Payload Information

General Information of This Payload
Payload ID
PAY0VVUQW
Name
Pokeweed antiviral protein (PAP)
Synonyms
Pokeweed antiviral protein (PAP)
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Target(s) Ribosome (RB)
 Target Info 
The activity data of This Payload
Standard Type Value Units Cell line Disease Model Cell line ID Reference
Half Maximal Inhibitory Concentration (IC50) 14±2.1 nM
Human peripheral blood mononuclear cells(hPBMCs)
Normal
CVCL_0140 
[1]
Half Maximal Inhibitory Concentration (IC50) 2.45 nM
KB cells
Human papillomavirus-related endocervical adenocarcinoma
CVCL_0372 
[2]
Each Antibody-drug Conjugate Related to This Payload
References
Ref 1 Pokeweed antiviral protein isoforms PAP-I, PAP-II, and PAP-III depurinate RNA of human immunodeficiency virus (HIV)-1. Biochem Biophys Res Commun. 1999 Jul 5;260(2):453-8.
Ref 2 2-cyanoaminopyrimidines as a class of antitumor agents that promote tubulin polymerization. Bioorg Med Chem Lett. 2007 Jun 1;17(11):3003-5. doi: 10.1016/j.bmcl.2007.03.070. Epub 2007 Mar 25.

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