Target Information

General Information of This Target (ID: PAYTAR0CVWHT)
Target Name
DNA topoisomerase 1 (TOP1)+RNA polymerase II
Full List of The ADC Related to This Target
Phase 1/2
Click To Hide/Show 2 ADC Related to This Stage
ADC Name Antibody Antigen Payload Linker ADC Info
KHN922 [1]
Patritumab
Receptor tyrosine-protein kinase erbB-3 (HER3)
Exatecan+Triptolide
Mc-PEG2-VA-PAB+DBCO-PEG4-GGFG
ADC Info
KH815 [2]
Sacituzumab
Tumor-associated calcium signal transducer 2 (TACSTD2)
Exatecan+Triptolide
Mc-PEG2-VA-PAB+DBCO-PEG4-GGFG
ADC Info
References
Ref 1 A novel dual-payload HER3-directed antibody-drug conjugate, shows potent antitumor efficacy in HER3-low in vivo tumor models
Ref 2 KH815, a novel dual-payload TROP2-directed antibody-drug conjugate, shows potent antitumor efficacy in pre-clinical tumor model