General Information of This Payload
Payload ID
PAY0VUPQZ
Name
Paclitaxel
Synonyms
33069-62-4; P88XT4IS4D; Paclitaxel; Taxol; Taxol A; Yewtaxan; Genaxol; Plaxicel; Abraxane; Ebetaxel; Genetaxyl; Capxol; Paxene; Onxol; Cyclopax; Genexol; Intaxel; Mitotax; Pacliex; TaxAlbin; OncoGel; Paxceed; EmPAC; Onxal; Zisu; Taxus stent; Taxus Liberte; ABI-007; Padexol; nab-paclitaxel; EndoTAG 1; LipoPac; Tocosol Paclitaxel; (-)-Paclitaxel; Nanoxel; Paclitaxol; Sindaxel; NSC-125973; Coroflex Please; Cypher select; Taxus Express; LEP-ETU; Genexol-PM; (NAB)-Paclitaxel; MBT 0206; BMS 181339-01; Cynviloq; Infinnium; HSDB 6839; ABI 007; DHP 107; DHP-107; Abraxane I.V. Suspension; BMS-181339-01; UNII-P88XT4IS4D; DRG-0190; Paclitaxel (Taxol); NK 105; Paclitaxel (taxus canadensis); QW 8184; EndoTAG-1; CCRIS 8143; Liposome-entrapped paclitaxel easy-to-use; DTXSID9023413; CHEBI:45863; ABI-007 COMPONENT PACLITAXEL; IG 001; NK-105; NSC125973; 5beta,20-Epoxy-1,2-alpha,4,7beta,10beta,13alpha-hexahydroxytax-11-en-9-one 4,10-diacetate 2-benzoate 13-ester with (2R,3S)-N-benzoyl-3-phenylisoserine; QW-8184; nabpaclitaxel; CHEMBL428647; DTXCID603413; (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-9-(((2R,3S)-3-benzamido-2-hydroxy-3-phenylpropanoyl)oxy)-12-(benzoyloxy)-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxete-6,12b-diyl diacetate; ORAXOL COMPONENT PACLITAXEL; Paclitaxel [USAN:USP:INN:BAN]; Abraxane (albumin-bound suspension); ABRAXANE COMPONENT PACLITAXEL; MBT-0206; NSC 125973; ABI 007 COMPONENT PACLITAXEL; (2aR-(2aalpha,4beta,4abeta,6beta,9alpha(alpha R*,betaS*),11alpha,12alpha,12balpha))-beta-(Benzoylamino)-alpha-hydroxybenzenepropanoic acid 6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca(3,4)benz(1,2-b)oxet-9-yl ester; NCGC00164367-01; NAB-PACLITAXEL COMPONENT PACLITAXEL; MFCD00869953; PACLITAXEL (MART.); PACLITAXEL [MART.]; PACLITAXEL (USP-RS); PACLITAXEL [USP-RS]; (1S,2S,3R,4S,7R,9S,10S,12R,15S)-4,12-bis(acetyloxy)-1,9-dihydroxy-15-{[(2R,3S)-2-hydroxy-3-phenyl-3-(phenylformamido)propanoyl]oxy}-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.0^{3,10}.0^{4,7}]heptadec-13-en-2-yl benzoate; PACLITAXEL (EP MONOGRAPH); PACLITAXEL (USP IMPURITY); PACLITAXEL [EP MONOGRAPH]; PACLITAXEL [USP IMPURITY]; PACLITAXEL (USP MONOGRAPH); PACLITAXEL [USP MONOGRAPH]; Xorane; 7,11-Methano-1H-cyclodeca[3,4]benz[1,2-b]oxete, benzenepropanoic acid deriv.; SMR000857385; SR-01000075350; Paclitaxel [USAN:BAN:INN]; paclitaxelum; Anzatax; Nanotaxel; Paclical; Pacligel; Paxoral; Bris Taxol; C47-H51-N-O14; Taxol, Bris; Paclitaxel,(S); Abraxane (TN); (2alpha,5beta,7beta,10beta,13alpha)-4,10-bis(acetyloxy)-1,7-dihydroxy-13-({(2R,3S)-2-hydroxy-3-phenyl-3-[(phenylcarbonyl)amino]propanoyl}oxy)-9-oxo-5,20-epoxytax-11-en-2-yl benzoate; (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-1,2a,3,4,4a,6,9,10,11,12,12a,12b-Dodecahydro-4,6,9,11,12,12b-hexahydroxy-4a,8,13,13-tetramethyl-7,11-methano-5H-cyclodeca(3,4)benz(1,2-b)oxet-5-one 6,12b-diacetate, 12-benzoate, 9-ester with (2R,3S)-N-benzoyl-3-phenylisoserine; [diacetoxy-[(2R,3S)-3-benzamido-2-hydroxy-3-phenyl-propanoyl]oxy-dihydroxy-tetramethyl-oxo-[?]yl] benzoate; 4alpha,10beta-bis(acetyloxy)-13alpha-((2S,3S)-3-benzamido-2-hydroxy-3-phenylpropanoyloxy)-1,7beta-dihydroxy-9-oxo-5beta,20-epoxytax-11-en-2alpha-yl benzoate; 4alpha,10beta-bis(acetyloxy)-13alpha-[(2S,3S)-3-benzamido-2-hydroxy-3-phenylpropanoyloxy]-1,7beta-dihydroxy-9-oxo-5beta,20-epoxytax-11-en-2alpha-yl benzoate; BENZENEPROPANOIC ACID, .BETA.-(BENZOYLAMINO)-.ALPHA.-HYDROXY-, (2AR,4S,4AS,6R,9S,11S,12S,12AR,12BS)-6,12B-BIS(ACETYLOXY)-12-(BENZOYLOXY)-2A,3,4,4A,5,6,9,10,11,12,12A,12B-DODECAHYDRO-4,11-DIHYDROXY-4A,8,13,13-TETRAMETHYL-5-OXO-7,11-METHANO-1H-CYCLODECA(3,4)BENZ(1,2-B)OXET-9-YL ESTER, (.ALPHA.R,.BETA.S)-; Benzenepropanoic acid, .beta.-(benzoylamino)-.alpha.-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (.alpha.R,.beta.S)-; Taxol (Paclitaxel); CAS-33069-62-4; PACITAXEL; BMS-181339; Paclitaxel-SSMM-VIP; P-SSMM-VIP; PACLITAXEL [MI]; PACLITAXEL [INN]; PACLITAXEL [JAN]; Prestwick3_000155; PACLITAXEL [HSDB]; PACLITAXEL [USAN]; TAXOL (TN); PACLITAXEL [VANDF]; SCHEMBL3976; 3PPC5TL76P; Nova-12005; PACLITAXEL [WHO-DD]; Paclitaxel, Taxus brevifolia; BIDD:PXR0046; BSPBio_000290; KBioGR_002509; KBioSS_002517; Paclitaxel (JAN/USP/INN); MLS002154218; MLS002695976; OAS-PAC-100; PACLITAXEL [EMA EPAR]; BPBio1_000320; GTPL2770; MEGxp0_001940; Taxol (TN) (Bristol Meyers); PACLITAXEL [GREEN BOOK]; PACLITAXEL [ORANGE BOOK]; ACon1_002231; KBio2_002509; KBio2_005077; KBio2_007645; KBio3_002987; ANX-513; DHP-208; DTS-301; L01CD01; SDP-013; cMAP_000068; RCINICONZNJXQF-MZXODVADSA-N; HMS2090D07; HMS2095O12; HMS2231A16; HMS3712O12; [(1S,2S,3R,4S,7R,9S,10S,12R,15S)-4,12-diacetyloxy-15-[(2R,3S)-3-benzamido-2-hydroxy-3-phenylpropanoyl]oxy-1,9-dihydroxy-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.03,10.04,7]heptadec-13-en-2-yl] benzoate; Benzenepropanoic acid, beta-(benzoylamino)-alpha-hydroxy-, 6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca(3,4)benz(1,2-b)oxet-9-yl ester, (2aR-(2a-alpha,4-beta,4a-beta,6-beta,9-alpha(alpha-R*,beta-S*),11-alpha,12-alpha,12a-alpha, 12b-alpha))-; Benzenepropanoic acid, beta-(benzoylamino)-alpha-hydroxy-, 6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca(3,4)benz(1,2-b)oxet-9-yl ester, (2aR-(2aalpha,4beta,4abeta,6beta,9alpha(alphaR*,betaS*),11alpha,12alpha,12aalpha,12balpha))-; HY-B0015; MPI-5018; Tax-11-en-9-one, 5beta,20-epoxy-1,2alpha,4,7beta,10beta,13alpha- hexahydroxy-, 4,10-diacetate 2-benzoate, 13-ester with (2R,3S)-N-benzoyl-3-phenylisoserine; Tox21_112107; BDBM50001839; NSC745099; AKOS007930675; AKOS015969673; AKOS025312303; CCG-220155; CS-1145; DB01229; GS-6554; NSC-745099; NCGC00164367-02; NCGC00164367-03; NCGC00164367-04; NCGC00164367-05; NCGC00164367-10; Paclitaxel, From Taxus brevifolia, 95%; NCI60_000601; Paclitaxel, from Taxus yannanensis, powder; PACLITAXEL IMPURITY L [EP IMPURITY]; AB00513812; D00491; EN300-117275; M02242; N88686; AB00513812-02; AB00513812-03; Paclitaxel, Antibiotic for Culture Media Use Only; Q423762; 7,4]benz[1,2-b]oxete,benzenepropanoic acid deriv.; Q-201533; SR-01000075350-1; SR-01000075350-3; SR-01000075350-6; SR-01000075350-7; SR-01000075350-9; BRD-K62008436-001-03-1; BRD-K62008436-001-05-6; BRD-K62008436-001-22-1; Paclitaxel, from semisynthetic (from Taxus sp.), >=97%; Paclitaxel, European Pharmacopoeia (EP) Reference Standard; Paclitaxel, from Taxus brevifolia, >=95% (HPLC), powder; Paclitaxel, United States Pharmacopeia (USP) Reference Standard; 12-benzoate, 9-ester with (2R,3S)-N-benzoyl-3-phenylisoserine; Paclitaxel, Pharmaceutical Secondary Standard; Certified Reference Material; Paclitaxel natural for peak identification, European Pharmacopoeia (EP) Reference Standard; (1S,2S,3R,4S,5R,7S,8S,10R,13S)-4,10-Diacetoxy-2-benzoyloxy-5,20-epoxy-1,7-dihydroxy-9-oxotax-11-en-13-yl (2R,3S)-3-benzoylamino-2-hydroxy-3-phenylpropionate; (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-1,2a,3,4,4a,6,9,10,11,12,12a,12b-Dodecahydro 4,6,9,11,12,12b-hexahydroxy-4a,8,13,13-tetramethyl-7,11-methano 5Hcyclodeca(3,4)benz(1,2-b)oxet-5-one 6,12b-diacetate,; (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-4,6,12b-Tris(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-11-hydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl (alphaR,betaS)-beta-(benzoylamino)-alpha-hydroxybenzenepropanoate; (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl (aR,bS)-b-(benzoylamino)-a-hydroxybenzenepropanoate; (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-9-(((2R,3S)-3-benzamido-2-hydroxy-3-phenylpropanoyl)oxy)-12-(benzoyloxy)-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-3,4,4a,5,6,9,10,11,12,12a-decahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxete-6,12b(2aH)-diyl diacetate; (2aR-(2aalpha,4beta,4abeta,6beta,9alpha(alpha R*,betaS*),11alpha,12alpha,12balpha))-beta-(Benzoylamino)-alpha-hydroxybenzenepropanoic acid 6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12; ,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca(3,4)benz(1,2-b)oxet-9-yl ester; ,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (alphaR,betaS)- (9CI); -cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, [2aR-[2aalpha,4beta,4abeta,6beta,9alpha(aR*,betaS*),11alpha,12alpha,12aalpha,12balpha]]-; [(1S,2S,3R,4S,7R,9S,10S,12R,15S)-4,12-diacetyloxy-15-[(2R,3S)-3-benzamido-2-hydroxy-3-phenylpropanoyl]oxy-1,9-dihydroxy-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.03,10.04,7]heptadec-13-en-2-yl]benzoate; 1203669-79-7; 4,7beta,10beta-tris(acetyloxy)-13alpha-[[(2R,3S)-3-benzamido-2-hydroxy-3-phenylpropanoyl]oxy]-1-hydroxy-9-oxo-5beta,20-epoxytax-11-en-2alpha-yl benzoate; 5-BETA,20-EPOXY-1,2-ALPHA,4,7-BETA,10-BETA,13-ALPHA-HEXAHYDROXY-TAX-11-EN-9-ONE 4,10-DIACETATE 2-BENZOATE 13-ESTER WITH (2R,3S)-N-BENZOYL-3-PHENYL-ISOSERINE; 5beta,20-Epoxy-1,2 alpha, 4,7beta, 10beta, 13alpha-hexahydroxy tax-11-en-9-one 4,10-diacetate 2-benzoate 13-ester with (2R, 3S)-N-benzoyl-3-phenylisoserine; Benzenepropanoic acid, 6,12b-bis(acetyl oxy)-12-(benzoyloxy)- 2a,3,4,4a,5,6,9,10,11,12,12a,12b,- dodecahydro-4,11- dihydroxy-4a,8,13,13-tetramethyl-5-oxo- 7,11-methano- 1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, [2aR- [2a.alpha.,4.beta.,4a.beta.,6.beta.,9.alpha.(alpha. R*,.beta.S*),11.alpha.,12.alpha.,12a.alpha.,12b.alpha.]]-; Benzenepropanoic acid, b-(benzoylamino)-.alpha.-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (aR,bS
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Target Microtubule (MT)
Structure
Formula
C47H51NO14
Isosmiles
CC1=C2[C@H](C(=O)[C@@]3([C@H](C[C@@H]4[C@]([C@H]3[C@@H]([C@@](C2(C)C)(C[C@@H]1OC(=O)[C@@H]([C@H](C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)O)C)OC(=O)C
PubChem CID
36314
InChI
InChI=1S/C47H51NO14/c1-25-31(60-43(56)36(52)35(28-16-10-7-11-17-28)48-41(54)29-18-12-8-13-19-29)23-47(57)40(61-42(55)30-20-14-9-15-21-30)38-45(6,32(51)22-33-46(38,24-58-33)62-27(3)50)39(53)37(59-26(2)49)34(25)44(47,4)5/h7-21,31-33,35-38,40,51-52,57H,22-24H2,1-6H3,(H,48,54)/t31-,32-,33+,35-,36+,37+,38-,40-,45+,46-,47+/m0/s1
InChIKey
RCINICONZNJXQF-MZXODVADSA-N
IUPAC Name
[(1S,2S,3R,4S,7R,9S,10S,12R,15S)-4,12-diacetyloxy-15-[(2R,3S)-3-benzamido-2-hydroxy-3-phenylpropanoyl]oxy-1,9-dihydroxy-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.03,10.04,7]heptadec-13-en-2-yl] benzoate
Pharmaceutical Properties
Molecule Weight
853.9
Polar area
221
Complexity
1790
xlogp Value
2.5
Heavy Count
62
Rot Bonds
14
Hbond acc
14
Hbond Donor
4
The activity data of This Payload
Standard Type Value Units Cell line Disease Model Cell line ID Reference
Half Maximal Inhibitory Concentration (IC50) 0.00013 ug/mL
A2780 cells
Ovarian endometrioid adenocarcinoma
CVCL_0134 
[1]
Half Maximal Inhibitory Concentration (IC50) 0.00029 ug/mL
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[1]
Half Maximal Inhibitory Concentration (IC50) 0.000587 ug/mL
A2780 cells
Ovarian endometrioid adenocarcinoma
CVCL_0134 
[2]
Half Maximal Inhibitory Concentration (IC50) 0.001 ug/mL
HL-60 cells
Adult acute myeloid leukemia
CVCL_0002 
Half Maximal Inhibitory Concentration (IC50) 0.001 ug/mL
CCRF-CEM cells
T acute lymphoblastic leukemia
CVCL_0207 
Half Maximal Effective Concentration (EC50) 0.001 ug/mL
KB cells
Human papillomavirus-related endocervical adenocarcinoma
CVCL_0372 
[3]
Half Maximal Effective Concentration (EC50) 0.001 ug/mL
KB cells
Human papillomavirus-related endocervical adenocarcinoma
CVCL_0372 
[4]
Half Maximal Effective Concentration (EC50) 0.001 ug/mL
A2780-1A9 cells
Ovarian adenocarcinoma
CVCL_H619 
[5]
Half Maximal Inhibitory Concentration (IC50) 0.001 ug/mL
KB cells
Human papillomavirus-related endocervical adenocarcinoma
CVCL_0372 
[6]
Half Maximal Inhibitory Concentration (IC50) 0.001 ug/mL
KB cells
Human papillomavirus-related endocervical adenocarcinoma
CVCL_0372 
[7]
Half Maximal Inhibitory Concentration (IC50) 0.001 ug/mL
HA59T/VGH cells
Hepatocellular carcinoma
CVCL_Y018 
[7]
Half Maximal Inhibitory Concentration (IC50) 0.00125 ug/mL
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[8]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 0.00127 ug/mL
PC-6 cells
Small cell lung carcinoma
CVCL_C002 
[9]
Half Maximal Inhibitory Concentration (IC50) 0.0013 ug/mL
KB cells
Human papillomavirus-related endocervical adenocarcinoma
CVCL_0372 
[10]
Half Maximal Inhibitory Concentration (IC50) 0.0015 ug/mL
KB cells
Human papillomavirus-related endocervical adenocarcinoma
CVCL_0372 
Half Maximal Inhibitory Concentration (IC50) 0.0015 ug/mL
KB cells
Human papillomavirus-related endocervical adenocarcinoma
CVCL_0372 
[11]
Half Maximal Inhibitory Concentration (IC50) 0.0016 ug/mL
KB cells
Human papillomavirus-related endocervical adenocarcinoma
CVCL_0372 
[12]
Half Maximal Inhibitory Concentration (IC50) 0.0019 ug/mL
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[12]
Half Maximal Effective Concentration (EC50) 0.002 ug/mL
KB cells
Human papillomavirus-related endocervical adenocarcinoma
CVCL_0372 
[5]
Half Maximal Inhibitory Concentration (IC50) 0.002 ug/mL
Lu-99 cells
Lung giant cell carcinoma
CVCL_3015 
Half Maximal Effective Concentration (EC50) 0.002 ug/mL
A2780-1A9 cells
Ovarian adenocarcinoma
CVCL_H619 
[4]
Half Maximal Inhibitory Concentration (IC50) 0.002 ug/mL
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[8]
Half Maximal Inhibitory Concentration (IC50) 0.002 ug/mL
DU145 cells
Prostate carcinoma
CVCL_0105 
[13]
Half Maximal Inhibitory Concentration (IC50) 0.002 ug/mL
HT-29 cells
Colon adenocarcinoma
CVCL_0320 
[14]
Half Maximal Inhibitory Concentration (IC50) 0.002 ug/mL
KB cells
Human papillomavirus-related endocervical adenocarcinoma
CVCL_0372 
[13]
Half Maximal Cell Growth Inhibitory Concentration (GI50) <0.0023 ug/mL
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[15]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 0.0023 ug/mL
A-431 cells
Skin squamous cell carcinoma
CVCL_0037 
[15]
Half Maximal Inhibitory Concentration (IC50) 0.0024 ug/mL
HT-29 cells
Colon adenocarcinoma
CVCL_0320 
Half Maximal Inhibitory Concentration (IC50) 0.0024 ug/mL
DU145 cells
Prostate carcinoma
CVCL_0105 
[12]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 0.00293 ug/mL
P388 cells
Lymphoma
CVCL_7222 
[9]
Half Maximal Inhibitory Concentration (IC50) <0.003 ug/mL
NCI-H226 cells
Pleural epithelioid mesothelioma
CVCL_1544 
[16]
Half Maximal Inhibitory Concentration (IC50) <0.003 ug/mL
NCI-H226 cells
Pleural epithelioid mesothelioma
CVCL_1544 
[17]
Half Maximal Inhibitory Concentration (IC50) <0.003 ug/mL
WiDr cells
Colon adenocarcinoma
CVCL_2760 
[16]
Half Maximal Inhibitory Concentration (IC50) <0.003 ug/mL
WiDr cells
Colon adenocarcinoma
CVCL_2760 
[17]
Half Maximal Inhibitory Concentration (IC50) <0.003 ug/mL
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[16]
Half Maximal Inhibitory Concentration (IC50) <0.003 ug/mL
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[17]
Half Maximal Inhibitory Concentration (IC50) <0.003 ug/mL
A498 cells
Renal carcinoma
CVCL_1056 
[16]
Half Maximal Inhibitory Concentration (IC50) <0.003 ug/mL
A498 cells
Renal carcinoma
CVCL_1056 
[17]
Half Maximal Inhibitory Concentration (IC50) <0.003 ug/mL
EVSA-T cells
Breast carcinoma
CVCL_1207 
[16]
Half Maximal Inhibitory Concentration (IC50) <0.003 ug/mL
EVSA-T cells
Breast carcinoma
CVCL_1207 
[17]
Half Maximal Inhibitory Concentration (IC50) <0.003 ug/mL
M19-MEL cells
Melanoma
CVCL_B415 
[16]
Half Maximal Inhibitory Concentration (IC50) <0.003 ug/mL
CHO-M19 cells
Normal
CVCL_H628 
[17]
Half Maximal Inhibitory Concentration (IC50) 0.0034 ug/mL
A-549 cells
Lung adenocarcinoma
CVCL_0023 
Half Maximal Cell Growth Inhibitory Concentration (GI50) 0.0035 ug/mL
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[18]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 0.0035 ug/mL
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[19]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 0.0035 ug/mL
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[20]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 0.0035 ug/mL
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[21]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 0.0035 ug/mL
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[22]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 0.0035 ug/mL
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[23]
Half Maximal Inhibitory Concentration (IC50) 0.0035 ug/mL
WRL68 cells
Embryonic hepatoma
CVCL_0581 
[6]
Half Maximal Inhibitory Concentration (IC50) 0.0037 ug/mL
DU145 cells
Prostate carcinoma
CVCL_0105 
[24]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 0.0038 ug/mL
PANC-1 cells
Pancreatic ductal adenocarcinoma
CVCL_0480 
[25]
Half Maximal Cell Growth Inhibitory Concentration (GI50) <0.004 ug/mL
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[26]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 0.004 ug/mL
PANC-1 cells
Pancreatic ductal adenocarcinoma
CVCL_0480 
[27]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 0.004 ug/mL
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[28]
Half Maximal Inhibitory Concentration (IC50) 0.004 ug/mL
HL-60 cells
Adult acute myeloid leukemia
CVCL_0002 
[29]
Half Maximal Inhibitory Concentration (IC50) 0.004 ug/mL
WRL68 cells
Embryonic hepatoma
CVCL_0581 
[30]
Half Maximal Inhibitory Concentration (IC50) 0.0041 ug/mL
B16-F10 cells
Mouse melanoma
CVCL_0159 
Half Maximal Inhibitory Concentration (IC50) 0.0043 ug/mL
WI-38 VA13 cells
Normal
CVCL_2759 
[31]
Half Maximal Inhibitory Concentration (IC50) 0.0045 ug/mL
COLO 320DM cells
Colon adenocarcinoma
CVCL_0219 
[6]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 0.0048 ug/mL
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[26]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 0.0048 ug/mL
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[19]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 0.0048 ug/mL
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[21]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 0.0048 ug/mL
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[22]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 0.0048 ug/mL
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[32]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 0.0048 ug/mL
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[20]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 0.0048 ug/mL
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[23]
Half Maximal Inhibitory Concentration (IC50) 0.0048 ug/mL
KB cells
Human papillomavirus-related endocervical adenocarcinoma
CVCL_0372 
[24]
Half Maximal Effective Concentration (EC50) 0.005 ug/mL
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[4]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 0.005 ug/mL
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[25]
Half Maximal Inhibitory Concentration (IC50) 0.005 ug/mL
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[6]
Half Maximal Inhibitory Concentration (IC50) 0.005 ug/mL
HL-60 cells
Adult acute myeloid leukemia
CVCL_0002 
[33]
Half Maximal Inhibitory Concentration (IC50) 0.0052 ug/mL
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[24]
Half Maximal Inhibitory Concentration (IC50) 0.0053 ug/mL
HT-29 cells
Colon adenocarcinoma
CVCL_0320 
[34]
Half Maximal Inhibitory Concentration (IC50) 0.0053 ug/mL
HT-29 cells
Colon adenocarcinoma
CVCL_0320 
[35]
Half Maximal Inhibitory Concentration (IC50) 0.006 ug/mL
PA-1 cells
Ovarian mixed germ cell tumor
CVCL_0479 
[6]
Half Maximal Inhibitory Concentration (IC50) 0.00676 ug/mL
A2780 cells
Ovarian endometrioid adenocarcinoma
CVCL_0134 
[8]
Half Maximal Inhibitory Concentration (IC50) 0.007 ug/mL
Caco-2 cells
Colon adenocarcinoma
CVCL_0025 
[6]
Half Maximal Inhibitory Concentration (IC50) 0.0078 ug/mL
Caco-2 cells
Colon adenocarcinoma
CVCL_0025 
[10]
Half Maximal Inhibitory Concentration (IC50) 0.008 ug/mL
Hep-G2 cells
Hepatoblastoma
CVCL_0027 
[10]
Half Maximal Inhibitory Concentration (IC50) 0.008 ug/mL
HCT 116 cells
Colon carcinoma
CVCL_0291 
[34]
Half Maximal Inhibitory Concentration (IC50) 0.008 ug/mL
HCT 116 cells
Colon carcinoma
CVCL_0291 
[35]
Half Maximal Inhibitory Concentration (IC50) 0.008 ug/mL
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[10]
Half Maximal Inhibitory Concentration (IC50) 0.008 ug/mL
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[36]
Half Maximal Inhibitory Concentration (IC50) 0.008 ug/mL
HEK293 cells
Normal
CVCL_0045 
[30]
Half Maximal Inhibitory Concentration (IC50) 0.0088 ug/mL
KB cells
Human papillomavirus-related endocervical adenocarcinoma
CVCL_0372 
Half Maximal Inhibitory Concentration (IC50) 0.0088 ug/mL
KB cells
Human papillomavirus-related endocervical adenocarcinoma
CVCL_0372 
[37]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 0.01 ug/mL
K-562 cells
Chronic myelogenous leukemia
CVCL_0004 
[38]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 0.01 ug/mL
K-562 cells
Chronic myelogenous leukemia
CVCL_0004 
[39]
Half Maximal Effective Concentration (EC50) 0.01 ug/mL
A-431 cells
Skin squamous cell carcinoma
CVCL_0037 
[5]
Half Maximal Effective Concentration (EC50) <0.01 ug/mL
Astrocyte cells
Normal
Undisclosed [40]
Half Maximal Inhibitory Concentration (IC50) 0.01 ug/mL
P388 cells
Lymphoma
CVCL_7222 
Half Maximal Inhibitory Concentration (IC50) 0.01 ug/mL
IGROV-1 cells
Ovarian endometrioid adenocarcinoma
CVCL_1304 
[16]
Half Maximal Inhibitory Concentration (IC50) 0.01 ug/mL
IGROV-1 cells
Ovarian endometrioid adenocarcinoma
CVCL_1304 
[17]
Half Maximal Inhibitory Concentration (IC50) 0.01 ug/mL
WI-38 VA13 cells
Normal
CVCL_2759 
[41]
Half Maximal Inhibitory Concentration (IC50) 0.01 ug/mL
WI-38 VA13 cells
Normal
CVCL_2759 
[42]
Half Maximal Inhibitory Concentration (IC50) 0.01 ug/mL
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[30]
Half Maximal Inhibitory Concentration (IC50) 0.01 ug/mL
BGC-823 cells
Stomach adenocarcinoma
CVCL_3360 
[43]
Half Maximal Effective Concentration (EC50) 0.011 ug/mL
HCT-8 cells
Ileocecal adenocarcinoma
CVCL_2478 
[3]
Half Maximal Effective Concentration (EC50) 0.011 ug/mL
HCT-8 cells
Ileocecal adenocarcinoma
CVCL_2478 
[4]
Half Maximal Inhibitory Concentration (IC50) 0.015 ug/mL
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[44]
Half Maximal Inhibitory Concentration (IC50) 0.018 ug/mL
K-562 cells
Chronic myelogenous leukemia
CVCL_0004 
[30]
Half Maximal Inhibitory Concentration (IC50) 0.01964 ug/mL
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[45]
Half Maximal Inhibitory Concentration (IC50) 0.01964 ug/mL
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[45]
Half Maximal Inhibitory Concentration (IC50) <0.02 ug/mL
A-549 cells
Lung adenocarcinoma
CVCL_0023 
Half Maximal Effective Concentration (EC50) 0.02 ug/mL
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[17]
