Payload Information

General Information of This Payload
Payload ID
PAY0XCFQG
Name
Pseudomonas exotoxin PE38 with protease-resistant (PE-LR)
Synonyms
Pseudomonas exotoxin PE38 with protease-resistant (PE-LR)
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Target(s) Eukaryotic elongation factor 2 (EEF2)
 Target Info 
The activity data of This Payload
Standard Type Value Units Cell line Disease Model Cell line ID Reference
Half-maximal effective concentration (EC50) 17.75 ng/mL
Jurkat cells
T acute lymphoblastic leukemia
CVCL_0065 
[1]
Half-maximal effective concentration (EC50) 4.969 ng/mL
Acute lymphoblastic leukemia cells
Acute lymphoblastic leukemia
Undisclosed [1]
Half-maximal effective concentration (EC50) 8.374 ng/mL
CCRF-CEM cells
T acute lymphoblastic leukemia
CVCL_0207 
[1]
Each Antibody-drug Conjugate Related to This Payload
References
Ref 1 Humanized CD7 nanobody-based immunotoxins exhibit promising anti-T-cell acute lymphoblastic leukemia potential. Int J Nanomedicine. 2017 Mar 13;12:1969-1983.

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