Antigen ID	TAR0OYOTT
Antigen Name	Epidermal growth factor receptor variant III (EGFRvIII)
Gene Name	EGFRvIII
Gene ID	1956
Synonym	ERBBvIII; ERBB1vIII; HER1vIII; Proto-oncogene c-ErbB-1vIII;Receptor tyrosine-protein kinase erbB-1vIII
Family	Tyr protein family
Function	EGFRvIII is a tumor-specific mutation that results from in-frame deletion of 801 base pairs spanning exons 27 of the coding sequence . This deletion removes 267 amino acids from the extracellular domain, creating a junction site between exons 1 and 8 and a new glycine residue.     Click to Show/Hide
Uniprot Entry	EGFR_HUMAN
HGNC ID	HGNC:3236
KEGG ID	hsa:1956

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	Hetero-Ang2-Cys5.5 conjugate	Angiopep-2 TFA	Undisclosed	Mal-DBCO-PEG3	[1]
ADC Info	Homo-Ang2-Cys5.5 conjugate DAR 4	Angiopep-2 TFA	Undisclosed	Mal-DBCO-PEG3	[1]
ADC Info	Homo-Ang2-Cys5.5 conjugate DAR 8	Angiopep-2 TFA	Undisclosed	Mal-DBCO-PEG3	[1]
ADC Info	EGFRvIII-16	DM1 derivative 16	Microtubule (MT)	Mc-Val-Cit-PABC	[2]
ADC Info	EGFRvIII-MCC-DM1	Mertansine DM1	Microtubule (MT)	Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)	[2]

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	AMG-595	Mertansine DM1	Microtubule (MT)	Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)	[3]

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	WO2017089895A1 ADC73	Monomethyl auristatin F	Microtubule (MT)	WO2017089895A1_ADC73 linker	[4]
ADC Info	WO2017089895A1 ADC74	Monomethyl auristatin E	Microtubule (MT)	WO2017089895A1_ADC74 linker	[4]
ADC Info	WO2017089895A1 ADC75	Monomethyl auristatin F	Microtubule (MT)	WO2017089895A1_ADC75 linker	[4]

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	REGN-3124-PBD	SG3199	Human Deoxyribonucleic acid (hDNA)	Mal-PEG8-Val-Ala-PABC	[5]

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	LCB14-19nm	Undisclosed	Undisclosed	Undisclosed	[6]
ADC Info	Anti-EGFRvIII antibody drug conjugate (Regeneron Pharmaceuticals, Inc.)	Undisclosed	Undisclosed	Undisclosed	[7]
ADC Info	LCB-76	Undisclosed	Undisclosed	Undisclosed	[8]
ADC Info	Anti-EGFRv3 antibody-drug conjugate	Undisclosed	Undisclosed	Undisclosed	[9]
ADC Info	EGFRvIII/MMAE antibody drug conjugate	Monomethyl auristatin E	Microtubule (MT)	Undisclosed	[10]

Differential expression pattern of antigen in diseases
The Studied Tissue	Gingival
The Specific Disease	Bacterial infection of gingival
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.121787504; Fold-change: -0.254498943; Z-score: -0.419900828
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Differential expression pattern of antigen in diseases
The Studied Tissue	Brainstem
The Specific Disease	Glioma
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 2.09E-05; Fold-change: 0.396422438; Z-score: 190.0757185
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The Studied Tissue	White matter
The Specific Disease	Glioma
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.000631625; Fold-change: 0.387503368; Z-score: 1.694165237
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The Studied Tissue	Brainstem
The Specific Disease	Neuroectodermal tumor
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 1.84E-08; Fold-change: -1.120738166; Z-score: -4.445591048
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The Studied Tissue	Nervous
The Specific Disease	Brain cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 8.30E-26; Fold-change: 0.062080465; Z-score: 0.13172412
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Differential expression pattern of antigen in diseases
The Studied Tissue	Whole blood
The Specific Disease	Polycythemia vera
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.023361705; Fold-change: 0.035974971; Z-score: 0.227643588
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The Studied Tissue	Whole blood
The Specific Disease	Myelofibrosis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.780007905; Fold-change: -0.012254581; Z-score: -0.090792428
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Differential expression pattern of antigen in diseases
The Studied Tissue	Bone marrow
The Specific Disease	Myelodysplastic syndromes
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.245724038; Fold-change: 0.010369981; Z-score: 0.049585497
The Expression Level of Disease Section Compare with the Adjacent Tissue	p-value: 0.168196738; Fold-change: -0.06784742; Z-score: -0.779471035
Disease-specific Antigen Abundances		Click to View the Clearer Original Diagram
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Differential expression pattern of antigen in diseases
The Studied Tissue	Tonsil
The Specific Disease	Lymphoma
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.382643541; Fold-change: -0.113681087; Z-score: -0.315728038
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Differential expression pattern of antigen in diseases
The Studied Tissue	Gastric
The Specific Disease	Gastric cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.252471843; Fold-change: -0.417321215; Z-score: -2.17289188
The Expression Level of Disease Section Compare with the Adjacent Tissue	p-value: 5.61E-08; Fold-change: 0.32109048; Z-score: 1.408689643
