE TDC [1]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
2A1-LC-Cys382ins
 Antibody Info 
ADC Name Payload Target Linker ADC Info
2A1-LC-Cys382ins-mc-vc-PAB-MMAE TDC [1]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
2A1-LC-Cys384
 Antibody Info 
ADC Name Payload Target Linker ADC Info
2A1-LC-Cys384ins-mc-vc-PAB-MMAE TDC [1]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
2A1-LC-Cys407ins
 Antibody Info 
ADC Name Payload Target Linker ADC Info
2A1-LC-Cys407ins-mc-vc-PAB-MMAE TDC [1]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
2A1-LC-Cys408ins
 Antibody Info 
ADC Name Payload Target Linker ADC Info
2A1-LC-Cys408ins-mc-vc-PAB-MMAE TDC [1]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
2A1-LC-Cys418ins
 Antibody Info 
ADC Name Payload Target Linker ADC Info
2A1-LC-Cys418ins-mc-vc-PAB-MMAE TDC [1]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
2A1-LC-Cys419ins
 Antibody Info 
ADC Name Payload Target Linker ADC Info
2A1-LC-Cys419ins-mc-vc-PAB-MMAE TDC [1]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
2A1-LC-Cys445ins
 Antibody Info 
ADC Name Payload Target Linker ADC Info
2A1-LC-Cys445ins-mc-vc-PAB-MMAE TDC [1]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
Anti-EGFRvIII mAb
 Antibody Info 
ADC Name Payload Target Linker ADC Info
AMG 595
DM1
Microtubule (MT)
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
 ADC Info 
Homo-Ang2-Cys5.5 conjugate DAR 4 [2]
Angiopep-2 TFA
Undisclosed
Mal-DBCO-PEG3
 ADC Info 
Homo-Ang2-Cys5.5 conjugate DAR 8 [2]
Angiopep-2 TFA
Undisclosed
Mal-DBCO-PEG3
 ADC Info 
Hetero-Ang2-Cys5.5 conjugate [2]
Angiopep-2 TFA
Undisclosed
Mal-DBCO-PEG3
 ADC Info 
EGFRvIII-16 [3]
DM1 derivative 16
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
EGFRvIII-MCC-DM1 [3]
Mertansine DM1
Microtubule (MT)
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
 ADC Info 
Chimeric anti-EGFRvIII AMG-595 mAb
 Antibody Info 
ADC Name Payload Target Linker ADC Info
EP4487874A1-3c [4]
undisclosed
Undisclosed
EP4487874A1-3linker
 ADC Info 
Depatuxizumab
 Antibody Info 
ADC Name Payload Target Linker ADC Info
WO2017089895A1 ADC73 [5]
Monomethyl auristatin F
Microtubule (MT)
WO2017089895A1_ADC73 linker
 ADC Info 
WO2017089895A1 ADC74 [5]
Monomethyl auristatin E
Microtubule (MT)
WO2017089895A1_ADC74 linker
 ADC Info 
WO2017089895A1 ADC75 [5]
Monomethyl auristatin F
Microtubule (MT)
WO2017089895A1_ADC75 linker
 ADC Info 
ADC Name Payload Target Linker ADC Info
PD0721-DOX ADC [6]
Doxorubicin
DNA topoisomerase 2-alpha (TOP2A)
dextran T-10
 ADC Info 
ADC Name Payload Target Linker ADC Info
REGN-3124-PBD [7]
SG3199
Human Deoxyribonucleic acid (hDNA)
Mal-PEG8-Val-Ala-PABC
 ADC Info 
Undisclosed
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Anti-EGFRvIII antibody drug conjugate (Regeneron Pharmaceuticals, Inc.) [8]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
LCB-76 [9]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
LCB14-19nm [10]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
Anti-EGFRv3 antibody-drug conjugate [11]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
EGFRvIII/MMAE antibody drug conjugate [12]
Monomethyl auristatin E
Microtubule (MT)
Undisclosed
 ADC Info 
References
Ref 1 Screening of site-specific conjugation sites of cysteine-engineered antibody-toxin complexes (TDCs)
Ref 2 Homogeneous antibody-angiopep 2 conjugates for effective brain targeting. RSC Adv. 2022 Jan 26;12(6):3359-3364.
Ref 3 Antibody drug conjugates of cleavable amino-alkyl and aryl maytansinoids. Bioorg Med Chem. 2018 May 15;26(9):2271-2279. doi: 10.1016/j.bmc.2018.02.025. Epub 2018 Feb 21.
Ref 4 Antibody-drug conjugate precursor and intermediate for synthesis thereof
Ref 5 Antibody-drug conjugates comprising branched linkers and methods related thereto; 2017-06-01.
Ref 6 Preparation and evaluation of the PD0721-DOX antibody-drug conjugate targeting EGFRvIII to inhibit glioblastoma
Ref 7 Introduction to basic information on ADC drug REGN3124-PBD.
Ref 8 Introduction to basic information on ADC drug Anti-EGFRvIII antibody drug conjugate (Regeneron Pharmaceuticals, Inc.)
Ref 9 Legochem biosciences: Biopharmaceutical company with robust milestone potential; 2019
Ref 10 ADC review: basic information about LCB14-19NM.
Ref 11 Introduction to basic information on ADC drug Anti-EGFRv3 antibody-drug conjugate(XDCExplorer)
Ref 12 Introduction to basic information on EGFRvIII/MMAE antibody drug conjugate(Abgenix, Inc.).