Half Maximal Effective Concentration (EC50) 0.02 ug/mL
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[5]
Half Maximal Inhibitory Concentration (IC50) <0.02 ug/mL
HCT 116 cells
Colon carcinoma
CVCL_0291 
Half Maximal Inhibitory Concentration (IC50) <0.02 ug/mL
B16 cells
Melanoma
CVCL_F936 
Half Maximal Inhibitory Concentration (IC50) <0.02 ug/mL
HCT-116/VP35 cells
Colon carcinoma
CVCL_N509 
Half Maximal Inhibitory Concentration (IC50) 0.02 ug/mL
WI-38 cells
Normal
CVCL_0579 
[41]
Half Maximal Inhibitory Concentration (IC50) 0.02 ug/mL
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[43]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 0.026 ug/mL
HCT 116 cells
Colon carcinoma
CVCL_0291 
[32]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 0.026 ug/mL
HCT 116 cells
Colon carcinoma
CVCL_0291 
[23]
Half Maximal Inhibitory Concentration (IC50) 0.026 ug/mL
MDA-MB-231 cells (5T4 overexpression)
Breast adenocarcinoma
CVCL_0062 
[30]
Half Maximal Inhibitory Concentration (IC50) 0.03 ug/mL
HT-29 cells
Colon adenocarcinoma
CVCL_0320 
[17]
Half Maximal Inhibitory Concentration (IC50) 0.03 ug/mL
P388 cells
Lymphoma
CVCL_7222 
[46]
Half Maximal Inhibitory Concentration (IC50) 0.034 ug/mL
WI-38 cells
Normal
CVCL_0579 
[31]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 0.039 ug/mL
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[47]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 0.04 ug/mL
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[48]
Half Maximal Effective Concentration (EC50) 0.041 ug/mL
A2780-1A9 cells
Ovarian adenocarcinoma
CVCL_H619 
[4]
Half Maximal Effective Concentration (EC50) 0.041 ug/mL
1A9/ptx-10 cells
Ovarian adenocarcinoma
CVCL_H620 
[3]
Half Maximal Inhibitory Concentration (IC50) 0.045 ug/mL
HCT 116 cells
Colon carcinoma
CVCL_0291 
[33]
Half Maximal Inhibitory Concentration (IC50) 0.046 ug/mL
P388 cells
Lymphoma
CVCL_7222 
Half Maximal Effective Concentration (EC50) 0.05 ug/mL
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[17]
Half Maximal Inhibitory Concentration (IC50) 0.05 ug/mL
Hep-G2 cells
Hepatoblastoma
CVCL_0027 
[41]
Half Maximal Inhibitory Concentration (IC50) 0.05 ug/mL
WI-38 cells
Normal
CVCL_0579 
[42]
Half Maximal Effective Concentration (EC50) 0.06 ug/mL
HCT-8 cells
Ileocecal adenocarcinoma
CVCL_2478 
[5]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 0.075 ug/mL
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[47]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 0.08 ug/mL
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[48]
Half Maximal Inhibitory Concentration (IC50) 0.08 ug/mL
Hep 3B2.1-7 cells
Childhood hepatocellular carcinoma
CVCL_0326 
[49]
Half Maximal Inhibitory Concentration (IC50) >0.085 ug/mL
KB cells
Human papillomavirus-related endocervical adenocarcinoma
CVCL_0372 
[13]
Half Maximal Inhibitory Concentration (IC50) <0.1 ug/mL
KB cells
Human papillomavirus-related endocervical adenocarcinoma
CVCL_0372 
[50]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 0.1 ug/mL
L929 cells
Normal
CVCL_0462 
[38]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 0.1 ug/mL
L929 cells
Normal
CVCL_0462 
[39]
Half Maximal Inhibitory Concentration (IC50) <0.1 ug/mL
B16 cells
Melanoma
CVCL_F936 
[51]
Half Maximal Inhibitory Concentration (IC50) <0.1 ug/mL
Hepa-1 cells
Hepatocellular carcinoma of the mouse
CVCL_S550 
[50]
Half Maximal Inhibitory Concentration (IC50) 0.1 ug/mL
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[52]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 0.12 ug/mL
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[25]
Half Maximal Inhibitory Concentration (IC50) 0.12 ug/mL
MDA-MB-231 cells (5T4 overexpression)
Breast adenocarcinoma
CVCL_0062 
[49]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 0.127 ug/mL
PANC-1 cells
Pancreatic ductal adenocarcinoma
CVCL_0480 
[28]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 0.1279 ug/mL
PANC-1 cells
Pancreatic ductal adenocarcinoma
CVCL_0480 
[18]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 0.1279 ug/mL
PANC-1 cells
Pancreatic ductal adenocarcinoma
CVCL_0480 
[26]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 0.1279 ug/mL
PANC-1 cells
Pancreatic ductal adenocarcinoma
CVCL_0480 
[19]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 0.1279 ug/mL
PANC-1 cells
Pancreatic ductal adenocarcinoma
CVCL_0480 
[21]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 0.1279 ug/mL
PANC-1 cells
Pancreatic ductal adenocarcinoma
CVCL_0480 
[22]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 0.13 ug/mL
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[27]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 0.133 ug/mL
THP-1 cells
Childhood acute monocytic leukemia
CVCL_0006 
[28]
Half Maximal Inhibitory Concentration (IC50) 0.136 ug/mL
A2780 cells
Ovarian endometrioid adenocarcinoma
CVCL_0134 
[53]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 0.1374 ug/mL
THP-1 cells
Childhood acute monocytic leukemia
CVCL_0006 
[18]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 0.1374 ug/mL
THP-1 cells
Childhood acute monocytic leukemia
CVCL_0006 
[26]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 0.1374 ug/mL
THP-1 cells
Childhood acute monocytic leukemia
CVCL_0006 
[32]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 0.1374 ug/mL
THP-1 cells
Childhood acute monocytic leukemia
CVCL_0006 
[23]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 0.14 ug/mL
THP-1 cells
Childhood acute monocytic leukemia
CVCL_0006 
[27]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 0.14 ug/mL
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[15]
Half Maximal Inhibitory Concentration (IC50) 0.14 ug/mL
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[49]
Half Maximal Inhibitory Concentration (IC50) 0.18 ug/mL
Hep-G2 cells
Hepatoblastoma
CVCL_0027 
[49]
Half Maximal Inhibitory Concentration (IC50) 0.2 ug/mL
P388 cells
Lymphoma
CVCL_7222 
[14]
Half Maximal Inhibitory Concentration (IC50) 0.2 ug/mL
SGC-7901 cells
Gastric carcinoma
CVCL_0520 
[52]
Half Maximal Inhibitory Concentration (IC50) 0.2 ug/mL
P388 cells
Lymphoma
CVCL_7222 
[33]
Half Maximal Inhibitory Concentration (IC50) 0.27 ug/mL
P388 cells
Lymphoma
CVCL_7222 
[54]
Half Maximal Inhibitory Concentration (IC50) 0.3 ug/mL
Human umbilical vein endothelial cells(HUVEC)
Normal
Undisclosed [51]
Half Maximal Effective Concentration (EC50) >0.3 ug/mL
Vero cells
Normal
CVCL_0059 
[55]
Half Maximal Inhibitory Concentration (IC50) 0.33 ug/mL
L1210 cells
Lymphoblastic leukemia
CVCL_0382 
Half Maximal Inhibitory Concentration (IC50) 0.33 ug/mL
L1210 cells
Lymphoblastic leukemia
CVCL_0382 
[37]
Half Maximal Inhibitory Concentration (IC50) 0.38 ug/mL
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[43]
Half Maximal Inhibitory Concentration (IC50) 0.38 ug/mL
HCT 116 cells
Colon carcinoma
CVCL_0291 
[56]
Half Maximal Inhibitory Concentration (IC50) 0.47 ug/mL
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[56]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 0.539 ug/mL
PC-12 cells
Adrenal phaeochromacytoma
CVCL_0481 
[9]
Half Maximal Inhibitory Concentration (IC50) 0.59 ug/mL
Hep-G2 cells
Hepatoblastoma
CVCL_0027 
[56]
Half Maximal Inhibitory Concentration (IC50) 0.61 ug/mL
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[57]
Half Maximal Inhibitory Concentration (IC50) 0.61 ug/mL
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[56]
Half Maximal Inhibitory Concentration (IC50) 0.63 ug/mL
B16 cells
Melanoma
CVCL_F936 
[57]
Half Maximal Inhibitory Concentration (IC50) 0.69 ug/mL
Hep-G2 cells
Hepatoblastoma
CVCL_0027 
[42]
Half Maximal Inhibitory Concentration (IC50) 0.7 ug/mL
RWPE-1 cells
Normal
CVCL_3791 
[58]
Half Maximal Inhibitory Concentration (IC50) 0.75 ug/mL
HSC-T6 cells
Normal
CVCL_0315 
[57]
Half Maximal Effective Concentration (EC50) 1 10<sup>-5</sup> ug/ml
KB cells
Human papillomavirus-related endocervical adenocarcinoma
CVCL_0372 
[59]
Half Maximal Effective Concentration (EC50) 1 10<sup>-5</sup> ug/ml
KB cells
Human papillomavirus-related endocervical adenocarcinoma
CVCL_0372 
[60]
Half Maximal Inhibitory Concentration (IC50) 1.06 10<sup>-8</sup> mg/Ml
Hep-G2 cells
Hepatoblastoma
CVCL_0027 
[2]
Half Maximal Inhibitory Concentration (IC50) 1.18 ug/mL
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[30]
Half Maximal Effective Concentration (EC50) 1.2 10<sup>-3</sup> ug/mL
KB cells
Human papillomavirus-related endocervical adenocarcinoma
CVCL_0372 
[61]
Half Maximal Inhibitory Concentration (IC50) 1.3 ug/mL
SiHa cells
Cervical squamous cell carcinoma
CVCL_0032 
[51]
Half Maximal Inhibitory Concentration (IC50) 1.7 ug/mL
LNCaP cells
Prostate carcinoma
CVCL_0395 
[58]
Half Maximal Inhibitory Concentration (IC50) 1.95 10<sup>-8</sup> mg/Ml
HCT 116 cells
Colon carcinoma
CVCL_0291 
[2]
Half Maximal Cell Growth Inhibitory Concentration (GI50) >10 ug/mL
Human umbilical vein endothelial cells(HUVEC)
Normal
Undisclosed [48]
Half Maximal Cell Growth Inhibitory Concentration (GI50) >100 ug/mL
THP-1 cells
Childhood acute monocytic leukemia
CVCL_0006 
[48]
Half Maximal Inhibitory Concentration (IC50) >100 ug/mL
Vero cells
Normal
CVCL_0059 
[62]
Half Maximal Inhibitory Concentration (IC50) 101.65 ug/mL
Hep-G2 cells
Hepatoblastoma
CVCL_0027 
[63]
Half Maximal Inhibitory Concentration (IC50) <2 ug/mL
HL-60 cells
Adult acute myeloid leukemia
CVCL_0002 
[64]
Half Maximal Effective Concentration (EC50) 2 10<sup>-2</sup> ug/mL
KB cells
Human papillomavirus-related endocervical adenocarcinoma
CVCL_0372 
Half Maximal Effective Concentration (EC50) 2 10<sup>-2</sup> ug/mL
KB cells
Human papillomavirus-related endocervical adenocarcinoma
CVCL_0372 
[55]
Half Maximal Inhibitory Concentration (IC50) 2 ug/mL
CCD 19Lu cells
Normal
CVCL_2382 
Half Maximal Inhibitory Concentration (IC50) 2.9 ug/mL
PC-3 cells
Prostate carcinoma
CVCL_0035 
[58]
Half Maximal Inhibitory Concentration (IC50) >3 ug/mL
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[64]
Half Maximal Inhibitory Concentration (IC50) 3.17 10<sup>-8</sup> mg/Ml
NCI-H1650 cells
Lung adenocarcinoma
CVCL_1483 
[2]
Half Maximal Inhibitory Concentration (IC50) 3.2 ug/mL
U-87MG ATCC cells
Glioblastoma
CVCL_0022 
[51]
Half Maximal Inhibitory Concentration (IC50) 3.8 ug/mL
NCI-H358 cells
Minimally invasive lung adenocarcinoma
CVCL_1559 
[65]
Half Maximal Inhibitory Concentration (IC50) 3.9 ug/mL
MDA-MB-231 cells (5T4 overexpression)
Breast adenocarcinoma
CVCL_0062 
[65]
Half Maximal Inhibitory Concentration (IC50) 32.95 ug/mL
L929 cells
Normal
CVCL_0462 
[63]
Half Maximal Inhibitory Concentration (IC50) 4 ug/mL
SK-OV-3 cells (FZD7 overexpression)
Ovarian serous cystadenocarcinoma
CVCL_0532 
[65]
Half Maximal Inhibitory Concentration (IC50) 4.79 ug/mL
A-549 cells
Lung adenocarcinoma
CVCL_0023 
Half Maximal Inhibitory Concentration (IC50) >400 ug/mL
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[63]
Half Maximal Inhibitory Concentration (IC50) 45 ug/mL
P388 cells
Lymphoma
CVCL_7222 
[66]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 5.21 ug/mL
HCT 116 cells
Colon carcinoma
CVCL_0291 
[47]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 5.7 ug/mL
THP-1 cells
Childhood acute monocytic leukemia
CVCL_0006 
[48]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 5.8 ug/mL
PANC-1 cells
Pancreatic ductal adenocarcinoma
CVCL_0480 
[48]
Half Maximal Inhibitory Concentration (IC50) 7.3 ug/mL
SH-SY5Y cells
Bone marrow neuroblastoma
CVCL_0019 
[30]
Half Maximal Inhibitory Concentration (IC50) 7.53 ug/mL
A498 cells
Renal carcinoma
CVCL_1056 
[30]
Half Maximal Inhibitory Concentration (IC50) 8.7 ug/mL
SK-OV-3 cells (FZD7 overexpression)
Ovarian serous cystadenocarcinoma
CVCL_0532 
[51]
Half Maximal Effective Concentration (EC50) 8.9 ug/mL
KB cells
Human papillomavirus-related endocervical adenocarcinoma
CVCL_0372 
[67]
Half Maximal Effective Concentration (EC50) 12 pM
SW626 cells
Colon adenocarcinoma
CVCL_1725 
[68]
Half Maximal Inhibitory Concentration (IC50) 0.00011 nM
HCT 116 cells
Colon carcinoma
CVCL_0291 
[69]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 0.0092 nM
2008 cells
Ovarian carcinoma
CVCL_0473 
[70]
Half Maximal Cell Growth Inhibitory Concentration (GI50) <0.01 nM
A-431 cells
Skin squamous cell carcinoma
CVCL_0037 
[71]
Half Maximal Cell Growth Inhibitory Concentration (GI50) <0.01 nM
MES-SA cells
Uterine sarcoma
CVCL_1404 
[71]
Half Maximal Inhibitory Concentration (IC50) 0.01 nM
SW626 cells
Colon adenocarcinoma
CVCL_1725 
[72]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 0.015 nM
PC-3 cells
Prostate carcinoma
CVCL_0035 
[70]
Half Maximal Inhibitory Concentration (IC50) 0.016 nM
Hep 3B2.1-7 cells
Childhood hepatocellular carcinoma
CVCL_0326 
[73]
Half Maximal Inhibitory Concentration (IC50) 0.016 nM
Hep 3B2.1-7 cells
Childhood hepatocellular carcinoma
CVCL_0326 
[74]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 0.017 nM
HBL-100 cells
Normal
CVCL_4362 
[75]
Half Maximal Inhibitory Concentration (IC50) 0.03 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[76]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 0.033 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[75]
Half Maximal Inhibitory Concentration (IC50) 0.04 nM
MES-SA/Dx5 cells
Uterine sarcoma
CVCL_2598 
[77]
Half Maximal Inhibitory Concentration (IC50) 0.04 nM
KB cells
Human papillomavirus-related endocervical adenocarcinoma
CVCL_0372 
[76]
Half Maximal Inhibitory Concentration (IC50) 0.056 nM
PC-9 cells
Lung adenocarcinoma
CVCL_B260 
[78]
Half Maximal Inhibitory Concentration (IC50) 0.077 nM
BGC-823 cells
Stomach adenocarcinoma
CVCL_3360 
[78]
Half Maximal Inhibitory Concentration (IC50) 0.09 nM
L1210 cells
Lymphoblastic leukemia
CVCL_0382 
[79]
Half Maximal Effective Concentration (EC50) 0.1 nM
HT-29 cells
Colon adenocarcinoma
CVCL_0320 
[80]
Half Maximal Effective Concentration (EC50) 0.1 nM
HT-29 cells
Colon adenocarcinoma
CVCL_0320 
[81]
Half Maximal Effective Concentration (EC50) 0.1 nM
HT-29 cells
Colon adenocarcinoma
CVCL_0320 
[82]
Half Maximal Inhibitory Concentration (IC50) <0.1 nM
SK-OV-3 cells (FZD7 overexpression)
Ovarian serous cystadenocarcinoma
CVCL_0532 
[83]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 0.1 nM
Panel NCI-60 cells
Normal
Undisclosed [84]
Half Maximal Inhibitory Concentration (IC50) 0.14 nM
NCI-H460 cells
Lung large cell carcinoma
CVCL_0459 
[77]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 0.15 nM
T-47D cells
Invasive breast carcinoma
CVCL_0553 
[75]
Half Maximal Inhibitory Concentration (IC50) 0.15 nM
HT-1080 cells (FAP expression)
Fibrosarcoma
CVCL_0317 
[85]
Half Maximal Inhibitory Concentration (IC50) 0.15 nM
HT-1080 cells (FAP expression)
Fibrosarcoma
CVCL_0317 
[86]
Half Maximal Inhibitory Concentration (IC50) 0.16 nM
HT-29 cells
Colon adenocarcinoma
CVCL_0320 
[77]
Half Maximal Inhibitory Concentration (IC50) 0.19 nM
Hep-G2 cells
Hepatoblastoma
CVCL_0027 
[87]
Half Maximal Inhibitory Concentration (IC50) 0.19 nM
Hep-G2 cells
Hepatoblastoma
CVCL_0027 
[88]
Half Maximal Inhibitory Concentration (IC50) 0.2 nM
OVCAR-3 cells (FZD7 overexpression)
Ovarian serous adenocarcinoma
CVCL_0465 
[17]
Half Maximal Inhibitory Concentration (IC50) 0.2 nM
ARO cells
Anaplastic thyroid carcinoma
CVCL_0144 
[89]
Half Maximal Inhibitory Concentration (IC50) 0.2 nM
ARO cells
Anaplastic thyroid carcinoma
CVCL_0144 
[90]
Half Maximal Inhibitory Concentration (IC50) 0.2 nM
HCT 116 cells
Colon carcinoma
CVCL_0291 
[91]
Half Maximal Inhibitory Concentration (IC50) 0.2 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[92]
Half Maximal Inhibitory Concentration (IC50) 0.2 nM
Hep-G2 cells
Hepatoblastoma
CVCL_0027 
[93]
Half Maximal Inhibitory Concentration (IC50) 0.2 nM
MDA-MB-435 cells
Amelanotic melanoma
CVCL_0417 
[94]
Half Maximal Inhibitory Concentration (IC50) 0.2 nM
MDA-MB-231 cells (5T4 overexpression)
Breast adenocarcinoma
CVCL_0062 
[95]
Half Maximal Inhibitory Concentration (IC50) 0.2 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[96]
Half Maximal Inhibitory Concentration (IC50) 0.206 nM
HCT 116 cells
Colon carcinoma
CVCL_0291 
[78]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 0.22 nM
WiDr cells
Colon adenocarcinoma
CVCL_2760 
[75]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 0.27 nM
A2780 cells
Ovarian endometrioid adenocarcinoma
CVCL_0134 
[75]
Half Maximal Inhibitory Concentration (IC50) 0.27 nM
CCRF-CEM cells
T acute lymphoblastic leukemia
CVCL_0207 
[85]
Half Maximal Inhibitory Concentration (IC50) 0.27 nM
CCRF-CEM cells
T acute lymphoblastic leukemia
CVCL_0207 
[86]
Half Maximal Inhibitory Concentration (IC50) 0.2869 nM
TE-15 cells
Esophageal squamous cell carcinom
CVCL_1763 
Half Maximal Inhibitory Concentration (IC50) 0.3 nM
MES-SA/Dx5 cells
Uterine sarcoma
CVCL_2598 
[97]
Half Maximal Inhibitory Concentration (IC50) 0.3 nM
NPC-TW01 cells
Nasopharyngeal carcinoma
CVCL_6008 
[98]
Half Maximal Inhibitory Concentration (IC50) 0.3 nM
UPCI-SCC-114 cells
Normal
CVCL_2227 
[99]
Half Maximal Inhibitory Concentration (IC50) 0.3 nM
MDA-MB-435 cells
Amelanotic melanoma
CVCL_0417 
[100]
Half Maximal Inhibitory Concentration (IC50) 0.31 nM
PG-49 cells
Lung non-small cell carcinoma
CVCL_D539 
[79]
Half Maximal Inhibitory Concentration (IC50) 0.3167 nM
LC-2-ad cells
Lung adenocarcinoma
CVCL_1373 
Half Maximal Inhibitory Concentration (IC50) 0.32 nM
WM 266-4 cells
Thigh metastasis of melanoma
CVCL_2765 
[69]
Half Maximal Inhibitory Concentration (IC50) 0.38 nM
U-87MG ATCC cells
Glioblastoma
CVCL_0022 
[78]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 0.4 nM
Hep 3B2.1-7 cells
Childhood hepatocellular carcinoma
CVCL_0326 
[101]
Half Maximal Effective Concentration (EC50) 0.4 nM
KB cells
Human papillomavirus-related endocervical adenocarcinoma
CVCL_0372 
[102]
Half Maximal Inhibitory Concentration (IC50) 0.4 nM
PC-3 cells
Prostate carcinoma
CVCL_0035 
[103]
Half Maximal Inhibitory Concentration (IC50) 0.4 nM
A2780 cells
Ovarian endometrioid adenocarcinoma
CVCL_0134 
[104]
Half Maximal Inhibitory Concentration (IC50) 0.4 nM
L1210 cells
Lymphoblastic leukemia
CVCL_0382 
[85]
Half Maximal Inhibitory Concentration (IC50) 0.4 nM
L1210 cells
Lymphoblastic leukemia
CVCL_0382 
[86]
Half Maximal Inhibitory Concentration (IC50) 0.4 nM
MDA-MB-435 cells
Amelanotic melanoma
CVCL_0417 
[105]
Half Maximal Inhibitory Concentration (IC50) 0.4 nM
MDA-MB-435 cells
Amelanotic melanoma
CVCL_0417 
[95]
Half Maximal Inhibitory Concentration (IC50) 0.4 nM
BGC-823 cells
Stomach adenocarcinoma
CVCL_3360 
[96]
Half Maximal Inhibitory Concentration (IC50) 0.43 nM
PC-3 cells
Prostate carcinoma
CVCL_0035 
[106]
Half Maximal Inhibitory Concentration (IC50) 0.44 nM
Hep-G2 cells
Hepatoblastoma
CVCL_0027 
[107]
Half Maximal Inhibitory Concentration (IC50) 0.5 nM
MKN45 cells
Gastric adenocarcinoma
CVCL_0434 
[98]
Half Maximal Inhibitory Concentration (IC50) 0.5 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[79]
Half Maximal Inhibitory Concentration (IC50) 0.5 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[98]
Half Maximal Inhibitory Concentration (IC50) 0.5 nM
MES-SA cells
Uterine sarcoma
CVCL_1404 
[98]
Half Maximal Inhibitory Concentration (IC50) 0.5 nM
Jurkat cells
T acute lymphoblastic leukemia
CVCL_0065 
[108]
Half Maximal Inhibitory Concentration (IC50) 0.5 nM
MDA-MB-435 cells
Amelanotic melanoma
CVCL_0417 
[109]
Half Maximal Inhibitory Concentration (IC50) 0.5 nM
KB 3-1 cells
Cervical epithelial carcinoma
CVCL_2088 
[110]
Half Maximal Inhibitory Concentration (IC50) 0.5 nM
M14 cells
Melanoma
CVCL_1395 
[111]
Half Maximal Inhibitory Concentration (IC50) 0.52 nM
MRC5 cells
Normal
CVCL_0440 
[112]
Half Maximal Inhibitory Concentration (IC50) 0.52 nM
MRC5 cells
Normal
CVCL_0440 
[113]
Half Maximal Inhibitory Concentration (IC50) 0.52 nM
MRC5 cells
Normal
CVCL_0440 
[114]
Half Maximal Inhibitory Concentration (IC50) 0.58 nM
L1210 cells
Lymphoblastic leukemia
CVCL_0382 
[79]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 0.6 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[115]
Half Maximal Inhibitory Concentration (IC50) 0.6 nM
HCT 116 cells
Colon carcinoma
CVCL_0291 
[98]
Half Maximal Inhibitory Concentration (IC50) 0.6 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[116]
Half Maximal Inhibitory Concentration (IC50) 0.6 nM
MES-SA cells
Uterine sarcoma
CVCL_1404 
[97]
Half Maximal Inhibitory Concentration (IC50) 0.6 nM
HT-29 cells
Colon adenocarcinoma
CVCL_0320 
[117]
Half Maximal Inhibitory Concentration (IC50) 0.6 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[118]
Half Maximal Inhibitory Concentration (IC50) 0.6 nM
BGC-823 cells
Stomach adenocarcinoma
CVCL_3360 
[91]
Half Maximal Inhibitory Concentration (IC50) 0.6 nM
NCI-H460 cells
Lung large cell carcinoma
CVCL_0459 
[119]
Half Maximal Inhibitory Concentration (IC50) 0.6 nM
MDA-MB-231 cells (5T4 overexpression)
Breast adenocarcinoma
CVCL_0062 
[100]
Half Maximal Inhibitory Concentration (IC50) 0.6 nM
SNU-398 cells
Hepatocellular carcinoma
CVCL_0077 
[120]
Half Maximal Inhibitory Concentration (IC50) 0.62 nM
OVCAR-3 cells (FZD7 overexpression)
Ovarian serous adenocarcinoma
CVCL_0465 
[121]
Half Maximal Inhibitory Concentration (IC50) 0.62 nM
A2780 cells
Ovarian endometrioid adenocarcinoma
CVCL_0134 
[122]
Half Maximal Inhibitory Concentration (IC50) 0.6681 nM
RL95-2 cells
Endometrial adenosquamous carcinoma
CVCL_0505 
Half Maximal Inhibitory Concentration (IC50) 0.7 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[104]
Half Maximal Inhibitory Concentration (IC50) 0.7 nM
MDA-MB-453 cells
Breast adenocarcinoma
CVCL_0418 
[123]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 0.71 nM
A2780-1A9 cells
Ovarian adenocarcinoma
CVCL_H619 
[124]
Half Maximal Inhibitory Concentration (IC50) 0.71 nM
K-562 cells
Chronic myelogenous leukemia
CVCL_0004 
[85]
Half Maximal Inhibitory Concentration (IC50) 0.71 nM
K-562 cells
Chronic myelogenous leukemia
CVCL_0004 
[86]
Half Maximal Inhibitory Concentration (IC50) 0.7294 nM
MZ1-PC cells
Pancreatic ductal adenocarcinoma
CVCL_1434 
Half Maximal Inhibitory Concentration (IC50) 0.762 nM
Hep-G2 cells
Hepatoblastoma
CVCL_0027 
[78]
Half Maximal Inhibitory Concentration (IC50) <0.8 nM
PC-3 cells
Prostate carcinoma
CVCL_0035 
[125]
Half Maximal Inhibitory Concentration (IC50) <0.8 nM
HCT 116 cells
Colon carcinoma
CVCL_0291 
[125]
Half Maximal Inhibitory Concentration (IC50) 0.8 nM
MDA-MB-435 cells
Amelanotic melanoma
CVCL_0417 
[126]
Half Maximal Inhibitory Concentration (IC50) 0.8 nM
HT-29 cells
Colon adenocarcinoma
CVCL_0320 
[127]
Half Maximal Inhibitory Concentration (IC50) 0.8 nM
KB cells
Human papillomavirus-related endocervical adenocarcinoma
CVCL_0372 
[128]
Half Maximal Inhibitory Concentration (IC50) 0.8 nM
BGC-823 cells
Stomach adenocarcinoma
CVCL_3360 
[129]
Half Maximal Inhibitory Concentration (IC50) 0.8 nM