Disease-specific Antigen Abundances		Click to View the Clearer Original Diagram
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Differential expression pattern of antigen in diseases
The Studied Tissue	Colon
The Specific Disease	Colon cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 5.14E-21; Fold-change: -0.549885654; Z-score: -1.154337396
The Expression Level of Disease Section Compare with the Adjacent Tissue	p-value: 1.48E-05; Fold-change: -0.209904054; Z-score: -0.392291048
Disease-specific Antigen Abundances		Click to View the Clearer Original Diagram
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Differential expression pattern of antigen in diseases
The Studied Tissue	Pancreas
The Specific Disease	Pancreatic cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.03639932; Fold-change: -0.64126062; Z-score: -1.023741138
The Expression Level of Disease Section Compare with the Adjacent Tissue	p-value: 0.001755119; Fold-change: -0.285448426; Z-score: -0.648715881
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Differential expression pattern of antigen in diseases
The Studied Tissue	Liver
The Specific Disease	Liver cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 2.70E-06; Fold-change: -0.504393522; Z-score: -1.087146684
The Expression Level of Disease Section Compare with the Adjacent Tissue	p-value: 0.033310941; Fold-change: -0.131769897; Z-score: -0.267655476
The Expression Level of Disease Section Compare with the Other Disease Section	p-value: 0.608500766; Fold-change: -0.18721522; Z-score: -0.18802746
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Differential expression pattern of antigen in diseases
The Studied Tissue	Lung
The Specific Disease	Lung cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.164956308; Fold-change: -0.042320445; Z-score: -0.085238641
The Expression Level of Disease Section Compare with the Adjacent Tissue	p-value: 0.001575769; Fold-change: -0.213812939; Z-score: -0.347873589
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Differential expression pattern of antigen in diseases
The Studied Tissue	Skin
The Specific Disease	Melanoma
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.160431517; Fold-change: -0.338741165; Z-score: -0.229797397
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Differential expression pattern of antigen in diseases
The Studied Tissue	Muscle
The Specific Disease	Sarcoma
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 3.73E-07; Fold-change: -0.312000231; Z-score: -0.878853628
The Expression Level of Disease Section Compare with the Adjacent Tissue	p-value: 0.000108127; Fold-change: -1.098281997; Z-score: -7.394373073
Disease-specific Antigen Abundances		Click to View the Clearer Original Diagram
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Differential expression pattern of antigen in diseases
The Studied Tissue	Breast
The Specific Disease	Breast cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 1.04E-65; Fold-change: -0.887115361; Z-score: -1.532278
The Expression Level of Disease Section Compare with the Adjacent Tissue	p-value: 2.77E-16; Fold-change: -0.949187635; Z-score: -1.790429737
Disease-specific Antigen Abundances		Click to View the Clearer Original Diagram
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Differential expression pattern of antigen in diseases
The Studied Tissue	Ovarian
The Specific Disease	Ovarian cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.925191665; Fold-change: -0.010248209; Z-score: -0.026218784
The Expression Level of Disease Section Compare with the Adjacent Tissue	p-value: 6.76E-06; Fold-change: -1.284050058; Z-score: -2.322986612
Disease-specific Antigen Abundances		Click to View the Clearer Original Diagram
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Differential expression pattern of antigen in diseases
The Studied Tissue	Cervical
The Specific Disease	Cervical cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.769460628; Fold-change: 0.010058153; Z-score: 0.021355021
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Differential expression pattern of antigen in diseases
The Studied Tissue	Endometrium
The Specific Disease	Uterine cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 1.71E-09; Fold-change: 0.623510206; Z-score: 0.938068284
The Expression Level of Disease Section Compare with the Adjacent Tissue	p-value: 0.390101917; Fold-change: -0.057920151; Z-score: -0.123770742
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Differential expression pattern of antigen in diseases
The Studied Tissue	Prostate
The Specific Disease	Prostate cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.000743224; Fold-change: -0.592164553; Z-score: -0.822129897
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Differential expression pattern of antigen in diseases
The Studied Tissue	Bladder
The Specific Disease	Bladder cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.58673616; Fold-change: 0.085155974; Z-score: 0.286686437
