Antibody-drug Conjugate Information

General Information of This Antibody-drug Conjugate (ADC)

ADC ID	DRG0LQFXO
ADC Name	Anti-FucGM1 mAb-IIIa-03
Synonyms	Anti-FucGM1-mAb-IIIa-03 Click to Show/Hide
Organization	Bristol Myers Squibb Co.
Drug Status	Investigative
Indication	In total 1 Indication(s) Small cell lung cancer [ICD11:2C25] Investigative
Drug-to-Antibody Ratio	2
	3D MOL	2D MOL
Antibody Name	Anti-FucGM1 mAb		Antibody Info
Antigen Name	Fucosylated monosialotetrahexosylganglioside (FucGM1)		Antigen Info
Payload Name	Undisclosed
Linker Name	Anti-FucGM1 mAb linker
Conjugate Type	Random conjugation through reduced inter-chain cysteines.

General Information of The Activity Data Related to This ADC

Revealed Based on the Cell Line Data

Click To Hide/Show 2 Activity Data Related to This Level

Standard Type	Value	Units	Cell Line	Disease Model
Half Maximal Inhibitory Concentration (IC50)	0.5-1.0	nM	CVCL_1501	Lung small cell carcinoma
Half Maximal Inhibitory Concentration (IC50)	0.6-1.7	nM	CVCL_1178	Small cell lung carcinoma

Full List of Activity Data of This Antibody-drug Conjugate

Revealed Based on the Cell Line Data

Click To Hide/Show 2 Activity Data Related to This Level

Experiment 1 Reporting the Activity Date of This ADC					[1]
Efficacy Data	Half Maximal Inhibitory Concentration (IC50)	0.5-1.0 nM	Positive FucGM1 expression (FucGM1+++/++)
Method Description	The MTS cell proliferation assay was performed as follows: CellTiter 96 Aqueous Non-Radioactive Cell proliferation Kit is used to determine the number of viable cells in cell proliferation assay. Tumor cells are plated at certain seeding densities in sterile 384-well black clear bottom Matrix plates at 40 uL per well and incubated overnight at 37°C in 5% CO₂ before assaying. Click to Show/Hide
In Vitro Model	Lung small cell carcinoma	NCI-H187 cells		CVCL_1501
Experiment 2 Reporting the Activity Date of This ADC					[1]
Efficacy Data	Half Maximal Inhibitory Concentration (IC50)	0.6-1.7 nM	Positive FucGM1 expression (FucGM1+++/++)
Method Description	The MTS cell proliferation assay was performed as follows: CellTiter 96 Aqueous Non-Radioactive Cell proliferation Kit is used to determine the number of viable cells in cell proliferation assay. Tumor cells are plated at certain seeding densities in sterile 384-well black clear bottom Matrix plates at 40 uL per well and incubated overnight at 37°C in 5% CO₂ before assaying. Click to Show/Hide
In Vitro Model	Small cell lung carcinoma	DMS-79 cells		CVCL_1178

References

Ref 1	Benzodiazepine dimers, conjugates thereof, and methods of making and using.