Antibody Information

General Information of This Antibody
Antibody ID
ANI0LXVLK
Antibody Name
Anti-ITGA5 mAb Fc
Antibody Type
Monoclonal antibody (mAb)
Antibody Subtype
Humanized IgG Fc
Antigen Name
Integrin alpha-5 (ITGA5)
  Antigen Info 
Each Antibody-drug Conjugate Related to This Antibody
Full Information of The Activity Data of The ADC(s) Related to This Antibody
PSG4R AP25 [Investigative]
 ADC Info 
Discovered Using Cell Line-derived Xenograft Model
Click To Hide/Show 1 Activity Data Related to This Level
Experiment 1 Reporting the Activity Date of This ADC [1]
Efficacy Data Tumor Growth Inhibition value (TGI) ≈ 38.00% (Day 15) Positive ITGA5 expression (ITGA5 +++/++)
Method Description
Sixty nude mice with good growth condition and good homogeneity of tumor size were selected when the tumors grew to about 80-100 mm3. The mice in each group were intravenously administrated with drugs at 0.2 mL/20 g body weight. .
In Vivo Model HCT-116 CDX model
In Vitro Model Colon carcinoma HCT 116 cells CVCL_0291
References
Ref 1 Anti-Tumor Activity and Pharmacokinetics of AP25-Fc Fusion Protein. Int J Med Sci. 2019 Jun 10;16(7):1032-1041. doi: 10.7150/ijms.34365. eCollection 2019.

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