Antibody Information

General Information of This Antibody
Antibody ID
ANI0MEDSF
Antibody Name
Anti-ITGA5 mAb h15H3
Antibody Type
Monoclonal antibody (mAb)
Antibody Subtype
Humanized IgG1-kappa
Antigen Name
Integrin alpha-5 (ITGA5)
  Antigen Info 
Each Antibody-drug Conjugate Related to This Antibody
Full Information of The Activity Data of The ADC(s) Related to This Antibody
h15H3-gluc-MMAE [Investigative]
 ADC Info 
Discovered Using Cell Line-derived Xenograft Model
Click To Hide/Show 2 Activity Data Related to This Level
Experiment 1 Reporting the Activity Date of This ADC [1]
Efficacy Data Tumor Growth Inhibition value (TGI) ≈ 88.93% (Day 29) Positive ITGA5 expression (ITGA5 +++/++)
Method Description
Mice were administered a single 3 mg/kg IP dose once tumors reached 100 mm3 and tumor size was measured at various time points.
In Vivo Model Detroit 562 CDX model
In Vitro Model Pharyngeal squamous cell carcinoma Detroit 562 cells CVCL_1171
Experiment 2 Reporting the Activity Date of This ADC [1]
Efficacy Data Tumor Growth Inhibition value (TGI) ≈ 88.94% (Day 25) Positive ITGA5 expression (ITGA5 +++/++)
Method Description
Mice were administered a single 3 mg/kg IP dose once tumors reached 100 mm3 and tumor size was measured at various time points.
In Vivo Model HPAF-II CDX model
In Vitro Model Pancreatic ductal adenocarcinoma HPAF-II cells CVCL_0313
References
Ref 1 A coiled-coil masking domain for selective activation of therapeutic antibodies. Nat Biotechnol. 2019 Jul;37(7):761-765. doi: 10.1038/s41587-019-0135-x. Epub 2019 May 27.

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