HT-29 cells
Colon adenocarcinoma
CVCL_0320 
[120]
Half Maximal Inhibitory Concentration (IC50) 0.8 nM
HT-29 cells
Colon adenocarcinoma
CVCL_0320 
[130]
Half Maximal Inhibitory Concentration (IC50) 0.8 nM
HT-29 cells
Colon adenocarcinoma
CVCL_0320 
[94]
Half Maximal Inhibitory Concentration (IC50) 0.8 nM
MDA-MB-231 cells (5T4 overexpression)
Breast adenocarcinoma
CVCL_0062 
[111]
Half Maximal Inhibitory Concentration (IC50) 0.82 nM
A2780 cells
Ovarian endometrioid adenocarcinoma
CVCL_0134 
[131]
Half Maximal Inhibitory Concentration (IC50) 0.9 nM
Renal proximal tubule epithelial (RPTEC) cells
Normal
Undisclosed [98]
Half Maximal Inhibitory Concentration (IC50) 0.9 nM
HCT 116 cells
Colon carcinoma
CVCL_0291 
[118]
Half Maximal Inhibitory Concentration (IC50) 0.99 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[128]
Half Maximal Inhibitory Concentration (IC50) <1 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[132]
Half Maximal Inhibitory Concentration (IC50) <1 nM
PC-3 cells
Prostate carcinoma
CVCL_0035 
[133]
Half Maximal Inhibitory Concentration (IC50) <1 nM
PC-3 cells
Prostate carcinoma
CVCL_0035 
[134]
Half Maximal Inhibitory Concentration (IC50) <1 nM
Hep-G2 cells
Hepatoblastoma
CVCL_0027 
[135]
Half Maximal Inhibitory Concentration (IC50) <1 nM
DU145 cells
Prostate carcinoma
CVCL_0105 
[135]
Half Maximal Inhibitory Concentration (IC50) <1 nM
A2780 cells
Ovarian endometrioid adenocarcinoma
CVCL_0134 
[136]
Half Maximal Inhibitory Concentration (IC50) <1 nM
A2780 cells
Ovarian endometrioid adenocarcinoma
CVCL_0134 
[137]
Half Maximal Inhibitory Concentration (IC50) <1 nM
A2780 cells
Ovarian endometrioid adenocarcinoma
CVCL_0134 
[138]
Half Maximal Inhibitory Concentration (IC50) <1 nM
A2780 cells
Ovarian endometrioid adenocarcinoma
CVCL_0134 
[139]
Half Maximal Inhibitory Concentration (IC50) <1 nM
B16-F10 cells
Mouse melanoma
CVCL_0159 
[135]
Half Maximal Cell Growth Inhibitory Concentration (GI50) <1 nM
HCT 116 cells
Colon carcinoma
CVCL_0291 
[140]
Half Maximal Inhibitory Concentration (IC50) <1 nM
HCT 116 cells
Colon carcinoma
CVCL_0291 
[134]
Half Maximal Inhibitory Concentration (IC50) <1 nM
HCT 116 cells
Colon carcinoma
CVCL_0291 
[135]
Half Maximal Inhibitory Concentration (IC50) 1 nM
HCT 116 cells
Colon carcinoma
CVCL_0291 
Half Maximal Cell Growth Inhibitory Concentration (GI50) 1 nM
HT-29 cells
Colon adenocarcinoma
CVCL_0320 
[141]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 1 nM
KB cells
Human papillomavirus-related endocervical adenocarcinoma
CVCL_0372 
[142]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 1 nM
MDA-MB-435 cells
Amelanotic melanoma
CVCL_0417 
[143]
Half Maximal Inhibitory Concentration (IC50) <1 nM
NCI-H460 cells
Lung large cell carcinoma
CVCL_0459 
[132]
Half Maximal Inhibitory Concentration (IC50) <1 nM
NCI-H460 cells
Lung large cell carcinoma
CVCL_0459 
[135]
Half Maximal Inhibitory Concentration (IC50) <1 nM
HGC-27 cells
Gastric carcinoma
CVCL_1279 
[135]
Half Maximal Inhibitory Concentration (IC50) <1 nM
MDA-MB-231 cells (5T4 overexpression)
Breast adenocarcinoma
CVCL_0062 
[133]
Half Maximal Inhibitory Concentration (IC50) <1 nM
MDA-MB-231 cells (5T4 overexpression)
Breast adenocarcinoma
CVCL_0062 
[144]
Half Maximal Inhibitory Concentration (IC50) <1 nM
MDA-MB-231 cells (5T4 overexpression)
Breast adenocarcinoma
CVCL_0062 
[135]
Half Maximal Inhibitory Concentration (IC50) <1 nM
SK-OV-3 cells (FZD7 overexpression)
Ovarian serous cystadenocarcinoma
CVCL_0532 
[145]
Half Maximal Inhibitory Concentration (IC50) <1 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[135]
Half Maximal Inhibitory Concentration (IC50) <1 nM
Fibroblast cells
Normal
Undisclosed [134]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 1 nM
HCC 2998 cells
Colon adenocarcinoma
CVCL_1266 
[146]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 1 nM
HCC 2998 cells
Colon adenocarcinoma
CVCL_1266 
[147]
Half Maximal Inhibitory Concentration (IC50) <1 nM
MES-SA cells
Uterine sarcoma
CVCL_1404 
[148]
Half Maximal Inhibitory Concentration (IC50) <1 nM
NCI-H1437 cells
Lung adenocarcinoma
CVCL_1472 
[135]
Half Maximal Inhibitory Concentration (IC50) <1 nM
BGC-823 cells
Stomach adenocarcinoma
CVCL_3360 
[136]
Half Maximal Inhibitory Concentration (IC50) <1 nM
BGC-823 cells
Stomach adenocarcinoma
CVCL_3360 
[137]
Half Maximal Inhibitory Concentration (IC50) <1 nM
BGC-823 cells
Stomach adenocarcinoma
CVCL_3360 
[138]
Half Maximal Inhibitory Concentration (IC50) <1 nM
BGC-823 cells
Stomach adenocarcinoma
CVCL_3360 
[139]
Half Maximal Inhibitory Concentration (IC50) <1 nM
BGC-823 cells
Stomach adenocarcinoma
CVCL_3360 
[135]
Half Maximal Effective Concentration (EC50) 1 nM
A2780-1A9 cells
Ovarian adenocarcinoma
CVCL_H619 
[149]
Half Maximal Inhibitory Concentration (IC50) 1 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[150]
Half Maximal Inhibitory Concentration (IC50) 1 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[151]
Half Maximal Inhibitory Concentration (IC50) 1 nM
SW48 cells
Colon adenocarcinoma
CVCL_1724 
[148]
Half Maximal Inhibitory Concentration (IC50) 1 nM
U-937 cells
Adult acute monocytic leukemia
CVCL_0007 
[152]
Half Maximal Inhibitory Concentration (IC50) 1 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[153]
Half Maximal Inhibitory Concentration (IC50) 1 nM
A2780 cells
Ovarian endometrioid adenocarcinoma
CVCL_0134 
[154]
Half Maximal Inhibitory Concentration (IC50) 1 nM
HCT 116 cells
Colon carcinoma
CVCL_0291 
[148]
Half Maximal Inhibitory Concentration (IC50) 1 nM
KB cells
Human papillomavirus-related endocervical adenocarcinoma
CVCL_0372 
[155]
Half Maximal Inhibitory Concentration (IC50) 1 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[156]
Half Maximal Inhibitory Concentration (IC50) 1 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[157]
Half Maximal Inhibitory Concentration (IC50) 1 nM
A2780 cells
Ovarian endometrioid adenocarcinoma
CVCL_0134 
[158]
Half Maximal Inhibitory Concentration (IC50) 1 nM
HT-29 cells
Colon adenocarcinoma
CVCL_0320 
[159]
Half Maximal Inhibitory Concentration (IC50) 1 nM
HT-29 cells
Colon adenocarcinoma
CVCL_0320 
[160]
Half Maximal Inhibitory Concentration (IC50) 1 nM
NCI-H460 cells
Lung large cell carcinoma
CVCL_0459 
[129]
Half Maximal Inhibitory Concentration (IC50) 1 nM
BGC-823 cells
Stomach adenocarcinoma
CVCL_3360 
[161]
Half Maximal Inhibitory Concentration (IC50) 1 nM
MDA-MB-468 cells
Breast adenocarcinoma
CVCL_0419 
[123]
Half Maximal Inhibitory Concentration (IC50) 1 nM
Hep-G2 cells
Hepatoblastoma
CVCL_0027 
[93]
Half Maximal Inhibitory Concentration (IC50) 1 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[162]
Half Maximal Inhibitory Concentration (IC50) 1 nM
A-431 cells
Skin squamous cell carcinoma
CVCL_0037 
[163]
Half Maximal Inhibitory Concentration (IC50) 1 nM
DU145 cells
Prostate carcinoma
CVCL_0105 
[162]
Half Maximal Inhibitory Concentration (IC50) 1 nM
HT-29 cells
Colon adenocarcinoma
CVCL_0320 
[162]
Half Maximal Inhibitory Concentration (IC50) 1 nM
MDA-MB-231 cells (5T4 overexpression)
Breast adenocarcinoma
CVCL_0062 
[164]
Half Maximal Inhibitory Concentration (IC50) 1.07 nM
A2780 cells
Ovarian endometrioid adenocarcinoma
CVCL_0134 
[165]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 1.1 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[166]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 1.1 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[167]
Half Maximal Effective Concentration (EC50) 1.1 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[149]
Half Maximal Inhibitory Concentration (IC50) 1.1 nM
A2780 cells
Ovarian endometrioid adenocarcinoma
CVCL_0134 
[168]
Half Maximal Inhibitory Concentration (IC50) 1.1 nM
CCRF-CEM cells
T acute lymphoblastic leukemia
CVCL_0207 
[169]
Half Maximal Inhibitory Concentration (IC50) 1.1 nM
CCRF-CEM cells
T acute lymphoblastic leukemia
CVCL_0207 
[170]
Half Maximal Inhibitory Concentration (IC50) 1.1 nM
HCT 116 cells
Colon carcinoma
CVCL_0291 
[171]
Half Maximal Inhibitory Concentration (IC50) 1.1 nM
HCT 116 cells
Colon carcinoma
CVCL_0291 
[172]
Half Maximal Inhibitory Concentration (IC50) 1.1 nM
HCT 116 cells
Colon carcinoma
CVCL_0291 
[173]
Half Maximal Inhibitory Concentration (IC50) 1.1 nM
A2780-1A9 cells
Ovarian adenocarcinoma
CVCL_H619 
[154]
Half Maximal Inhibitory Concentration (IC50) 1.1 nM
PANC-1 cells
Pancreatic ductal adenocarcinoma
CVCL_0480 
[73]
Half Maximal Inhibitory Concentration (IC50) 1.1 nM
PANC-1 cells
Pancreatic ductal adenocarcinoma
CVCL_0480 
[74]
Half Maximal Inhibitory Concentration (IC50) 1.1 nM
PC-3 cells
Prostate carcinoma
CVCL_0035 
[174]
Half Maximal Inhibitory Concentration (IC50) 1.1 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[165]
Half Maximal Inhibitory Concentration (IC50) 1.1 nM
DU145 cells
Prostate carcinoma
CVCL_0105 
[175]
Half Maximal Inhibitory Concentration (IC50) 1.1 nM
SW780 cells
Bladder carcinoma
CVCL_1728 
[156]
Half Maximal Inhibitory Concentration (IC50) 1.1 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[176]
Half Maximal Inhibitory Concentration (IC50) 1.1 nM
PC-3 cells
Prostate carcinoma
CVCL_0035 
[177]
Half Maximal Inhibitory Concentration (IC50) 1.15 nM
DU145 cells
Prostate carcinoma
CVCL_0105 
[177]
Half Maximal Inhibitory Concentration (IC50) 1.174 nM
TE-8 cells
Esophageal squamous cell carcinoma
CVCL_1766 
Half Maximal Inhibitory Concentration (IC50) 1.187 nM
SW 954 cells
Vulva squamous carcinoma
CVCL_1732 
Half Maximal Inhibitory Concentration (IC50) 1.2 nM
CCRF-CEM cells
T acute lymphoblastic leukemia
CVCL_0207 
[173]
Half Maximal Inhibitory Concentration (IC50) 1.2 nM
KB 3-1 cells
Cervical epithelial carcinoma
CVCL_2088 
[178]
Half Maximal Inhibitory Concentration (IC50) 1.2 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[179]
Half Maximal Inhibitory Concentration (IC50) 1.2 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[180]
Half Maximal Inhibitory Concentration (IC50) 1.2 nM
CCRF-CEM cells
T acute lymphoblastic leukemia
CVCL_0207 
[181]
Half Maximal Inhibitory Concentration (IC50) 1.2 nM
HT-1080 cells (FAP expression)
Fibrosarcoma
CVCL_0317 
[182]
Half Maximal Inhibitory Concentration (IC50) 1.21 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[183]
Half Maximal Inhibitory Concentration (IC50) 1.231 nM
TE-11 cells
Esophageal squamous cell carcinoma
CVCL_1761 
Half Maximal Inhibitory Concentration (IC50) 1.25 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[184]
Half Maximal Inhibitory Concentration (IC50) 1.274 nM
CCRF-CEM cells
T acute lymphoblastic leukemia
CVCL_0207 
[185]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 1.29 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[186]
Half Maximal Effective Concentration (EC50) 1.3 nM
DU145 cells
Prostate carcinoma
CVCL_0105 
[149]
Half Maximal Inhibitory Concentration (IC50) 1.3 nM
A2780 cells
Ovarian endometrioid adenocarcinoma
CVCL_0134 
[187]
Half Maximal Inhibitory Concentration (IC50) 1.3 nM
CCRF-CEM cells
T acute lymphoblastic leukemia
CVCL_0207 
[185]
Half Maximal Inhibitory Concentration (IC50) 1.3 nM
HCT 116 cells
Colon carcinoma
CVCL_0291 
[185]
Half Maximal Inhibitory Concentration (IC50) 1.3 nM
HCT 116 cells
Colon carcinoma
CVCL_0291 
[188]
Half Maximal Inhibitory Concentration (IC50) 1.3 nM
DU145 cells
Prostate carcinoma
CVCL_0105 
[85]
Half Maximal Inhibitory Concentration (IC50) 1.3 nM
DU145 cells
Prostate carcinoma
CVCL_0105 
[86]
Half Maximal Inhibitory Concentration (IC50) 1.3 nM
HCT 116 cells
Colon carcinoma
CVCL_0291 
[189]
Half Maximal Inhibitory Concentration (IC50) 1.3 nM
Human umbilical vein endothelial cells(HUVEC)
Normal
Undisclosed [190]
Half Maximal Inhibitory Concentration (IC50) 1.3 nM
M14 cells
Melanoma
CVCL_1395 
[191]
Half Maximal Inhibitory Concentration (IC50) 1.3 nM
M14 cells
Melanoma
CVCL_1395 
[123]
Half Maximal Inhibitory Concentration (IC50) 1.3 nM
BGC-823 cells
Stomach adenocarcinoma
CVCL_3360 
[192]
Half Maximal Inhibitory Concentration (IC50) 1.301 nM
PSN1 cells
Pancreatic adenocarcinoma
CVCL_1644 
Half Maximal Cell Growth Inhibitory Concentration (GI50) 1.34 nM
SK-OV-3 cells (FZD7 overexpression)
Ovarian serous cystadenocarcinoma
CVCL_0532 
[193]
Half Maximal Inhibitory Concentration (IC50) 1.34 nM
SK-OV-3 cells (FZD7 overexpression)
Ovarian serous cystadenocarcinoma
CVCL_0532 
[194]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 1.36 nM
SK-OV-3 cells (FZD7 overexpression)
Ovarian serous cystadenocarcinoma
CVCL_0532 
[195]
Half Maximal Inhibitory Concentration (IC50) 1.38 nM
A2780 cells
Ovarian endometrioid adenocarcinoma
CVCL_0134 
[196]
Half Maximal Inhibitory Concentration (IC50) 1.38 nM
A2780 cells
Ovarian endometrioid adenocarcinoma
CVCL_0134 
[197]
Half Maximal Inhibitory Concentration (IC50) 1.38 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[198]
Half Maximal Inhibitory Concentration (IC50) 1.38 nM
A2780 cells
Ovarian endometrioid adenocarcinoma
CVCL_0134 
[199]
Half Maximal Inhibitory Concentration (IC50) 1.4 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[70]
Half Maximal Inhibitory Concentration (IC50) 1.4 nM
PC-3 cells
Prostate carcinoma
CVCL_0035 
[200]
Half Maximal Inhibitory Concentration (IC50) 1.4 nM
HT-29 cells
Colon adenocarcinoma
CVCL_0320 
[201]
Half Maximal Inhibitory Concentration (IC50) 1.4 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[202]
Half Maximal Inhibitory Concentration (IC50) 1.4 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[203]
Half Maximal Inhibitory Concentration (IC50) 1.4 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[204]
Half Maximal Inhibitory Concentration (IC50) 1.4 nM
HT-29 cells
Colon adenocarcinoma
CVCL_0320 
[205]
Half Maximal Inhibitory Concentration (IC50) 1.4 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[206]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 1.47 nM
DU145 cells
Prostate carcinoma
CVCL_0105 
[193]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 1.48 nM
Human umbilical vein endothelial cells(HUVEC)
Normal
Undisclosed [207]
Half Maximal Inhibitory Concentration (IC50) 1.493 nM
MOLT-4 cells
Adult T acute lymphoblastic leukemia
CVCL_0013 
Half Maximal Inhibitory Concentration (IC50) 1.495 nM
697 cells
Childhood B acute lymphoblastic leukemia
CVCL_0079 
Half Maximal Cell Growth Inhibitory Concentration (GI50) 1.5 nM
SW1573 cells
Lung carcinoma
CVCL_1720 
[208]
Half Maximal Inhibitory Concentration (IC50) 1.5 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[209]
Half Maximal Inhibitory Concentration (IC50) 1.5 nM
CCRF-CEM cells
T acute lymphoblastic leukemia
CVCL_0207 
[210]
Half Maximal Inhibitory Concentration (IC50) 1.5 nM
HCT 116 cells
Colon carcinoma
CVCL_0291 
[169]
Half Maximal Inhibitory Concentration (IC50) 1.5 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[211]
Half Maximal Inhibitory Concentration (IC50) 1.5 nM
DU145 cells
Prostate carcinoma
CVCL_0105 
[174]
Half Maximal Inhibitory Concentration (IC50) 1.5 nM
DU145 cells
Prostate carcinoma
CVCL_0105 
[191]
Half Maximal Inhibitory Concentration (IC50) 1.5 nM
A2780 cells
Ovarian endometrioid adenocarcinoma
CVCL_0134 
[212]
Half Maximal Inhibitory Concentration (IC50) 1.5 nM
OVCAR-3 cells (FZD7 overexpression)
Ovarian serous adenocarcinoma
CVCL_0465 
[130]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 1.52 nM
DU145 cells
Prostate carcinoma
CVCL_0105 
[195]
Half Maximal Inhibitory Concentration (IC50) 1.521 nM
ETK-1 cells
Cholangiocarcinoma
CVCL_1206 
Half Maximal Effective Concentration (EC50) 1.53 nM
NCI-ADR-RES cells
High grade ovarian serous adenocarcinoma
CVCL_1452 
[213]
Half Maximal Inhibitory Concentration (IC50) 1.543 nM
TE-10 cells
Esophageal squamous cell carcinoma
CVCL_1760 
Half Maximal Inhibitory Concentration (IC50) 1.55 nM
KB cells
Human papillomavirus-related endocervical adenocarcinoma
CVCL_0372 
[214]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 1.6 nM
SW1573 cells
Lung carcinoma
CVCL_1720 
[208]
Half Maximal Inhibitory Concentration (IC50) 1.6 nM
MOLT-4 cells
Adult T acute lymphoblastic leukemia
CVCL_0013 
[152]
Half Maximal Inhibitory Concentration (IC50) 1.6 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[215]
Half Maximal Inhibitory Concentration (IC50) 1.6 nM
A2780 cells
Ovarian endometrioid adenocarcinoma
CVCL_0134 
[216]
Half Maximal Inhibitory Concentration (IC50) 1.6 nM
HCT 116 cells
Colon carcinoma
CVCL_0291 
[217]
Half Maximal Inhibitory Concentration (IC50) 1.6 nM
MES-SA cells
Uterine sarcoma
CVCL_1404 
[218]
Half Maximal Inhibitory Concentration (IC50) 1.6 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[219]
Half Maximal Inhibitory Concentration (IC50) 1.6 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[220]
Half Maximal Inhibitory Concentration (IC50) 1.6 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[146]
Half Maximal Inhibitory Concentration (IC50) 1.6 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[147]
Half Maximal Inhibitory Concentration (IC50) 1.6 nM
A375 cells
Amelanotic melanoma
CVCL_0132 
[111]
Half Maximal Inhibitory Concentration (IC50) 1.62 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[221]
Half Maximal Inhibitory Concentration (IC50) 1.62 nM
MV4-11 cells
Childhood acute monocytic leukemia
CVCL_0064 
[222]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 1.65 nM
NCI-H460 cells
Lung large cell carcinoma
CVCL_0459 
[195]
Half Maximal Inhibitory Concentration (IC50) 1.66 nM
U-937 cells
Adult acute monocytic leukemia
CVCL_0007 
[223]
Half Maximal Inhibitory Concentration (IC50) 1.682 nM
HuTu 80 cells
Duodenal adenocarcinoma
CVCL_1301 
Half Maximal Inhibitory Concentration (IC50) 1.7 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
Half Maximal Inhibitory Concentration (IC50) 1.7 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
Half Maximal Inhibitory Concentration (IC50) 1.7 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
Half Maximal Inhibitory Concentration (IC50) 1.7 nM
A2780 cells
Ovarian endometrioid adenocarcinoma
CVCL_0134 
[197]
Half Maximal Inhibitory Concentration (IC50) 1.7 nM
A2780 cells
Ovarian endometrioid adenocarcinoma
CVCL_0134 
[224]
Half Maximal Inhibitory Concentration (IC50) 1.7 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[225]
Half Maximal Inhibitory Concentration (IC50) 1.7 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[226]
Half Maximal Inhibitory Concentration (IC50) 1.7 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[227]
Half Maximal Inhibitory Concentration (IC50) 1.7 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[228]
Half Maximal Inhibitory Concentration (IC50) 1.7 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[229]
Half Maximal Inhibitory Concentration (IC50) 1.7 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[230]
Half Maximal Inhibitory Concentration (IC50) 1.7 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[231]
Half Maximal Inhibitory Concentration (IC50) 1.7 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[232]
Half Maximal Inhibitory Concentration (IC50) 1.7 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[196]
Half Maximal Inhibitory Concentration (IC50) 1.7 nM
MCF7S cells
Breast carcinoma
Undisclosed [233]
Half Maximal Inhibitory Concentration (IC50) 1.7 nM
HL-60 cells
Adult acute myeloid leukemia
CVCL_0002 
[234]
Half Maximal Inhibitory Concentration (IC50) 1.7 nM
U-937 cells
Adult acute monocytic leukemia
CVCL_0007 
[235]
Half Maximal Inhibitory Concentration (IC50) 1.7 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[236]
Half Maximal Inhibitory Concentration (IC50) 1.7 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[104]
Half Maximal Inhibitory Concentration (IC50) 1.7 nM
A375 cells
Amelanotic melanoma
CVCL_0132 
[123]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 1.76 nM
COLO 205 cells
Colon adenocarcinoma
CVCL_0218 
[237]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 1.76 nM
NCI-H460 cells
Lung large cell carcinoma
CVCL_0459 
[193]
Half Maximal Inhibitory Concentration (IC50) 1.76 nM
HEK-293T cells
Normal
CVCL_0063 
[238]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 1.792 nM
Bel-7402 cells
Hepatoma
CVCL_5492 
[186]
Half Maximal Effective Concentration (EC50) 1.8 nM
KB cells
Human papillomavirus-related endocervical adenocarcinoma
CVCL_0372 
[149]
Half Maximal Inhibitory Concentration (IC50) 1.8 nM
HL-60 cells
Adult acute myeloid leukemia
CVCL_0002 
[239]
Half Maximal Inhibitory Concentration (IC50) 1.8 nM
MOLT-4 cells
Adult T acute lymphoblastic leukemia
CVCL_0013 
[240]
Half Maximal Inhibitory Concentration (IC50) 1.8 nM
HCT 116 cells
Colon carcinoma
CVCL_0291 
[96]
Half Maximal Inhibitory Concentration (IC50) 1.8 nM
OVCAR-3 cells (FZD7 overexpression)
Ovarian serous adenocarcinoma
CVCL_0465 
[100]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 1.9 nM
MDA-MB-435 cells
Amelanotic melanoma
CVCL_0417 
[143]
Half Maximal Inhibitory Concentration (IC50) 1.9 nM
HT-29 cells
Colon adenocarcinoma
CVCL_0320 
[209]
Half Maximal Inhibitory Concentration (IC50) 1.9 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[241]
Half Maximal Inhibitory Concentration (IC50) 1.9 nM
NCI-H69 cells
Small cell lung carcinoma
CVCL_1579 
[218]
Half Maximal Inhibitory Concentration (IC50) 1.9 nM
U-937 cells
Adult acute monocytic leukemia
CVCL_0007 
[240]
Half Maximal Inhibitory Concentration (IC50) 1.9 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[242]
Half Maximal Inhibitory Concentration (IC50) 1.9 nM
KB cells
Human papillomavirus-related endocervical adenocarcinoma
CVCL_0372 
[165]
Half Maximal Inhibitory Concentration (IC50) 1.9 nM
LNCaP cells
Prostate carcinoma
CVCL_0395 
[243]
Half Maximal Inhibitory Concentration (IC50) 1.9 nM
PC-3 cells
Prostate carcinoma
CVCL_0035 
[191]
Half Maximal Inhibitory Concentration (IC50) 1.9 nM
Hep-G2 cells
Hepatoblastoma
CVCL_0027 
[96]
Half Maximal Inhibitory Concentration (IC50) 1.93 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[214]
Half Maximal Inhibitory Concentration (IC50) 1.93 nM
MDA-MB-435 cells
Amelanotic melanoma
CVCL_0417 
[183]
Half Maximal Inhibitory Concentration (IC50) 1.98 nM
HT-29 cells
Colon adenocarcinoma
CVCL_0320 
[244]
Half Maximal Inhibitory Concentration (IC50) 1.99 nM
HL-60 cells
Adult acute myeloid leukemia
CVCL_0002 
[223]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 10 nM
A-172 cells
Glioblastoma
CVCL_0131 
[245]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 10 nM
A-172 cells
Glioblastoma
CVCL_0131 
[246]
Half Maximal Cell Growth Inhibitory Concentration (GI50) <10 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[247]
Half Maximal Cell Growth Inhibitory Concentration (GI50) <10 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[248]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 10 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[140]
Half Maximal Cell Growth Inhibitory Concentration (GI50) <10 nM