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Differential expression pattern of antigen in diseases
The Studied Tissue	Uvea
The Specific Disease	Retinoblastoma tumor
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 7.30E-06; Fold-change: -0.662124792; Z-score: -2.090981006
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Differential expression pattern of antigen in diseases
The Studied Tissue	Thyroid
The Specific Disease	Thyroid cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.683903471; Fold-change: -0.029613946; Z-score: -0.057603505
The Expression Level of Disease Section Compare with the Adjacent Tissue	p-value: 1.68E-08; Fold-change: 0.500840739; Z-score: 1.453378587
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Differential expression pattern of antigen in diseases
The Studied Tissue	Adrenal cortex
The Specific Disease	Adrenocortical carcinoma
The Expression Level of Disease Section Compare with the Other Disease Section	p-value: 0.109089592; Fold-change: 0.031285712; Z-score: 0.129918335
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Differential expression pattern of antigen in diseases
The Studied Tissue	Head and neck
The Specific Disease	Head and neck cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 5.84E-05; Fold-change: 0.319225343; Z-score: 0.547839158
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Differential expression pattern of antigen in diseases
The Studied Tissue	Pituitary
The Specific Disease	Pituitary gonadotrope tumor
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.015412629; Fold-change: -0.489406007; Z-score: -1.140504972
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The Studied Tissue	Pituitary
The Specific Disease	Pituitary cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.122089427; Fold-change: -0.293885551; Z-score: -0.80993597
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Differential expression pattern of antigen in diseases
The Studied Tissue	Whole blood
The Specific Disease	Thrombocytopenia
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.942721697; Fold-change: -0.042865227; Z-score: -0.191437293
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Differential expression pattern of antigen in diseases
The Studied Tissue	Whole blood
The Specific Disease	Lupus erythematosus
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.060176056; Fold-change: -0.170491985; Z-score: -0.261805293
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Differential expression pattern of antigen in diseases
The Studied Tissue	Peripheral monocyte
The Specific Disease	Autoimmune uveitis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.634565667; Fold-change: 0.029451646; Z-score: 0.140909164
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Differential expression pattern of antigen in diseases
The Studied Tissue	Whole blood
The Specific Disease	Familial hypercholesterolemia
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.000346456; Fold-change: -0.350577711; Z-score: -0.993142958
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Differential expression pattern of antigen in diseases
The Studied Tissue	Superior temporal cortex
The Specific Disease	Schizophrenia
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.23777059; Fold-change: -0.084417876; Z-score: -0.573046233
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Differential expression pattern of antigen in diseases
The Studied Tissue	Spinal cord
The Specific Disease	Multiple sclerosis
The Expression Level of Disease Section Compare with the Adjacent Tissue	p-value: 0.520674685; Fold-change: -0.119960855; Z-score: -0.442952499
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The Studied Tissue	Plasmacytoid dendritic cells
The Specific Disease	Multiple sclerosis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.474407287; Fold-change: 0.195749632; Z-score: 0.662938559
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Differential expression pattern of antigen in diseases
The Studied Tissue	Peritumoral cortex
The Specific Disease	Epilepsy
The Expression Level of Disease Section Compare with the Other Disease Section	p-value: 0.659908366; Fold-change: 0.078503686; Z-score: 0.435042009
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Differential expression pattern of antigen in diseases
The Studied Tissue	Whole blood
The Specific Disease	Cardioembolic Stroke
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.39698865; Fold-change: 0.035946392; Z-score: 0.19461223
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The Studied Tissue	Peripheral blood
The Specific Disease	Ischemic stroke
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.073526156; Fold-change: 0.108240012; Z-score: 0.73718389
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Differential expression pattern of antigen in diseases
The Studied Tissue	White matter
The Specific Disease	HIV
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.133889529; Fold-change: -0.176283458; Z-score: -0.387609293
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Differential expression pattern of antigen in diseases
