Payload Information

General Information of This Payload
Payload ID
PAY0ZSIWY
Name
DeBouganin
Synonyms
DeBouganin
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Target(s) Microtubule (MT)
 Target Info 
The activity data of This Payload
Standard Type Value Units Cell line Disease Model Cell line ID Reference
Half Maximal Inhibitory Concentration (IC50) >1000 nM
BT-474 cells
Invasive breast carcinoma
CVCL_0179 
[1]
Half Maximal Inhibitory Concentration (IC50) >1000 nM
NCI-N87 cells
Gastric tubular adenocarcinoma
CVCL_1603 
[1]
Half Maximal Inhibitory Concentration (IC50) >1000 nM
OE19 cells
Esophageal adenocarcinoma
CVCL_1622 
[1]
Half Maximal Inhibitory Concentration (IC50) >1000 nM
SK-BR-3 cells
Breast adenocarcinoma
CVCL_0033 
[1]
Half Maximal Inhibitory Concentration (IC50) >1000 nM
Calu-3 cells
Lung adenocarcinoma
CVCL_0609 
[1]
Half Maximal Inhibitory Concentration (IC50) >1000 nM
HCC1954 cells
Breast ductal carcinoma
CVCL_1259 
[1]
Half Maximal Inhibitory Concentration (IC50) >1000 nM
HCC1419 cells
Breast ductal carcinoma
CVCL_1251 
[1]
Half Maximal Inhibitory Concentration (IC50) >1000 nM
HCC1569 cells
Breast ductal carcinoma
CVCL_1255 
[1]
Half Maximal Inhibitory Concentration (IC50) >1000 nM
HCC2218 cells
Breast ductal carcinoma
CVCL_1263 
[1]
Half Maximal Inhibitory Concentration (IC50) >1000 nM
HCC202 cells
Breast ductal carcinoma
CVCL_2062 
[1]
Each Antibody-drug Conjugate Related to This Payload
References
Ref 1 DeBouganin Diabody Fusion Protein Overcomes Drug Resistance to ADCs Comprised of Anti-Microtubule Agents. Molecules. 2016 Dec 17;21(12):1741.

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