Jurkat cells
T acute lymphoblastic leukemia
CVCL_0065 
[249]
Half Maximal Inhibitory Concentration (IC50) <10 nM
Jurkat cells
T acute lymphoblastic leukemia
CVCL_0065 
[250]
Half Maximal Inhibitory Concentration (IC50) <10 nM
PC-3 cells
Prostate carcinoma
CVCL_0035 
[250]
Half Maximal Cell Growth Inhibitory Concentration (GI50) <10 nM
Hep-G2 cells
Hepatoblastoma
CVCL_0027 
[251]
Half Maximal Inhibitory Concentration (IC50) <10 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[250]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 10 nM
DLD-1 cells
Colon adenocarcinoma
CVCL_0248 
[245]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 10 nM
DLD-1 cells
Colon adenocarcinoma
CVCL_0248 
[246]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 10 nM
HCT 116 cells
Colon carcinoma
CVCL_0291 
[252]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 10 nM
SNB-19 cells
Astrocytoma
CVCL_0535 
[253]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 10 nM
SNB-19 cells
Astrocytoma
CVCL_0535 
[146]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 10 nM
SNB-19 cells
Astrocytoma
CVCL_0535 
[147]
Half Maximal Inhibitory Concentration (IC50) <10 nM
786-O cells
Renal cell carcinoma
CVCL_1051 
[250]
Half Maximal Cell Growth Inhibitory Concentration (GI50) <10 nM
MDA-MB-231 cells (5T4 overexpression)
Breast adenocarcinoma
CVCL_0062 
[247]
Half Maximal Cell Growth Inhibitory Concentration (GI50) <10 nM
MDA-MB-231 cells (5T4 overexpression)
Breast adenocarcinoma
CVCL_0062 
[248]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 10 nM
MDA-MB-231 cells (5T4 overexpression)
Breast adenocarcinoma
CVCL_0062 
[254]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 10 nM
SK-OV-3 cells (FZD7 overexpression)
Ovarian serous cystadenocarcinoma
CVCL_0532 
[253]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 10 nM
A375 cells
Amelanotic melanoma
CVCL_0132 
[255]
Half Maximal Cell Growth Inhibitory Concentration (GI50) <10 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[251]
Half Maximal Inhibitory Concentration (IC50) <10 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[250]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 10 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[140]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 10 nM
SNU-398 cells
Hepatocellular carcinoma
CVCL_0077 
[256]
Half Maximal Cell Growth Inhibitory Concentration (GI50) <10 nM
IMR-32 cells
Neuroblastoma
CVCL_0346 
[251]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 10 nM
M14 cells
Melanoma
CVCL_1395 
[253]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 10 nM
UACC-62 cells
Melanoma
CVCL_1780 
[141]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 10 nM
B16 cells
Melanoma
CVCL_F936 
[245]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 10 nM
B16 cells
Melanoma
CVCL_F936 
[246]
Half Maximal Cell Growth Inhibitory Concentration (GI50) <10 nM
WPMY-1 cells
Normal
CVCL_3814 
[248]
Half Maximal Inhibitory Concentration (IC50) 10 nM
DU145 cells
Prostate carcinoma
CVCL_0105 
[151]
Half Maximal Inhibitory Concentration (IC50) 10 nM
KB cells
Human papillomavirus-related endocervical adenocarcinoma
CVCL_0372 
[257]
Half Maximal Inhibitory Concentration (IC50) 10 nM
KB cells
Human papillomavirus-related endocervical adenocarcinoma
CVCL_0372 
[258]
Half Maximal Inhibitory Concentration (IC50) 10 nM
KB cells
Human papillomavirus-related endocervical adenocarcinoma
CVCL_0372 
[259]
Half Maximal Inhibitory Concentration (IC50) 10 nM
KB cells
Human papillomavirus-related endocervical adenocarcinoma
CVCL_0372 
[260]
Half Maximal Inhibitory Concentration (IC50) 10 nM
NCI-H460 cells
Lung large cell carcinoma
CVCL_0459 
[257]
Half Maximal Inhibitory Concentration (IC50) 10 nM
NCI-H460 cells
Lung large cell carcinoma
CVCL_0459 
[258]
Half Maximal Inhibitory Concentration (IC50) 10 nM
NCI-H460 cells
Lung large cell carcinoma
CVCL_0459 
[259]
Half Maximal Inhibitory Concentration (IC50) 10 nM
NCI-H460 cells
Lung large cell carcinoma
CVCL_0459 
[260]
Half Maximal Inhibitory Concentration (IC50) 10 nM
OVCAR-3 cells (FZD7 overexpression)
Ovarian serous adenocarcinoma
CVCL_0465 
[89]
Half Maximal Inhibitory Concentration (IC50) 10 nM
OVCAR-3 cells (FZD7 overexpression)
Ovarian serous adenocarcinoma
CVCL_0465 
[90]
Half Maximal Inhibitory Concentration (IC50) 10 nM
RKO cells
Colon carcinoma
CVCL_0504 
[257]
Half Maximal Inhibitory Concentration (IC50) 10 nM
RKO cells
Colon carcinoma
CVCL_0504 
[258]
Half Maximal Inhibitory Concentration (IC50) 10 nM
RKO cells
Colon carcinoma
CVCL_0504 
[259]
Half Maximal Inhibitory Concentration (IC50) 10 nM
RKO cells
Colon carcinoma
CVCL_0504 
[260]
Half Maximal Inhibitory Concentration (IC50) 10 nM
SK-OV-3 cells (FZD7 overexpression)
Ovarian serous cystadenocarcinoma
CVCL_0532 
[257]
Half Maximal Inhibitory Concentration (IC50) 10 nM
SK-OV-3 cells (FZD7 overexpression)
Ovarian serous cystadenocarcinoma
CVCL_0532 
[258]
Half Maximal Inhibitory Concentration (IC50) 10 nM
SK-OV-3 cells (FZD7 overexpression)
Ovarian serous cystadenocarcinoma
CVCL_0532 
[259]
Half Maximal Inhibitory Concentration (IC50) 10 nM
SK-OV-3 cells (FZD7 overexpression)
Ovarian serous cystadenocarcinoma
CVCL_0532 
[260]
Half Maximal Inhibitory Concentration (IC50) 10 nM
SF268 cells
Astrocytoma
CVCL_1689 
[257]
Half Maximal Inhibitory Concentration (IC50) 10 nM
SF268 cells
Astrocytoma
CVCL_1689 
[258]
Half Maximal Inhibitory Concentration (IC50) 10 nM
SF268 cells
Astrocytoma
CVCL_1689 
[259]
Half Maximal Inhibitory Concentration (IC50) 10 nM
SF268 cells
Astrocytoma
CVCL_1689 
[260]
Half Maximal Inhibitory Concentration (IC50) 10 nM
HEK293 cells
Normal
CVCL_0045 
[261]
Half Maximal Inhibitory Concentration (IC50) 10 nM
DG-75 cells
Burkitt lymphoma
CVCL_0244 
[29]
Half Maximal Inhibitory Concentration (IC50) 10 nM
P388 cells
Lymphoma
CVCL_7222 
[262]
Half Maximal Inhibitory Concentration (IC50) 10 nM
P388 cells
Lymphoma
CVCL_7222 
[263]
Half Maximal Inhibitory Concentration (IC50) 10 nM
Mutu-1 cells
Burkitt lymphoma
CVCL_7202 
[29]
Half Maximal Inhibitory Concentration (IC50) 10 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[264]
Half Maximal Inhibitory Concentration (IC50) 10 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[265]
Half Maximal Inhibitory Concentration (IC50) 10 nM
HL-60 cells
Adult acute myeloid leukemia
CVCL_0002 
[266]
Half Maximal Inhibitory Concentration (IC50) 10 nM
Jurkat cells
T acute lymphoblastic leukemia
CVCL_0065 
[267]
Half Maximal Inhibitory Concentration (IC50) 10 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[183]
Half Maximal Inhibitory Concentration (IC50) 10 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[268]
Half Maximal Inhibitory Concentration (IC50) 10 nM
A2780 cells
Ovarian endometrioid adenocarcinoma
CVCL_0134 
[267]
Half Maximal Inhibitory Concentration (IC50) 10 nM
KB cells
Human papillomavirus-related endocervical adenocarcinoma
CVCL_0372 
[269]
Half Maximal Inhibitory Concentration (IC50) 10 nM
NCI-H460 cells
Lung large cell carcinoma
CVCL_0459 
[269]
Half Maximal Inhibitory Concentration (IC50) 10 nM
NCI-H460 cells
Lung large cell carcinoma
CVCL_0459 
[270]
Half Maximal Inhibitory Concentration (IC50) 10 nM
NCI-H460 cells
Lung large cell carcinoma
CVCL_0459 
[271]
Half Maximal Inhibitory Concentration (IC50) 10 nM
NCI-H460 cells
Lung large cell carcinoma
CVCL_0459 
[272]
Half Maximal Inhibitory Concentration (IC50) 10 nM
NCI-H358 cells
Minimally invasive lung adenocarcinoma
CVCL_1559 
[273]
Half Maximal Inhibitory Concentration (IC50) 10 nM
OVCAR-8 cells
High grade ovarian serous adenocarcinoma
CVCL_1629 
[274]
Half Maximal Inhibitory Concentration (IC50) 10 nM
OVCAR-8 cells
High grade ovarian serous adenocarcinoma
CVCL_1629 
[275]
Half Maximal Inhibitory Concentration (IC50) 10 nM
SK-OV-3 cells (FZD7 overexpression)
Ovarian serous cystadenocarcinoma
CVCL_0532 
[269]
Half Maximal Inhibitory Concentration (IC50) 10 nM
SF268 cells
Astrocytoma
CVCL_1689 
[269]
Half Maximal Inhibitory Concentration (IC50) 10 nM
A375 cells
Amelanotic melanoma
CVCL_0132 
[272]
Half Maximal Inhibitory Concentration (IC50) 10 nM
DG-75 cells
Burkitt lymphoma
CVCL_0244 
[276]
Half Maximal Inhibitory Concentration (IC50) 10 nM
Mutu-1 cells
Burkitt lymphoma
CVCL_7202 
[276]
Half Maximal Inhibitory Concentration (IC50) >10 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[265]
Half Maximal Inhibitory Concentration (IC50) 10 nM
HT-29 cells
Colon adenocarcinoma
CVCL_0320 
[164]
Half Maximal Inhibitory Concentration (IC50) 10 nM
KB cells
Human papillomavirus-related endocervical adenocarcinoma
CVCL_0372 
[277]
Half Maximal Inhibitory Concentration (IC50) >10 nM
NCI-H460 cells
Lung large cell carcinoma
CVCL_0459 
[278]
Half Maximal Inhibitory Concentration (IC50) 10 nM
Kasumi-1 cells
Myeloid leukemia with maturation
CVCL_0589 
[250]
Half Maximal Inhibitory Concentration (IC50) 10 nM
SW1990 cells
Pancreatic adenocarcinoma
CVCL_1723 
[135]
Half Maximal Inhibitory Concentration (IC50) >10 nM
MDA-MB-231 cells (5T4 overexpression)
Breast adenocarcinoma
CVCL_0062 
[265]
Half Maximal Inhibitory Concentration (IC50) 10 nM
U-87MG ATCC cells
Glioblastoma
CVCL_0022 
[250]
Half Maximal Inhibitory Concentration (IC50) 10 nM
HEK-293T cells
Normal
CVCL_0063 
[279]
Half Maximal Inhibitory Concentration (IC50) 10 nM
NCI-H727 cells
Lung carcinoid tumor
CVCL_1584 
[280]
Half Maximal Inhibitory Concentration (IC50) 10 nM
Lewis lung carcinoma cells
Lung carcinoma
CVCL_4358 
[281]
Half Maximal Inhibitory Concentration (IC50) 10.08 nM
SNU-16 cells
Gastric adenocarcinoma
CVCL_0076 
Half Maximal Inhibitory Concentration (IC50) 10.1 nM
Hep-G2 cells
Hepatoblastoma
CVCL_0027 
[282]
Half Maximal Inhibitory Concentration (IC50) 10.1 nM
Hep-G2 cells
Hepatoblastoma
CVCL_0027 
[283]
Half Maximal Inhibitory Concentration (IC50) 10.12 nM
Calu-6 cells
Lung adenocarcinoma
CVCL_0236 
Half Maximal Inhibitory Concentration (IC50) 10.2 nM
Hep-G2 cells
Hepatoblastoma
CVCL_0027 
[284]
Half Maximal Inhibitory Concentration (IC50) 10.26 nM
SR cells
Leukemia
CVCL_1711 
Half Maximal Inhibitory Concentration (IC50) 10.3 nM
KB cells
Human papillomavirus-related endocervical adenocarcinoma
CVCL_0372 
[285]
Half Maximal Inhibitory Concentration (IC50) 10.33 nM
QIMR-WIL cells
Acute myeloid leukemia
CVCL_1645 
Half Maximal Inhibitory Concentration (IC50) 10.4 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[286]
Half Maximal Inhibitory Concentration (IC50) 10.51 nM
LB647-SCLC cells
Lung small cell carcinoma
CVCL_1368 
Half Maximal Inhibitory Concentration (IC50) 10.7 nM
MDA-MB-231 cells (5T4 overexpression)
Breast adenocarcinoma
CVCL_0062 
[287]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 100 nM
MDA-MB-468 cells
Breast adenocarcinoma
CVCL_0419 
[288]
Half Maximal Cell Growth Inhibitory Concentration (GI50) <100 nM
PC-3 cells
Prostate carcinoma
CVCL_0035 
[141]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 100 nM
K-562 cells
Chronic myelogenous leukemia
CVCL_0004 
[141]
Half Maximal Inhibitory Concentration (IC50) <100 nM
HCT 116 cells
Colon carcinoma
CVCL_0291 
[289]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 100 nM
NCI-H460 cells
Lung large cell carcinoma
CVCL_0459 
[141]
Half Maximal Inhibitory Concentration (IC50) <100 nM
BEAS-2B cells
Normal
CVCL_0168 
[290]
Half Maximal Inhibitory Concentration (IC50) <100 nM
Bel-7402 cells
Hepatoma
CVCL_5492 
[289]
Half Maximal Inhibitory Concentration (IC50) <100 nM
L02 cells
Cervical carcinoma
CVCL_6926 
[290]
Half Maximal Inhibitory Concentration (IC50) 100 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[291]
Half Maximal Inhibitory Concentration (IC50) 100 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[292]
Half Maximal Inhibitory Concentration (IC50) 100 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[291]
Half Maximal Inhibitory Concentration (IC50) 100 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[292]
Half Maximal Inhibitory Concentration (IC50) 100 nM
Human umbilical vein endothelial cells(HUVEC)
Normal
Undisclosed [293]
Half Maximal Inhibitory Concentration (IC50) 100 nM
NB-4 cells
Promyelocytic leukemia
CVCL_0005 
[291]
Half Maximal Inhibitory Concentration (IC50) 100 nM
NB-4 cells
Promyelocytic leukemia
CVCL_0005 
[292]
Half Maximal Inhibitory Concentration (IC50) 100 nM
Bel-7402 cells
Hepatoma
CVCL_5492 
[294]
Half Maximal Inhibitory Concentration (IC50) 100 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[295]
Half Maximal Inhibitory Concentration (IC50) 100 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[182]
Half Maximal Inhibitory Concentration (IC50) 100 nM
ES2 cells
Ewing sarcoma
CVCL_AX39 
[273]
Half Maximal Inhibitory Concentration (IC50) 100 nM
SK-OV-3 cells (FZD7 overexpression)
Ovarian serous cystadenocarcinoma
CVCL_0532 
[273]
Half Maximal Inhibitory Concentration (IC50) 100 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[296]
Half Maximal Inhibitory Concentration (IC50) 100 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[297]
Half Maximal Inhibitory Concentration (IC50) 100 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[298]
Half Maximal Inhibitory Concentration (IC50) 100 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[299]
Half Maximal Inhibitory Concentration (IC50) 100 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[300]
Half Maximal Inhibitory Concentration (IC50) 100 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[301]
Half Maximal Inhibitory Concentration (IC50) >100 nM
SK-BR-3 cells
Breast adenocarcinoma
CVCL_0033 
[302]
Half Maximal Inhibitory Concentration (IC50) >100 nM
ZR-75-1 cells
Invasive breast carcinoma
CVCL_0588 
[302]
Half Maximal Effective Concentration (EC50) >100 nM
Hep-G2 cells
Hepatoblastoma
CVCL_0027 
[303]
Half Maximal Inhibitory Concentration (IC50) 100 nM
MIA PaCa-2 cells (MSLN expression)
Pancreatic ductal adenocarcinoma
CVCL_0428 
[304]
Half Maximal Inhibitory Concentration (IC50) 100 nM
MDA-MB-231 cells (5T4 overexpression)
Breast adenocarcinoma
CVCL_0062 
[305]
Half Maximal Inhibitory Concentration (IC50) 100 nM
MDA-MB-231 cells (5T4 overexpression)
Breast adenocarcinoma
CVCL_0062 
[306]
Half Maximal Inhibitory Concentration (IC50) 100 nM
A375 cells
Amelanotic melanoma
CVCL_0132 
[307]
Half Maximal Inhibitory Concentration (IC50) 100 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[306]
Half Maximal Effective Concentration (EC50) >100 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[303]
Half Maximal Inhibitory Concentration (IC50) >100 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[302]
Half Maximal Inhibitory Concentration (IC50) 100 nM
Fibroblast cells
Normal
Undisclosed [280]
Half Maximal Inhibitory Concentration (IC50) 100 nM
RCC4 cells
Clear cell renal cell carcinoma
CVCL_0498 
[250]
Half Maximal Cell Growth Inhibitory Concentration (GI50) >100 nM
HCT-8 cells
Ileocecal adenocarcinoma
CVCL_2478 
[308]
Half Maximal Effective Concentration (EC50) >100 nM
HCT-8 cells
Ileocecal adenocarcinoma
CVCL_2478 
[303]
Half Maximal Inhibitory Concentration (IC50) >100 nM
MES-SA/Dx5 cells
Uterine sarcoma
CVCL_2598 
[309]
Half Maximal Inhibitory Concentration (IC50) <1000 nM
PANC-1 cells
Pancreatic ductal adenocarcinoma
CVCL_0480 
[310]
Half Maximal Inhibitory Concentration (IC50) <1000 nM
MDA-MB-231 cells (5T4 overexpression)
Breast adenocarcinoma
CVCL_0062 
[310]
Half Maximal Inhibitory Concentration (IC50) <1000 nM
SK-OV-3 cells (FZD7 overexpression)
Ovarian serous cystadenocarcinoma
CVCL_0532 
[311]
Half Maximal Inhibitory Concentration (IC50) 1000 nM
Coronary artery smooth muscle cells
Normal
Undisclosed [312]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 1000 nM
UO-31 cells
Renal carcinoma
CVCL_1911 
[253]
Half Maximal Inhibitory Concentration (IC50) 1000 nM
NCI-ADR-RES cells
High grade ovarian serous adenocarcinoma
CVCL_1452 
[313]
Half Maximal Inhibitory Concentration (IC50) 1000 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[314]
Half Maximal Inhibitory Concentration (IC50) 1000 nM
4T1 cells
Mammary carcinoma
CVCL_0125 
[315]
Half Maximal Inhibitory Concentration (IC50) >1000 nM
NCI-H1650 cells
Lung adenocarcinoma
CVCL_1483 
[91]
Half Maximal Inhibitory Concentration (IC50) >1000 nM
A2780 ADR cells
Ovarian endometrioid adenocarcinoma
CVCL_1941 
[156]
Half Maximal Inhibitory Concentration (IC50) >1000 nM
MES-SA/Dx5 cells
Uterine sarcoma
CVCL_2598 
[218]
Half Maximal Inhibitory Concentration (IC50) >1000 nM
A549/TR cells
Lung adenocarcinoma
CVCL_C5S0 
[123]
Half Maximal Inhibitory Concentration (IC50) >1000 nM
DU145-TxR cells
Prostate carcinoma
CVCL_ZX03 
[175]
Half Maximal Inhibitory Concentration (IC50) <10000 nM
HT-29 cells
Colon adenocarcinoma
CVCL_0320 
[316]
Half Maximal Inhibitory Concentration (IC50) <10000 nM
HT-29 cells
Colon adenocarcinoma
CVCL_0320 
[317]
Half Maximal Inhibitory Concentration (IC50) <10000 nM
AGS cells
Gastric adenocarcinoma
CVCL_0139 
[316]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 10000 nM
MES-SA/Dx5 cells
Uterine sarcoma
CVCL_2598 
[318]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 10000 nM
MES-SA/Dx5 cells
Uterine sarcoma
CVCL_2598 
[319]
Half Maximal Inhibitory Concentration (IC50) 10000 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[320]
Half Maximal Inhibitory Concentration (IC50) 10000 nM
MES-SA/Dx5 cells
Uterine sarcoma
CVCL_2598 
[321]
Half Maximal Cell Growth Inhibitory Concentration (GI50) >10000 nM
Jurkat cells
T acute lymphoblastic leukemia
CVCL_0065 
[249]
Half Maximal Cell Growth Inhibitory Concentration (GI50) >10000 nM
Jurkat cells
T acute lymphoblastic leukemia
CVCL_0065 
[249]
Half Maximal Inhibitory Concentration (IC50) 10000 nM
Hep-G2 cells
Hepatoblastoma
CVCL_0027 
[322]
Half Maximal Inhibitory Concentration (IC50) >10000 nM
HT-29 cells
Colon adenocarcinoma
CVCL_0320 
[323]
Half Maximal Inhibitory Concentration (IC50) >10000 nM
RKO cells
Colon carcinoma
CVCL_0504 
[324]
Half Maximal Inhibitory Concentration (IC50) >10000 nM
NCI-ADR-RES cells
High grade ovarian serous adenocarcinoma
CVCL_1452 
[272]
Half Maximal Inhibitory Concentration (IC50) >10000 nM
NCI-ADR-RES cells
High grade ovarian serous adenocarcinoma
CVCL_1452 
[325]
Half Maximal Inhibitory Concentration (IC50) >10000 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[326]
Half Maximal Inhibitory Concentration (IC50) >10000 nM
Human umbilical vein endothelial cells(HUVEC)
Normal
Undisclosed [164]
Half Maximal Inhibitory Concentration (IC50) >10000 nM
Human umbilical vein endothelial cells(HUVEC)
Normal
Undisclosed [164]
Half Maximal Inhibitory Concentration (IC50) >10000 nM
WI-38 cells
Normal
CVCL_0579 
[327]
Half Maximal Inhibitory Concentration (IC50) >10000 nM
MCF-10A cells
Normal
CVCL_0598 
[327]
Half Maximal Inhibitory Concentration (IC50) >10000 nM
RD cells
Rhabdomyosarcoma
CVCL_1649 
[328]
Half Maximal Inhibitory Concentration (IC50) >10000 nM
KB-V1 cells
Cervical carcinoma
CVCL_2089 
[329]
Half Maximal Cell Growth Inhibitory Concentration (GI50) >10000 nM
MES-SA/Dx5 cells
Uterine sarcoma
CVCL_2598 
[330]
Half Maximal Inhibitory Concentration (IC50) >10000 nM
HFF-1 cells
Normal
CVCL_3285 
[164]
Half Maximal Inhibitory Concentration (IC50) >10000 nM
HFF-1 cells
Normal
CVCL_3285 
[164]
Half Maximal Inhibitory Concentration (IC50) >10000 nM
Bel-7402 cells
Hepatoma
CVCL_5492 
[331]
Half Maximal Inhibitory Concentration (IC50) >10000 nM
CT26 cells
Colon carcinoma
CVCL_7254 
[307]
Half Maximal Inhibitory Concentration (IC50) >10000 nM
MM96L cells
Melanoma
CVCL_D853 
[164]
Half Maximal Inhibitory Concentration (IC50) >100000 nM
K-562 cells
Chronic myelogenous leukemia
CVCL_0004 
[332]
Half Maximal Inhibitory Concentration (IC50) >100000 nM
Hep-G2 cells
Hepatoblastoma
CVCL_0027 
[304]
Half Maximal Inhibitory Concentration (IC50) >100000 nM
NCI-ADR-RES cells
High grade ovarian serous adenocarcinoma
CVCL_1452 
[285]
Half Maximal Inhibitory Concentration (IC50) >100000 nM
L02 cells
Cervical carcinoma
CVCL_6926 
[289]
Half Maximal Inhibitory Concentration (IC50) >100000 nM
L02 cells
Cervical carcinoma
CVCL_6926 
[333]
Half Maximal Inhibitory Concentration (IC50) >1000000 nM
A2780 ADR cells
Ovarian endometrioid adenocarcinoma
CVCL_1941 
[314]
Half Maximal Inhibitory Concentration (IC50) 10027 nM
A2780-TC1 cells
Ovarian endometrioid adenocarcinoma
CVCL_1F93 
[197]
Half Maximal Inhibitory Concentration (IC50) 10027 nM
A2780-TC1 cells
Ovarian endometrioid adenocarcinoma
CVCL_1F93 
[224]
Half Maximal Inhibitory Concentration (IC50) 10038.58 nM
LB2241-RCC cells
Renal cell carcinoma
CVCL_1365 
Half Maximal Inhibitory Concentration (IC50) 101.6 nM
GAK cells
Vulvar melanoma
CVCL_1225 
Half Maximal Inhibitory Concentration (IC50) 1017 nM
A549-Taxol cells
Lung adenocarcinoma
CVCL_W218 
[176]
Half Maximal Inhibitory Concentration (IC50) 102 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[89]
Half Maximal Inhibitory Concentration (IC50) 103.61 nM
BC1 cells
Primary effusion lymphoma
CVCL_1079 
Half Maximal Inhibitory Concentration (IC50) 103.8 nM
A375/TxR cells
Amelanotic melanoma
Undisclosed [123]
Half Maximal Inhibitory Concentration (IC50) 1030 nM
MEXF514 cells
Melanoma
CVCL_D129 
[334]
Half Maximal Inhibitory Concentration (IC50) 10320 nM
Hep-G2 cells
Hepatoblastoma
CVCL_0027 
[335]
Half Maximal Inhibitory Concentration (IC50) 10320 nM
Hep-G2 cells
Hepatoblastoma
CVCL_0027 
[336]
Half Maximal Inhibitory Concentration (IC50) 10320 nM
Hep-G2 cells
Hepatoblastoma
CVCL_0027 
[337]
Half Maximal Inhibitory Concentration (IC50) 10320 nM
Hep-G2 cells
Hepatoblastoma
CVCL_0027 
[338]
Half Maximal Inhibitory Concentration (IC50) 10333.33 nM
EW-13 cells
Ewing sarcoma
CVCL_1211 
Half Maximal Inhibitory Concentration (IC50) 1037.8 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[339]
Half Maximal Inhibitory Concentration (IC50) 104.1 nM
HEY cells
Ovarian carcinoma
CVCL_0297 
[340]
Half Maximal Inhibitory Concentration (IC50) 104.43 nM
KLE cells
Endometrial adenocarcinoma
CVCL_1329 
Half Maximal Inhibitory Concentration (IC50) 1040 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[341]
Half Maximal Inhibitory Concentration (IC50) 1046.51 nM
NCI-H1650 cells
Lung adenocarcinoma
CVCL_1483 
Half Maximal Effective Concentration (EC50) 105 nM
Human umbilical vein endothelial cells(HUVEC)
Normal
Undisclosed [102]
Half Maximal Inhibitory Concentration (IC50) 105 nM
MDA-MB-435 cells
Amelanotic melanoma
CVCL_0417 
[342]
Half Maximal Inhibitory Concentration (IC50) 105 nM
MDA-MB-231/PacR cells
Breast adenocarcinoma
CVCL_4Z64 
[111]
Half Maximal Inhibitory Concentration (IC50) 1050 nM
C-26 cells
Normal
CVCL_XC68 
[273]
Half Maximal Inhibitory Concentration (IC50) 10540 nM
Bel7402/5-FU cells
HPV-related endocervical adenocarcinoma
CVCL_5493 
[343]
Half Maximal Inhibitory Concentration (IC50) 106200 nM
GES1 cells
Normal
CVCL_EQ22 
[317]
Half Maximal Inhibitory Concentration (IC50) 107 nM
