Antigen Information

General Information of This Antigen (ID: TAR0FQEWV)
Antigen Name
Integrin alpha-5 (ITGA5)
Gene Name
ITGA5
Gene ID
3678
Synonym
FNRA; CD49 antigen-like family member E; Fibronectin receptor subunit alpha; Integrin alpha-F; VLA-5; CD49e
Sequence
MGSRTPESPLHAVQLRWGPRRRPPLLPLLLLLLPPPPRVGGFNLDAEAPAVLSGPPGSFF
GFSVEFYRPGTDGVSVLVGAPKANTSQPGVLQGGAVYLCPWGASPTQCTPIEFDSKGSRL
LESSLSSSEGEEPVEYKSLQWFGATVRAHGSSILACAPLYSWRTEKEPLSDPVGTCYLST
DNFTRILEYAPCRSDFSWAAGQGYCQGGFSAEFTKTGRVVLGGPGSYFWQGQILSATQEQ
IAESYYPEYLINLVQGQLQTRQASSIYDDSYLGYSVAVGEFSGDDTEDFVAGVPKGNLTY
GYVTILNGSDIRSLYNFSGEQMASYFGYAVAATDVNGDGLDDLLVGAPLLMDRTPDGRPQ
EVGRVYVYLQHPAGIEPTPTLTLTGHDEFGRFGSSLTPLGDLDQDGYNDVAIGAPFGGET
QQGVVFVFPGGPGGLGSKPSQVLQPLWAASHTPDFFGSALRGGRDLDGNGYPDLIVGSFG
VDKAVVYRGRPIVSASASLTIFPAMFNPEERSCSLEGNPVACINLSFCLNASGKHVADSI
GFTVELQLDWQKQKGGVRRALFLASRQATLTQTLLIQNGAREDCREMKIYLRNESEFRDK
LSPIHIALNFSLDPQAPVDSHGLRPALHYQSKSRIEDKAQILLDCGEDNICVPDLQLEVF
GEQNHVYLGDKNALNLTFHAQNVGEGGAYEAELRVTAPPEAEYSGLVRHPGNFSSLSCDY
FAVNQSRLLVCDLGNPMKAGASLWGGLRFTVPHLRDTKKTIQFDFQILSKNLNNSQSDVV
SFRLSVEAQAQVTLNGVSKPEAVLFPVSDWHPRDQPQKEEDLGPAVHHVYELINQGPSSI
SQGVLELSCPQALEGQQLLYVTRVTGLNCTTNHPINPKGLELDPEGSLHHQQKREAPSRS
SASSGPQILKCPEAECFRLRCELGPLHQQESQSLQLHFRVWAKTFLQREHQPFSLQCEAV
YKALKMPYRILPRQLPQKERQVATAVQWTKAEGSYGVPLWIIILAILFGLLLLGLLIYIL
YKLGFFKRSLPYGTAMEKAQLKPPATSDA

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Family
Integrin alpha chain family
Function
Integrin alpha-5/beta-1 (ITGA5:ITGB1) is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. ITGA5:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1. ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1. ITGA5:ITGB1 acts as a receptor for fibronectin (FN1) and mediates R-G-D-dependent cell adhesion to FN1. ITGA5:ITGB1 is a receptor for IL1B and binding is essential for IL1B signaling. ITGA5:ITGB3 is a receptor for soluble CD40LG and is required for CD40/CD40LG signaling. (Microbial infection) Integrin ITGA5:ITGB1 acts as a receptor for Human metapneumovirus. (Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human parvovirus B19. (Microbial infection) In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.

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Uniprot Entry
ITA5_HUMAN
HGNC ID
HGNC:6141
KEGG ID
hsa:3678
Each Antibody-drug Conjugate and Its Component Related to This Antigen
Full List of The ADC Related to This Antigen
The Numbers of ADCs, Their Three Components, Payload Targets, and Corresponding Diseases for This Antigens
Anti-ITGA5 mAb CC2B-h15H3
 Antibody Info 
ADC Name Payload Target Linker ADC Info
CC2B-h15H3-gluc-MMAE [1]
Monomethyl auristatin E
Microtubule (MT)
Quaternary ammonium linker Gluc
 ADC Info 
Anti-ITGA5 mAb CNT095
 Antibody Info 
ADC Name Payload Target Linker ADC Info
CNT095-SPP-DM1 (CNTO 364) [2]
CNT095-SPP-DM1(CNTO 364) payload
Undisclosed
CNT095-SPP-DM1(CNTO 364) linker
 ADC Info 
CNT095-SSNPB-DM4 (CNTO 365) [2]
CNT095-SSNPB-DM4(CNTO 365) payload
Undisclosed
CNT095-SSNPB-DM4(CNTO 365) linker
 ADC Info 
CNT095-SSNPP-DM4 (CNTO 366) [2]
CNT095-SSNPP-DM4(CNTO 366) payload
Undisclosed
CNT095-SSNPP-DM4(CNTO 366) linker
 ADC Info 
CNT095-SPDB-DM4 (CNTO 365) [2]
CNT095-SPDB-DM4(CNTO 365) payload
Undisclosed
CNT095-SPDB-DM4(CNTO 365) linker
 ADC Info 
CNT095-SPP-DM4 (CNTO 366) [2]
CNT095-SPP-DM4(CNTO 366) payload
Undisclosed
CNT095-SPP-DM4(CNTO 366) linker
 ADC Info 
Anti-ITGA5 mAb F105
 Antibody Info 
ADC Name Payload Target Linker ADC Info
F105-SSNPB-DM4 [2]
F105-SSNPB-DM4 payload
Undisclosed
F105-SSNPB-DM4 linker
 ADC Info 
F105-SPDB-DM4 [2]
F105-SPDB-DM4 payload
Undisclosed
F105-SPDB-DM4 linker
 ADC Info 
Anti-ITGA5 mAb Fc
 Antibody Info 
ADC Name Payload Target Linker ADC Info
PPDN1 AP25 [3]
AP25
Integrin alpha-5 (ITGA5)
Undisclosed
 ADC Info 
PPDN2 AP25 [3]
AP25
Integrin alpha-5 (ITGA5)
Undisclosed
 ADC Info 
PPDN3 AP25 [3]
AP25
Integrin alpha-5 (ITGA5)
Undisclosed
 ADC Info 
PSG4R AP25 [3]
AP25
Integrin alpha-5 (ITGA5)
Undisclosed
 ADC Info 
Anti-ITGA5 mAb h15H3
 Antibody Info 
ADC Name Payload Target Linker ADC Info
H15H3-gluc-MMAE [1]
Monomethyl auristatin E
Microtubule (MT)
Quaternary ammonium linker Gluc
 ADC Info 
References
Ref 1 A coiled-coil masking domain for selective activation of therapeutic antibodies. Nat Biotechnol. 2019 Jul;37(7):761-765. doi: 10.1038/s41587-019-0135-x. Epub 2019 May 27.
Ref 2 anti-EGFR antibodies and antibody drug conjugates.
Ref 3 Anti-Tumor Activity and Pharmacokinetics of AP25-Fc Fusion Protein. Int J Med Sci. 2019 Jun 10;16(7):1032-1041. doi: 10.7150/ijms.34365. eCollection 2019.