Antigen Information

General Information of This Antigen

Antigen ID	TAR0NGPYZ
Antigen Name	Metalloreductase STEAP1 (STEAP1)
Gene Name	STEAP1
Synonym	PRSS24; STEAP; Six-transmembrane epithelial antigen of prostate 1
Sequence	MESRKDITNQEELWKMKPRRNLEEDDYLHKDTGETSMLKRPVLLHLHQTAHADEFDCPSE LQHTQELFPQWHLPIKIAAIIASLTFLYTLLREVIHPLATSHQQYFYKIPILVINKVLPM VSITLLALVYLPGVIAAIVQLHNGTKYKKFPHWLDKWMLTRKQFGLLSFFFAVLHAIYSL SYPMRRSYRYKLLNWAYQQVQQNKEDAWIEHDVWRMEIYVSLGIVGLAILALLAVTSIPS VSDSLTWREFHYIQSKLGIVSLLLGTIHALIFAWNKWIDIKQFVWYTPPTFMIAVFLPIV VLIFKSILFLPCLRKKILKIRHGWEDVTKINKTEICSQL Click to Show/Hide
Family	Small leucine-rich proteoglycan family
Function	Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor. Click to Show/Hide
Uniprot Entry	STEA1_HUMAN
HGNC ID	HGNC:11378
KEGG ID	hsa:26872

Each Antibody-drug Conjuate AND It's Component Related to This Antigen

Full List of The ADC Related to This Antigen

Anti-STEAP1 antibody

Antibody Info

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	ADRX-0405	AP052	DNA topoisomerase 1 (TOP1)	A cleavable linker

