Antigen Information

General Information of This Antigen (ID: TAR0JUHTG)
Antigen Name
Interleukin-3 receptor subunit alpha (IL3RA)
Gene Name
IL3RA
Gene ID
3563
Synonym
IL3R; CD123
Sequence
MVLLWLTLLLIALPCLLQTKEDPNPPITNLRMKAKAQQLTWDLNRNVTDIECVKDADYSM
PAVNNSYCQFGAISLCEVTNYTVRVANPPFSTWILFPENSGKPWAGAENLTCWIHDVDFL
SCSWAVGPGAPADVQYDLYLNVANRRQQYECLHYKTDAQGTRIGCRFDDISRLSSGSQSS
HILVRGRSAAFGIPCTDKFVVFSQIEILTPPNMTAKCNKTHSFMHWKMRSHFNRKFRYEL
QIQKRMQPVITEQVRDRTSFQLLNPGTYTVQIRARERVYEFLSAWSTPQRFECDQEEGAN
TRAWRTSLLIALGTLLALVCVFVICRRYLVMQRLFPRIPHMKDPIGDSFQNDKLVVWEAG
KAGLEECLVTEVQVVQKT

    Click to Show/Hide
Family
Cytokine receptor type I family
Function
Cell surface receptor for IL3 expressed on hematopoietic progenitor cells, monocytes and B-lymphocytes that controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells. Ligand stimulation rapidly induces hetrodimerization with IL3RB, phosphorylation and enzyme activity of effector proteins such as JAK2 and PI3K that play a role in signaling cell proliferation and differentiation. Activation of JAK2 leads to STAT5-mediated transcriptional program.

    Click to Show/Hide
Uniprot Entry
IL3RA_HUMAN
HGNC ID
HGNC:6012
KEGG ID
hsa:3563
Each Antibody-drug Conjugate and Its Component Related to This Antigen
Full List of The ADC Related to This Antigen
The Numbers of ADCs, Their Three Components, Payload Targets, and Corresponding Diseases for This Antigens
023 (CD123)
 Antibody Info 
ADC Name Payload Target Linker ADC Info
WO2024222841A1 ADC60 [1]
(S)B19
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1)
OXDc-VA-PAB (PEG)
 ADC Info 
WO2024222841A1 ADC67 [1]
(S)B19
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1)
Mc-Val-Ala-PABC
 ADC Info 
ADC Name Payload Target Linker ADC Info
WO2024105205A1 1e-1015 [2]
KSPI6-1
Undisclosed
Undisclosed
 ADC Info 
WO2024105205A1 2e-1015 [2]
KSPI6-1
Undisclosed
Undisclosed
 ADC Info 
WO2024105205A1 3e-1015 [2]
KSPI6-1
Undisclosed
Undisclosed
 ADC Info 
WO2024105205A1 4c-1015 [2]
KSPI6-1
Undisclosed
WO2024105205A1-4c-1015-Linker
 ADC Info 
WO2024105205A1 5e-1015 [2]
KSPI6-1
Undisclosed
Undisclosed
 ADC Info 
WO2024105205A1 6e-1015 [2]
KSPI6-1
Undisclosed
WO2024105205A1-6e-1015-Linker
 ADC Info 
WO2024105205A1 7e-1015 [2]
KSPI6-1
Undisclosed
WO2024105205A1-7e-1015-Linker
 ADC Info 
WO2024105205A1 8e-1015 [2]
KSPI6-1
Undisclosed
Undisclosed
 ADC Info 
WO2024105205A1 11e-1015b [2]
KSPI6-1
Undisclosed
Undisclosed
 ADC Info 
WO2024105205A1 12e-1015a (DAR12) [2]
KSPI6-1
Undisclosed
Undisclosed
 ADC Info 
WO2024105205A1 12e-1015a (DAR6) [2]
KSPI6-1
Undisclosed
Undisclosed
 ADC Info 
WO2024105205A1 13e-1015 [2]
KSPI6-1
Undisclosed
Undisclosed
 ADC Info 
WO2024105205A1 14e-1015 [2]
KSPI6-1
Undisclosed
Undisclosed
 ADC Info 
ADC Name Payload Target Linker ADC Info
JP2024177330A5 16D6-CPI [3]
Cyclopropylpyrroloindoline (CPI) payload
Human Deoxyribonucleic acid (hDNA)
Undisclosed
 ADC Info 
ADC Name Payload Target Linker ADC Info