The Studied Tissue	Whole blood
The Specific Disease	Influenza
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.139528889; Fold-change: 0.412341351; Z-score: 1.852115602
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Differential expression pattern of antigen in diseases
The Studied Tissue	Whole blood
The Specific Disease	Chronic hepatitis C
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.582291712; Fold-change: 0.047900891; Z-score: 0.46130085
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Differential expression pattern of antigen in diseases
The Studied Tissue	Whole blood
The Specific Disease	Sepsis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.402318482; Fold-change: 0.039282315; Z-score: 0.13131953
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Differential expression pattern of antigen in diseases
The Studied Tissue	Whole blood
The Specific Disease	Septic shock
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.086003296; Fold-change: 0.069049426; Z-score: 0.200171879
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Differential expression pattern of antigen in diseases
The Studied Tissue	Peripheral blood
The Specific Disease	Pediatric respiratory syncytial virus infection
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.395692091; Fold-change: -0.06026284; Z-score: -0.455226207
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Differential expression pattern of antigen in diseases
The Studied Tissue	Peripheral blood
The Specific Disease	Essential hypertension
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.741457622; Fold-change: 0.066107405; Z-score: 0.417449878
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Differential expression pattern of antigen in diseases
The Studied Tissue	Peripheral blood
The Specific Disease	Myocardial infarction
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.176114839; Fold-change: 0.198467306; Z-score: 0.232030886
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Differential expression pattern of antigen in diseases
The Studied Tissue	Peripheral blood
The Specific Disease	Coronary artery disease
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.314246566; Fold-change: -0.117301611; Z-score: -0.664369762
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Differential expression pattern of antigen in diseases
The Studied Tissue	Calcified aortic valve
The Specific Disease	Aortic stenosis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.130891099; Fold-change: -0.540734048; Z-score: -1.146145153
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Differential expression pattern of antigen in diseases
The Studied Tissue	Peripheral blood
The Specific Disease	Arteriosclerosis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.696195472; Fold-change: -0.002257291; Z-score: -0.014839449
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Differential expression pattern of antigen in diseases
The Studied Tissue	Intracranial artery
The Specific Disease	Aneurysm
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.712803996; Fold-change: 0.021868361; Z-score: 0.07116771
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Differential expression pattern of antigen in diseases
The Studied Tissue	Peripheral blood
The Specific Disease	Immunodeficiency
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.258565971; Fold-change: 0.061648407; Z-score: 0.539830147
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Differential expression pattern of antigen in diseases
The Studied Tissue	Hyperplastic tonsil
The Specific Disease	Apnea
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.204433132; Fold-change: -0.516404571; Z-score: -1.886059739
Disease-specific Antigen Abundances		Click to View the Clearer Original Diagram
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Differential expression pattern of antigen in diseases
The Studied Tissue	Peripheral blood
The Specific Disease	Olive pollen allergy
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.022020098; Fold-change: 0.07425653; Z-score: 0.747551657
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Differential expression pattern of antigen in diseases
The Studied Tissue	Sinus mucosa
The Specific Disease	Chronic rhinosinusitis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.259827013; Fold-change: -0.146718283; Z-score: -0.51397612
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Differential expression pattern of antigen in diseases
The Studied Tissue	Lung
The Specific Disease	Chronic obstructive pulmonary disease
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.025955331; Fold-change: 0.299929709; Z-score: 0.559328432
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The Studied Tissue	Small airway epithelium
The Specific Disease	Chronic obstructive pulmonary disease
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 1.48E-05; Fold-change: -0.377524026; Z-score: -0.569260054
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Differential expression pattern of antigen in diseases
The Studied Tissue	Nasal and bronchial airway
