Antibody-drug Conjugate Information

General Information of This Antibody-drug Conjugate (ADC)
ADC ID
DRG0NDOBI
ADC Name
CD79b-A Antibody-Compound (XLIII)
Synonyms
CD79b-A Antibody Compound (XLIII)
   Click to Show/Hide
Organization
Orum Therapeutics, Inc.
Drug Status
Investigative
Indication
In total 1 Indication(s)
Diffuse large B-cell lymphoma [ICD11:2A81]
Investigative
Drug-to-Antibody Ratio
1-2
Antibody Name
Polatuzumab
  Antibody Info 
Antigen Name
B-cell antigen receptor complex-associated protein beta chain (CD79B)
  Antigen Info 
Payload Name
Undisclosed
Linker Name
CD79b-A Antibody-Compound (XLIII) linker
General Information of The Activity Data Related to This ADC
Revealed Based on the Cell Line Data
Click To Hide/Show 1 Activity Data Related to This Level
Standard Type Value Units Cell Line Disease Model
Half Maximal Inhibitory Concentration (IC50) 
0.3
nM
Ramos cells
Burkitt lymphoma
Full List of Activity Data of This Antibody-drug Conjugate
Revealed Based on the Cell Line Data
Click To Hide/Show 1 Activity Data Related to This Level
Experiment 1 Reporting the Activity Date of This ADC [1]
Efficacy Data Half Maximal Inhibitory Concentration (IC50) 0.30 nM Positive CD79b expression (CD79b+++/++)
Method Description
The cells, at a predetermined concentration, were plated into 96 well plates, and, after overnight incubation at 37°C/5% CO2, serial dilutions of each test article (TA) were added to the cells. Cells were incubated with test articles for 72 hours. and viability was detected with CellTiter-Gloreagent.
In Vitro Model Burkitt lymphoma Ramos cells CVCL_0597
References
Ref 1 Linkers for use in antibody drug conjugates; 2023-03-16.

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