Antigen Information

General Information of This Antigen (ID: TAR0NGPYZ)
Antigen Name
Metalloreductase STEAP1 (STEAP1)
Gene Name
STEAP1
Gene ID
26872
Synonym
PRSS24; STEAP; Six-transmembrane epithelial antigen of prostate 1
Sequence
MESRKDITNQEELWKMKPRRNLEEDDYLHKDTGETSMLKRPVLLHLHQTAHADEFDCPSE
LQHTQELFPQWHLPIKIAAIIASLTFLYTLLREVIHPLATSHQQYFYKIPILVINKVLPM
VSITLLALVYLPGVIAAIVQLHNGTKYKKFPHWLDKWMLTRKQFGLLSFFFAVLHAIYSL
SYPMRRSYRYKLLNWAYQQVQQNKEDAWIEHDVWRMEIYVSLGIVGLAILALLAVTSIPS
VSDSLTWREFHYIQSKLGIVSLLLGTIHALIFAWNKWIDIKQFVWYTPPTFMIAVFLPIV
VLIFKSILFLPCLRKKILKIRHGWEDVTKINKTEICSQL

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Family
Small leucine-rich proteoglycan family
Function
Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor.

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Uniprot Entry
STEA1_HUMAN
HGNC ID
HGNC:11378
KEGG ID
hsa:26872
Each Antibody-drug Conjugate and Its Component Related to This Antigen
Full List of The ADC Related to This Antigen
The Numbers of ADCs, Their Three Components, Payload Targets, and Corresponding Diseases for This Antigens
Anti-STEAP1 antibody
 Antibody Info 
ADC Name Payload Target Linker ADC Info
ADRX-0405
Undisclosed
DNA topoisomerase 1 (TOP1)
A cleavable linker
 ADC Info 
Vandortuzumab
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Vandortuzumab vedotin
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
WO2024239281A1 C031 [1]
Exatecan-Gly amide
DNA topoisomerase I (TOP1)
Mal-PEG-Ala-Ala-Ala linker
 ADC Info 
WO2024239281A1 C039 [1]
Exatecan-Gly amide
DNA topoisomerase I (TOP1)
Mal-PEG-Val-Ala linker
 ADC Info 
WO2024239281A1 C054 [1]
Exatecan-aminoethoxy
DNA topoisomerase I (TOP1)
Mal-PEG-Val-Ala linker
 ADC Info 
WO2024239281A1 C060 [1]
Exatecan-carbamate (aminoethyl)
DNA topoisomerase I (TOP1)
Mal-PEG-Val-Ala linker
 ADC Info 
WO2024239281A1 C078 [1]
Exatecan-L-Ala amide
DNA topoisomerase I (TOP1)
Maleimide-PEG-L-Valine linker
 ADC Info 
WO2024239281A1 C084 [1]
Exatecan-Gly amide
DNA topoisomerase I (TOP1)
Bis-maleimide-PEG linker
 ADC Info 
WO2024239281A1 C084C [1]
Exatecan-Gly amide
DNA topoisomerase I (TOP1)
WO2024239281A1, C084C, Linker
 ADC Info 
WO2024239281A1 C112 [1]
Exatecan-Gly amide
DNA topoisomerase I (TOP1)
WO2024239281A1, C112, Linker
 ADC Info 
WO2024239281A1 C117 [1]
Exatecan-aminoethoxy
DNA topoisomerase I (TOP1)
WO2024239281A1, C117, Linker
 ADC Info 
WO2024239281A1 C144 [1]
Exatecan-Gly amide
DNA topoisomerase I (TOP1)
WO2024239281A1, C144, Linker
 ADC Info 
WO2024239281A1 C158 [1]
Exatecan-Gly amide
DNA topoisomerase I (TOP1)
WO2024239281A1, C158, Linker
 ADC Info 
WO2024239281A1 C193 [1]
(R)-5- (3- ((S)-2- ((S)-2-amino-3-methylbutanamido)propanamido)-4- hydroxyphenyl)-4- (2- ((6S,9R,11R)-6- ((S)-sec-butyl)-9-isopropyl-2,3,3,8-tetramethyl-4,7,13-trioxo-12-oxa-2,5,8-triazatetradecan-11-yl)thiazole-4-carboxamido)pentanoic acid