A2780 cells
Ovarian endometrioid adenocarcinoma
CVCL_0134 
[344]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 107.4 nM
A498 cells
Renal carcinoma
CVCL_1056 
[345]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 1070 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[346]
Half Maximal Inhibitory Concentration (IC50) 1070 nM
Bel-7402 cells
Hepatoma
CVCL_5492 
[151]
Half Maximal Inhibitory Concentration (IC50) 109.8 nM
EW-3 cells
Ewing sarcoma
CVCL_1216 
Half Maximal Inhibitory Concentration (IC50) 10900 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[347]
Half Maximal Inhibitory Concentration (IC50) 10900 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[348]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 1093.96 nM
UO-31 cells
Renal carcinoma
CVCL_1911 
[345]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 11 nM
HCT 15 cells
Colon adenocarcinoma
CVCL_0292 
[71]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 11 nM
SK-HEP1 cells
Hepatoma
CVCL_0525 
[349]
Half Maximal Inhibitory Concentration (IC50) 11 nM
DLD-1 cells
Colon adenocarcinoma
CVCL_0248 
[313]
Half Maximal Inhibitory Concentration (IC50) 11 nM
HT-29 cells
Colon adenocarcinoma
CVCL_0320 
[350]
Half Maximal Inhibitory Concentration (IC50) 11 nM
OVCAR-3 cells (FZD7 overexpression)
Ovarian serous adenocarcinoma
CVCL_0465 
[350]
Half Maximal Inhibitory Concentration (IC50) 11 nM
SW480 cells
Colon adenocarcinoma
CVCL_0546 
[351]
Half Maximal Inhibitory Concentration (IC50) 11 nM
HT-29 cells
Colon adenocarcinoma
CVCL_0320 
[352]
Half Maximal Inhibitory Concentration (IC50) 11.02 nM
RPMI-8226 cells
Plasma cell myeloma
CVCL_0014 
Half Maximal Inhibitory Concentration (IC50) 11.12 nM
SK-PN-DW cells
Primitive neuroectodermal tumor
CVCL_1703 
Half Maximal Inhibitory Concentration (IC50) 11.2 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[353]
Half Maximal Inhibitory Concentration (IC50) 11.2 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[354]
Half Maximal Inhibitory Concentration (IC50) 11.2 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[156]
Half Maximal Inhibitory Concentration (IC50) 11.2 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[355]
Half Maximal Inhibitory Concentration (IC50) 11.2 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[356]
Half Maximal Inhibitory Concentration (IC50) 11.3 nM
QGY-7703 cells
Cervical carcinoma
CVCL_6715 
[339]
Half Maximal Inhibitory Concentration (IC50) 11.4 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[357]
Half Maximal Inhibitory Concentration (IC50) 11.46 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[358]
Half Maximal Inhibitory Concentration (IC50) 11.51 nM
SF268 cells
Astrocytoma
CVCL_1689 
Half Maximal Inhibitory Concentration (IC50) 11.63 nM
HD-MY-Z cells
Acute myeloid leukemia
CVCL_1273 
Half Maximal Inhibitory Concentration (IC50) 11.7 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[359]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 11.9 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[254]
Half Maximal Inhibitory Concentration (IC50) 110 nM
SK-BR-3 cells
Breast adenocarcinoma
CVCL_0033 
[360]
Half Maximal Inhibitory Concentration (IC50) 110 nM
Hep-G2 cells
Hepatoblastoma
CVCL_0027 
[151]
Half Maximal Inhibitory Concentration (IC50) 110 nM
SK-BR-3 cells
Breast adenocarcinoma
CVCL_0033 
[361]
Half Maximal Inhibitory Concentration (IC50) 110 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[362]
Half Maximal Inhibitory Concentration (IC50) 110 nM
HEp-2 cells
Laryngeal carcinoma
CVCL_1906 
[363]
Half Maximal Inhibitory Concentration (IC50) 110.7 nM
PC3/DX cells
Prostate carcinoma
CVCL_C3M5 
[175]
Half Maximal Inhibitory Concentration (IC50) 1100 nM
A2780 cells
Ovarian endometrioid adenocarcinoma
CVCL_0134 
[314]
Half Maximal Inhibitory Concentration (IC50) 1100 nM
L02 cells
Cervical carcinoma
CVCL_6926 
[364]
Half Maximal Inhibitory Concentration (IC50) 1100 nM
MIP-101 cells
Colon adenocarcinoma
CVCL_H689 
[321]
Half Maximal Inhibitory Concentration (IC50) 1101.24 nM
DMS-153 cells
Lung small cell carcinoma
CVCL_1175 
Half Maximal Inhibitory Concentration (IC50) 112.1 nM
A375/TxR cells
Amelanotic melanoma
Undisclosed [111]
Half Maximal Inhibitory Concentration (IC50) 112.44 nM
D-336MG cells
Glioblastoma
CVCL_1156 
Half Maximal Inhibitory Concentration (IC50) 11200 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[314]
Half Maximal Inhibitory Concentration (IC50) 11260 nM
A375 cells
Amelanotic melanoma
CVCL_0132 
[338]
Half Maximal Inhibitory Concentration (IC50) 113.01 nM
NB69 cells
Neuroblastoma
CVCL_1448 
Half Maximal Cell Growth Inhibitory Concentration (GI50) 113.24 nM
TK-10 cells
Renal carcinoma
CVCL_1773 
[345]
Half Maximal Inhibitory Concentration (IC50) 11400 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[365]
Half Maximal Inhibitory Concentration (IC50) 1150 nM
BGC-823 cells
Stomach adenocarcinoma
CVCL_3360 
[366]
Half Maximal Inhibitory Concentration (IC50) 11500 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[367]
Half Maximal Inhibitory Concentration (IC50) 1160 nM
K-562 cells
Chronic myelogenous leukemia
CVCL_0004 
[368]
Half Maximal Inhibitory Concentration (IC50) 1160 nM
K-562 cells
Chronic myelogenous leukemia
CVCL_0004 
[369]
Half Maximal Inhibitory Concentration (IC50) 1160 nM
K-562 cells
Chronic myelogenous leukemia
CVCL_0004 
[370]
Half Maximal Inhibitory Concentration (IC50) 1160 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[371]
Half Maximal Inhibitory Concentration (IC50) 1160 nM
K-562 cells
Chronic myelogenous leukemia
CVCL_0004 
[372]
Half Maximal Inhibitory Concentration (IC50) 11669.4 nM
EW-11 cells
Ewing sarcoma
CVCL_1209 
Half Maximal Inhibitory Concentration (IC50) 117 nM
NCI-H460 cells
Lung large cell carcinoma
CVCL_0459 
[119]
Half Maximal Inhibitory Concentration (IC50) 117.12 nM
D-263MG cells
Glioblastoma
CVCL_1154 
Half Maximal Inhibitory Concentration (IC50) 1170 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[373]
Half Maximal Inhibitory Concentration (IC50) 1180 nM
PANC-1 cells
Pancreatic ductal adenocarcinoma
CVCL_0480 
[374]
Half Maximal Inhibitory Concentration (IC50) 1185 nM
MCF7R cells
Breast carcinoma
CVCL_Y493 
[375]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 12 nM
PANC-1 cells
Pancreatic ductal adenocarcinoma
CVCL_0480 
[247]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 12 nM
HT-29 cells
Colon adenocarcinoma
CVCL_0320 
[376]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 12 nM
SF268 cells
Astrocytoma
CVCL_1689 
[376]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 12 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[376]
Half Maximal Inhibitory Concentration (IC50) 12 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[377]
Half Maximal Inhibitory Concentration (IC50) 12 nM
NCI-H460 cells
Lung large cell carcinoma
CVCL_0459 
[378]
Half Maximal Inhibitory Concentration (IC50) 12 nM
PC-3 cells
Prostate carcinoma
CVCL_0035 
[268]
Half Maximal Inhibitory Concentration (IC50) 12 nM
Hep-G2 cells
Hepatoblastoma
CVCL_0027 
[118]
Half Maximal Inhibitory Concentration (IC50) 12 nM
A2780 cells
Ovarian endometrioid adenocarcinoma
CVCL_0134 
[379]
Half Maximal Inhibitory Concentration (IC50) 12 nM
SK-OV-3 cells (FZD7 overexpression)
Ovarian serous cystadenocarcinoma
CVCL_0532 
[380]
Half Maximal Inhibitory Concentration (IC50) 12 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[381]
Half Maximal Inhibitory Concentration (IC50) 12 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[382]
Half Maximal Inhibitory Concentration (IC50) 12 nM
PC-3 cells
Prostate carcinoma
CVCL_0035 
[304]
Half Maximal Inhibitory Concentration (IC50) 12 nM
Huh-7 cells
Adult hepatocellular carcinoma
CVCL_0336 
[134]
Half Maximal Inhibitory Concentration (IC50) 12 nM
T98G cells
Glioblastoma
CVCL_0556 
[279]
Half Maximal Inhibitory Concentration (IC50) 12 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[352]
Half Maximal Inhibitory Concentration (IC50) 12.04 nM
SCC-3 cells
B-cell non-Hodgkin lymphoma
CVCL_1683 
Half Maximal Inhibitory Concentration (IC50) 12.04 nM
ST486 cells
Burkitt lymphoma
CVCL_1712 
Half Maximal Inhibitory Concentration (IC50) 12.06 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[383]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 12.08 nM
SF-295 cells
Glioblastoma
CVCL_1690 
[345]
Half Maximal Inhibitory Concentration (IC50) 12.1 nM
SW480 cells
Colon adenocarcinoma
CVCL_0546 
[339]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 12.11 nM
SNB-19 cells
Astrocytoma
CVCL_0535 
[345]
Half Maximal Inhibitory Concentration (IC50) 12.14 nM
NALM-6 cells
B acute lymphoblastic leukemia
CVCL_0092 
Half Maximal Cell Growth Inhibitory Concentration (GI50) 12.3 nM
DMS 114 cells
Lung small cell carcinoma
CVCL_1174 
[237]
Half Maximal Inhibitory Concentration (IC50) 12.3 nM
BEL-7404 tumor cells
Endocervical adenocarcinoma
CVCL_6568 
[384]
Half Maximal Inhibitory Concentration (IC50) 12.3 nM
A2780S cells
Ovarian endometrioid adenocarcinoma
CVCL_4863 
[385]
Half Maximal Inhibitory Concentration (IC50) 12.31 nM
NCI-H1436 cells
Lung small cell carcinoma
CVCL_1471 
Half Maximal Inhibitory Concentration (IC50) 12.34 nM
KE-37 cells
T acute lymphoblastic leukemia
CVCL_1327 
Half Maximal Inhibitory Concentration (IC50) 12.4 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[282]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 12.5 nM
MDA-MB-468 cells
Breast adenocarcinoma
CVCL_0419 
[146]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 12.5 nM
T-47D cells
Invasive breast carcinoma
CVCL_0553 
[147]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 12.5 nM
NCI-H322M cells
Minimally invasive lung adenocarcinoma
CVCL_1557 
[146]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 12.5 nM
NCI-H322M cells
Minimally invasive lung adenocarcinoma
CVCL_1557 
[147]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 12.5 nM
MDA-MB-231 cells (5T4 overexpression)
Breast adenocarcinoma
CVCL_0062 
[146]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 12.5 nM
MDA-MB-231 cells (5T4 overexpression)
Breast adenocarcinoma
CVCL_0062 
[147]
Half Maximal Inhibitory Concentration (IC50) 12.56 nM
RPMI-8402 cells
T acute lymphoblastic leukemia
CVCL_1667 
Half Maximal Inhibitory Concentration (IC50) 12.57 nM
RXF 393 cells
Renal carcinoma
CVCL_1673 
Half Maximal Inhibitory Concentration (IC50) 12.6 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[386]
Half Maximal Inhibitory Concentration (IC50) 12.6 nM
Hep-G2 cells
Hepatoblastoma
CVCL_0027 
[387]
Half Maximal Inhibitory Concentration (IC50) 12.62 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[184]
Half Maximal Inhibitory Concentration (IC50) 12.7 nM
KARPAS-45 cells
T acute lymphoblastic leukemia
CVCL_1326 
Half Maximal Cell Growth Inhibitory Concentration (GI50) 12.88 nM
HOP-62 cells
Non-small cell lung carcinoma
CVCL_1285 
[345]
Half Maximal Inhibitory Concentration (IC50) 12.88 nM
ES1 cells
Ewing sarcoma
CVCL_1198 
Half Maximal Inhibitory Concentration (IC50) 120 nM
L1210 cells
Lymphoblastic leukemia
CVCL_0382 
[388]
Half Maximal Inhibitory Concentration (IC50) 120 nM
SMMC-7721 cells
Hepatocellular carcinoma
CVCL_0534 
[234]
Half Maximal Inhibitory Concentration (IC50) 120 nM
PC-3 cells
Prostate carcinoma
CVCL_0035 
[363]
Half Maximal Inhibitory Concentration (IC50) 1200 nM
CCRF-CEM cells
T acute lymphoblastic leukemia
CVCL_0207 
[173]
Half Maximal Inhibitory Concentration (IC50) 1200 nM
Eca-109 cells
Esophageal squamous cell carcinoma
CVCL_6898 
[389]
Half Maximal Inhibitory Concentration (IC50) 1200 nM
SK-OV-3 cells (FZD7 overexpression)
Ovarian serous cystadenocarcinoma
CVCL_0532 
[390]
Half Maximal Inhibitory Concentration (IC50) 1200 nM
SK-OV-3 cells (FZD7 overexpression)
Ovarian serous cystadenocarcinoma
CVCL_0532 
[391]
Half Maximal Inhibitory Concentration (IC50) 12000 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[392]
Half Maximal Inhibitory Concentration (IC50) 12133.4 nM
NCI-H128 cells
Lung carcinoma
CVCL_1460 
Half Maximal Inhibitory Concentration (IC50) 1215.34 nM
A498 cells
Renal carcinoma
CVCL_1056 
Half Maximal Inhibitory Concentration (IC50) 1217 nM
Hep-G2 cells
Hepatoblastoma
CVCL_0027 
[133]
Half Maximal Inhibitory Concentration (IC50) 122.91 nM
KP-N-YS cells
Adrenal gland neuroblastoma
CVCL_1342 
Half Maximal Inhibitory Concentration (IC50) 1225.57 nM
U-698-M cells
Lymphoblastic lymphoma
CVCL_0017 
Half Maximal Inhibitory Concentration (IC50) 1239 nM
A2780 cells
Ovarian endometrioid adenocarcinoma
CVCL_0134 
[224]
Half Maximal Inhibitory Concentration (IC50) 1244 nM
A2780 ADR cells
Ovarian endometrioid adenocarcinoma
CVCL_1941 
[104]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 125 nM
HCT 15 cells
Colon adenocarcinoma
CVCL_0292 
[146]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 125 nM
HCT 15 cells
Colon adenocarcinoma
CVCL_0292 
[147]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 125 nM
UO-31 cells
Renal carcinoma
CVCL_1911 
[146]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 125 nM
UO-31 cells
Renal carcinoma
CVCL_1911 
[147]
Half Maximal Inhibitory Concentration (IC50) 125.58 nM
NCI-H1155 cells
Lung large cell carcinoma
CVCL_1456 
Half Maximal Inhibitory Concentration (IC50) 125.79 nM
BOKU cells
Cervical squamous cell carcinoma
CVCL_1089 
Half Maximal Inhibitory Concentration (IC50) 1250 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[393]
Half Maximal Inhibitory Concentration (IC50) 1250 nM
Bel-7402 cells
Hepatoma
CVCL_5492 
[394]
Half Maximal Inhibitory Concentration (IC50) 1260 nM
K-562 cells
Chronic myelogenous leukemia
CVCL_0004 
[331]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 127.94 nM
EKVX cells
Non-small cell lung carcinoma
CVCL_1195 
[345]
Half Maximal Inhibitory Concentration (IC50) 1270 nM
CCRF-CEM cells
T acute lymphoblastic leukemia
CVCL_0207 
[395]
Half Maximal Inhibitory Concentration (IC50) 1270 nM
CCRF-CEM cells
T acute lymphoblastic leukemia
CVCL_0207 
[189]
Half Maximal Inhibitory Concentration (IC50) 1270 nM
CCRF-CEM cells
T acute lymphoblastic leukemia
CVCL_0207 
[396]
Half Maximal Inhibitory Concentration (IC50) 1270 nM
CCRF-CEM cells
T acute lymphoblastic leukemia
CVCL_0207 
[181]
Half Maximal Inhibitory Concentration (IC50) 12700 nM
SK-BR-3 cells
Breast adenocarcinoma
CVCL_0033 
[322]
Half Maximal Inhibitory Concentration (IC50) 1274 nM
CCRF-CEM cells
T acute lymphoblastic leukemia
CVCL_0207 
[171]
Half Maximal Inhibitory Concentration (IC50) 1274 nM
CCRF-CEM cells
T acute lymphoblastic leukemia
CVCL_0207 
[188]
Half Maximal Inhibitory Concentration (IC50) 128 nM
U-251MG cells
Astrocytoma
CVCL_0021 
[397]
Half Maximal Inhibitory Concentration (IC50) 129.9 nM
LAMA-84 cells
Chronic myeloid leukemia
CVCL_0388 
Half Maximal Inhibitory Concentration (IC50) 1290 nM
NIH3T3 cells
Normal
CVCL_0594 
[398]
Half Maximal Inhibitory Concentration (IC50) 12950 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[289]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 13 nM
PC-3 cells
Prostate carcinoma
CVCL_0035 
[349]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 13 nM
NCI-H322M cells
Minimally invasive lung adenocarcinoma
CVCL_1557 
[399]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 13 nM
NCI-H322M cells
Minimally invasive lung adenocarcinoma
CVCL_1557 
[400]
Half Maximal Inhibitory Concentration (IC50) 13 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[378]
Half Maximal Inhibitory Concentration (IC50) 13 nM
HCT-8 cells
Ileocecal adenocarcinoma
CVCL_2478 
[155]
Half Maximal Inhibitory Concentration (IC50) 13 nM
A2780 cells
Ovarian endometrioid adenocarcinoma
CVCL_0134 
[401]
Half Maximal Inhibitory Concentration (IC50) 13 nM
A2780 cells
Ovarian endometrioid adenocarcinoma
CVCL_0134 
[402]
Half Maximal Inhibitory Concentration (IC50) 13 nM
MDA-MB-435 cells
Amelanotic melanoma
CVCL_0417 
[403]
Half Maximal Inhibitory Concentration (IC50) 13 nM
OVCAR-3 cells (FZD7 overexpression)
Ovarian serous adenocarcinoma
CVCL_0465 
[403]
Half Maximal Inhibitory Concentration (IC50) 13 nM
HeLa S3 cells
Endocervical adenocarcinoma
CVCL_0058 
[404]
Half Maximal Inhibitory Concentration (IC50) 13 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[405]
Half Maximal Inhibitory Concentration (IC50) 13 nM
Hep-G2 cells
Hepatoblastoma
CVCL_0027 
[406]
Half Maximal Inhibitory Concentration (IC50) 13 nM
A2780 cells
Ovarian endometrioid adenocarcinoma
CVCL_0134 
[407]
Half Maximal Inhibitory Concentration (IC50) 13 nM
A2780 cells
Ovarian endometrioid adenocarcinoma
CVCL_0134 
[408]
Half Maximal Inhibitory Concentration (IC50) 13 nM
A2780 cells
Ovarian endometrioid adenocarcinoma
CVCL_0134 
[409]
Half Maximal Inhibitory Concentration (IC50) 13 nM
Huh-7 cells
Adult hepatocellular carcinoma
CVCL_0336 
[280]
Half Maximal Inhibitory Concentration (IC50) 13 nM
RPMI-7951 cells
Malignant melanoma
CVCL_1666 
[410]
Half Maximal Inhibitory Concentration (IC50) 13 nM
Bel-7402 cells
Hepatoma
CVCL_5492 
[163]
Half Maximal Inhibitory Concentration (IC50) 13.2 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[411]
Half Maximal Inhibitory Concentration (IC50) 13.4 nM
A2780 cells
Ovarian endometrioid adenocarcinoma
CVCL_0134 
[412]
Half Maximal Inhibitory Concentration (IC50) 13.5 nM
SK-MES-1 cells
Lung squamous cell carcinoma
CVCL_0630 
[411]
Half Maximal Inhibitory Concentration (IC50) 13.5 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[413]
Half Maximal Inhibitory Concentration (IC50) 13.51 nM
L-363 cells
Plasma cell myeloma
CVCL_1357 
Half Maximal Inhibitory Concentration (IC50) 13.6 nM
HCT 116 cells
Colon carcinoma
CVCL_0291 
[414]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 13.7 nM
WI-38 cells
Normal
CVCL_0579 
[415]
Half Maximal Inhibitory Concentration (IC50) 13.7 nM
A2780 cells
Ovarian endometrioid adenocarcinoma
CVCL_0134 
[416]
Half Maximal Inhibitory Concentration (IC50) 13.7 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[96]
Half Maximal Inhibitory Concentration (IC50) 13.73 nM
GI-1 cells
Gliosarcoma
CVCL_1231 
Half Maximal Inhibitory Concentration (IC50) 13.8 nM
ID8 cells
Normal
CVCL_IU14 
[417]
Half Maximal Inhibitory Concentration (IC50) 130 nM
Hep 3B2.1-7 cells
Childhood hepatocellular carcinoma
CVCL_0326 
[359]
Half Maximal Inhibitory Concentration (IC50) 130 nM
HCT-8 cells
Ileocecal adenocarcinoma
CVCL_2478 
[418]
Half Maximal Inhibitory Concentration (IC50) 1300 nM
NCI-ADR-RES cells
High grade ovarian serous adenocarcinoma
CVCL_1452 
[419]
Half Maximal Inhibitory Concentration (IC50) 1300 nM
NCI-ADR-RES cells
High grade ovarian serous adenocarcinoma
CVCL_1452 
[420]
Half Maximal Inhibitory Concentration (IC50) 1300 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[421]
Half Maximal Inhibitory Concentration (IC50) 1300 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[422]
Half Maximal Inhibitory Concentration (IC50) 1300 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[374]
Half Maximal Inhibitory Concentration (IC50) 1300 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[423]
Half Maximal Inhibitory Concentration (IC50) 13000 nM
NCI-ADR-RES cells
High grade ovarian serous adenocarcinoma
CVCL_1452 
[267]
Half Maximal Inhibitory Concentration (IC50) 13050 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[424]
Half Maximal Inhibitory Concentration (IC50) 1307.19 nM
NCI-H1092 cells
Lung small cell carcinoma
CVCL_1454 
Half Maximal Inhibitory Concentration (IC50) 131.17 nM
Raji cells
EBV-related Burkitt lymphoma
CVCL_0511 
Half Maximal Inhibitory Concentration (IC50) 132 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[344]
Half Maximal Inhibitory Concentration (IC50) 13230 nM
MDA-MB-231 cells (5T4 overexpression)
Breast adenocarcinoma
CVCL_0062 
[425]
Half Maximal Inhibitory Concentration (IC50) 133.07 nM
Lu-65 cells
Lung giant cell carcinoma
CVCL_1392 
Half Maximal Inhibitory Concentration (IC50) 1330 nM
Calu-1 cells
Lung squamous cell carcinoma
CVCL_0608 
[374]
Half Maximal Inhibitory Concentration (IC50) 13300 nM
HCT-8 cells
Ileocecal adenocarcinoma
CVCL_2478 
[273]
Half Maximal Inhibitory Concentration (IC50) 1331.9 nM
NCI-H23 cells
Lung adenocarcinoma
CVCL_1547 
Half Maximal Inhibitory Concentration (IC50) 135 nM
NCI-ADR-RES cells
High grade ovarian serous adenocarcinoma
CVCL_1452 
[381]
Half Maximal Inhibitory Concentration (IC50) 1350 nM
SK-OV-3 cells (FZD7 overexpression)
Ovarian serous cystadenocarcinoma
CVCL_0532 
[393]
Half Maximal Inhibitory Concentration (IC50) 1370 nM
HCT 116 cells
Colon carcinoma
CVCL_0291 
[426]
Half Maximal Inhibitory Concentration (IC50) 1375 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[339]
Half Maximal Inhibitory Concentration (IC50) 139.24 nM
NCI-H187 cells
Lung small cell carcinoma
CVCL_1501 
Half Maximal Inhibitory Concentration (IC50) 13990 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[427]
Half Maximal Inhibitory Concentration (IC50) 14 nM
A2780 cells
Ovarian endometrioid adenocarcinoma
CVCL_0134 
[428]
Half Maximal Inhibitory Concentration (IC50) 14 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[429]
Half Maximal Inhibitory Concentration (IC50) 14 nM
A2780 cells
Ovarian endometrioid adenocarcinoma
CVCL_0134 
[430]
Half Maximal Inhibitory Concentration (IC50) 14 nM
HCT 116 cells
Colon carcinoma
CVCL_0291 
[431]
Half Maximal Inhibitory Concentration (IC50) 14 nM
HT-29 cells
Colon adenocarcinoma
CVCL_0320 
[432]
Half Maximal Inhibitory Concentration (IC50) 14 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[73]
Half Maximal Inhibitory Concentration (IC50) 14 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[74]
Half Maximal Inhibitory Concentration (IC50) 14 nM
Caco-2 cells
Colon adenocarcinoma
CVCL_0025 
[433]
Half Maximal Inhibitory Concentration (IC50) 14 nM
Caco-2 cells
Colon adenocarcinoma
CVCL_0025 
[280]
Half Maximal Inhibitory Concentration (IC50) 14.5 nM
SK-OV-3 cells (FZD7 overexpression)
Ovarian serous cystadenocarcinoma
CVCL_0532 
[434]
Half Maximal Inhibitory Concentration (IC50) 14.6 nM
NCI-H460 cells
Lung large cell carcinoma
CVCL_0459 
[434]
Half Maximal Inhibitory Concentration (IC50) 14.9 nM
A2780 cells
Ovarian endometrioid adenocarcinoma
CVCL_0134 
[200]
Half Maximal Inhibitory Concentration (IC50) 14.96 nM
SNU-C2B cells
Cecum adenocarcinoma
CVCL_1710 
Half Maximal Inhibitory Concentration (IC50) 14.96 nM
TE-5 cells
Esophageal squamous cell carcinoma
CVCL_1764 
Half Maximal Inhibitory Concentration (IC50) 140 nM
CCRF-CEM cells
T acute lymphoblastic leukemia
CVCL_0207 
[210]
Half Maximal Inhibitory Concentration (IC50) 140 nM
HCT 15 cells
Colon adenocarcinoma
CVCL_0292 
[435]
Half Maximal Inhibitory Concentration (IC50) 140 nM
PC-3 cells
Prostate carcinoma
CVCL_0035 
[273]
Half Maximal Inhibitory Concentration (IC50) 140 nM
Eca-109 cells
Esophageal squamous cell carcinoma
CVCL_6898 
[73]