JP2024177330A5 18G3-CPI [3]
Cyclopropylpyrroloindoline (CPI) payload
Human Deoxyribonucleic acid (hDNA)
Undisclosed
 ADC Info 
JP2024177330A5 18G3-iPr [3]
iPr-calicheamicin
Undisclosed
Undisclosed
 ADC Info 
JP2024177330A5 18G3-CTI [3]
CTl payload
Undisclosed
Undisclosed
 ADC Info 
ADC Name Payload Target Linker ADC Info
JP2024177330A5 20D7-CPI [3]
Cyclopropylpyrroloindoline (CPI) payload
Human Deoxyribonucleic acid (hDNA)
Undisclosed
 ADC Info 
ADC Name Payload Target Linker ADC Info
JP2024177330A5 3D1-CPI [3]
Cyclopropylpyrroloindoline (CPI) payload
Human Deoxyribonucleic acid (hDNA)
Undisclosed
 ADC Info 
US20240091372A1 3D1-KGDEVD-MMAE [4]
Monomethyl auristatin E
Microtubule (MT)
KGDEVD linker
 ADC Info 
US20240091372A1 3D1-vc-MMAE [4]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
ADC Name Payload Target Linker ADC Info
WO2024105205A1 1c-9476 [2]
KSPI6-1
Undisclosed
WO2024105205A1-1c-9476-Linker
 ADC Info 
WO2024105205A1 3c--9476 [2]
KSPI6-1
Undisclosed
WO2024105205A1-3c--9476-Linker
 ADC Info 
WO2024105205A1 5e-9476 [2]
KSPI6-1
Undisclosed
WO2024105205A1-5e-9476-Linker
 ADC Info 
WO2024105205A1 8e-9476 [2]
KSPI6-1
Undisclosed
WO2024105205A1-8e-946-Linker
 ADC Info 
Anti-CD123 antibody
 Antibody Info 
ADC Name Payload Target Linker ADC Info
BAY-943 [5]
Proprietary BAY-943 spindle protein inhibitor
kinesin spindle protein (KSP)
Lysine-linked legumain-cleavable linker
 ADC Info 
Anti-CD123 IgG1 mAb
 Antibody Info 
ADC Name Payload Target Linker ADC Info
BYON-4413
Seco-DUBA
Human deoxyribonucleic acid (hDNA)
Mal-PEG2-Val-Cit-PABA-Cyclization Spacer
 ADC Info 
ADC Name Payload Target Linker ADC Info
TW201803600A ADC-3 [6]
PBD
Undisclosed
Undisclosed
 ADC Info 
ADC Name Payload Target Linker ADC Info
IGAC-87 [7]
IG-L-18 Payload
Undisclosed
IG-L-25 linker
 ADC Info 
ADC Name Payload Target Linker ADC Info
SGN-CD123A
SGD-1882
Human deoxyribonucleic acid (hDNA)
Mc-Val-Ala
 ADC Info 
TW201803600A ADC-4 [6]
PBD
Undisclosed
Undisclosed
 ADC Info 
ADC Name Payload Target Linker ADC Info
Lixarkitug samrotecan
AZ14170132 (AZ0132)
DNA topoisomerase 1 (TOP1)
Mal-PEG8-Val-Ala
 ADC Info 
Pivekimab
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Pivekimab sunirine
DGN549
Human deoxyribonucleic acid (hDNA)
Mal-adipamide-Ala-Ala
 ADC Info 
pivekimab
 Antibody Info 
ADC Name Payload Target Linker ADC Info
IGAC-94 [7]
IG-L-18 Payload
Undisclosed
IG-L-25 linker
 ADC Info 
ADC Name Payload Target Linker ADC Info
CN109310781A ADC-1 [8]
CN109310781A ADC-1 payload
Undisclosed
CN109310781A ADC-1 linker
 ADC Info 
CN109310781A ADC-3 [8]
CN109310781A ADC-3 payload
Undisclosed
CN109310781A ADC-3 linker
 ADC Info 
ADC Name Payload Target Linker ADC Info
CN109310781A ADC-2 [8]
CN109310781A ADC-2 payload
Undisclosed
CN109310781A ADC-2 linker
 ADC Info 
CN109310781A ADC-4 [8]
CN109310781A ADC-4 payload
Undisclosed
CN109310781A ADC-4 linker
 ADC Info 
ADC Name Payload Target Linker ADC Info
CN109310781A ADC-5 [8]