DNA topoisomerase I (TOP1)
WO2024239281A1, C193, Linker
 ADC Info 
WO2024239281A1 C200 [1]
(R)-5- (3- ((S)-2- ((S)-2-amino-3-methylbutanamido)propanamido)-4- hydroxyphenyl)-4- (2- ((6S,9R,11R)-6- ((S)-sec-butyl)-9-isopropyl-2,3,3,8-tetramethyl-4,7,13-trioxo-12-oxa-2,5,8-triazatetradecan-11-yl)thiazole-4-carboxamido)pentanoic acid
DNA topoisomerase I (TOP1)
WO2024239281A1, C200, Linker
 ADC Info 
WO2024239281A1 C207 [1]
Exatecan-aminoethoxy
DNA topoisomerase I (TOP1)
WO2024239281A1, C207, Linker
 ADC Info 
WO2024239281A1 C207C [1]
Exatecan-aminoethoxy
DNA topoisomerase I (TOP1)
WO2024239281A1, C207C, Linker
 ADC Info 
WO2024239281A1 C213 [1]
Exatecan-phenoxy-Ala
DNA topoisomerase I (TOP1)
Maleimide-PEG-L-Valine linker
 ADC Info 
WO2024239281A1 C218 [1]
4- ((S)-2-aminopropanamido)benzyl (2- ((S)-4,11-diethyl-8-fluoro-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl)oxy)ethyl)carbonate
DNA topoisomerase I (TOP1)
WO2024239281A1, C218, Linker
 ADC Info 
WO2024239281A1 C225 [1]
2- (( (S)-4,11-diethyl-8-fluoro-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl)oxy)ethyl (4- ((S)-2-aminopropanamido)benzyl)carbamate
DNA topoisomerase I (TOP1)
Maleimide-PEG-L-Valine linker
 ADC Info 
WO2024239281A1 C230 [1]
Exatecan-phenoxy-PEG2-Ala
DNA topoisomerase I (TOP1)
Maleimide-PEG-L-Valine linker
 ADC Info 
WO2024239281A1 C237 [1]
Exatecan-PEG2-Ala
DNA topoisomerase I (TOP1)
Maleimide-PEG-L-Valine linker
 ADC Info 
WO2024239281A1 C257 [1]
Exatecan-aminoethoxy
DNA topoisomerase I (TOP1)
WO2024239281A1, C257, Linker
 ADC Info 
WO2024239281A1 C263 [1]
Exatecan-aminoethoxy
DNA topoisomerase I (TOP1)
WO2024239281A1, C263, Linker
 ADC Info 
WO2024239281A1 C266 [1]
Exatecan-aminoethoxy
DNA topoisomerase I (TOP1)
WO2024239281A1, C266, Linker
 ADC Info 
WO2024239281A1 C266C [1]
Exatecan-aminoethoxy
DNA topoisomerase I (TOP1)
WO2024239281A1, C266C, Linker
 ADC Info 
WO2024239281A1 C269 [1]
Exatecan-aminoethoxy
DNA topoisomerase I (TOP1)
WO2024239281A1, C269, Linker
 ADC Info 
WO2024239281A1 C269C [1]
Exatecan-aminoethoxy
DNA topoisomerase I (TOP1)
WO2024239281A1, C269C, Linker
 ADC Info 
vandortuzumab
 Antibody Info 
ADC Name Payload Target Linker ADC Info
WO2024239281A1 C031 4.3 [1]
undisclosed
Undisclosed
Undisclosed
 ADC Info 
WO2024239281A1 c039 4.2 [1]
undisclosed
Undisclosed
Undisclosed
 ADC Info 
WO2024239281A1 c054 7.6 [1]
undisclosed
Undisclosed
Undisclosed
 ADC Info 
WO2024239281A1 c060 7.7 [1]
undisclosed
Undisclosed
Undisclosed
 ADC Info 
WO2024239281A1 c078 7.4 [1]
undisclosed
Undisclosed
Undisclosed
 ADC Info 
WO2024239281A1 c084 4.1 [1]
undisclosed
Undisclosed
Undisclosed
 ADC Info 
WO2024239281A1 c084c 4.1 [1]
undisclosed
Undisclosed
Undisclosed
 ADC Info 