Half Maximal Inhibitory Concentration (IC50) 140 nM
Eca-109 cells
Esophageal squamous cell carcinoma
CVCL_6898 
[74]
Half Maximal Inhibitory Concentration (IC50) 140 nM
CHO-VV 3-2 cells
Normal
CVCL_Y287 
[85]
Half Maximal Inhibitory Concentration (IC50) 140 nM
CHO-VV 3-2 cells
Normal
CVCL_Y287 
[86]
Half Maximal Inhibitory Concentration (IC50) 1400 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[360]
Half Maximal Inhibitory Concentration (IC50) 1400 nM
HepG2/Adm cells
Hepatoblastoma
CVCL_M187 
[436]
Half Maximal Inhibitory Concentration (IC50) 1400 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[437]
Half Maximal Inhibitory Concentration (IC50) 1400 nM
SiHa cells
Cervical squamous cell carcinoma
CVCL_0032 
[438]
Half Maximal Inhibitory Concentration (IC50) 1420 nM
SMMC-7721 cells
Hepatocellular carcinoma
CVCL_0534 
[439]
Half Maximal Inhibitory Concentration (IC50) 14200 nM
RD cells
Rhabdomyosarcoma
CVCL_1649 
[440]
Half Maximal Inhibitory Concentration (IC50) 1421.77 nM
JVM-2 cells
Mantle cell lymphoma
CVCL_1319 
Half Maximal Inhibitory Concentration (IC50) 1428 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[431]
Half Maximal Inhibitory Concentration (IC50) 143 nM
SMMC-7721 cells
Hepatocellular carcinoma
CVCL_0534 
[441]
Half Maximal Inhibitory Concentration (IC50) 1430 nM
NCI-H460 cells
Lung large cell carcinoma
CVCL_0459 
[374]
Half Maximal Inhibitory Concentration (IC50) 14300 nM
MCF-10A cells
Normal
CVCL_0598 
[374]
Half Maximal Inhibitory Concentration (IC50) 1439.05 nM
MSTO-211H cells
Pleural biphasic mesothelioma
CVCL_1430 
Half Maximal Inhibitory Concentration (IC50) 14500 nM
PC-3 cells
Prostate carcinoma
CVCL_0035 
[322]
Half Maximal Inhibitory Concentration (IC50) 14560 nM
HT-29 cells
Colon adenocarcinoma
CVCL_0320 
[425]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 1460 nM
PC-3 cells
Prostate carcinoma
CVCL_0035 
[346]
Half Maximal Inhibitory Concentration (IC50) 149.01 nM
GCIY cells
Gastric adenocarcinoma
CVCL_1228 
Half Maximal Inhibitory Concentration (IC50) <15 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[442]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 15 nM
HT-29 cells
Colon adenocarcinoma
CVCL_0320 
[443]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 15 nM
HT-29 cells
Colon adenocarcinoma
CVCL_0320 
[444]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 15 nM
HT-29 cells
Colon adenocarcinoma
CVCL_0320 
[445]
Half Maximal Inhibitory Concentration (IC50) <15 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[442]
Half Maximal Inhibitory Concentration (IC50) <15 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[325]
Half Maximal Inhibitory Concentration (IC50) 15 nM
A2780 cells
Ovarian endometrioid adenocarcinoma
CVCL_0134 
[446]
Half Maximal Inhibitory Concentration (IC50) 15 nM
NCI-H1299 cells (MMAE resistant)
Lung large cell carcinoma
CVCL_0060 
[447]
Half Maximal Inhibitory Concentration (IC50) 15 nM
NCI-H1299 cells (MMAE resistant)
Lung large cell carcinoma
CVCL_0060 
[17]
Half Maximal Inhibitory Concentration (IC50) 15 nM
OV-1063 cells
Ovarian carcinoma
CVCL_4366 
[448]
Half Maximal Inhibitory Concentration (IC50) 15 nM
J774 cells
Mouse reticulum cell sarcoma
CVCL_4692 
[448]
Half Maximal Inhibitory Concentration (IC50) 15 nM
A2780 cells
Ovarian endometrioid adenocarcinoma
CVCL_0134 
[449]
Half Maximal Inhibitory Concentration (IC50) 15 nM
HT-29 cells
Colon adenocarcinoma
CVCL_0320 
[432]
Half Maximal Inhibitory Concentration (IC50) 15 nM
KB cells
Human papillomavirus-related endocervical adenocarcinoma
CVCL_0372 
[234]
Half Maximal Inhibitory Concentration (IC50) 15 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[450]
Half Maximal Inhibitory Concentration (IC50) 15 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[451]
Half Maximal Inhibitory Concentration (IC50) 15 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[452]
Half Maximal Inhibitory Concentration (IC50) 15 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[453]
Half Maximal Inhibitory Concentration (IC50) 15.16 nM
K-562 cells
Chronic myelogenous leukemia
CVCL_0004 
Half Maximal Inhibitory Concentration (IC50) 15.2 nM
A2780 cells
Ovarian endometrioid adenocarcinoma
CVCL_0134 
[454]
Half Maximal Inhibitory Concentration (IC50) 15.3 nM
SF268 cells
Astrocytoma
CVCL_1689 
[414]
Half Maximal Inhibitory Concentration (IC50) 15.4 nM
SNB-75 cells
Glioblastoma
CVCL_1706 
Half Maximal Inhibitory Concentration (IC50) 15.7 nM
K-562 cells
Chronic myelogenous leukemia
CVCL_0004 
[339]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 15.8 nM
NCI-H522 cells
Non-small cell lung carcinoma
CVCL_1567 
[146]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 15.8 nM
NCI-H522 cells
Non-small cell lung carcinoma
CVCL_1567 
[147]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 15.8 nM
RXF 393 cells
Renal carcinoma
CVCL_1673 
[146]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 15.8 nM
RXF 393 cells
Renal carcinoma
CVCL_1673 
[147]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 15.85 nM
HOP-62 cells
Non-small cell lung carcinoma
CVCL_1285 
[253]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 15.85 nM
SF-295 cells
Glioblastoma
CVCL_1690 
[253]
Half Maximal Inhibitory Concentration (IC50) 150 nM
WALKER cells
Breast carcinoma
Undisclosed
Half Maximal Inhibitory Concentration (IC50) 150 nM
SK-MEL-5 cells
Cutaneous melanoma
CVCL_0527 
[361]
Half Maximal Inhibitory Concentration (IC50) 150 nM
SW480 cells
Colon adenocarcinoma
CVCL_0546 
[455]
Half Maximal Inhibitory Concentration (IC50) 150 nM
SW480 cells
Colon adenocarcinoma
CVCL_0546 
[456]
Half Maximal Inhibitory Concentration (IC50) 150 nM
SMMC-7721 cells
Hepatocellular carcinoma
CVCL_0534 
[107]
Half Maximal Inhibitory Concentration (IC50) 150 nM
JC cells
Malignant neoplasms of the mouse mammary gland
CVCL_3530 
[457]
Half Maximal Inhibitory Concentration (IC50) 150 nM
NCI-H441 cells
Lung papillary adenocarcinoma
CVCL_1561 
[250]
Half Maximal Inhibitory Concentration (IC50) 150 nM
PC-3 cells
Prostate carcinoma
CVCL_0035 
[438]
Half Maximal Inhibitory Concentration (IC50) 150.8 nM
NCI-H2107 cells
Lung small cell carcinoma
CVCL_1527 
Half Maximal Cell Growth Inhibitory Concentration (GI50) 1500 nM
SW1573 cells
Lung carcinoma
CVCL_1720 
[458]
Half Maximal Inhibitory Concentration (IC50) 1500 nM
A2780 ADR cells
Ovarian endometrioid adenocarcinoma
CVCL_1941 
[168]
Half Maximal Inhibitory Concentration (IC50) 1500 nM
BGC-823 cells
Stomach adenocarcinoma
CVCL_3360 
[422]
Half Maximal Inhibitory Concentration (IC50) 1500 nM
BGC-1 cells
Normal
CVCL_6572 
[459]
Half Maximal Inhibitory Concentration (IC50) 1500 nM
PC-3 cells
Prostate carcinoma
CVCL_0035 
[460]
Half Maximal Inhibitory Concentration (IC50) 1500 nM
DU145 cells
Prostate carcinoma
CVCL_0105 
[461]
Half Maximal Inhibitory Concentration (IC50) 1500 nM
NCI-ADR-RES cells
High grade ovarian serous adenocarcinoma
CVCL_1452 
[462]
Half Maximal Inhibitory Concentration (IC50) 1500 nM
NCI-H1299 cells (MMAE resistant)
Lung large cell carcinoma
CVCL_0060 
[463]
Half Maximal Inhibitory Concentration (IC50) 1500 nM
BGC-823 cells
Stomach adenocarcinoma
CVCL_3360 
[423]
Half Maximal Cell Growth Inhibitory Concentration (GI50) >15000 nM
NCI-ADR-RES cells
High grade ovarian serous adenocarcinoma
CVCL_1452 
[166]
Half Maximal Cell Growth Inhibitory Concentration (GI50) >15000 nM
P388/ADR cells
Lymphoma
CVCL_IZ75 
[166]
Half Maximal Inhibitory Concentration (IC50) 150000 nM
EKVX cells
Non-small cell lung carcinoma
CVCL_1195 
[464]
Half Maximal Inhibitory Concentration (IC50) 1511.91 nM
A704 cells
Renal carcinoma
CVCL_1065 
Half Maximal Inhibitory Concentration (IC50) 152.66 nM
NCI-H1522 cells
Lung small cell carcinoma
CVCL_1474 
Half Maximal Inhibitory Concentration (IC50) 1525 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[465]
Half Maximal Inhibitory Concentration (IC50) 1530 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[466]
Half Maximal Inhibitory Concentration (IC50) 1530 nM
RPMI-8226 cells
Plasma cell myeloma
CVCL_0014 
[467]
Half Maximal Inhibitory Concentration (IC50) 15400 nM
AGS cells
Gastric adenocarcinoma
CVCL_0139 
[336]
Half Maximal Inhibitory Concentration (IC50) 15400 nM
AGS cells
Gastric adenocarcinoma
CVCL_0139 
[337]
Half Maximal Inhibitory Concentration (IC50) 15416.65 nM
AM-38 cells
Glioblastoma
CVCL_1070 
Half Maximal Inhibitory Concentration (IC50) 1549.49 nM
ECC4 cells
Rectal adenocarcinoma
CVCL_1190 
Half Maximal Inhibitory Concentration (IC50) 1550 nM
HCT 116 cells
Colon carcinoma
CVCL_0291 
[374]
Half Maximal Inhibitory Concentration (IC50) 156.23 nM
NB6 cells
Neuroblastoma
CVCL_8823 
Half Maximal Inhibitory Concentration (IC50) 15600 nM
Hep-G2 cells
Hepatoblastoma
CVCL_0027 
[468]
Half Maximal Inhibitory Concentration (IC50) 15600 nM
Hep-G2 cells
Hepatoblastoma
CVCL_0027 
[469]
Half Maximal Inhibitory Concentration (IC50) 157 nM
1A9/ptx-10 cells
Ovarian adenocarcinoma
CVCL_H620 
[446]
Half Maximal Inhibitory Concentration (IC50) 157.06 nM
EM-2 cells
Chronic myeloid leukemia
CVCL_1196 
Half Maximal Cell Growth Inhibitory Concentration (GI50) 157.4 nM
HOP-18 cells
Non-small cell lung adenocarcinoma
CVCL_H642 
[345]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 158 nM
Caki-1 cells
Clear cell renal cell carcinoma
CVCL_0234 
[146]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 158 nM
Caki-1 cells
Clear cell renal cell carcinoma
CVCL_0234 
[147]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 158 nM
HCT 15 cells
Colon adenocarcinoma
CVCL_0292 
[399]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 158 nM
HCT 15 cells
Colon adenocarcinoma
CVCL_0292 
[400]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 158 nM
ACHN cells
Renal adenocarcinoma
CVCL_1067 
[146]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 158 nM
ACHN cells
Renal adenocarcinoma
CVCL_1067 
[147]
Half Maximal Inhibitory Concentration (IC50) 15800 nM
A375 cells
Amelanotic melanoma
CVCL_0132 
[470]
Half Maximal Inhibitory Concentration (IC50) 1584 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[405]
Half Maximal Inhibitory Concentration (IC50) 159.8 nM
HCC2218 cells
Breast ductal carcinoma
CVCL_1263 
Half Maximal Inhibitory Concentration (IC50) 15990 nM
Farage cells
Normal
CVCL_0214 
[471]
Half Maximal Cell Growth Inhibitory Concentration (GI50) <16 nM
Hep-G2 cells
Hepatoblastoma
CVCL_0027 
[251]
Half Maximal Cell Growth Inhibitory Concentration (GI50) <16 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[251]
Half Maximal Cell Growth Inhibitory Concentration (GI50) <16 nM
DU145 cells
Prostate carcinoma
CVCL_0105 
[251]
Half Maximal Cell Growth Inhibitory Concentration (GI50) <16 nM
MDA-MB-231 cells (5T4 overexpression)
Breast adenocarcinoma
CVCL_0062 
[251]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 16 nM
LOX IMVI cells
Melanoma
CVCL_1381 
[252]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 16 nM
P388 cells
Lymphoma
CVCL_7222 
[166]
Half Maximal Inhibitory Concentration (IC50) 16 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[136]
Half Maximal Inhibitory Concentration (IC50) 16 nM
PC-3 cells
Prostate carcinoma
CVCL_0035 
[472]
Half Maximal Inhibitory Concentration (IC50) 16 nM
SK-OV-3 cells (FZD7 overexpression)
Ovarian serous cystadenocarcinoma
CVCL_0532 
[153]
Half Maximal Inhibitory Concentration (IC50) 16 nM
P388 cells
Lymphoma
CVCL_7222 
[473]
Half Maximal Inhibitory Concentration (IC50) 16 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[137]
Half Maximal Inhibitory Concentration (IC50) 16 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[83]
Half Maximal Inhibitory Concentration (IC50) 16 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[138]
Half Maximal Inhibitory Concentration (IC50) 16 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[139]
Half Maximal Inhibitory Concentration (IC50) 16 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[274]
Half Maximal Inhibitory Concentration (IC50) 16 nM
DLD-1 cells
Colon adenocarcinoma
CVCL_0248 
[344]
Half Maximal Inhibitory Concentration (IC50) 16 nM
MDA-MB-435 cells
Amelanotic melanoma
CVCL_0417 
[106]
Half Maximal Inhibitory Concentration (IC50) 16.3 nM
HEK293 cells
Normal
CVCL_0045 
[454]
Half Maximal Inhibitory Concentration (IC50) 16.37 nM
MOLT-13 cells
T acute lymphoblastic leukemia
CVCL_1422 
Half Maximal Inhibitory Concentration (IC50) 16.6 nM
Hep-G2 cells
Hepatoblastoma
CVCL_0027 
[222]
Half Maximal Inhibitory Concentration (IC50) 16.64 nM
LS-123 cells
Colon adenocarcinoma
CVCL_1383 
Half Maximal Cell Growth Inhibitory Concentration (GI50) 16.67 nM
SR cells
Leukemia
CVCL_1711 
[345]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 160 nM
MES-SA/Dx5 cells
Uterine sarcoma
CVCL_2598 
[71]
Half Maximal Inhibitory Concentration (IC50) 160.7 nM
1A9/ptx-22 cells
Ovarian adenocarcinoma
CVCL_H621 
[196]
Half Maximal Inhibitory Concentration (IC50) 160.7 nM
1A9/ptx-22 cells
Ovarian adenocarcinoma
CVCL_H621 
[197]
Half Maximal Inhibitory Concentration (IC50) 160.7 nM
1A9/ptx-22 cells
Ovarian adenocarcinoma
CVCL_H621 
[199]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 1600 nM
SW1573 cells
Lung carcinoma
CVCL_1720 
[458]
Half Maximal Inhibitory Concentration (IC50) 1600 nM
AGS cells
Gastric adenocarcinoma
CVCL_0139 
[107]
Half Maximal Inhibitory Concentration (IC50) 1600 nM
MDA-MB-231 cells (5T4 overexpression)
Breast adenocarcinoma
CVCL_0062 
[474]
Half Maximal Inhibitory Concentration (IC50) 16000 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[475]
Half Maximal Inhibitory Concentration (IC50) 16000 nM
fR2 cells
Normal
CVCL_2444 
[268]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 16170 nM
Hep 3B2.1-7 cells
Childhood hepatocellular carcinoma
CVCL_0326 
[101]
Half Maximal Inhibitory Concentration (IC50) 1620 nM
CCRF-CEM cells
T acute lymphoblastic leukemia
CVCL_0207 
[210]
Half Maximal Inhibitory Concentration (IC50) 163.76 nM
NCI-H748 cells
Lung small cell carcinoma
CVCL_1588 
Half Maximal Inhibitory Concentration (IC50) 1636 nM
P388/ADR cells
Lymphoma
CVCL_IZ75 
[342]
Half Maximal Inhibitory Concentration (IC50) 164.2 nM
A2780 cells
Ovarian endometrioid adenocarcinoma
CVCL_0134 
[340]
Half Maximal Inhibitory Concentration (IC50) 165.37 nM
MS-1 cells
Lung small cell carcinoma
CVCL_1429 
Half Maximal Inhibitory Concentration (IC50) 165.97 nM
NB5 cells
Neuroblastoma
CVCL_8822 
Half Maximal Inhibitory Concentration (IC50) 1650 nM
Human umbilical vein endothelial cells(HUVEC)
Normal
Undisclosed [293]
Half Maximal Inhibitory Concentration (IC50) 16500 nM
KB cells
Human papillomavirus-related endocervical adenocarcinoma
CVCL_0372 
[476]
Half Maximal Inhibitory Concentration (IC50) 166.88 nM
OMC-1 cells
Cervical squamous cell carcinoma
CVCL_1623 
Half Maximal Inhibitory Concentration (IC50) 169.28 nM
NCI-H345 cells
Lung carcinoma
CVCL_1558 
Half Maximal Inhibitory Concentration (IC50) 169.45 nM
L-428 cells
Hodgkin lymphoma
CVCL_1361 
Half Maximal Inhibitory Concentration (IC50) 17 nM
PC-3 cells
Prostate carcinoma
CVCL_0035 
[241]
Half Maximal Inhibitory Concentration (IC50) 17 nM
A498 cells
Renal carcinoma
CVCL_1056 
[241]
Half Maximal Inhibitory Concentration (IC50) 17 nM
Capan-2 cells
Pancreatic ductal adenocarcinoma
CVCL_0026 
[118]
Half Maximal Inhibitory Concentration (IC50) 17 nM
MV4-11 cells
Childhood acute monocytic leukemia
CVCL_0064 
[477]
Half Maximal Inhibitory Concentration (IC50) 17 nM
A2780 cells
Ovarian endometrioid adenocarcinoma
CVCL_0134 
[478]
Half Maximal Inhibitory Concentration (IC50) 17 nM
MDA-MB-231 cells (5T4 overexpression)
Breast adenocarcinoma
CVCL_0062 
[403]
Half Maximal Inhibitory Concentration (IC50) 17.01 nM
SNU-5 cells
Gastric adenocarcinoma
CVCL_0078 
Half Maximal Inhibitory Concentration (IC50) 17.08 nM
Daudi cells
Burkitt lymphoma
CVCL_0008 
Half Maximal Inhibitory Concentration (IC50) 17.3 nM
LOX IMVI cells
Melanoma
CVCL_1381 
[479]
Half Maximal Inhibitory Concentration (IC50) 17.38 nM
A-253 cells
Submandibular gland squamous cell carcinoma
CVCL_1060 
Half Maximal Inhibitory Concentration (IC50) 17.4 nM
HCT-8 cells
Ileocecal adenocarcinoma
CVCL_2478 
[385]
Half Maximal Inhibitory Concentration (IC50) 17.52 nM
TGBC1TKB cells
Gallbladder undifferentiated carcinoma
CVCL_1769 
Half Maximal Inhibitory Concentration (IC50) 17.67 nM
SJSA-1 cells
Osteosarcoma
CVCL_1697 
Half Maximal Inhibitory Concentration (IC50) 17.69 nM
NCC-IT cells
Testicular embryonal carcinoma
CVCL_1451 
Half Maximal Inhibitory Concentration (IC50) 17.78 nM
NCI-H69 cells
Small cell lung carcinoma
CVCL_1579 
Half Maximal Inhibitory Concentration (IC50) 170 nM
P388 cells
Lymphoma
CVCL_7222 
[473]
Half Maximal Inhibitory Concentration (IC50) 170 nM
CHO cells
Normal
CVCL_0213 
[86]
Half Maximal Inhibitory Concentration (IC50) 170 nM
PC-3 cells
Prostate carcinoma
CVCL_0035 
[305]
Half Maximal Inhibitory Concentration (IC50) 170 nM
MDA-MB-231 cells (5T4 overexpression)
Breast adenocarcinoma
CVCL_0062 
[105]
Half Maximal Inhibitory Concentration (IC50) 170 nM
HCT-8 cells
Ileocecal adenocarcinoma
CVCL_2478 
[362]
Half Maximal Inhibitory Concentration (IC50) 1700 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[480]
Half Maximal Inhibitory Concentration (IC50) 1700 nM
KB cells
Human papillomavirus-related endocervical adenocarcinoma
CVCL_0372 
[377]
Half Maximal Inhibitory Concentration (IC50) 1700 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[481]
Half Maximal Inhibitory Concentration (IC50) 1700 nM
EL4 cells
Thymoma
CVCL_0255 
[482]
Half Maximal Inhibitory Concentration (IC50) 17133 nM
HEK293 cells
Normal
CVCL_0045 
[483]
Half Maximal Inhibitory Concentration (IC50) 1714.89 nM
NCI-H226 cells
Pleural epithelioid mesothelioma
CVCL_1544 
Half Maximal Inhibitory Concentration (IC50) 17200 nM
DU145 cells
Prostate carcinoma
CVCL_0105 
[322]
Half Maximal Inhibitory Concentration (IC50) 1731 nM
CCRF-CEM cells
T acute lymphoblastic leukemia
CVCL_0207 
[169]
Half Maximal Inhibitory Concentration (IC50) 1736.51 nM
NCI-H719 cells
Lung small cell carcinoma
CVCL_1582 
Half Maximal Inhibitory Concentration (IC50) 1764 nM
MES-SA/Dx5 cells
Uterine sarcoma
CVCL_2598 
[484]
Half Maximal Inhibitory Concentration (IC50) 1764 nM
MES-SA/Dx5 cells
Uterine sarcoma
CVCL_2598 
[440]
Half Maximal Inhibitory Concentration (IC50) 1764 nM
MES-SA/Dx5 cells
Uterine sarcoma
CVCL_2598 
[328]
Half Maximal Inhibitory Concentration (IC50) 17680 nM
NCI-ADR-RES cells
High grade ovarian serous adenocarcinoma
CVCL_1452 
[343]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 179.89 nM
SK-MEL-28 cells (BRAF inhibitor resistant)
Cutaneous melanoma
CVCL_0526 
[345]
Half Maximal Inhibitory Concentration (IC50) 1790 nM
DU145 cells
Prostate carcinoma
CVCL_0105 
[341]
Half Maximal Inhibitory Concentration (IC50) 17929.87 nM
NCI-H716 cells
Cecum adenocarcinoma
CVCL_1581 
Half Maximal Inhibitory Concentration (IC50) 18 nM
HCT 116 cells
Colon carcinoma
CVCL_0291 
[344]
Half Maximal Inhibitory Concentration (IC50) 18 nM
MDA-MB-231 cells (5T4 overexpression)
Breast adenocarcinoma
CVCL_0062 
[76]
Half Maximal Inhibitory Concentration (IC50) 18 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[485]
Half Maximal Inhibitory Concentration (IC50) 18 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[282]
Half Maximal Inhibitory Concentration (IC50) 18 nM
A2780 cells
Ovarian endometrioid adenocarcinoma
CVCL_0134 
[162]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 18.16 nM
PC-3 cells
Prostate carcinoma
CVCL_0035 
[345]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 18.73 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[186]
Half Maximal Inhibitory Concentration (IC50) 18.9 nM
BGC-823 cells
Stomach adenocarcinoma
CVCL_3360 
[153]
Half Maximal Inhibitory Concentration (IC50) 18.9 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[411]
Half Maximal Inhibitory Concentration (IC50) 18.94 nM
A2780S cells
Ovarian endometrioid adenocarcinoma
CVCL_4863 
[486]
Half Maximal Inhibitory Concentration (IC50) 18.95 nM
SH-4 cells
Melanoma
CVCL_1692 
Half Maximal Cell Growth Inhibitory Concentration (GI50) 180 nM
Hep-G2 cells
Hepatoblastoma
CVCL_0027 
[487]
Half Maximal Inhibitory Concentration (IC50) 180 nM
Hep-G2 cells
Hepatoblastoma
CVCL_0027 
[467]
Half Maximal Inhibitory Concentration (IC50) 180 nM
SW1990 cells
Pancreatic adenocarcinoma
CVCL_1723 
[163]
Half Maximal Inhibitory Concentration (IC50) 180 nM
OCI-Ly1 cells
Lymphoma
CVCL_1879 
[331]
Half Maximal Inhibitory Concentration (IC50) 180 nM
T29 cells
Normal
CVCL_2G67 
[327]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 1800 nM
MES-SA/Dx5 cells
Uterine sarcoma
CVCL_2598 
[488]
Half Maximal Inhibitory Concentration (IC50) 1800 nM
Bel-7402 cells
Hepatoma
CVCL_5492 
[489]
Half Maximal Inhibitory Concentration (IC50) 1800 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[461]
Half Maximal Inhibitory Concentration (IC50) 181 nM
NCI-ADR-RES cells
High grade ovarian serous adenocarcinoma
CVCL_1452 
[490]
Half Maximal Inhibitory Concentration (IC50) 183 nM
A2780 ADR cells
Ovarian endometrioid adenocarcinoma
CVCL_1941 
[491]
Half Maximal Inhibitory Concentration (IC50) 1830 nM
A549/TR cells
Lung adenocarcinoma
CVCL_C5S0 
[485]
Half Maximal Inhibitory Concentration (IC50) 18385.11 nM
NCI-H1770 cells
Lung non-small cell carcinoma
CVCL_1493 
Half Maximal Inhibitory Concentration (IC50) 186.3 nM
M14 cells
Melanoma
CVCL_1395 
[111]
Half Maximal Inhibitory Concentration (IC50) 186.85 nM
SCH cells
Gastric choriocarcinoma
CVCL_1687 
Half Maximal Inhibitory Concentration (IC50) 1860 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[332]
Half Maximal Inhibitory Concentration (IC50) 188 nM
PC-3 cells
Prostate carcinoma
CVCL_0035 
[106]
Half Maximal Inhibitory Concentration (IC50) 188 nM
PC3/DX cells
Prostate carcinoma
CVCL_C3M5 
[103]
Half Maximal Inhibitory Concentration (IC50) 189 nM
Lewis lung carcinoma cells
Lung carcinoma
CVCL_4358 
[470]
Half Maximal Inhibitory Concentration (IC50) 189.4 nM
HCT-8 cells
Ileocecal adenocarcinoma
CVCL_2478 
[492]
Half Maximal Inhibitory Concentration (IC50) 1890 nM
Bel-7402 cells
Hepatoma
CVCL_5492 
[493]
Half Maximal Inhibitory Concentration (IC50) 1890 nM
Bel-7402 cells
Hepatoma
CVCL_5492 
[494]
Half Maximal Inhibitory Concentration (IC50) 1890 nM
Bel-7402 cells
Hepatoma
CVCL_5492 
[495]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 19 nM
HOP-62 cells
Non-small cell lung carcinoma
CVCL_1285 
[146]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 19 nM
HOP-62 cells
Non-small cell lung carcinoma
CVCL_1285 
[147]
Half Maximal Inhibitory Concentration (IC50) 19 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[294]
Half Maximal Inhibitory Concentration (IC50) 19 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[496]
Half Maximal Inhibitory Concentration (IC50) 19 nM
B16 cells
Melanoma
CVCL_F936 
[497]
Half Maximal Inhibitory Concentration (IC50) 19 nM
