Target Information

General Information of This Target
Target ID
PAYTAR0CVWHT
Target Name
DNA topoisomerase 1 (TOP1)+RNA polymerase II
Full List of The ADC Related to This Target
Phase 1/2
Click To Hide/Show 2 ADC Related to This Stage
ADC Info ADC Name Antibody Antigen Payload Linker Ref
ADC Info
KHN922
Patritumab
HER3
Exatecan; Triptolide
Mc-PEG2-VA-PAB+DBCO-PEG4-GGFG
 [1]
ADC Info
KH815
Sacituzumab
TROP2
Exatecan; Triptolide
Mc-PEG2-VA-PAB+DBCO-PEG4-GGFG
 [2]
References
Ref 1 A novel dual-payload HER3-directed antibody-drug conjugate, shows potent antitumor efficacy in HER3-low in vivo tumor models
Ref 2 KH815, a novel dual-payload TROP2-directed antibody-drug conjugate, shows potent antitumor efficacy in pre-clinical tumor model