Antigen Information

General Information of This Antigen
Antigen ID
TAR0JUHTG
Antigen Name
Interleukin-3 receptor subunit alpha (IL3RA)
Gene Name
IL3RA
Gene ID
3563
Synonym
IL3R; CD_antigen=CD123
Sequence
MVLLWLTLLLIALPCLLQTKEDPNPPITNLRMKAKAQQLTWDLNRNVTDIECVKDADYSM
PAVNNSYCQFGAISLCEVTNYTVRVANPPFSTWILFPENSGKPWAGAENLTCWIHDVDFL
SCSWAVGPGAPADVQYDLYLNVANRRQQYECLHYKTDAQGTRIGCRFDDISRLSSGSQSS
HILVRGRSAAFGIPCTDKFVVFSQIEILTPPNMTAKCNKTHSFMHWKMRSHFNRKFRYEL
QIQKRMQPVITEQVRDRTSFQLLNPGTYTVQIRARERVYEFLSAWSTPQRFECDQEEGAN
TRAWRTSLLIALGTLLALVCVFVICRRYLVMQRLFPRIPHMKDPIGDSFQNDKLVVWEAG
KAGLEECLVTEVQVVQKT

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Family
Cytokine receptor type I family
Function
Cell surface receptor for IL3 expressed on hematopoietic progenitor cells, monocytes and B-lymphocytes that controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells. Ligand stimulation rapidly induces hetrodimerization with IL3RB, phosphorylation and enzyme activity of effector proteins such as JAK2 and PI3K that play a role in signaling cell proliferation and differentiation. Activation of JAK2 leads to STAT5-mediated transcriptional program.