The Specific Disease	Asthma
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.000167329; Fold-change: -0.029477334; Z-score: -0.025194139
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Differential expression pattern of antigen in diseases
The Studied Tissue	Nasal Epithelium
The Specific Disease	Human rhinovirus infection
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.502808824; Fold-change: 0.01809045; Z-score: 0.091197206
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Differential expression pattern of antigen in diseases
The Studied Tissue	Lung
The Specific Disease	Idiopathic pulmonary fibrosis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.284675553; Fold-change: -0.211015104; Z-score: -1.280194482
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Differential expression pattern of antigen in diseases
The Studied Tissue	Gingival
The Specific Disease	Periodontal disease
The Expression Level of Disease Section Compare with the Adjacent Tissue	p-value: 0.881106979; Fold-change: -0.029473829; Z-score: -0.057108694
Disease-specific Antigen Abundances		Click to View the Clearer Original Diagram
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Differential expression pattern of antigen in diseases
The Studied Tissue	Gastric antrum
The Specific Disease	Eosinophilic gastritis
The Expression Level of Disease Section Compare with the Adjacent Tissue	p-value: 0.069975734; Fold-change: 0.210013435; Z-score: 1.295629095
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Differential expression pattern of antigen in diseases
The Studied Tissue	Liver
The Specific Disease	Liver failure
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.693235121; Fold-change: -0.121806232; Z-score: -0.428675273
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Differential expression pattern of antigen in diseases
The Studied Tissue	Colon mucosal
The Specific Disease	Ulcerative colitis
The Expression Level of Disease Section Compare with the Adjacent Tissue	p-value: 0.128069098; Fold-change: -0.582105542; Z-score: -0.634041508
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Differential expression pattern of antigen in diseases
The Studied Tissue	Rectal colon
The Specific Disease	Irritable bowel syndrome
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.04321468; Fold-change: -0.108196459; Z-score: -0.240973064
Disease-specific Antigen Abundances		Click to View the Clearer Original Diagram
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Differential expression pattern of antigen in diseases
The Studied Tissue	Skin
The Specific Disease	Atopic dermatitis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.607264349; Fold-change: -0.037926194; Z-score: -0.150138764
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Differential expression pattern of antigen in diseases
The Studied Tissue	Skin
The Specific Disease	Psoriasis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 1.86E-07; Fold-change: -0.273914732; Z-score: -0.422333791
The Expression Level of Disease Section Compare with the Adjacent Tissue	p-value: 1.31E-21; Fold-change: 1.020001767; Z-score: 1.933164624
Disease-specific Antigen Abundances		Click to View the Clearer Original Diagram
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Differential expression pattern of antigen in diseases
The Studied Tissue	Skin
The Specific Disease	Vitiligo
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.039775146; Fold-change: -0.12804772; Z-score: -1.523423318
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Differential expression pattern of antigen in diseases
The Studied Tissue	Skin from scalp
The Specific Disease	Alopecia
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.761815148; Fold-change: 0.010639659; Z-score: 0.023002255
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Differential expression pattern of antigen in diseases
The Studied Tissue	Skin
The Specific Disease	Sensitive skin
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.218614761; Fold-change: 0.115539239; Z-score: 0.433164694
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Differential expression pattern of antigen in diseases
The Studied Tissue	Synovial
The Specific Disease	Osteoarthritis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.374847232; Fold-change: -0.43201832; Z-score: -0.514913639
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Differential expression pattern of antigen in diseases
The Studied Tissue	Peripheral blood
The Specific Disease	Arthropathy
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.081997621; Fold-change: 0.093549116; Z-score: 0.578331579
Disease-specific Antigen Abundances		Click to View the Clearer Original Diagram
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Differential expression pattern of antigen in diseases
The Studied Tissue	Peripheral blood
The Specific Disease	Arthritis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.660682419; Fold-change: 0.011173661; Z-score: 0.080134733
Disease-specific Antigen Abundances		Click to View the Clearer Original Diagram
