Antigen Information

General Information of This Antigen

Antigen ID	TAR0BIGJP
Antigen Name	Fucosylated monosialotetrahexosylganglioside (FucGM1)
Function	Gangliosides are cell surface glycosphingolipids that play important functional roles in cell-cell recognition, cell adhesion, and signal transduction. Although gangliosides are mostly expressed in neural tissue, abundant ganglioside expression has been observed in some tumors. For example, fucosylated monosialotetrahexosylganglioside (FucGM1) is normally expressed in a subset of peripheral sensory neurons and dorsal root ganglia, with occasional scattered expression on cells in the spleen, thymus, small intestine, and pancreas However, a large percentage of SCLC tumors express very high levels of FucGM1. Click to Show/Hide

Each Antibody-drug Conjuate AND It's Component Related to This Antigen

Full List of The ADC Related to This Antigen

Anti-FucGM1 mAb

Antibody Info

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	Anti-FucGM1-45 ADC	Tetrahydroisoquinoline-based PBD dimer 17	Human Deoxyribonucleic acid (hDNA)	Mc-Val-Cit-PABC	[1]
ADC Info	Anti-FucGM1-46 ADC	Tetrahydroisoquinoline-based PBD dimer 17	Human Deoxyribonucleic acid (hDNA)	PEG2-Val-Cit-PABC	[1]
ADC Info	Anti-FucGM1-47 ADC	Tetrahydroisoquinoline-based PBD dimer 17	Human Deoxyribonucleic acid (hDNA)	PEG4-Val-Cit-PABC	[1]
ADC Info	Anti-FucGM1-48 ADC	Tetrahydroisoquinoline-based PBD dimer 17	Human Deoxyribonucleic acid (hDNA)	PEG8-Val-Cit-PABC	[1]
ADC Info	Anti-FucGM1 mAb-IIIa-01	Anti-FucGM1 mAb-IIIa-01 payload	Undisclosed	Anti-FucGM1 mAb linker	[2]
ADC Info	Anti-FucGM1 mAb-IIIa-02	Anti-FucGM1 mAb-IIIa-02 payload	Undisclosed	Anti-FucGM1 mAb linker	[2]
ADC Info	Anti-FucGM1 mAb-IIIa-03	Anti-FucGM1 mAb-IIIa-03 payload	Undisclosed	Anti-FucGM1 mAb linker	[2]
ADC Info	Anti-FucGM1 mAb-IIIa-04	Anti-FucGM1 mAb-IIIa-04 payload	Undisclosed	Anti-FucGM1 mAb linker	[2]
ADC Info	Anti-FucGM1 mAb-IIIa-05	Anti-FucGM1 mAb-IIIa-05 payload	Undisclosed	Anti-FucGM1 mAb linker	[2]
ADC Info	Anti-FucGM1 mAb-IIIa-06	Anti-FucGM1 mAb-IIIa-06 payload	Undisclosed	Anti-FucGM1 mAb linker	[2]
ADC Info	Anti-FucGM1 mAb-IIIa-07	Anti-FucGM1 mAb-IIIa-07 payload	Undisclosed	Anti-FucGM1 mAb linker	[2]
ADC Info	Anti-FucGM1 mAb-IIIa-08	Anti-FucGM1 mAb-IIIa-08 payload	Undisclosed	Anti-FucGM1 mAb linker	[2]
ADC Info	Anti-FucGM1 mAb-IIIb-01	Anti-FucGM1 mAb-IIIb-01 payload	Undisclosed	Anti-FucGM1 mAb linker	[2]
ADC Info	Anti-FucGM1 mAb-IIIb-02	Anti-FucGM1 mAb-IIIb-02 payload	Undisclosed	Anti-FucGM1 mAb linker	[2]
ADC Info	Anti-FucGM1 mAb-IIIb-03	Anti-FucGM1 mAb-IIIb-03 payload	Undisclosed	Anti-FucGM1 mAb linker	[2]
ADC Info	Anti-FucGM1 mAb-IIIb-04	Anti-FucGM1 mAb-IIIb-04 payload	Undisclosed	Anti-FucGM1 mAb linker	[2]
ADC Info	Anti-FucGM1 mAb-IIIb-05	Anti-FucGM1 mAb-IIIb-05 payload	Undisclosed	Anti-FucGM1 mAb linker	[2]
ADC Info	Anti-FucGM1 mAb-IIIb-06	Anti-FucGM1 mAb-IIIb-06 payload	Undisclosed	Anti-FucGM1 mAb linker	[2]
ADC Info	Anti-FucGM1 mAb-IIIb-07	Anti-FucGM1 mAb-IIIb-07 payload	Undisclosed	Anti-FucGM1 mAb linker	[2]
ADC Info	Anti-FucGM1 mAb-IIIb-08	Anti-FucGM1 mAb-IIIb-08 payload	Undisclosed	Anti-FucGM1 mAb linker	[2]
ADC Info	Anti-FucGM1 mAb-IIIb-09	Anti-FucGM1 mAb-IIIb-09 payload	Undisclosed	Anti-FucGM1 mAb linker	[2]
ADC Info	Anti-FucGM1 mAb-IIIc-01	Anti-FucGM1 mAb-IIIc-01 payload	Undisclosed	Anti-FucGM1 mAb linker	[2]
ADC Info	Anti-FucGM1 mAb-IIIc-02	Anti-FucGM1 mAb-IIIc-02 payload	Undisclosed	Anti-FucGM1 mAb linker	[2]
ADC Info	Anti-FucGM1 mAb-IIIc-03	Anti-FucGM1 mAb-IIIc-03 payload	Undisclosed	Anti-FucGM1 mAb linker	[2]
ADC Info	Anti-FucGM1 mAb-IIIc-04	Anti-FucGM1 mAb-IIIc-04 payload	Undisclosed	Anti-FucGM1 mAb linker	[2]
ADC Info	Anti-FucGM1 mAb-IIIc-05	Anti-FucGM1 mAb-IIIc-05 payload	Undisclosed	Anti-FucGM1 mAb linker	[2]
ADC Info	Anti-FucGM1 mAb-IIIc-06	Anti-FucGM1 mAb-IIIc-06 payload	Undisclosed	Anti-FucGM1 mAb linker	[2]
ADC Info	Anti-FucGM1 mAb-IIIc-07	Anti-FucGM1 mAb-IIIc-07 payload	Undisclosed	Anti-FucGM1 mAb linker	[2]
ADC Info	Anti-FucGM1 mAb-IIIc-08	Anti-FucGM1 mAb-IIIc-08 payload	Undisclosed	Anti-FucGM1 mAb linker	[2]

References

Ref 1	Design, Synthesis, and Structure-Activity Relationships of Novel Tetrahydroisoquinolino Benzodiazepine Dimer Antitumor Agents and Their Application in Antibody-Drug Conjugates. J Med Chem. 2020 Nov 25;63(22):13913-13950. doi: 10.1021/acs.jmedchem.0c01385.
Ref 2	Benzodiazepine dimers, conjugates thereof, and methods of making and using.

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Correspondence

Prof. Feng ZHU (zhufeng@zju.edu.cn)

Prof. Xiaowu DONG (dongxw@zju.edu.cn)

Prof. Luo FANG (fangluo@zjcc.org.cn)