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Uniprot Entry
IL3RA_HUMAN
HGNC ID
HGNC:6012
KEGG ID
hsa:3563
Each Antibody-drug Conjuate AND It's Component Related to This Antigen
Full List of The ADC Related to This Antigen
023 (CD123)
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
WO2024222841A1 ADC60
(S)B19
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1)
OXDc-VA-PAB (PEG)
 [1]
 ADC Info 
WO2024222841A1 ADC67
(S)B19
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1)
Mc-Val-Ala-PABC
 [1]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
WO2024105205A1 1e-1015
KSPI6-1
Undisclosed
Undisclosed
 [2]
 ADC Info 
WO2024105205A1 2e-1015
KSPI6-1
Undisclosed
Undisclosed
 [2]
 ADC Info 
WO2024105205A1 3e-1015
KSPI6-1
Undisclosed
Undisclosed
 [2]
 ADC Info 
WO2024105205A1 4c-1015
KSPI6-1
Undisclosed
WO2024105205A1-4c-1015-Linker
 [2]
 ADC Info 
WO2024105205A1 5e-1015
KSPI6-1
Undisclosed
Undisclosed
 [2]
 ADC Info 
WO2024105205A1 6e-1015
KSPI6-1
Undisclosed
WO2024105205A1-6e-1015-Linker
 [2]
 ADC Info 
WO2024105205A1 7e-1015
KSPI6-1
Undisclosed
WO2024105205A1-7e-1015-Linker
 [2]
 ADC Info 
WO2024105205A1 8e-1015
KSPI6-1
Undisclosed
Undisclosed
 [2]
 ADC Info 
WO2024105205A1 11e-1015b
KSPI6-1
Undisclosed
Undisclosed
 [2]
 ADC Info 
WO2024105205A1 12e-1015a (DAR12)
KSPI6-1
Undisclosed
Undisclosed
 [2]
 ADC Info 
WO2024105205A1 12e-1015a (DAR6)
KSPI6-1
Undisclosed
Undisclosed
 [2]
 ADC Info 
WO2024105205A1 13e-1015
KSPI6-1
Undisclosed
Undisclosed
 [2]
 ADC Info 
WO2024105205A1 14e-1015
KSPI6-1
Undisclosed
Undisclosed
 [2]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
JP2024177330A5 16D6-CPI
Cyclopropylpyrroloindoline (CPI) payload
Human Deoxyribonucleic acid (hDNA)
Undisclosed
 [3]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
JP2024177330A5 18G3-CPI
Cyclopropylpyrroloindoline (CPI) payload
Human Deoxyribonucleic acid (hDNA)
Undisclosed
 [3]
 ADC Info 
JP2024177330A5 18G3-iPr
iPr-calicheamicin
Undisclosed
Undisclosed
 [3]
 ADC Info 
JP2024177330A5 18G3-CTI
CTl payload
Undisclosed
Undisclosed
 [3]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
JP2024177330A5 20D7-CPI
Cyclopropylpyrroloindoline (CPI) payload
Human Deoxyribonucleic acid (hDNA)
Undisclosed
 [3]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
JP2024177330A5 3D1-CPI
Cyclopropylpyrroloindoline (CPI) payload
Human Deoxyribonucleic acid (hDNA)
Undisclosed
 [3]
 ADC Info 
US20240091372A1 3D1-KGDEVD-MMAE
Monomethyl auristatin E
Microtubule (MT)
KGDEVD linker
 [4]
 ADC Info 
US20240091372A1 3D1-vc-MMAE
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 [4]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
WO2024105205A1 1c-9476
KSPI6-1
Undisclosed
WO2024105205A1-1c-9476-Linker
 [2]
 ADC Info 
WO2024105205A1 3c--9476
KSPI6-1
Undisclosed
WO2024105205A1-3c--9476-Linker
 [2]
 ADC Info 
WO2024105205A1 5e-9476
KSPI6-1
Undisclosed
WO2024105205A1-5e-9476-Linker
 [2]
 ADC Info 
WO2024105205A1 8e-9476
KSPI6-1
Undisclosed
WO2024105205A1-8e-946-Linker
 [2]
Anti-CD123 antibody
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
BAY-943
Proprietary BAY-943 spindle protein inhibitor
kinesin spindle protein (KSP)
Lysine-linked legumain-cleavable linker
 [5]
Anti-CD123 IgG1 mAb
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
BYON-4413
Seco-DUBA
Human deoxyribonucleic acid (hDNA)
Mal-PEG2-Val-Cit-PABA-Cyclization Spacer
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
TW201803600A ADC-3
PBD
Undisclosed
Undisclosed
 [6]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
IGAC-87
IG-L-18 Payload
Undisclosed
IG-L-25 linker
 [7]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
SGN-CD123A
SGD-1882
Human deoxyribonucleic acid (hDNA)
Mc-Val-Ala
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
TW201803600A ADC-4
PBD
Undisclosed
Undisclosed
 [6]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
Lixarkitug samrotecan
AZ14170132 (AZ0132)
DNA topoisomerase 1 (TOP1)
Mal-PEG8-Val-Ala
Pivekimab
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
Pivekimab sunirine
DGN549
Human deoxyribonucleic acid (hDNA)
Mal-adipamide-Ala-Ala
pivekimab
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
IGAC-94
IG-L-18 Payload
Undisclosed
IG-L-25 linker
 [7]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
CN109310781A ADC-1
CN109310781A ADC-1 payload
Undisclosed
CN109310781A ADC-1 linker
 [8]
 ADC Info 
CN109310781A ADC-3
CN109310781A ADC-3 payload
Undisclosed
CN109310781A ADC-3 linker
 [8]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
CN109310781A ADC-2
CN109310781A ADC-2 payload
Undisclosed
CN109310781A ADC-2 linker
 [8]
 ADC Info 
CN109310781A ADC-4
CN109310781A ADC-4 payload
Undisclosed
CN109310781A ADC-4 linker
 [8]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
CN109310781A ADC-5
CN109310781A ADC-5 payload
Undisclosed
CN109310781A ADC-5 linker
 [8]
 ADC Info 
CN110072556B 1c-8987
KSP Inhbitor
Kinesin spindle protein (KSP)
CN110072556B+Conjugate1+Linker
 [9]
 ADC Info 
R1c-8987
KSP Inhbitor
Kinesin spindle protein (KSP)
CN110072556B+ConjugateR1+Linker
 [9]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
CN109310781A ADC-6
CN109310781A ADC-6 payload
Undisclosed
CN109310781A ADC-6 linker
 [8]
 ADC Info 
CN110072556B 1c-8988
KSP Inhbitor
Kinesin spindle protein (KSP)
CN110072556B+Conjugate1+Linker
 [9]
 ADC Info 
R1c-8988
KSP Inhbitor
Kinesin spindle protein (KSP)
CN110072556B+ConjugateR1+Linker
 [9]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
CN109310781A ADC-7
CN109310781A ADC-7 payload
Undisclosed
CN109310781A ADC-7 linker
 [8]
 ADC Info 
CN110072556B 1c-9476
KSP Inhbitor
Kinesin spindle protein (KSP)
CN110072556B+Conjugate1+Linker
 [9]
 ADC Info 
R1c-9476
KSP Inhbitor
Kinesin spindle protein (KSP)
CN110072556B+ConjugateR1+Linker
 [9]
 ADC Info 
WO2024105206A1 12c-9476
CHH0189, 12i-5657, Payload
Undisclosed
CHH0189, 12i-5657, Linker
 [10]
Undisclosed
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
Anti-CD123 monoclonal antibody CPI conjugate
Undisclosed
Undisclosed
Undisclosed
 [11]
 ADC Info 
PYX-203
Cyclopropylpyrroloindole (CPI) DNA-damaging payload
Human Deoxyribonucleic acid (hDNA)
Lysosomal cleavable linker
 [12]
 ADC Info 
CD123-CPI ADC (Pfizer)
Cyclopropylpyrroloindoline (CPI) payload
Human Deoxyribonucleic acid (hDNA)
Undisclosed
 [13]
undisclosed
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
37493255 7E7-DM4 ADC
Mertansine DM4
Microtubule (MT)
Undisclosed
 [14]
References
Ref 1 Antibody-drug conjugate
Ref 2 Antibody-drug conjugates (A2DCs) with enzymatically cleavable groups
Ref 3 JP2024177330A5 - Google Patents
Ref 4 Anti-doppel antibody drug conjugates
Ref 5 IL3RA-Targeting Antibody-Drug Conjugate BAY-943 with a Kinesin Spindle Protein Inhibitor Payload Shows Efficacy in Preclinical Models of Hematologic Malignancies. Cancers (Basel). 2020 Nov 20;12(11):3464. doi: 10.3390/cancers12113464.
Ref 6 Antibody-drug conjugates mainly based on PBD and combinations with FLT3 inhibitors
Ref 7 Isoindolinone-glutarimide antibody conjugates, and uses thereof
Ref 8 Specific antibody-drug-conjugate (ADC) with KSP inhibitor and anti-CD123- antibody.
Ref 9 Specific antibody-drug conjugates (ADCs) having KSP inhibitors
Ref 10 Antibody-drug conjugates cleavable in a tumor microenvironment
Ref 11 Introduction to basic information on anti-CD123 monoclonal antibody CPI conjugate (Anti-CD123-CPI)-Pfizer.
Ref 12 Pyxis oncology presents preclinical data and details on antibody-drug conjugate candidates supporting therapeutic potential
Ref 13 Generation and preclinical characterization of CD123-CPI antibody-drug conjugate (ADC). Cancer Res (2018) 78 (13_Supplement): 935.
Ref 14 Use of Payload Binding Selectivity Enhancers to Improve Therapeutic Index of Maytansinoid-Antibody-Drug Conjugates