1A9/ptx-22 cells
Ovarian adenocarcinoma
CVCL_H621 
[154]
Half Maximal Inhibitory Concentration (IC50) 19 nM
HCT-8 cells
Ileocecal adenocarcinoma
CVCL_2478 
[381]
Half Maximal Inhibitory Concentration (IC50) 19 nM
A2780 cells
Ovarian endometrioid adenocarcinoma
CVCL_0134 
[163]
Half Maximal Inhibitory Concentration (IC50) 19.24 nM
HCC1187 cells
Breast ductal carcinoma
CVCL_1247 
Half Maximal Inhibitory Concentration (IC50) 19.3 nM
MDA-MB-231 cells (5T4 overexpression)
Breast adenocarcinoma
CVCL_0062 
[452]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 19.7 nM
OVCAR-3 cells (FZD7 overexpression)
Ovarian serous adenocarcinoma
CVCL_0465 
[237]
Half Maximal Inhibitory Concentration (IC50) 19.87 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[498]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 19.9 nM
RPMI-8226 cells
Plasma cell myeloma
CVCL_0014 
[146]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 19.9 nM
RPMI-8226 cells
Plasma cell myeloma
CVCL_0014 
[147]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 19.9 nM
TK-10 cells
Renal carcinoma
CVCL_1773 
[146]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 19.9 nM
TK-10 cells
Renal carcinoma
CVCL_1773 
[147]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 19.95 nM
786-O cells
Renal cell carcinoma
CVCL_1051 
[253]
Half Maximal Inhibitory Concentration (IC50) 190 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[499]
Half Maximal Inhibitory Concentration (IC50) 190 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[371]
Half Maximal Inhibitory Concentration (IC50) 190 nM
SW480 cells
Colon adenocarcinoma
CVCL_0546 
[500]
Half Maximal Inhibitory Concentration (IC50) 190 nM
Hep-G2 cells
Hepatoblastoma
CVCL_0027 
[290]
Half Maximal Inhibitory Concentration (IC50) 190 nM
MCF7R cells
Breast carcinoma
CVCL_Y493 
[135]
Half Maximal Inhibitory Concentration (IC50) 1900 nM
A2780 ADR cells
Ovarian endometrioid adenocarcinoma
CVCL_1941 
[122]
Half Maximal Inhibitory Concentration (IC50) 1900 nM
PC-3 cells
Prostate carcinoma
CVCL_0035 
[501]
Half Maximal Inhibitory Concentration (IC50) 1900 nM
Bel-7402 cells
Hepatoma
CVCL_5492 
[389]
Half Maximal Inhibitory Concentration (IC50) 190000 nM
HCT 15 cells
Colon adenocarcinoma
CVCL_0292 
[464]
Half Maximal Inhibitory Concentration (IC50) 1904.81 nM
KMS-12-PE cells
Multiple myeloma
CVCL_1333 
Half Maximal Inhibitory Concentration (IC50) 19140 nM
B16-F10 cells
Mouse melanoma
CVCL_0159 
[502]
Half Maximal Inhibitory Concentration (IC50) 192.27 nM
NCI-H1417 cells
Lung small cell carcinoma
CVCL_1469 
Half Maximal Inhibitory Concentration (IC50) 1920 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[503]
Half Maximal Inhibitory Concentration (IC50) 19310 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[427]
Half Maximal Inhibitory Concentration (IC50) 1941.82 nM
MPP-89 cells
Pleural epithelioid mesothelioma
CVCL_1427 
Half Maximal Inhibitory Concentration (IC50) 195.32 nM
COLO 320HSR cells
Colon adenocarcinoma
CVCL_0220 
Half Maximal Inhibitory Concentration (IC50) 1950 nM
Bel-7402 cells
Hepatoma
CVCL_5492 
[504]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 196 nM
SW1573 cells
Lung carcinoma
CVCL_1720 
[208]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 196000 nM
SW1573 cells
Lung carcinoma
CVCL_1720 
[458]
Half Maximal Inhibitory Concentration (IC50) 1970 nM
SW620/AD300 cells
Colon adenocarcinoma
CVCL_ZZ39 
[110]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 199.53 nM
HCT 15 cells
Colon adenocarcinoma
CVCL_0292 
[253]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 2 nM
RPMI-8226 cells
Plasma cell myeloma
CVCL_0014 
[399]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 2 nM
RPMI-8226 cells
Plasma cell myeloma
CVCL_0014 
[400]
Half Maximal Inhibitory Concentration (IC50) 2 nM
HCT 116 cells
Colon carcinoma
CVCL_0291 
Half Maximal Inhibitory Concentration (IC50) 2 nM
HCT 116 cells
Colon carcinoma
CVCL_0291 
Half Maximal Cell Growth Inhibitory Concentration (GI50) 2 nM
HT-29 cells
Colon adenocarcinoma
CVCL_0320 
[399]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 2 nM
HT-29 cells
Colon adenocarcinoma
CVCL_0320 
[400]
Half Maximal Effective Concentration (EC50) 2 nM
Lu1 cells
Lung carcinoma
Undisclosed [102]
Half Maximal Inhibitory Concentration (IC50) 2 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[505]
Half Maximal Inhibitory Concentration (IC50) 2 nM
CCRF-CEM cells
T acute lymphoblastic leukemia
CVCL_0207 
[148]
Half Maximal Inhibitory Concentration (IC50) 2 nM
HCT 116 cells
Colon carcinoma
CVCL_0291 
[435]
Half Maximal Inhibitory Concentration (IC50) 2 nM
LNCaP cells
Prostate carcinoma
CVCL_0395 
[506]
Half Maximal Inhibitory Concentration (IC50) 2 nM
SW480 cells
Colon adenocarcinoma
CVCL_0546 
[148]
Half Maximal Inhibitory Concentration (IC50) 2 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[507]
Half Maximal Inhibitory Concentration (IC50) 2 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[508]
Half Maximal Inhibitory Concentration (IC50) 2 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[509]
Half Maximal Inhibitory Concentration (IC50) 2 nM
MCF7S cells
Breast carcinoma
Undisclosed [375]
Half Maximal Inhibitory Concentration (IC50) 2 nM
KB 3-1 cells
Cervical epithelial carcinoma
CVCL_2088 
[510]
Half Maximal Inhibitory Concentration (IC50) 2 nM
A2780-1A9 cells
Ovarian adenocarcinoma
CVCL_H619 
[155]
Half Maximal Inhibitory Concentration (IC50) 2 nM
HL-60 cells
Adult acute myeloid leukemia
CVCL_0002 
[321]
Half Maximal Inhibitory Concentration (IC50) 2 nM
HL-60 cells
Adult acute myeloid leukemia
CVCL_0002 
[511]
Half Maximal Inhibitory Concentration (IC50) 2 nM
HL-60 cells
Adult acute myeloid leukemia
CVCL_0002 
[235]
Half Maximal Inhibitory Concentration (IC50) 2 nM
PC-3 cells
Prostate carcinoma
CVCL_0035 
[512]
Half Maximal Inhibitory Concentration (IC50) 2 nM
PC-3 cells
Prostate carcinoma
CVCL_0035 
[513]
Half Maximal Inhibitory Concentration (IC50) 2 nM
MDA-MB-435 cells
Amelanotic melanoma
CVCL_0417 
[211]
Half Maximal Inhibitory Concentration (IC50) 2 nM
OVCAR-3 cells (FZD7 overexpression)
Ovarian serous adenocarcinoma
CVCL_0465 
[109]
Half Maximal Inhibitory Concentration (IC50) 2 nM
NCI-H358 cells
Minimally invasive lung adenocarcinoma
CVCL_1559 
[344]
Half Maximal Inhibitory Concentration (IC50) 2 nM
OVCAR-8 cells
High grade ovarian serous adenocarcinoma
CVCL_1629 
[462]
Half Maximal Inhibitory Concentration (IC50) 2 nM
SK-OV-3 cells (FZD7 overexpression)
Ovarian serous cystadenocarcinoma
CVCL_0532 
[158]
Half Maximal Inhibitory Concentration (IC50) 2 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[514]
Half Maximal Inhibitory Concentration (IC50) 2 nM
Daoy cells
Medulloblastoma
CVCL_1167 
[284]
Half Maximal Inhibitory Concentration (IC50) 2 nM
MES-SA/Dx5 cells
Uterine sarcoma
CVCL_2598 
[309]
Half Maximal Inhibitory Concentration (IC50) 2 nM
BGC-823 cells
Stomach adenocarcinoma
CVCL_3360 
[284]
Half Maximal Inhibitory Concentration (IC50) 2 nM
L02 cells
Cervical carcinoma
CVCL_6926 
[515]
Half Maximal Inhibitory Concentration (IC50) 2 nM
PC-3 cells
Prostate carcinoma
CVCL_0035 
[280]
Half Maximal Inhibitory Concentration (IC50) 2 nM
A-431 cells
Skin squamous cell carcinoma
CVCL_0037 
[516]
Half Maximal Inhibitory Concentration (IC50) 2 nM
A2780 cells
Ovarian endometrioid adenocarcinoma
CVCL_0134 
[517]
Half Maximal Inhibitory Concentration (IC50) 2 nM
A2780 cells
Ovarian endometrioid adenocarcinoma
CVCL_0134 
[518]
Half Maximal Inhibitory Concentration (IC50) 2 nM
HCT 116 cells
Colon carcinoma
CVCL_0291 
[280]
Half Maximal Inhibitory Concentration (IC50) 2 nM
HT-29 cells
Colon adenocarcinoma
CVCL_0320 
[305]
Half Maximal Inhibitory Concentration (IC50) 2 nM
Huh-7 cells
Adult hepatocellular carcinoma
CVCL_0336 
[517]
Half Maximal Inhibitory Concentration (IC50) 2 nM
SK-OV-3 cells (FZD7 overexpression)
Ovarian serous cystadenocarcinoma
CVCL_0532 
[519]
Half Maximal Inhibitory Concentration (IC50) 2 nM
A375 cells
Amelanotic melanoma
CVCL_0132 
[212]
Half Maximal Inhibitory Concentration (IC50) 2 nM
HaCaT cells
Normal
CVCL_0038 
[134]
Half Maximal Inhibitory Concentration (IC50) 2.00E-08 nM
SK-OV-3 cells (FZD7 overexpression)
Ovarian serous cystadenocarcinoma
CVCL_0532 
[520]
Half Maximal Inhibitory Concentration (IC50) 2.088 nM
NTERA-2-cl-D1 cells
Teratocarcinoma
CVCL_3407 
Half Maximal Effective Concentration (EC50) 2.09 nM
A2780-1A9 cells
Ovarian adenocarcinoma
CVCL_H619 
[303]
Half Maximal Effective Concentration (EC50) 2.1 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[521]
Half Maximal Inhibitory Concentration (IC50) 2.1 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[169]
Half Maximal Inhibitory Concentration (IC50) 2.1 nM
TSU-Pr1 cells
Bladder carcinoma
CVCL_4014 
[506]
Half Maximal Inhibitory Concentration (IC50) 2.1 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[235]
Half Maximal Inhibitory Concentration (IC50) >2.1 nM
KB 3-1 cells
Cervical epithelial carcinoma
CVCL_2088 
[522]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 2.12 nM
U-937 cells
Adult acute monocytic leukemia
CVCL_0007 
[523]
Half Maximal Inhibitory Concentration (IC50) 2.12 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[223]
Half Maximal Inhibitory Concentration (IC50) 2.14 nM
PG-49 cells
Lung non-small cell carcinoma
CVCL_D539 
[79]
Half Maximal Inhibitory Concentration (IC50) 2.2 nM
A2780 cells
Ovarian endometrioid adenocarcinoma
CVCL_0134 
[224]
Half Maximal Inhibitory Concentration (IC50) 2.2 nM
MOLT-4 cells
Adult T acute lymphoblastic leukemia
CVCL_0013 
[239]
Half Maximal Inhibitory Concentration (IC50) 2.2 nM
IGROV-1 cells
Ovarian endometrioid adenocarcinoma
CVCL_1304 
[524]
Half Maximal Inhibitory Concentration (IC50) 2.2 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[525]
Half Maximal Inhibitory Concentration (IC50) 2.2 nM
HL-60 cells
Adult acute myeloid leukemia
CVCL_0002 
[526]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 2.232 nM
MOLT-4 cells
Adult T acute lymphoblastic leukemia
CVCL_0013 
[186]
Half Maximal Effective Concentration (EC50) 2.3 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[149]
Half Maximal Inhibitory Concentration (IC50) 2.3 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[384]
Half Maximal Inhibitory Concentration (IC50) 2.3 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[434]
Half Maximal Inhibitory Concentration (IC50) 2.3 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[527]
Half Maximal Inhibitory Concentration (IC50) 2.3 nM
U-937 cells
Adult acute monocytic leukemia
CVCL_0007 
[528]
Half Maximal Inhibitory Concentration (IC50) 2.3 nM
DU145 cells
Prostate carcinoma
CVCL_0105 
[106]
Half Maximal Inhibitory Concentration (IC50) 2.3 nM
DU145 cells
Prostate carcinoma
CVCL_0105 
[223]
Half Maximal Inhibitory Concentration (IC50) 2.3 nM
DU145 cells
Prostate carcinoma
CVCL_0105 
[235]
Half Maximal Inhibitory Concentration (IC50) 2.3 nM
NB-4 cells
Promyelocytic leukemia
CVCL_0005 
[328]
Half Maximal Inhibitory Concentration (IC50) 2.3 nM
HEK-293T cells
Normal
CVCL_0063 
[529]
Half Maximal Inhibitory Concentration (IC50) 2.3 nM
HCT 116 cells
Colon carcinoma
CVCL_0291 
[212]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 2.34 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[523]
Half Maximal Inhibitory Concentration (IC50) 2.35 nM
DU145 cells
Prostate carcinoma
CVCL_0105 
[214]
Half Maximal Inhibitory Concentration (IC50) 2.39 nM
SK-OV-3 cells (FZD7 overexpression)
Ovarian serous cystadenocarcinoma
CVCL_0532 
[530]
Half Maximal Inhibitory Concentration (IC50) 2.399 nM
HCT 116 cells
Colon carcinoma
CVCL_0291 
[531]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 2.4 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[532]
Half Maximal Inhibitory Concentration (IC50) 2.4 nM
HCT 116 cells
Colon carcinoma
CVCL_0291 
Half Maximal Inhibitory Concentration (IC50) 2.4 nM
HCT 116 cells
Colon carcinoma
CVCL_0291 
[533]
Half Maximal Inhibitory Concentration (IC50) 2.4 nM
HCT 116 cells
Colon carcinoma
CVCL_0291 
[241]
Half Maximal Inhibitory Concentration (IC50) 2.4 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[302]
Half Maximal Inhibitory Concentration (IC50) 2.4 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[534]
Half Maximal Inhibitory Concentration (IC50) 2.45 nM
KB cells
Human papillomavirus-related endocervical adenocarcinoma
CVCL_0372 
[535]
Half Maximal Inhibitory Concentration (IC50) 2.47 nM
MES-SA cells
Uterine sarcoma
CVCL_1404 
[238]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 2.5 nM
DU145 cells
Prostate carcinoma
CVCL_0105 
[536]
Half Maximal Inhibitory Concentration (IC50) 2.5 nM
KB cells
Human papillomavirus-related endocervical adenocarcinoma
CVCL_0372 
[537]
Half Maximal Inhibitory Concentration (IC50) 2.5 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[538]
Half Maximal Inhibitory Concentration (IC50) 2.5 nM
H69AR cells
Lung small cell carcinoma
CVCL_3513 
[218]
Half Maximal Inhibitory Concentration (IC50) 2.5 nM
PC-3 cells
Prostate carcinoma
CVCL_0035 
[539]
Half Maximal Inhibitory Concentration (IC50) 2.5 nM
U-937 cells
Adult acute monocytic leukemia
CVCL_0007 
[239]
Half Maximal Inhibitory Concentration (IC50) 2.5 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[540]
Half Maximal Inhibitory Concentration (IC50) 2.5 nM
NCI-H1975 cells
Lung adenocarcinoma
CVCL_1511 
[328]
Half Maximal Inhibitory Concentration (IC50) 2.5 nM
LC-2-ad cells
Lung adenocarcinoma
CVCL_1373 
[271]
Half Maximal Inhibitory Concentration (IC50) 2.5 nM
HL-60 cells
Adult acute myeloid leukemia
CVCL_0002 
[525]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 2.512 nM
HT-29 cells
Colon adenocarcinoma
CVCL_0320 
[253]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 2.512 nM
MDA-MB-435 cells
Amelanotic melanoma
CVCL_0417 
[253]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 2.512 nM
SR cells
Leukemia
CVCL_1711 
[253]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 2.55 nM
DU145 cells
Prostate carcinoma
CVCL_0105 
[541]
Half Maximal Inhibitory Concentration (IC50) 2.55 nM
786-O cells
Renal cell carcinoma
CVCL_1051 
[222]
Half Maximal Effective Concentration (EC50) 2.56 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[303]
Half Maximal Effective Concentration (EC50) 2.6 nM
LNCaP cells
Prostate carcinoma
CVCL_0395 
[149]
Half Maximal Inhibitory Concentration (IC50) 2.6 nM
MKN45 cells
Gastric adenocarcinoma
CVCL_0434 
[241]
Half Maximal Inhibitory Concentration (IC50) 2.6 nM
HCT 116 cells
Colon carcinoma
CVCL_0291 
[210]
Half Maximal Inhibitory Concentration (IC50) 2.6 nM
HL-60 cells
Adult acute myeloid leukemia
CVCL_0002 
[542]
Half Maximal Inhibitory Concentration (IC50) 2.6 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[543]
Half Maximal Inhibitory Concentration (IC50) 2.6 nM
MDA-MB-231 cells (5T4 overexpression)
Breast adenocarcinoma
CVCL_0062 
[544]
Half Maximal Inhibitory Concentration (IC50) 2.6 nM
MDA-MB-231 cells (5T4 overexpression)
Breast adenocarcinoma
CVCL_0062 
[545]
Half Maximal Inhibitory Concentration (IC50) 2.6 nM
SK-OV-3 cells (FZD7 overexpression)
Ovarian serous cystadenocarcinoma
CVCL_0532 
[85]
Half Maximal Inhibitory Concentration (IC50) 2.6 nM
SK-OV-3 cells (FZD7 overexpression)
Ovarian serous cystadenocarcinoma
CVCL_0532 
[86]
Half Maximal Inhibitory Concentration (IC50) 2.6 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[309]
Half Maximal Inhibitory Concentration (IC50) 2.6 nM
MDA435/LCC6 cells
Amelanotic melanoma
CVCL_IN99 
[546]
Half Maximal Inhibitory Concentration (IC50) 2.61 nM
HCT 116 cells
Colon carcinoma
CVCL_0291 
[325]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 2.65 nM
KB cells
Human papillomavirus-related endocervical adenocarcinoma
CVCL_0372 
[541]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 2.667 nM
CCRF-CEM cells
T acute lymphoblastic leukemia
CVCL_0207 
[345]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 2.673 nM
RPMI-8226 cells
Plasma cell myeloma
CVCL_0014 
[345]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 2.679 nM
HCT 116 cells
Colon carcinoma
CVCL_0291 
[345]
Half Maximal Inhibitory Concentration (IC50) 2.68 nM
MFH-ino cells
Pleomorphic sarcoma
CVCL_1407 
Half Maximal Inhibitory Concentration (IC50) 2.7 nM
DU145 cells
Prostate carcinoma
CVCL_0105 
[506]
Half Maximal Inhibitory Concentration (IC50) 2.7 nM
MOLT-4 cells
Adult T acute lymphoblastic leukemia
CVCL_0013 
[528]
Half Maximal Inhibitory Concentration (IC50) 2.7 nM
HCT 116 cells
Colon carcinoma
CVCL_0291 
[547]
Half Maximal Inhibitory Concentration (IC50) 2.7 nM
PC-9 cells
Lung adenocarcinoma
CVCL_B260 
[534]
Half Maximal Inhibitory Concentration (IC50) 2.7 nM
MDA-MB-231 cells (5T4 overexpression)
Breast adenocarcinoma
CVCL_0062 
[463]
Half Maximal Inhibitory Concentration (IC50) 2.7 nM
SK-OV-3 cells (FZD7 overexpression)
Ovarian serous cystadenocarcinoma
CVCL_0532 
[524]
Half Maximal Inhibitory Concentration (IC50) 2.7 nM
MDA-MB-231 cells (5T4 overexpression)
Breast adenocarcinoma
CVCL_0062 
[94]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 2.729 nM
HT-29 cells
Colon adenocarcinoma
CVCL_0320 
[345]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 2.76 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[548]
Half Maximal Inhibitory Concentration (IC50) 2.8 nM
A2780 cells
Ovarian endometrioid adenocarcinoma
CVCL_0134 
[491]
Half Maximal Inhibitory Concentration (IC50) 2.8 nM
A2780 cells
Ovarian endometrioid adenocarcinoma
CVCL_0134 
[549]
Half Maximal Inhibitory Concentration (IC50) 2.8 nM
MCF7-VP cells
Breast carcinoma
CVCL_5I65 
[538]
Half Maximal Inhibitory Concentration (IC50) 2.8 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[550]
Half Maximal Inhibitory Concentration (IC50) 2.8 nM
HCT 116 cells
Colon carcinoma
CVCL_0291 
[133]
Half Maximal Inhibitory Concentration (IC50) 2.8 nM
LS180 cells
Colon carcinoma
CVCL_0397 
[511]
Half Maximal Inhibitory Concentration (IC50) 2.8 nM
MCF7-VP cells
Breast carcinoma
CVCL_5I65 
[551]
Half Maximal Inhibitory Concentration (IC50) 2.8 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[552]
Half Maximal Inhibitory Concentration (IC50) 2.8 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[390]
Half Maximal Inhibitory Concentration (IC50) 2.8 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[391]
Half Maximal Inhibitory Concentration (IC50) 2.8 nM
A2780 cells
Ovarian endometrioid adenocarcinoma
CVCL_0134 
[553]
Half Maximal Inhibitory Concentration (IC50) 2.8 nM
MDA-MB-231 cells (5T4 overexpression)
Breast adenocarcinoma
CVCL_0062 
[123]
Half Maximal Inhibitory Concentration (IC50) 2.802 nM
IA-LM cells
Lung large cell carcinoma
CVCL_1302 
Half Maximal Cell Growth Inhibitory Concentration (GI50) 2.812 nM
KM-20L2 cells
Colon carcinoma
CVCL_D889 
[345]
Half Maximal Effective Concentration (EC50) 2.87 nM
KB cells
Human papillomavirus-related endocervical adenocarcinoma
CVCL_0372 
[303]
Half Maximal Inhibitory Concentration (IC50) 2.87 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[79]
Half Maximal Inhibitory Concentration (IC50) 2.888 nM
MC116 cells
B-cell non-Hodgkin lymphoma
CVCL_1399 
Half Maximal Inhibitory Concentration (IC50) 2.9 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[210]
Half Maximal Inhibitory Concentration (IC50) 2.9 nM
MDA-MB-435 cells
Amelanotic melanoma
CVCL_0417 
[342]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 2.904 nM
DMS 114 cells
Lung small cell carcinoma
CVCL_1174 
[345]
Half Maximal Inhibitory Concentration (IC50) 2.92 nM
KB 3-1 cells
Cervical epithelial carcinoma
CVCL_2088 
[554]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 2.924 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[345]
Half Maximal Inhibitory Concentration (IC50) 2.93 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[555]
Half Maximal Inhibitory Concentration (IC50) 2.95 nM
SK-OV-3 cells (FZD7 overexpression)
Ovarian serous cystadenocarcinoma
CVCL_0532 
[198]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 2.958 nM
NCI-H460 cells
Lung large cell carcinoma
CVCL_0459 
[345]
Half Maximal Inhibitory Concentration (IC50) 2.96 nM
MES-SA cells
Uterine sarcoma
CVCL_1404 
[556]
Half Maximal Inhibitory Concentration (IC50) 2.96 nM
MES-SA cells
Uterine sarcoma
CVCL_1404 
[557]
Half Maximal Inhibitory Concentration (IC50) 2.96 nM
MES-SA cells
Uterine sarcoma
CVCL_1404 
[558]
Half Maximal Inhibitory Concentration (IC50) 2.977 nM
RKO cells
Colon carcinoma
CVCL_0504 
Half Maximal Inhibitory Concentration (IC50) 2.99 nM
MRK-nu-1 cells
Breast carcinoma
CVCL_1428 
Half Maximal Inhibitory Concentration (IC50) 2.996 nM
VA-ES-BJ cells
Epithelioid sarcoma
CVCL_1785 
Half Maximal Cell Growth Inhibitory Concentration (GI50) 20 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[245]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 20 nM
OVCAR-3 cells (FZD7 overexpression)
Ovarian serous adenocarcinoma
CVCL_0465 
[252]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 20 nM
786-O cells
Renal cell carcinoma
CVCL_1051 
[141]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 20 nM
U-87MG ATCC cells
Glioblastoma
CVCL_0022 
[245]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 20 nM
U-87MG ATCC cells
Glioblastoma
CVCL_0022 
[246]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 20 nM
B16-F1 cells
Melanoma
CVCL_0158 
[255]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 20 nM
NUGC-3 cells
Gastric carcinoma
CVCL_1612 
[487]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 20 nM
HONE1 cells
Nasopharyngeal carcinoma
CVCL_8706 
[487]
Half Maximal Inhibitory Concentration (IC50) 20 nM
Caco-2 cells
Colon adenocarcinoma
CVCL_0025 
[125]
Half Maximal Inhibitory Concentration (IC50) 20 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[366]
Half Maximal Inhibitory Concentration (IC50) 20 nM
A2780 cells
Ovarian endometrioid adenocarcinoma
CVCL_0134 
[509]
Half Maximal Inhibitory Concentration (IC50) 20 nM
AsPC-1 cells
Pancreatic ductal adenocarcinoma
CVCL_0152 
[313]
Half Maximal Inhibitory Concentration (IC50) 20 nM
KB cells
Human papillomavirus-related endocervical adenocarcinoma
CVCL_0372 
[72]
Half Maximal Inhibitory Concentration (IC50) 20 nM
KB cells
Human papillomavirus-related endocervical adenocarcinoma
CVCL_0372 
[559]
Half Maximal Inhibitory Concentration (IC50) 20 nM
LNCaP cells
Prostate carcinoma
CVCL_0395 
[72]
Half Maximal Inhibitory Concentration (IC50) 20 nM
RKO cells
Colon carcinoma
CVCL_0504 
[324]
Half Maximal Inhibitory Concentration (IC50) 20 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[72]
Half Maximal Inhibitory Concentration (IC50) 20 nM
BT-549 cells
Breast ductal carcinoma
CVCL_1092 
[559]
Half Maximal Inhibitory Concentration (IC50) 20 nM
BGC-823 cells
Stomach adenocarcinoma
CVCL_3360 
[151]
Half Maximal Inhibitory Concentration (IC50) 20 nM
Col2 cells
Colon carcinoma
CVCL_D645 
[72]