Vandortuzumab

Antibody Info

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	Vandortuzumab vedotin	MMAE	Microtubule (MT)	Mc-Val-Cit-PABC
ADC Info	wO2024239281A1 C031	Exatecan-Gly amide	DNA topoisomerase I (TOP1)	Mal-PEG-Ala-Ala-Ala linker	[1]
ADC Info	wO2024239281A1 C039	Exatecan-Gly amide	DNA topoisomerase I (TOP1)	Mal-PEG-Val-Ala linker	[1]
ADC Info	wO2024239281A1 C054	Exatecan-aminoethoxy	DNA topoisomerase I (TOP1)	Mal-PEG-Val-Ala linker	[1]
ADC Info	wO2024239281A1 C060	Exatecan-carbamate (aminoethyl)	DNA topoisomerase I (TOP1)	Mal-PEG-Val-Ala linker	[1]
ADC Info	wO2024239281A1 C078	Exatecan-L-Ala amide	DNA topoisomerase I (TOP1)	Maleimide-PEG-L-Valine linker	[1]
ADC Info	wO2024239281A1 C084	Exatecan-Gly amide	DNA topoisomerase I (TOP1)	Bis-maleimide-PEG linker	[1]
ADC Info	wO2024239281A1 C084C	Exatecan-Gly amide	DNA topoisomerase I (TOP1)	WO2024239281A1, C084C, Linker	[1]
ADC Info	wO2024239281A1 C112	Exatecan-Gly amide	DNA topoisomerase I (TOP1)	WO2024239281A1, C112, Linker	[1]
ADC Info	wO2024239281A1 C117	Exatecan-aminoethoxy	DNA topoisomerase I (TOP1)	WO2024239281A1, C117, Linker	[1]
ADC Info	wO2024239281A1 C144	Exatecan-Gly amide	DNA topoisomerase I (TOP1)	WO2024239281A1, C144, Linker	[1]
ADC Info	wO2024239281A1 C158	Exatecan-Gly amide	DNA topoisomerase I (TOP1)	WO2024239281A1, C158, Linker	[1]
ADC Info	wO2024239281A1 C193	(R)-5- (3- ((S)-2- ((S)-2-amino-3-methylbutanamido)propanamido)-4- hydroxyphenyl)-4- (2- ((6S,9R,11R)-6- ((S)-sec-butyl)-9-isopropyl-2,3,3,8-tetramethyl-4,7,13-trioxo-12-oxa-2,5,8-triazatetradecan-11-yl)thiazole-4-carboxamido)pentanoic acid	DNA topoisomerase I (TOP1)	WO2024239281A1, C193, Linker	[1]
ADC Info	wO2024239281A1 C200	(R)-5- (3- ((S)-2- ((S)-2-amino-3-methylbutanamido)propanamido)-4- hydroxyphenyl)-4- (2- ((6S,9R,11R)-6- ((S)-sec-butyl)-9-isopropyl-2,3,3,8-tetramethyl-4,7,13-trioxo-12-oxa-2,5,8-triazatetradecan-11-yl)thiazole-4-carboxamido)pentanoic acid	DNA topoisomerase I (TOP1)	WO2024239281A1, C200, Linker	[1]
ADC Info	wO2024239281A1 C207	Exatecan-aminoethoxy	DNA topoisomerase I (TOP1)	WO2024239281A1, C207, Linker	[1]
ADC Info	wO2024239281A1 C207C	Exatecan-aminoethoxy	DNA topoisomerase I (TOP1)	WO2024239281A1, C207C, Linker	[1]
ADC Info	wO2024239281A1 C213	Exatecan-phenoxy-Ala	DNA topoisomerase I (TOP1)	Maleimide-PEG-L-Valine linker	[1]
ADC Info	wO2024239281A1 C218	4- ((S)-2-aminopropanamido)benzyl (2- ((S)-4,11-diethyl-8-fluoro-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl)oxy)ethyl)carbonate	DNA topoisomerase I (TOP1)	WO2024239281A1, C218, Linker	[1]
ADC Info	wO2024239281A1 C225	2- (( (S)-4,11-diethyl-8-fluoro-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl)oxy)ethyl (4- ((S)-2-aminopropanamido)benzyl)carbamate	DNA topoisomerase I (TOP1)	Maleimide-PEG-L-Valine linker	[1]
ADC Info	wO2024239281A1 C230	Exatecan-phenoxy-PEG2-Ala	DNA topoisomerase I (TOP1)	Maleimide-PEG-L-Valine linker	[1]
ADC Info	wO2024239281A1 C237	Exatecan-PEG2-Ala	DNA topoisomerase I (TOP1)	Maleimide-PEG-L-Valine linker	[1]
ADC Info	wO2024239281A1 C257	Exatecan-aminoethoxy	DNA topoisomerase I (TOP1)	WO2024239281A1, C257, Linker	[1]
ADC Info	wO2024239281A1 C263	Exatecan-aminoethoxy	DNA topoisomerase I (TOP1)	WO2024239281A1, C263, Linker	[1]
ADC Info	wO2024239281A1 C266	Exatecan-aminoethoxy	DNA topoisomerase I (TOP1)	WO2024239281A1, C266, Linker	[1]
ADC Info	wO2024239281A1 C266C	Exatecan-aminoethoxy	DNA topoisomerase I (TOP1)	WO2024239281A1, C266C, Linker	[1]
ADC Info	wO2024239281A1 C269	Exatecan-aminoethoxy	DNA topoisomerase I (TOP1)	WO2024239281A1, C269, Linker	[1]
ADC Info	wO2024239281A1 C269C	Exatecan-aminoethoxy	DNA topoisomerase I (TOP1)	WO2024239281A1, C269C, Linker	[1]

