Antigen Information

General Information of This Antigen
Antigen ID
TAR0FQEWV
Antigen Name
Integrin alpha-5 (ITGA5)
Gene Name
ITGA5
Synonym
FNRA; CD49 antigen-like family member E; Fibronectin receptor subunit alpha; Integrin alpha-F; VLA-5; CD_antigen=CD49e
Sequence
MGSRTPESPLHAVQLRWGPRRRPPLLPLLLLLLPPPPRVGGFNLDAEAPAVLSGPPGSFF
GFSVEFYRPGTDGVSVLVGAPKANTSQPGVLQGGAVYLCPWGASPTQCTPIEFDSKGSRL
LESSLSSSEGEEPVEYKSLQWFGATVRAHGSSILACAPLYSWRTEKEPLSDPVGTCYLST
DNFTRILEYAPCRSDFSWAAGQGYCQGGFSAEFTKTGRVVLGGPGSYFWQGQILSATQEQ
IAESYYPEYLINLVQGQLQTRQASSIYDDSYLGYSVAVGEFSGDDTEDFVAGVPKGNLTY
GYVTILNGSDIRSLYNFSGEQMASYFGYAVAATDVNGDGLDDLLVGAPLLMDRTPDGRPQ
EVGRVYVYLQHPAGIEPTPTLTLTGHDEFGRFGSSLTPLGDLDQDGYNDVAIGAPFGGET
QQGVVFVFPGGPGGLGSKPSQVLQPLWAASHTPDFFGSALRGGRDLDGNGYPDLIVGSFG
VDKAVVYRGRPIVSASASLTIFPAMFNPEERSCSLEGNPVACINLSFCLNASGKHVADSI
GFTVELQLDWQKQKGGVRRALFLASRQATLTQTLLIQNGAREDCREMKIYLRNESEFRDK
LSPIHIALNFSLDPQAPVDSHGLRPALHYQSKSRIEDKAQILLDCGEDNICVPDLQLEVF
GEQNHVYLGDKNALNLTFHAQNVGEGGAYEAELRVTAPPEAEYSGLVRHPGNFSSLSCDY
FAVNQSRLLVCDLGNPMKAGASLWGGLRFTVPHLRDTKKTIQFDFQILSKNLNNSQSDVV
SFRLSVEAQAQVTLNGVSKPEAVLFPVSDWHPRDQPQKEEDLGPAVHHVYELINQGPSSI
SQGVLELSCPQALEGQQLLYVTRVTGLNCTTNHPINPKGLELDPEGSLHHQQKREAPSRS
SASSGPQILKCPEAECFRLRCELGPLHQQESQSLQLHFRVWAKTFLQREHQPFSLQCEAV
YKALKMPYRILPRQLPQKERQVATAVQWTKAEGSYGVPLWIIILAILFGLLLLGLLIYIL
YKLGFFKRSLPYGTAMEKAQLKPPATSDA

    Click to Show/Hide
Family
Integrin alpha chain family
Function
Integrin alpha-5/beta-1 (ITGA5:ITGB1) is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. ITGA5:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1. ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1. ITGA5:ITGB1 acts as a receptor for fibronectin (FN1) and mediates R-G-D-dependent cell adhesion to FN1. ITGA5:ITGB1 is a receptor for IL1B and binding is essential for IL1B signaling. ITGA5:ITGB3 is a receptor for soluble CD40LG and is required for CD40/CD40LG signaling. (Microbial infection) Integrin ITGA5:ITGB1 acts as a receptor for Human metapneumovirus. (Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human parvovirus B19. (Microbial infection) In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.

    Click to Show/Hide
Uniprot Entry
ITA5_HUMAN
HGNC ID
HGNC:6141
KEGG ID
hsa:3678
Each Antibody-drug Conjuate AND It's Component Related to This Antigen
Full List of The ADC Related to This Antigen
Anti-ITGA5 mAb CC2B-h15H3
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
CC2B-h15H3-gluc-MMAE
Monomethyl auristatin E
Microtubule (MT)
Quaternary ammonium linker Gluc
 [1]
Anti-ITGA5 mAb CNT095
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
CNT095-SPP-DM1 (CNTO 364)
CNT095-SPP-DM1(CNTO 364) payload
Undisclosed
CNT095-SPP-DM1(CNTO 364) linker
 [2]
 ADC Info 
CNT095-SSNPB-DM4 (CNTO 365)
CNT095-SSNPB-DM4(CNTO 365) payload
Undisclosed
CNT095-SSNPB-DM4(CNTO 365) linker
 [2]
 ADC Info 
CNT095-SSNPP-DM4 (CNTO 366)
CNT095-SSNPP-DM4(CNTO 366) payload
Undisclosed
CNT095-SSNPP-DM4(CNTO 366) linker
 [2]
 ADC Info 
CNT095-SPDB-DM4 (CNTO 365)
CNT095-SPDB-DM4(CNTO 365) payload
Undisclosed
CNT095-SPDB-DM4(CNTO 365) linker
 [2]
 ADC Info 
CNT095-SPP-DM4 (CNTO 366)
CNT095-SPP-DM4(CNTO 366) payload
Undisclosed
CNT095-SPP-DM4(CNTO 366) linker
 [2]
Anti-ITGA5 mAb F105
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
F105-SPDB-DM4
F105-SPDB-DM4 payload
Undisclosed
F105-SPDB-DM4 linker
 [2]
 ADC Info 
F105-SSNPB-DM4
F105-SSNPB-DM4 payload
Undisclosed
F105-SSNPB-DM4 linker
 [2]
Anti-ITGA5 mAb Fc
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
PPDN1 AP25
AP25
Integrin alpha-5 (ITGA5)
Undisclosed
 [3]
 ADC Info 
PPDN2 AP25
AP25
Integrin alpha-5 (ITGA5)
Undisclosed
 [3]
 ADC Info 
PPDN3 AP25
AP25
Integrin alpha-5 (ITGA5)
Undisclosed
 [3]
 ADC Info 
PSG4R AP25
AP25
Integrin alpha-5 (ITGA5)
Undisclosed
 [3]
Anti-ITGA5 mAb h15H3
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
H15H3-gluc-MMAE
Monomethyl auristatin E
Microtubule (MT)
Quaternary ammonium linker Gluc
 [1]
References
Ref 1 A coiled-coil masking domain for selective activation of therapeutic antibodies. Nat Biotechnol. 2019 Jul;37(7):761-765. doi: 10.1038/s41587-019-0135-x. Epub 2019 May 27.
Ref 2 anti-EGFR antibodies and antibody drug conjugates.
Ref 3 Anti-Tumor Activity and Pharmacokinetics of AP25-Fc Fusion Protein. Int J Med Sci. 2019 Jun 10;16(7):1032-1041. doi: 10.7150/ijms.34365. eCollection 2019.