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Differential expression pattern of antigen in diseases
The Studied Tissue	Synovial
The Specific Disease	Rheumatoid arthritis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.122507686; Fold-change: -0.125025436; Z-score: -0.217847322
Disease-specific Antigen Abundances		Click to View the Clearer Original Diagram
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Differential expression pattern of antigen in diseases
The Studied Tissue	Pheripheral blood
The Specific Disease	Ankylosing spondylitis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.158435174; Fold-change: -0.062122187; Z-score: -1.017017264
Disease-specific Antigen Abundances		Click to View the Clearer Original Diagram
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Differential expression pattern of antigen in diseases
The Studied Tissue	Bone marrow
The Specific Disease	Osteoporosis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.445033355; Fold-change: 0.159205073; Z-score: 0.271891529
Disease-specific Antigen Abundances		Click to View the Clearer Original Diagram
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Differential expression pattern of antigen in diseases
The Studied Tissue	Endometrium
The Specific Disease	Endometriosis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.439314111; Fold-change: -0.042348765; Z-score: -0.111463532
Disease-specific Antigen Abundances		Click to View the Clearer Original Diagram
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Differential expression pattern of antigen in diseases
The Studied Tissue	Bladder
The Specific Disease	Interstitial cystitis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.009627001; Fold-change: -0.491183087; Z-score: -1.395256103
Disease-specific Antigen Abundances		Click to View the Clearer Original Diagram
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Differential expression pattern of antigen in diseases
The Studied Tissue	Myometrium
The Specific Disease	Preterm birth
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.818446567; Fold-change: 0.232284409; Z-score: 0.329395343
Disease-specific Antigen Abundances		Click to View the Clearer Original Diagram
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Differential expression pattern of antigen in diseases
The Studied Tissue	Bone marrow
The Specific Disease	Acute myelocytic leukemia
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.004841358; Fold-change: 0.05212256; Z-score: 0.265545336
Disease-specific Antigen Abundances		Click to View the Clearer Original Diagram
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Differential expression pattern of antigen in diseases
The Studied Tissue	Bone marrow
The Specific Disease	Myeloma
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.003869536; Fold-change: -0.239001275; Z-score: -1.376881647
Disease-specific Antigen Abundances		Click to View the Clearer Original Diagram
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The Studied Tissue	Peripheral blood
The Specific Disease	Myeloma
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.208147725; Fold-change: 0.177778545; Z-score: 0.795850504
Disease-specific Antigen Abundances		Click to View the Clearer Original Diagram
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Differential expression pattern of antigen in diseases
The Studied Tissue	Oral
The Specific Disease	Oral cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.212472997; Fold-change: 0.032061442; Z-score: 0.041211697
The Expression Level of Disease Section Compare with the Adjacent Tissue	p-value: 0.993394276; Fold-change: -0.043058508; Z-score: -0.06018442
Disease-specific Antigen Abundances		Click to View the Clearer Original Diagram
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Differential expression pattern of antigen in diseases
The Studied Tissue	Esophagus
The Specific Disease	Esophagal cancer
The Expression Level of Disease Section Compare with the Adjacent Tissue	p-value: 0.744114966; Fold-change: -0.927773326; Z-score: -1.08206894
Disease-specific Antigen Abundances		Click to View the Clearer Original Diagram
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Differential expression pattern of antigen in diseases
The Studied Tissue	Rectal colon
The Specific Disease	Rectal cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.010708348; Fold-change: -0.247293493; Z-score: -1.631764056
The Expression Level of Disease Section Compare with the Adjacent Tissue	p-value: 0.000124299; Fold-change: -0.588712023; Z-score: -3.166205249
Disease-specific Antigen Abundances		Click to View the Clearer Original Diagram
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Differential expression pattern of antigen in diseases
The Studied Tissue	Skin
The Specific Disease	Skin cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 2.11E-56; Fold-change: -1.777974925; Z-score: -2.29660524
The Expression Level of Disease Section Compare with the Adjacent Tissue	p-value: 1.45E-13; Fold-change: -0.830092946; Z-score: -1.578689736
Disease-specific Antigen Abundances		Click to View the Clearer Original Diagram