CN109310781A ADC-5 payload
Undisclosed
CN109310781A ADC-5 linker
 ADC Info 
CN110072556B 1c-8987 [9]
KSP Inhbitor
Kinesin spindle protein (KSP)
CN110072556B+Conjugate1+Linker
 ADC Info 
R1c-8987 [9]
KSP Inhbitor
Kinesin spindle protein (KSP)
CN110072556B+ConjugateR1+Linker
 ADC Info 
ADC Name Payload Target Linker ADC Info
CN109310781A ADC-6 [8]
CN109310781A ADC-6 payload
Undisclosed
CN109310781A ADC-6 linker
 ADC Info 
CN110072556B 1c-8988 [9]
KSP Inhbitor
Kinesin spindle protein (KSP)
CN110072556B+Conjugate1+Linker
 ADC Info 
R1c-8988 [9]
KSP Inhbitor
Kinesin spindle protein (KSP)
CN110072556B+ConjugateR1+Linker
 ADC Info 
ADC Name Payload Target Linker ADC Info
CN109310781A ADC-7 [8]
CN109310781A ADC-7 payload
Undisclosed
CN109310781A ADC-7 linker
 ADC Info 
CN110072556B 1c-9476 [9]
KSP Inhbitor
Kinesin spindle protein (KSP)
CN110072556B+Conjugate1+Linker
 ADC Info 
R1c-9476 [9]
KSP Inhbitor
Kinesin spindle protein (KSP)
CN110072556B+ConjugateR1+Linker
 ADC Info 
WO2024105206A1 12c-9476 [10]
CHH0189, 12i-5657, Payload
Undisclosed
CHH0189, 12i-5657, Linker
 ADC Info 
Undisclosed
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Anti-CD123 monoclonal antibody CPI conjugate [11]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
PYX-203 [12]
Cyclopropylpyrroloindole (CPI) DNA-damaging payload
Human Deoxyribonucleic acid (hDNA)
Lysosomal cleavable linker
 ADC Info 
CD123-CPI ADC (Pfizer) [13]
Cyclopropylpyrroloindoline (CPI) payload
Human Deoxyribonucleic acid (hDNA)
Undisclosed
 ADC Info 
37493255 7E7-DM4 ADC [14]
Mertansine DM4
Microtubule (MT)
Undisclosed
 ADC Info 
References
Ref 1 Antibody-drug conjugate
Ref 2 Antibody-drug conjugates (A2DCs) with enzymatically cleavable groups
Ref 3 JP2024177330A5 - Google Patents
Ref 4 Anti-doppel antibody drug conjugates
Ref 5 IL3RA-Targeting Antibody-Drug Conjugate BAY-943 with a Kinesin Spindle Protein Inhibitor Payload Shows Efficacy in Preclinical Models of Hematologic Malignancies. Cancers (Basel). 2020 Nov 20;12(11):3464. doi: 10.3390/cancers12113464.
Ref 6 Antibody-drug conjugates mainly based on PBD and combinations with FLT3 inhibitors
Ref 7 Isoindolinone-glutarimide antibody conjugates, and uses thereof
Ref 8 Specific antibody-drug-conjugate (ADC) with KSP inhibitor and anti-CD123- antibody.
Ref 9 Specific antibody-drug conjugates (ADCs) having KSP inhibitors
Ref 10 Antibody-drug conjugates cleavable in a tumor microenvironment
Ref 11 Introduction to basic information on anti-CD123 monoclonal antibody CPI conjugate (Anti-CD123-CPI)-Pfizer.
Ref 12 Pyxis oncology presents preclinical data and details on antibody-drug conjugate candidates supporting therapeutic potential
Ref 13 Generation and preclinical characterization of CD123-CPI antibody-drug conjugate (ADC). Cancer Res (2018) 78 (13_Supplement): 935.
Ref 14 Use of Payload Binding Selectivity Enhancers to Improve Therapeutic Index of Maytansinoid-Antibody-Drug Conjugates