WO2024239281A1 c112 4.4 [1]
undisclosed
Undisclosed
Undisclosed
 ADC Info 
WO2024239281A1 c117 4.4 [1]
undisclosed
Undisclosed
Undisclosed
 ADC Info 
WO2024239281A1 c144 8.2 [1]
undisclosed
Undisclosed
Undisclosed
 ADC Info 
WO2024239281A1 c158 7.8 [1]
undisclosed
Undisclosed
Undisclosed
 ADC Info 
WO2024239281A1 c193 7.6 [1]
undisclosed
Undisclosed
Undisclosed
 ADC Info 
WO2024239281A1 c200 7.8 [1]
undisclosed
Undisclosed
Undisclosed
 ADC Info 
WO2024239281A1 c207 4.4 [1]
undisclosed
Undisclosed
Undisclosed
 ADC Info 
WO2024239281A1 c207c 4.4 [1]
undisclosed
Undisclosed
Undisclosed
 ADC Info 
WO2024239281A1 c213 7.4 [1]
undisclosed
Undisclosed
Undisclosed
 ADC Info 
WO2024239281A1 c218 7.6 [1]
undisclosed
Undisclosed
Undisclosed
 ADC Info 
WO2024239281A1 c225 7.6 [1]
undisclosed
Undisclosed
Undisclosed
 ADC Info 
WO2024239281A1 c230 7.6 [1]
undisclosed
Undisclosed
Undisclosed
 ADC Info 
WO2024239281A1 c237 7.6 [1]
undisclosed
Undisclosed
Undisclosed
 ADC Info 
WO2024239281A1 c257 7.6 [1]
undisclosed
Undisclosed
Undisclosed
 ADC Info 
WO2024239281A1 c263 7.6 [1]
undisclosed
Undisclosed
Undisclosed
 ADC Info 
WO2024239281A1 c266 4.2 [1]
undisclosed
Undisclosed
Undisclosed
 ADC Info 
WO2024239281A1 c266c 4.2 [1]
undisclosed
Undisclosed
Undisclosed
 ADC Info 
WO2024239281A1 c269 4.2 [1]
undisclosed
Undisclosed
Undisclosed
 ADC Info 
WO2024239281A1 c269c 4.2 [1]
undisclosed
Undisclosed
Undisclosed
 ADC Info 
WO2024239281A1 c289 [1]
undisclosed
Undisclosed
Undisclosed
 ADC Info 
WO2024239281A1 c289c [1]
undisclosed
Undisclosed
Undisclosed
 ADC Info 
WO2024239281A1 c418 [1]
undisclosed
Undisclosed
Undisclosed
 ADC Info 
WO2024239281A1 c420 [1]
undisclosed
Undisclosed
Undisclosed
 ADC Info 
WO2024239281A1 c422 [1]
undisclosed
Undisclosed
Undisclosed
 ADC Info 
WO2024239281A1 c427 [1]
undisclosed
Undisclosed
Undisclosed
 ADC Info 
WO2024239281A1 c429 [1]
undisclosed
Undisclosed
Undisclosed
 ADC Info 
WO2024239281A1 c431 [1]
undisclosed
Undisclosed
Undisclosed
 ADC Info 
WO2024239281A1 c433 [1]
undisclosed
Undisclosed
Undisclosed
 ADC Info 
WO2024239281A1 c441 [1]
undisclosed
Undisclosed
Undisclosed
 ADC Info 
WO2024239281A1 c443 [1]
undisclosed
Undisclosed
Undisclosed
 ADC Info 
WO2024239281A1 c480 [1]
undisclosed
Undisclosed
Undisclosed
 ADC Info 
WO2024239281A1 c482 [1]
undisclosed
Undisclosed
Undisclosed
 ADC Info 
WO2024239281A1 c484 [1]
undisclosed
Undisclosed
Undisclosed
 ADC Info 
WO2024239281A1 C486 [1]
undisclosed
Undisclosed
Undisclosed
 ADC Info 
Undisclosed
 Antibody Info 
ADC Name Payload Target Linker ADC Info
HLX-80 [2]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
References
Ref 1 Targeted treatment of prostate cancers and other tumors by an antibody-drug conjugate
Ref 2 Introduction to basic information on ADC drug HLX-80.