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Differential expression pattern of antigen in diseases
The Studied Tissue	Kidney
The Specific Disease	Renal cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.344182483; Fold-change: -0.222447507; Z-score: -0.552134691
The Expression Level of Disease Section Compare with the Adjacent Tissue	p-value: 0.141472764; Fold-change: -0.30395708; Z-score: -0.480230635
Disease-specific Antigen Abundances		Click to View the Clearer Original Diagram
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Differential expression pattern of antigen in diseases
The Studied Tissue	Urothelium
The Specific Disease	Ureter cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.534150833; Fold-change: -0.07320583; Z-score: -0.70982248
Disease-specific Antigen Abundances		Click to View the Clearer Original Diagram
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Differential expression pattern of antigen in diseases
The Studied Tissue	Adipose
The Specific Disease	Simpson golabi behmel syndrome
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.532863679; Fold-change: 0.260946163; Z-score: 0.844238137
Disease-specific Antigen Abundances		Click to View the Clearer Original Diagram
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Differential expression pattern of antigen in diseases
The Studied Tissue	Perituberal
The Specific Disease	Tuberous sclerosis complex
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.076094338; Fold-change: 0.246412841; Z-score: 1.045838611
Disease-specific Antigen Abundances		Click to View the Clearer Original Diagram
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Differential expression pattern of antigen in diseases
The Studied Tissue	Bone marrow
The Specific Disease	Anemia
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.056871452; Fold-change: 0.714282409; Z-score: 1.667897026
Disease-specific Antigen Abundances		Click to View the Clearer Original Diagram
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Differential expression pattern of antigen in diseases
The Studied Tissue	Peripheral blood
The Specific Disease	Sickle cell disease
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.277108; Fold-change: 0.095389332; Z-score: 0.392017394
Disease-specific Antigen Abundances		Click to View the Clearer Original Diagram
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Differential expression pattern of antigen in diseases
The Studied Tissue	Whole blood
The Specific Disease	Thrombocythemia
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.203720308; Fold-change: 0.06210334; Z-score: 0.408177455
Disease-specific Antigen Abundances		Click to View the Clearer Original Diagram
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Differential expression pattern of antigen in diseases
The Studied Tissue	Whole blood
The Specific Disease	Scleroderma
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.017626982; Fold-change: -0.16727954; Z-score: -1.270306628
Disease-specific Antigen Abundances		Click to View the Clearer Original Diagram
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Differential expression pattern of antigen in diseases
The Studied Tissue	Salivary gland
The Specific Disease	Sjogren syndrome
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.219555624; Fold-change: 0.401515374; Z-score: 0.802727293
The Expression Level of Disease Section Compare with the Adjacent Tissue	p-value: 0.002961811; Fold-change: -0.842359448; Z-score: -2.480067337
Disease-specific Antigen Abundances		Click to View the Clearer Original Diagram
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Differential expression pattern of antigen in diseases
The Studied Tissue	Peripheral blood
The Specific Disease	Behcet disease
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.596404505; Fold-change: -0.018694152; Z-score: -0.097984568
Disease-specific Antigen Abundances		Click to View the Clearer Original Diagram
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Differential expression pattern of antigen in diseases
The Studied Tissue	Whole blood
The Specific Disease	Autosomal dominant monocytopenia
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.778417804; Fold-change: -0.053832; Z-score: -0.46066501
Disease-specific Antigen Abundances		Click to View the Clearer Original Diagram
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Differential expression pattern of antigen in diseases
The Studied Tissue	Liver
The Specific Disease	Type 2 diabetes
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.949677634; Fold-change: -0.406337736; Z-score: -0.511049171
Disease-specific Antigen Abundances		Click to View the Clearer Original Diagram
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Differential expression pattern of antigen in diseases
The Studied Tissue	Vastus lateralis muscle
The Specific Disease	Polycystic ovary syndrome
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.546835014; Fold-change: -0.06801586; Z-score: -0.280234912
Disease-specific Antigen Abundances		Click to View the Clearer Original Diagram