vandortuzumab

Antibody Info

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	wO2024239281A1 C031 4.3	undisclosed	Undisclosed	Undisclosed	[1]
ADC Info	wO2024239281A1 c039 4.2	undisclosed	Undisclosed	Undisclosed	[1]
ADC Info	wO2024239281A1 c054 7.6	undisclosed	Undisclosed	Undisclosed	[1]
ADC Info	wO2024239281A1 c060 7.7	undisclosed	Undisclosed	Undisclosed	[1]
ADC Info	wO2024239281A1 c078 7.4	undisclosed	Undisclosed	Undisclosed	[1]
ADC Info	wO2024239281A1 c084 4.1	undisclosed	Undisclosed	Undisclosed	[1]
ADC Info	wO2024239281A1 c084c 4.1	undisclosed	Undisclosed	Undisclosed	[1]
ADC Info	wO2024239281A1 c112 4.4	undisclosed	Undisclosed	Undisclosed	[1]
ADC Info	wO2024239281A1 c117 4.4	undisclosed	Undisclosed	Undisclosed	[1]
ADC Info	wO2024239281A1 c144 8.2	undisclosed	Undisclosed	Undisclosed	[1]
ADC Info	wO2024239281A1 c158 7.8	undisclosed	Undisclosed	Undisclosed	[1]
ADC Info	wO2024239281A1 c193 7.6	undisclosed	Undisclosed	Undisclosed	[1]
ADC Info	wO2024239281A1 c200 7.8	undisclosed	Undisclosed	Undisclosed	[1]
ADC Info	wO2024239281A1 c207 4.4	undisclosed	Undisclosed	Undisclosed	[1]
ADC Info	wO2024239281A1 c207c 4.4	undisclosed	Undisclosed	Undisclosed	[1]
ADC Info	wO2024239281A1 c213 7.4	undisclosed	Undisclosed	Undisclosed	[1]
ADC Info	wO2024239281A1 c218 7.6	undisclosed	Undisclosed	Undisclosed	[1]
ADC Info	wO2024239281A1 c225 7.6	undisclosed	Undisclosed	Undisclosed	[1]
ADC Info	wO2024239281A1 c230 7.6	undisclosed	Undisclosed	Undisclosed	[1]
ADC Info	wO2024239281A1 c237 7.6	undisclosed	Undisclosed	Undisclosed	[1]
ADC Info	wO2024239281A1 c257 7.6	undisclosed	Undisclosed	Undisclosed	[1]
ADC Info	wO2024239281A1 c263 7.6	undisclosed	Undisclosed	Undisclosed	[1]
ADC Info	wO2024239281A1 c266 4.2	undisclosed	Undisclosed	Undisclosed	[1]
ADC Info	wO2024239281A1 c266c 4.2	undisclosed	Undisclosed	Undisclosed	[1]
ADC Info	wO2024239281A1 c269 4.2	undisclosed	Undisclosed	Undisclosed	[1]
ADC Info	wO2024239281A1 c269c 4.2	undisclosed	Undisclosed	Undisclosed	[1]
ADC Info	wO2024239281A1 c289	undisclosed	Undisclosed	Undisclosed	[1]
ADC Info	wO2024239281A1 c289c	undisclosed	Undisclosed	Undisclosed	[1]
ADC Info	wO2024239281A1 c418	undisclosed	Undisclosed	Undisclosed	[1]
ADC Info	wO2024239281A1 c420	undisclosed	Undisclosed	Undisclosed	[1]
ADC Info	wO2024239281A1 c422	undisclosed	Undisclosed	Undisclosed	[1]
ADC Info	wO2024239281A1 c427	undisclosed	Undisclosed	Undisclosed	[1]
ADC Info	wO2024239281A1 c429	undisclosed	Undisclosed	Undisclosed	[1]
ADC Info	wO2024239281A1 c431	undisclosed	Undisclosed	Undisclosed	[1]
ADC Info	wO2024239281A1 c433	undisclosed	Undisclosed	Undisclosed	[1]
ADC Info	wO2024239281A1 c441	undisclosed	Undisclosed	Undisclosed	[1]
ADC Info	wO2024239281A1 c443	undisclosed	Undisclosed	Undisclosed	[1]
ADC Info	wO2024239281A1 c480	undisclosed	Undisclosed	Undisclosed	[1]
ADC Info	wO2024239281A1 c482	undisclosed	Undisclosed	Undisclosed	[1]
ADC Info	wO2024239281A1 c484	undisclosed	Undisclosed	Undisclosed	[1]
ADC Info	wO2024239281A1 C486	undisclosed	Undisclosed	Undisclosed	[1]

Undisclosed

Antibody Info

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	HLX-80	Undisclosed	Undisclosed	Undisclosed	[2]

References

Ref 1	Targeted treatment of prostate cancers and other tumors by an antibody-drug conjugate
Ref 2	Introduction to basic information on ADC drug HLX-80.

Antigen Information

Citation

Visitor Map

Correspondence

Prof. Feng ZHU (zhufeng@zju.edu.cn)

Prof. Xiaowu DONG (dongxw@zju.edu.cn)

Prof. Luo FANG (fangluo@zjcc.org.cn)