Antigen Information

General Information of This Antigen (ID: TAR0KZVDX)
Antigen Name
B-cell antigen receptor complex-associated protein beta chain (CD79B)
Gene Name
CD79B
Gene ID
974
Synonym
B29; IGB; B-cell-specific glycoprotein B29;Ig-beta;Immunoglobulin-associated B29 protein;CD79b
Sequence
MARLALSPVPSHWMVALLLLLSAEPVPAARSEDRYRNPKGSACSRIWQSPRFIARKRGFT
VKMHCYMNSASGNVSWLWKQEMDENPQQLKLEKGRMEESQNESLATLTIQGIRFEDNGIY
FCQQKCNNTSEVYQGCGTELRVMGFSTLAQLKQRNTLKDGIIMIQTLLIILFIIVPIFLL
LDKDDSKAGMEEDHTYEGLDIDQTATYEDIVTLRTGEVKWSVGEHPGQE

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Function
Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation.

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Uniprot Entry
CD79B_HUMAN
HGNC ID
HGNC:1699
KEGG ID
hsa:974
Each Antibody-drug Conjugate and Its Component Related to This Antigen
Full List of The ADC Related to This Antigen
The Numbers of ADCs, Their Three Components, Payload Targets, and Corresponding Diseases for This Antigens
Anti-CD79b antibody
 Antibody Info 
ADC Name Payload Target Linker ADC Info
NBT508
Monomethyl auristatin E
Microtubule (MT)
TetraM-Val-Cit-PABC
 ADC Info 
ABBV-291 [1]
TOP1 inhibitor
DNA topoisomerase 1 (TOP1)
Undisclosed
 ADC Info 
CD79b-B Anti-ody
 Antibody Info 
ADC Name Payload Target Linker ADC Info
CD79b-B Antibody-Compound (X) [2]
CD79b-B Antibody-Compound (X) payload
Undisclosed
CD79b-B Antibody-Compound (X) linker
 ADC Info 
CD79b-B Antibody-Compound (XI) [2]
CD79b-B Antibody-Compound (XI) payload
Undisclosed
CD79b-B Antibody-Compound (XI) linker
 ADC Info 
CD79b-B Antibody-Compound (XIV) [2]
CD79b-B Antibody-Compound (XIV) payload
Undisclosed
CD79b-B Antibody-Compound (XIV) linker
 ADC Info 
CD79b-B Antibody-Compound (XVIII) [2]
CD79b-B Antibody-Compound (XVIII) payload
Undisclosed
CD79b-B Antibody-Compound (XVIII) linker
 ADC Info 
CD79b-B Antibody-Compound (Ie) [2]
CD79b-B Antibody-Compound (Ie) payload
Undisclosed
CD79b-B Antibody-Compound (Ie) linker
 ADC Info 
CD79b-B Antibody-Compound (XIX) [2]
CD79b-B Antibody-Compound (XIX) payload
Undisclosed
CD79b-B Antibody-Compound (XIX) linker
 ADC Info 
CD79b-B Antibody-Compound (Ii) [2]
CD79b-B Antibody-Compound (Ii) payload
Undisclosed
CD79b-B Antibody-Compound (Ii) linker
 ADC Info 
CD79b-B Antibody-Compound (XLI) [2]
CD79b-B Antibody-Compound (XLI) payload
Undisclosed
CD79b-B Antibody-Compound (XLI) linker
 ADC Info 
CD79b-B Antibody-Compound (XVI) [2]
CD79b-B Antibody-Compound (XIX) payload
Undisclosed
CD79b-B Antibody-Compound (XIX) linker
 ADC Info 
CD79b-B Antibody-Compound (XL) [2]
CD79b-B Antibody-Compound (XL) payload
Undisclosed
CD79b-B Antibody-Compound (XL) linker
 ADC Info 
CD79b-B Antibody-Compound (XLIII) [2]
CD79b-B Antibody-Compound (XLIII) payload
Undisclosed
CD79b-B Antibody-Compound (XLIII) linker
 ADC Info 
CD79b-B Antibody-Compound (XLII) [2]
CD79b-B Antibody-Compound (XLII) payload
Undisclosed
CD79b-B Antibody-Compound (XLII) linker
 ADC Info 
CD79b-B Antibody-Compound (XV) [2]
CD79b-B Antibody-Compound (XV) payload
Undisclosed
CD79b-B Antibody-Compound (XV) linker
 ADC Info 
hAb015-10
 Antibody Info 
ADC Name Payload Target Linker ADC Info
EP4470568A1 ADC-5 [3]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
EP4470568A1 ADC-6 [3]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
EP4470568A1 ADC-7 [3]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
hAb017-10
 Antibody Info 
ADC Name Payload Target Linker ADC Info
EP4470568A1 ADC-3 [3]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
Iladatuzumab
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Iladatuzumab vedotin
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
Polatuzumab
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Polatuzumab vedotin [4]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
CD79b-A Antibody-Compound (X) [2]
CD79b-A Antibody-Compound (X) payload
Undisclosed
CD79b-A Antibody-Compound (X) linker
 ADC Info 
CD79b-A Antibody-Compound (XI) [2]
CD79b-A Antibody-Compound (XI) payload
Undisclosed
CD79b-A Antibody-Compound (XI) linker
 ADC Info 
CD79b-A Antibody-Compound (XIV) [2]
CD79b-A Antibody-Compound (XIV) payload
Undisclosed
CD79b-A Antibody-Compound (XIV) linker
 ADC Info 
CD79b-A Antibody-Compound (XVIII) [2]
CD79b-A Antibody-Compound (XVIII) payload