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Differential expression pattern of antigen in diseases
The Studied Tissue	Subcutaneous Adipose
The Specific Disease	Obesity
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.124507134; Fold-change: -0.078661149; Z-score: -0.36928348
Disease-specific Antigen Abundances		Click to View the Clearer Original Diagram
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Differential expression pattern of antigen in diseases
The Studied Tissue	Biceps muscle
The Specific Disease	Pompe disease
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.144693726; Fold-change: 0.282351398; Z-score: 0.912041551
Disease-specific Antigen Abundances		Click to View the Clearer Original Diagram
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Differential expression pattern of antigen in diseases
The Studied Tissue	Whole blood
The Specific Disease	Batten disease
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.051539027; Fold-change: 0.098915352; Z-score: 1.441146048
Disease-specific Antigen Abundances		Click to View the Clearer Original Diagram
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Differential expression pattern of antigen in diseases
The Studied Tissue	Whole blood
The Specific Disease	Autism
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.058857611; Fold-change: -0.104536145; Z-score: -0.500851731
Disease-specific Antigen Abundances		Click to View the Clearer Original Diagram
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Differential expression pattern of antigen in diseases
The Studied Tissue	Whole blood
The Specific Disease	Anxiety disorder
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.92299867; Fold-change: -0.020057963; Z-score: -0.099634657
Disease-specific Antigen Abundances		Click to View the Clearer Original Diagram
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Differential expression pattern of antigen in diseases
The Studied Tissue	Substantia nigra
The Specific Disease	Parkinson disease
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.892864426; Fold-change: 0.087279758; Z-score: 0.228343572
Disease-specific Antigen Abundances		Click to View the Clearer Original Diagram
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Differential expression pattern of antigen in diseases
The Studied Tissue	Whole blood
The Specific Disease	Huntington disease
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.007018374; Fold-change: 0.16800984; Z-score: 1.202443013
Disease-specific Antigen Abundances		Click to View the Clearer Original Diagram
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Differential expression pattern of antigen in diseases
The Studied Tissue	Entorhinal cortex
The Specific Disease	Alzheimer disease
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 2.67E-05; Fold-change: 0.17669589; Z-score: 0.555604455
Disease-specific Antigen Abundances		Click to View the Clearer Original Diagram
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Differential expression pattern of antigen in diseases
The Studied Tissue	Whole blood
The Specific Disease	Seizure
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.982857988; Fold-change: -0.002190559; Z-score: -0.010466464
Disease-specific Antigen Abundances		Click to View the Clearer Original Diagram
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Differential expression pattern of antigen in diseases
The Studied Tissue	Skin
The Specific Disease	Lateral sclerosis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.108235245; Fold-change: -0.815041646; Z-score: -1.653864007
Disease-specific Antigen Abundances		Click to View the Clearer Original Diagram
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The Studied Tissue	Cervical spinal cord
The Specific Disease	Lateral sclerosis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.816613059; Fold-change: 0.013862287; Z-score: 0.066052452
Disease-specific Antigen Abundances		Click to View the Clearer Original Diagram
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Differential expression pattern of antigen in diseases
The Studied Tissue	Muscle
The Specific Disease	Muscular atrophy
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.605459319; Fold-change: 0.061419252; Z-score: 0.208202258
Disease-specific Antigen Abundances		Click to View the Clearer Original Diagram
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Differential expression pattern of antigen in diseases
The Studied Tissue	Muscle
The Specific Disease	Myopathy
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.358729957; Fold-change: 0.11474649; Z-score: 0.327795785
Disease-specific Antigen Abundances		Click to View the Clearer Original Diagram
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Ref 1	Homogeneous antibody-angiopep 2 conjugates for effective brain targeting. RSC Adv. 2022 Jan 26;12(6):3359-3364.
Ref 2	Antibody drug conjugates of cleavable amino-alkyl and aryl maytansinoids. Bioorg Med Chem. 2018 May 15;26(9):2271-2279. doi: 10.1016/j.bmc.2018.02.025. Epub 2018 Feb 21.
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