Antigen Information

General Information of This Antigen (ID: TAR0DPWRE)
Antigen Name
Leukocyte antigen CD37 (CD37)
Gene Name
CD37
Gene ID
951
Synonym
TSPAN26; Tetraspanin-26;CD37
Sequence
MSAQESCLSLIKYFLFVFNLFFFVLGSLIFCFGIWILIDKTSFVSFVGLAFVPLQIWSKV
LAISGIFTMGIALLGCVGALKELRCLLGLYFGMLLLLFATQITLGILISTQRAQLERSLR
DVVEKTIQKYGTNPEETAAEESWDYVQFQLRCCGWHYPQDWFQVLILRGNGSEAHRVPCS
CYNLSATNDSTILDKVILPQLSRLGHLARSRHSADICAVPAESHIYREGCAQGLQKWLHN
NLISIVGICLGVGLLELGFMTLSIFLCRNLDHVYNRLARYR

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Family
Syndecan proteoglycan family
Uniprot Entry
CD37_HUMAN
HGNC ID
HGNC:1666
KEGG ID
hsa:951
Each Antibody-drug Conjugate and Its Component Related to This Antigen
Full List of The ADC Related to This Antigen
The Numbers of ADCs, Their Three Components, Payload Targets, and Corresponding Diseases for This Antigens
ADC Name Payload Target Linker ADC Info
AGS67E
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
Anti-CD37 antibody
 Antibody Info 
ADC Name Payload Target Linker ADC Info
HDP-102 [1]
Amanitin
RNA polymerase II
Undisclosed
 ADC Info 
Anti-CD37 mAb
 Antibody Info 
ADC Name Payload Target Linker ADC Info
DS3790a
DXd
DNA topoisomerase 1 (TOP1)
Mc-Gly-Gly-Phe-Gly
 ADC Info 
hmAb-H11a
 Antibody Info 
ADC Name Payload Target Linker ADC Info
hmAb-H11aL11-DXd [2]
Undisclosed
Undisclosed
Succinimidyl-4- (N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
 ADC Info 
hmAb-H541
 Antibody Info 
ADC Name Payload Target Linker ADC Info
hmAb-H541L11-DXd [2]
Undisclosed
Undisclosed
Succinimidyl-4- (N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
 ADC Info 
hmAb-H551
 Antibody Info 
ADC Name Payload Target Linker ADC Info
hmAb-H551L11-DXd [2]
Undisclosed
Undisclosed
Succinimidyl-4- (N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
 ADC Info 
ADC Name Payload Target Linker ADC Info
hmAbH11L11-Dxd [2]
Undisclosed
Undisclosed
Succinimidyl-4- (N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
 ADC Info 
Naratuximab
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Naratuximab emtansine
DM1
Microtubule (MT)
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
 ADC Info 
IMGN529 [2]
Mertansine DM1
Microtubule (MT)
Succinimidyl-4- (N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
 ADC Info 
Debio 1562M
DM1
Microtubule (MT)
MultilinkTM Cleavable Linker
 ADC Info 
Undisclosed
 Antibody Info 
ADC Name Payload Target Linker ADC Info
NNV-014 [3]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
JAB-X1800 [4]
STING agonist
Stimulator of interferon genes protein (STING1)
Undisclosed
 ADC Info 
NNV-019 [5]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
References
Ref 1 Introduction to basic information on ADC drug by Heidelberg-pharma.
Ref 2 Anti-CD37 antibody-drug conjugate
Ref 3 Nordic Nanovector biotechnology company product pipeline
Ref 4 A JAB-X1800/JAB-BX400 introduction by Jacobio Pharmaceuticals.
Ref 5 ADC review LCB14-15XX (NNV019)