Undisclosed
CD79b-A Antibody-Compound (XVIII) linker
 ADC Info 
CD79b-A Antibody-Compound (Ie) [2]
CD79b-A Antibody-Compound (Ie) payload
Undisclosed
CD79b-A Antibody-Compound (Ie) linker
 ADC Info 
CD79b-A Antibody-Compound (XIX) [2]
CD79b-A Antibody-Compound (XIX) payload
Undisclosed
CD79b-A Antibody-Compound (XIX) linker
 ADC Info 
CD79b-A Antibody-Compound (Ii) [2]
CD79b-A Antibody-Compound (Ii) payload
Undisclosed
CD79b-A Antibody-Compound (Ii) linker
 ADC Info 
CD79b-A Antibody-Compound (XLI) [2]
CD79b-A Antibody-Compound (XLI) payload
Undisclosed
CD79b-A Antibody-Compound (XLI) linker
 ADC Info 
CD79b-A Antibody-Compound (XVI) [2]
CD79b-A Antibody-Compound (XIX) payload
Undisclosed
CD79b-A Antibody-Compound (XIX) linker
 ADC Info 
CD79b-A Antibody-Compound (XL) [2]
CD79b-A Antibody-Compound (XL) payload
Undisclosed
CD79b-A Antibody-Compound (XL) linker
 ADC Info 
CD79b-A Antibody-Compound (XLIII) [2]
CD79b-A Antibody-Compound (XLIII) payload
Undisclosed
CD79b-A Antibody-Compound (XLIII) linker
 ADC Info 
CD79b-A Antibody-Compound (XLII) [2]
CD79b-A Antibody-Compound (XLII) payload
Undisclosed
CD79b-A Antibody-Compound (XLII) linker
 ADC Info 
Polatuzumab-compound (XV) [2]
Polatuzumab-Compound (XV) payload
Undisclosed
Polatuzumab-Compound (XV) linker
 ADC Info 
JP7623413B2 ExampleADC53 [5]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
JP7560255B2 ControlADC53 [7]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
polatuzumab
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Polatuzumab-compound 1-1.64 [6]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
Polatuzumab-compound 2-1.71 [6]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
Polatuzumab-compound 3-1.75 [6]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
Polatuzumab-compound 4-1.82 [6]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
Polatuzumab-compound 5-1.81 [6]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
ADC Name Payload Target Linker ADC Info
SHR-A1912
SHR9265
DNA topoisomerase 1 (TOP1)
Mc-Gly-Gly-Phe-Gly
 ADC Info 
ADC Name Payload Target Linker ADC Info
EP4470568A1 ADC-8 [3]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
Undisclosed
 Antibody Info 
ADC Name Payload Target Linker ADC Info
ARC-02 [8]
Monomethyl auristatin E
Microtubule (MT)
Undisclosed
 ADC Info 
POZ-polymer ADCs [9]
Rotigotine
D(1A) dopamine receptor (DRD1)
Undisclosed
 ADC Info 
Anti.CD79b_ValCitPABC_MMAE [10]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
Anti-CD79b-RKAA-MMAE ADC [11]
Monomethyl auristatin E
Microtubule (MT)
RKAA-PABC
 ADC Info 
CD79b-3 [12]
BTK PROTAC 1
Undisclosed
Undisclosed
 ADC Info 
CD79b-4 [12]
BTK PROTAC 1
Undisclosed
Undisclosed
 ADC Info 
CD79b-MMAE [12]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
BioLink018
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
References
Ref 1 A phase 1 first-in-human study evaluating safety, pharmacokinetics, and efficacy of ABBV-291, a CD79b-targeting antibody-drug conjugate, in patients with relapsed/refractory B-cell non-Hodgkin lymphoma
Ref 2 Linkers for use in antibody drug conjugates; 2023-03-16.
Ref 3 Pharmaceutical composition comprising anti-CD79b antibody-drug conjugate and use thereof
Ref 4 FDA Approval Summary: Polatuzumab Vedotin in the First-Line Treatment of Select Large B-Cell Lymphomas
Ref 5 Antibody-drug complexes containing hemiasterlin derivatives
Ref 6 Antibody conjugates specific for mucin-1 and methods of use thereof
Ref 7 Pharmaceuticals containing antibody-drug complexes containing hemiasterin derivatives
Ref 8 A CD79b Targeting ADC with Superior Anti-Tumor Activity and Safety Resulting in Significantly Improved Therapeutic Index (TI): Safe and Efficacious CD79b ADC. Blood. 2022 ;140():11568-11569. doi: 10.1182/blood-2022-160056.
Ref 9 Introduction to basic information on POZ-polymer ADCs.
Ref 10 A comparison of the activity, lysosomal stability, and efficacy of legumain-cleavable and cathepsin-cleavable ADC linkers
Ref 11 Broadening the Therapeutic Window of ADCs Using Site-Specific Bioconjugation Showcased by an MMAE-Containing Peptide Linker in a CD79b-Targeting ADC
Ref 12 Design, Synthesis, and In Vitro and In Vivo Evaluation of Cereblon Binding Bruton's Tyrosine Kinase (BTK) Degrader CD79b Targeted Antibody-Drug Conjugates