Antigen ID	TAR0OYOTT
Antigen Name	Epidermal growth factor receptor variant III (EGFRvIII)
Gene Name	EGFRvIII
Gene ID	1956
Synonym	ERBBvIII; ERBB1vIII; HER1vIII; Proto-oncogene c-ErbB-1vIII;Receptor tyrosine-protein kinase erbB-1vIII
Family	Tyr protein family
Function	EGFRvIII is a tumor-specific mutation that results from in-frame deletion of 801 base pairs spanning exons 27 of the coding sequence . This deletion removes 267 amino acids from the extracellular domain, creating a junction site between exons 1 and 8 and a new glycine residue.     Click to Show/Hide
Uniprot Entry	EGFR_HUMAN
HGNC ID	HGNC:3236
KEGG ID	hsa:1956

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	2A1-LC-Cys110ins-mc-vc-PAB-MMAE TDC	Monomethyl auristatin E	Microtubule (MT)	Mc-Val-Cit-PABC	[1]

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	2A1-LC-Cys111ins-mc-vc-PAB-MMAE TDC	Monomethyl auristatin E	Microtubule (MT)	Mc-Val-Cit-PABC	[1]

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	2A1-LC-Cys142ins-mc-vc-PAB-MMAE TDC	Monomethyl auristatin E	Microtubule (MT)	Mc-Val-Cit-PABC	[1]

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	2A1-LC-Cys272ins-mc-vc-PAB-MMAE TDC (1.74)	Monomethyl auristatin E	Microtubule (MT)	Mc-Val-Cit-PABC	[1]

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	2A1-LC-Cys272ins-mc-vc-PAB-MMAE TDC (1.77)	Monomethyl auristatin E	Microtubule (MT)	Mc-Val-Cit-PABC	[1]

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	2A1-LC-Cys275ins-mc-vc-PAB-MMAE TDC	Monomethyl auristatin E	Microtubule (MT)	Mc-Val-Cit-PABC	[1]

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	2A1-LC-Cys276ins-mc-vc-PAB-MMAE TDC	Monomethyl auristatin E	Microtubule (MT)	Mc-Val-Cit-PABC	[1]

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	2A1-LC-Cys381ins-mc-vc-PAB-MMAE TDC	Monomethyl auristatin E	Microtubule (MT)	Mc-Val-Cit-PABC	[1]

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	2A1-LC-Cys382ins-mc-vc-PAB-MMAE TDC	Monomethyl auristatin E	Microtubule (MT)	Mc-Val-Cit-PABC	[1]

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	2A1-LC-Cys384ins-mc-vc-PAB-MMAE TDC	Monomethyl auristatin E	Microtubule (MT)	Mc-Val-Cit-PABC	[1]

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	2A1-LC-Cys407ins-mc-vc-PAB-MMAE TDC	Monomethyl auristatin E	Microtubule (MT)	Mc-Val-Cit-PABC	[1]

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	2A1-LC-Cys408ins-mc-vc-PAB-MMAE TDC	Monomethyl auristatin E	Microtubule (MT)	Mc-Val-Cit-PABC	[1]

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	2A1-LC-Cys418ins-mc-vc-PAB-MMAE TDC	Monomethyl auristatin E	Microtubule (MT)	Mc-Val-Cit-PABC	[1]

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	2A1-LC-Cys419ins-mc-vc-PAB-MMAE TDC	Monomethyl auristatin E	Microtubule (MT)	Mc-Val-Cit-PABC	[1]

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	2A1-LC-Cys445ins-mc-vc-PAB-MMAE TDC	Monomethyl auristatin E	Microtubule (MT)	Mc-Val-Cit-PABC	[1]

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	AMG 595	DM1	Microtubule (MT)	Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
ADC Info	Homo-Ang2-Cys5.5 conjugate DAR 4	Angiopep-2 TFA	Undisclosed	Mal-DBCO-PEG3	[2]
ADC Info	Homo-Ang2-Cys5.5 conjugate DAR 8	Angiopep-2 TFA	Undisclosed	Mal-DBCO-PEG3	[2]
ADC Info	Hetero-Ang2-Cys5.5 conjugate	Angiopep-2 TFA	Undisclosed	Mal-DBCO-PEG3	[2]
ADC Info	EGFRvIII-16	DM1 derivative 16	Microtubule (MT)	Mc-Val-Cit-PABC	[3]
ADC Info	EGFRvIII-MCC-DM1	Mertansine DM1	Microtubule (MT)	Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)	[3]

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	EP4487874A1-3c	undisclosed	Undisclosed	EP4487874A1-3linker	[4]

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	WO2017089895A1 ADC73	Monomethyl auristatin F	Microtubule (MT)	WO2017089895A1_ADC73 linker	[5]
ADC Info	WO2017089895A1 ADC74	Monomethyl auristatin E	Microtubule (MT)	WO2017089895A1_ADC74 linker	[5]
ADC Info	WO2017089895A1 ADC75	Monomethyl auristatin F	Microtubule (MT)	WO2017089895A1_ADC75 linker	[5]

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	PD0721-DOX ADC	Doxorubicin	DNA topoisomerase 2-alpha (TOP2A)	dextran T-10	[6]

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	REGN-3124-PBD	SG3199	Human Deoxyribonucleic acid (hDNA)	Mal-PEG8-Val-Ala-PABC	[7]

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	Anti-EGFRvIII antibody drug conjugate (Regeneron Pharmaceuticals, Inc.)	Undisclosed	Undisclosed	Undisclosed	[8]
ADC Info	LCB-76	Undisclosed	Undisclosed	Undisclosed	[9]
ADC Info	LCB14-19nm	Undisclosed	Undisclosed	Undisclosed	[10]
ADC Info	Anti-EGFRv3 antibody-drug conjugate	Undisclosed	Undisclosed	Undisclosed	[11]
ADC Info	EGFRvIII/MMAE antibody drug conjugate	Monomethyl auristatin E	Microtubule (MT)	Undisclosed	[12]

Ref 1	Screening of site-specific conjugation sites of cysteine-engineered antibody-toxin complexes (TDCs)
Ref 2	Homogeneous antibody-angiopep 2 conjugates for effective brain targeting. RSC Adv. 2022 Jan 26;12(6):3359-3364.
Ref 3	Antibody drug conjugates of cleavable amino-alkyl and aryl maytansinoids. Bioorg Med Chem. 2018 May 15;26(9):2271-2279. doi: 10.1016/j.bmc.2018.02.025. Epub 2018 Feb 21.
Ref 4	Antibody-drug conjugate precursor and intermediate for synthesis thereof
Ref 5	Antibody-drug conjugates comprising branched linkers and methods related thereto; 2017-06-01.
Ref 6	Preparation and evaluation of the PD0721-DOX antibody-drug conjugate targeting EGFRvIII to inhibit glioblastoma
Ref 7	Introduction to basic information on ADC drug REGN3124-PBD.
Ref 8	Introduction to basic information on ADC drug Anti-EGFRvIII antibody drug conjugate (Regeneron Pharmaceuticals, Inc.)
Ref 9	Legochem biosciences: Biopharmaceutical company with robust milestone potential; 2019
Ref 10	ADC review: basic information about LCB14-19NM.
Ref 11	Introduction to basic information on ADC drug Anti-EGFRv3 antibody-drug conjugate(XDCExplorer)
Ref 12	Introduction to basic information on EGFRvIII/MMAE antibody drug conjugate(Abgenix, Inc.).