Half Maximal Inhibitory Concentration (IC50) 20 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[297]
Half Maximal Inhibitory Concentration (IC50) 20 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[298]
Half Maximal Inhibitory Concentration (IC50) 20 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[299]
Half Maximal Inhibitory Concentration (IC50) 20 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[300]
Half Maximal Inhibitory Concentration (IC50) 20 nM
PC-3 cells
Prostate carcinoma
CVCL_0035 
[560]
Half Maximal Inhibitory Concentration (IC50) 20 nM
PC-3 cells
Prostate carcinoma
CVCL_0035 
[561]
Half Maximal Inhibitory Concentration (IC50) 20 nM
Hep-G2 cells
Hepatoblastoma
CVCL_0027 
[161]
Half Maximal Inhibitory Concentration (IC50) 20 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[267]
Half Maximal Inhibitory Concentration (IC50) 20 nM
A2780 cells
Ovarian endometrioid adenocarcinoma
CVCL_0134 
[562]
Half Maximal Inhibitory Concentration (IC50) 20 nM
A2780 cells
Ovarian endometrioid adenocarcinoma
CVCL_0134 
[273]
Half Maximal Inhibitory Concentration (IC50) 20 nM
HCT 116 cells
Colon carcinoma
CVCL_0291 
[500]
Half Maximal Inhibitory Concentration (IC50) 20 nM
HT-29 cells
Colon adenocarcinoma
CVCL_0320 
[563]
Half Maximal Inhibitory Concentration (IC50) 20 nM
Hep 3B2.1-7 cells
Childhood hepatocellular carcinoma
CVCL_0326 
[564]
Half Maximal Inhibitory Concentration (IC50) 20 nM
ES2 cells
Ewing sarcoma
CVCL_AX39 
[344]
Half Maximal Inhibitory Concentration (IC50) 20 nM
HCT-8 cells
Ileocecal adenocarcinoma
CVCL_2478 
[565]
Half Maximal Inhibitory Concentration (IC50) 20 nM
Caco-2 cells
Colon adenocarcinoma
CVCL_0025 
[134]
Half Maximal Inhibitory Concentration (IC50) 20 nM
A2780 cells
Ovarian endometrioid adenocarcinoma
CVCL_0134 
[418]
Half Maximal Inhibitory Concentration (IC50) 20 nM
HCT 116 cells
Colon carcinoma
CVCL_0291 
[382]
Half Maximal Inhibitory Concentration (IC50) 20 nM
HCT 116 cells
Colon carcinoma
CVCL_0291 
[250]
Half Maximal Inhibitory Concentration (IC50) 20 nM
MDA-MB-231 cells (5T4 overexpression)
Breast adenocarcinoma
CVCL_0062 
[405]
Half Maximal Inhibitory Concentration (IC50) 20 nM
HCT-8 cells
Ileocecal adenocarcinoma
CVCL_2478 
[418]
Half Maximal Inhibitory Concentration (IC50) 20.36 nM
ONS-76 cells
Medulloblastoma
CVCL_1624 
Half Maximal Inhibitory Concentration (IC50) 20.39 nM
KU812 cells
Chronic myeloid leukemia
CVCL_0379 
Half Maximal Inhibitory Concentration (IC50) 20.4 nM
A2780 cells
Ovarian endometrioid adenocarcinoma
CVCL_0134 
[91]
Half Maximal Inhibitory Concentration (IC50) 20.47 nM
ML-2 cells
Acute myeloid leukemia
CVCL_1418 
Half Maximal Inhibitory Concentration (IC50) 20.5 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[182]
Half Maximal Inhibitory Concentration (IC50) 20.5 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[566]
Half Maximal Inhibitory Concentration (IC50) 20.92 nM
HCE-T cells
Nornal
CVCL_1272 
Half Maximal Cell Growth Inhibitory Concentration (GI50) 200 nM
OVCAR-3 cells (FZD7 overexpression)
Ovarian serous adenocarcinoma
CVCL_0465 
[141]
Half Maximal Inhibitory Concentration (IC50) 200 nM
PC-3 cells
Prostate carcinoma
CVCL_0035 
[291]
Half Maximal Inhibitory Concentration (IC50) 200 nM
PC-3 cells
Prostate carcinoma
CVCL_0035 
[292]
Half Maximal Inhibitory Concentration (IC50) 200 nM
L2987 cells
Lung adenocarcinoma
CVCL_H586 
[17]
Half Maximal Inhibitory Concentration (IC50) 200 nM
BNL cells
Hepatocellular carcinoma
Undisclosed [90]
Half Maximal Inhibitory Concentration (IC50) 200 nM
SH-SY5Y cells
Bone marrow neuroblastoma
CVCL_0019 
[291]
Half Maximal Inhibitory Concentration (IC50) 200 nM
SH-SY5Y cells
Bone marrow neuroblastoma
CVCL_0019 
[292]
Half Maximal Inhibitory Concentration (IC50) 200 nM
4T1 cells
Mammary carcinoma
CVCL_0125 
[90]
Half Maximal Inhibitory Concentration (IC50) 200 nM
PC-3 cells
Prostate carcinoma
CVCL_0035 
[297]
Half Maximal Inhibitory Concentration (IC50) 200 nM
PC-3 cells
Prostate carcinoma
CVCL_0035 
[298]
Half Maximal Inhibitory Concentration (IC50) 200 nM
PC-3 cells
Prostate carcinoma
CVCL_0035 
[299]
Half Maximal Inhibitory Concentration (IC50) 200 nM
Hep-G2 cells
Hepatoblastoma
CVCL_0027 
[563]
Half Maximal Inhibitory Concentration (IC50) 200 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[567]
Half Maximal Inhibitory Concentration (IC50) 200 nM
SH-SY5Y cells
Bone marrow neuroblastoma
CVCL_0019 
[297]
Half Maximal Inhibitory Concentration (IC50) 200 nM
SH-SY5Y cells
Bone marrow neuroblastoma
CVCL_0019 
[298]
Half Maximal Inhibitory Concentration (IC50) 200 nM
SH-SY5Y cells
Bone marrow neuroblastoma
CVCL_0019 
[299]
Half Maximal Inhibitory Concentration (IC50) 200 nM
MDA-MB-468 cells
Breast adenocarcinoma
CVCL_0419 
[306]
Half Maximal Inhibitory Concentration (IC50) 200 nM
T-47D cells
Invasive breast carcinoma
CVCL_0553 
[306]
Half Maximal Inhibitory Concentration (IC50) 200 nM
MDA-MB-231 cells (5T4 overexpression)
Breast adenocarcinoma
CVCL_0062 
[164]
Half Maximal Inhibitory Concentration (IC50) >200 nM
HCT-116/VM46 cells
Colon carcinoma
CVCL_N508 
[568]
Half Maximal Inhibitory Concentration (IC50) >2000 nM
Bel-7402 cells
Hepatoma
CVCL_5492 
[273]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 20000 nM
NCI-H226 cells
Pleural epithelioid mesothelioma
CVCL_1544 
[140]
Half Maximal Inhibitory Concentration (IC50) >200000 nM
MRC5 cells
Normal
CVCL_0440 
[362]
Half Maximal Inhibitory Concentration (IC50) 20010 nM
NIH3T3 cells
Normal
CVCL_0594 
[569]
Half Maximal Inhibitory Concentration (IC50) 2010 nM
MDA-MB-231 cells (5T4 overexpression)
Breast adenocarcinoma
CVCL_0062 
[570]
Half Maximal Inhibitory Concentration (IC50) 2013 nM
KB-V1 cells
Cervical carcinoma
CVCL_2089 
[537]
Half Maximal Inhibitory Concentration (IC50) 2013 nM
KB-V1 cells
Cervical carcinoma
CVCL_2089 
[535]
Half Maximal Inhibitory Concentration (IC50) 2013 nM
KB-V1 cells
Cervical carcinoma
CVCL_2089 
[571]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 203.24 nM
Caki-1 cells
Clear cell renal cell carcinoma
CVCL_0234 
[345]
Half Maximal Inhibitory Concentration (IC50) 2078000 nM
NCI-H460 cells
Lung large cell carcinoma
CVCL_0459 
[572]
Half Maximal Inhibitory Concentration (IC50) 208.92 nM
BT474-M1 cells
Invasive breast carcinoma
CVCL_0179 
Half Maximal Inhibitory Concentration (IC50) 20898.45 nM
JVM-3 cells
B-cell prolymphocytic leukemia
CVCL_1320 
Half Maximal Inhibitory Concentration (IC50) 20960 nM
LNCaP cells
Prostate carcinoma
CVCL_0395 
[362]
Half Maximal Inhibitory Concentration (IC50) 21 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[573]
Half Maximal Inhibitory Concentration (IC50) 21 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[574]
Half Maximal Inhibitory Concentration (IC50) 21 nM
Pt K2 cells
Normal
CVCL_0514 
[575]
Half Maximal Inhibitory Concentration (IC50) 21 nM
PC-3 cells
Prostate carcinoma
CVCL_0035 
[282]
Half Maximal Inhibitory Concentration (IC50) 21 nM
A2780 cells
Ovarian endometrioid adenocarcinoma
CVCL_0134 
[576]
Half Maximal Inhibitory Concentration (IC50) 21 nM
HCT 116 cells
Colon carcinoma
CVCL_0291 
[451]
Half Maximal Inhibitory Concentration (IC50) 21 nM
B16-F0 cells
Mouse melanoma
CVCL_0604 
[382]
Half Maximal Inhibitory Concentration (IC50) 21 nM
MDA-MB-231 cells (5T4 overexpression)
Breast adenocarcinoma
CVCL_0062 
[433]
Half Maximal Inhibitory Concentration (IC50) 21.1 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[211]
Half Maximal Inhibitory Concentration (IC50) 21.12 nM
NCI-H446 cells
Lung small cell carcinoma
CVCL_1562 
Half Maximal Cell Growth Inhibitory Concentration (GI50) 21.23 nM
UACC-257 cells
Melanoma
CVCL_1779 
[345]
Half Maximal Inhibitory Concentration (IC50) 21.49 nM
RPMI-6666 cells
Normal
CVCL_1665 
Half Maximal Inhibitory Concentration (IC50) 21.53 nM
MOLT-16 cells
T acute lymphoblastic leukemia
CVCL_1424 
Half Maximal Inhibitory Concentration (IC50) 21.7 nM
SF268 cells
Astrocytoma
CVCL_1689 
[353]
Half Maximal Inhibitory Concentration (IC50) 21.7 nM
SF268 cells
Astrocytoma
CVCL_1689 
[354]
Half Maximal Inhibitory Concentration (IC50) 21.71 nM
Hep-G2 cells
Hepatoblastoma
CVCL_0027 
[577]
Half Maximal Inhibitory Concentration (IC50) 21.76 nM
JIYOYE cells
Burkitts lymhoma
CVCL_1317 
Half Maximal Cell Growth Inhibitory Concentration (GI50) 21.9 nM
NCI-H460 cells
Lung large cell carcinoma
CVCL_0459 
[237]
Half Maximal Inhibitory Concentration (IC50) 21.91 nM
MHH-PREB-1 cells
B-cell non-Hodgkin lymphoma
CVCL_1413 
Half Maximal Inhibitory Concentration (IC50) 210 nM
MES-SA/Dx5 cells
Uterine sarcoma
CVCL_2598 
[578]
Half Maximal Inhibitory Concentration (IC50) 210 nM
C-26 cells
Normal
CVCL_XC68 
[344]
Half Maximal Inhibitory Concentration (IC50) 2100 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[579]
Half Maximal Inhibitory Concentration (IC50) 2100 nM
U-937 cells
Adult acute monocytic leukemia
CVCL_0007 
[579]
Half Maximal Inhibitory Concentration (IC50) 2100 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[580]
Half Maximal Inhibitory Concentration (IC50) 21020 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[427]
Half Maximal Inhibitory Concentration (IC50) 2110 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[368]
Half Maximal Inhibitory Concentration (IC50) 2110 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[370]
Half Maximal Inhibitory Concentration (IC50) 2110 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[372]
Half Maximal Inhibitory Concentration (IC50) 21134.86 nM
CW-2 cells
Colon adenocarcinoma
CVCL_1151 
Half Maximal Inhibitory Concentration (IC50) 21469.06 nM
YT cells
Natural killer cell lymphoblastic leukemia
CVCL_1797 
Half Maximal Inhibitory Concentration (IC50) 219.71 nM
GDM-1 cells
Acute myeloid leukemia
CVCL_1230 
Half Maximal Cell Growth Inhibitory Concentration (GI50) 2190 nM
SK-N-SH cells
Neuroblastoma
CVCL_0531 
[346]
Half Maximal Inhibitory Concentration (IC50) 22 nM
DLD-1 cells
Colon adenocarcinoma
CVCL_0248 
[419]
Half Maximal Inhibitory Concentration (IC50) 22 nM
DLD-1 cells
Colon adenocarcinoma
CVCL_0248 
[420]
Half Maximal Inhibitory Concentration (IC50) 22 nM
P388 cells
Lymphoma
CVCL_7222 
[342]
Half Maximal Inhibitory Concentration (IC50) 22 nM
A375 cells
Amelanotic melanoma
CVCL_0132 
[118]
Half Maximal Inhibitory Concentration (IC50) 22.5 nM
MX1 cells
Breast carcinoma
CVCL_4774 
[169]
Half Maximal Inhibitory Concentration (IC50) 22.75 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[128]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 22.91 nM
M14 cells
Melanoma
CVCL_1395 
[345]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 220 nM
MDA-MB-231 cells (5T4 overexpression)
Breast adenocarcinoma
CVCL_0062 
[288]
Half Maximal Inhibitory Concentration (IC50) 220 nM
Hep-G2 cells
Hepatoblastoma
CVCL_0027 
[93]
Half Maximal Inhibitory Concentration (IC50) 220 nM
Hep-G2 cells
Hepatoblastoma
CVCL_0027 
[301]
Half Maximal Inhibitory Concentration (IC50) 2202 nM
HCT 116 cells
Colon carcinoma
CVCL_0291 
[307]
Half Maximal Inhibitory Concentration (IC50) 2205.93 nM
NCI-H2171 cells
Lung small cell carcinoma
CVCL_1536 
Half Maximal Inhibitory Concentration (IC50) 222.35 nM
NCI-H2196 cells
Lung small cell carcinoma
CVCL_1539 
Half Maximal Inhibitory Concentration (IC50) 22274.64 nM
C8166 cells
Leukemia
CVCL_1099 
Half Maximal Inhibitory Concentration (IC50) 223.49 nM
KP-N-RT-BM-1 cells
Adrenal gland neuroblastoma
CVCL_1339 
Half Maximal Inhibitory Concentration (IC50) 2247.37 nM
CHP-126 cells
Neuroblastoma
CVCL_1123 
Half Maximal Inhibitory Concentration (IC50) 2276.44 nM
DMS-79 cells
Small cell lung carcinoma
CVCL_1178 
Half Maximal Inhibitory Concentration (IC50) 2280 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[369]
Half Maximal Inhibitory Concentration (IC50) 229.58 nM
KNS-81-FD cells
Glioblastoma
CVCL_1336 
Half Maximal Inhibitory Concentration (IC50) 2290 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[581]
Half Maximal Inhibitory Concentration (IC50) 2290.87 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[582]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 23 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[248]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 23 nM
NCI-H1299 cells (MMAE resistant)
Lung large cell carcinoma
CVCL_0060 
[583]
Half Maximal Effective Concentration (EC50) 23 nM
TERT-RPE1 cells
Normal
CVCL_4388 
[102]
Half Maximal Inhibitory Concentration (IC50) 23 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[381]
Half Maximal Inhibitory Concentration (IC50) 23 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[118]
Half Maximal Inhibitory Concentration (IC50) 23 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[515]
Half Maximal Inhibitory Concentration (IC50) 23 nM
U-251MG cells
Astrocytoma
CVCL_0021 
[344]
Half Maximal Inhibitory Concentration (IC50) 23 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[542]
Half Maximal Inhibitory Concentration (IC50) 23 nM
IGROV-1 cells
Ovarian endometrioid adenocarcinoma
CVCL_1304 
[524]
Half Maximal Inhibitory Concentration (IC50) 23 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[584]
Half Maximal Inhibitory Concentration (IC50) 23.1 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[414]
Half Maximal Inhibitory Concentration (IC50) 23.18 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[486]
Half Maximal Inhibitory Concentration (IC50) 23.26 nM
MC/CAR cells
Normal
CVCL_1397 
Half Maximal Inhibitory Concentration (IC50) 23.29 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[184]
Half Maximal Inhibitory Concentration (IC50) 23.3 nM
KB 3-1 cells
Cervical epithelial carcinoma
CVCL_2088 
[329]
Half Maximal Inhibitory Concentration (IC50) 23.4 nM
A2780 cells
Ovarian endometrioid adenocarcinoma
CVCL_0134 
[585]
Half Maximal Inhibitory Concentration (IC50) 23.4 nM
A2780 cells
Ovarian endometrioid adenocarcinoma
CVCL_0134 
[586]
Half Maximal Inhibitory Concentration (IC50) 23.44 nM
BC-3 cells
Primary effusion lymphoma
CVCL_1080 
Half Maximal Inhibitory Concentration (IC50) 23.55 nM
KINGS-1 cells
Anaplastic astrocytoma
CVCL_1328 
Half Maximal Inhibitory Concentration (IC50) 23.78 nM
PF-382 cells
T acute lymphoblastic leukemia
CVCL_1641 
Half Maximal Inhibitory Concentration (IC50) 23.83 nM
J-RT3-T3-5 cells
T acute lymphoblastic leukemi
CVCL_1316 
Half Maximal Cell Growth Inhibitory Concentration (GI50) 23.93 nM
DU145 cells
Prostate carcinoma
CVCL_0105 
[345]
Half Maximal Inhibitory Concentration (IC50) 230 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[587]
Half Maximal Inhibitory Concentration (IC50) 2300 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[579]
Half Maximal Inhibitory Concentration (IC50) 2300 nM
SW620 cells
Colon adenocarcinoma
CVCL_0547 
[588]
Half Maximal Inhibitory Concentration (IC50) >2300 nM
KB-V1 cells
Cervical carcinoma
CVCL_2089 
[72]
Half Maximal Inhibitory Concentration (IC50) 23000 nM
CCD-112CoN cells
Normal
CVCL_6382 
[159]
Half Maximal Inhibitory Concentration (IC50) 23000 nM
CCD-112CoN cells
Normal
CVCL_6382 
[117]
Half Maximal Inhibitory Concentration (IC50) 23000 nM
CCD-112CoN cells
Normal
CVCL_6382 
[160]
Half Maximal Inhibitory Concentration (IC50) 2306.78 nM
SCC-15 cells
Squamous carcinoma
CVCL_1681 
Half Maximal Inhibitory Concentration (IC50) 2311.65 nM
Reh cells
B acute lymphoblastic leukemia
CVCL_1650 
Half Maximal Inhibitory Concentration (IC50) 2320 nM
184B5 cells
Normal
CVCL_4688 
[581]
Half Maximal Inhibitory Concentration (IC50) 2323.15 nM
NCI-H2081 cells
Lung small cell carcinoma
CVCL_1522 
Half Maximal Inhibitory Concentration (IC50) 23251.25 nM
SUP-T1 cells
T lymphoblastic lymphoma
CVCL_1714 
Half Maximal Inhibitory Concentration (IC50) 23511.93 nM
Kasumi-1 cells
Myeloid leukemia with maturation
CVCL_0589 
Half Maximal Inhibitory Concentration (IC50) 236.75 nM
COLO-668 cells
Lung small cell carcinoma
CVCL_1128 
Half Maximal Inhibitory Concentration (IC50) 23697.87 nM
IM-9 cells
Multiple myeloma
CVCL_1305 
Half Maximal Inhibitory Concentration (IC50) 23900 nM
A2780/PTX cells
Ovarian endometrioid adenocarcinoma
CVCL_C0D6 
[454]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 24 nM
NCI-H460 cells
Lung large cell carcinoma
CVCL_0459 
[376]
Half Maximal Inhibitory Concentration (IC50) 24 nM
U2OS cells
Osteosarcoma
CVCL_0042 
[209]
Half Maximal Inhibitory Concentration (IC50) 24 nM
NCI-H630 cells
Colon carcinoma
CVCL_1572 
[241]
Half Maximal Inhibitory Concentration (IC50) 24 nM
A2780 cells
Ovarian endometrioid adenocarcinoma
CVCL_0134 
[589]
Half Maximal Inhibitory Concentration (IC50) 24 nM
HCT 15 cells
Colon adenocarcinoma
CVCL_0292 
[344]
Half Maximal Inhibitory Concentration (IC50) 24 nM
HaCaT cells
Normal
CVCL_0038 
[73]
Half Maximal Inhibitory Concentration (IC50) 24 nM
HaCaT cells
Normal
CVCL_0038 
[74]
Half Maximal Inhibitory Concentration (IC50) 24 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[552]
Half Maximal Inhibitory Concentration (IC50) 24 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[390]
Half Maximal Inhibitory Concentration (IC50) 24 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[391]
Half Maximal Inhibitory Concentration (IC50) 24.01 nM
SF539 cells
Gliosarcoma
CVCL_1691 
Half Maximal Inhibitory Concentration (IC50) 24.2 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[590]
Half Maximal Inhibitory Concentration (IC50) 24.55 nM
SF-295 cells
Glioblastoma
CVCL_1690 
[557]
Half Maximal Inhibitory Concentration (IC50) 24.85 nM
LB831-BLC cells
Bladder carcinoma
CVCL_1370 
Half Maximal Inhibitory Concentration (IC50) 240 nM
HCT 15 cells
Colon adenocarcinoma
CVCL_0292 
[271]
Half Maximal Inhibitory Concentration (IC50) 240 nM
SK-HEP1 cells
Hepatoma
CVCL_0525 
[273]
Half Maximal Inhibitory Concentration (IC50) 240 nM
HCT-8 cells
Ileocecal adenocarcinoma
CVCL_2478 
[163]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 2400 nM
NCI-H2073 cells
Lung adenocarcinoma
CVCL_1521 
[319]
Half Maximal Inhibitory Concentration (IC50) 2400 nM
K-562 cells
Chronic myelogenous leukemia
CVCL_0004 
[591]
Half Maximal Inhibitory Concentration (IC50) 2400 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[250]
Half Maximal Inhibitory Concentration (IC50) 24000 nM
L1210 cells
Lymphoblastic leukemia
CVCL_0382 
[592]
Half Maximal Inhibitory Concentration (IC50) 24000 nM
NCI-H460 cells
Lung large cell carcinoma
CVCL_0459 
[273]
Half Maximal Inhibitory Concentration (IC50) 240000 nM
UO-31 cells
Renal carcinoma
CVCL_1911 
[464]
Half Maximal Inhibitory Concentration (IC50) 24165.43 nM
NH-12 cells
Adrenal gland neuroblastoma
CVCL_1605 
Half Maximal Inhibitory Concentration (IC50) 2430 nM
SK-OV-3 cells (FZD7 overexpression)
Ovarian serous cystadenocarcinoma
CVCL_0532 
[593]
Half Maximal Inhibitory Concentration (IC50) 24530 nM
A549/TR cells
Lung adenocarcinoma
CVCL_C5S0 
[343]
Half Maximal Inhibitory Concentration (IC50) 2460 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[368]
Half Maximal Inhibitory Concentration (IC50) 2460 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[370]
Half Maximal Inhibitory Concentration (IC50) 2460 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[372]
Half Maximal Inhibitory Concentration (IC50) <25 nM
PC-3 cells
Prostate carcinoma
CVCL_0035 
[144]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 25 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[594]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 25 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[595]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 25 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[596]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 25 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[596]
Half Maximal Inhibitory Concentration (IC50) <25 nM
MDA-MB-231 cells (5T4 overexpression)
Breast adenocarcinoma
CVCL_0062 
[132]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 25 nM
HOP-92 cells
Non-small cell lung carcinoma
CVCL_1286 
[146]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 25 nM
HOP-92 cells
Non-small cell lung carcinoma
CVCL_1286 
[147]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 25 nM
SF-295 cells
Glioblastoma
CVCL_1690 
[146]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 25 nM
SF-295 cells
Glioblastoma
CVCL_1690 
[147]
Half Maximal Inhibitory Concentration (IC50) 25 nM
A2780 cells
Ovarian endometrioid adenocarcinoma
CVCL_0134 
[17]
Half Maximal Inhibitory Concentration (IC50) 25 nM
A2780 cells
Ovarian endometrioid adenocarcinoma
CVCL_0134 
[597]
Half Maximal Inhibitory Concentration (IC50) 25 nM
ACHN cells
Renal adenocarcinoma
CVCL_1067 
[218]
Half Maximal Inhibitory Concentration (IC50) 25 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[268]
Half Maximal Inhibitory Concentration (IC50) 25 nM
HT-29 cells
Colon adenocarcinoma
CVCL_0320 
[515]
Half Maximal Inhibitory Concentration (IC50) 25 nM
NIH3T3 cells
Normal
CVCL_0594 
[598]
Half Maximal Inhibitory Concentration (IC50) 25.02 nM
DMS 114 cells
Lung small cell carcinoma
CVCL_1174 
Half Maximal Inhibitory Concentration (IC50) 25.1 nM
A-431 cells
Skin squamous cell carcinoma
CVCL_0037 
[599]
Half Maximal Inhibitory Concentration (IC50) 25.1 nM
LB1047-RCC cells
Renal cell carcinoma
CVCL_1364 
Half Maximal Inhibitory Concentration (IC50) 25.34 nM
BB65-RCC cells
Renal cell carcinoma
CVCL_1078 
Half Maximal Inhibitory Concentration (IC50) 25.34 nM
LB771-HNC cells
Head and neck squamous cell carcinoma
CVCL_1369 
Half Maximal Inhibitory Concentration (IC50) 25.54 nM
BV-173 cells
Chronic myelogenous leukemia
CVCL_0181 
Half Maximal Inhibitory Concentration (IC50) 25.81 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[577]
Half Maximal Inhibitory Concentration (IC50) >250 nM
Fibroblast cells
Normal
Undisclosed [433]
Half Maximal Inhibitory Concentration (IC50) 2500 nM
MIA PaCa-2 cells (MSLN expression)
Pancreatic ductal adenocarcinoma
CVCL_0428 
[600]
Half Maximal Inhibitory Concentration (IC50) 2500 nM
NCI-H2126 cells
Lung large cell carcinoma
CVCL_1532 
[107]
Half Maximal Inhibitory Concentration (IC50) 2500 nM
MIA PaCa-2 cells (MSLN expression)
Pancreatic ductal adenocarcinoma
CVCL_0428 
[501]
Half Maximal Inhibitory Concentration (IC50) 25000 nM
MDA-MB-231 cells (5T4 overexpression)
Breast adenocarcinoma
CVCL_0062 
[601]
Half Maximal Inhibitory Concentration (IC50) >25000 nM
Bel-7402 cells
Hepatoma
CVCL_5492 
[602]
Half Maximal Inhibitory Concentration (IC50) 2500000 nM
NCI-ADR-RES cells
High grade ovarian serous adenocarcinoma
CVCL_1452 
[475]
Half Maximal Inhibitory Concentration (IC50) 25120 nM
A2780/Taxol cells
Ovarian endometrioid adenocarcinoma
CVCL_IJ13 
[385]
Half Maximal Inhibitory Concentration (IC50) 2540 nM
KB cells
Human papillomavirus-related endocervical adenocarcinoma
CVCL_0372 
[593]
Half Maximal Inhibitory Concentration (IC50) 2559.72 nM
NCI-H720 cells
Lung carcinoid tumor
CVCL_1583 
Half Maximal Inhibitory Concentration (IC50) 2560 nM
MDA-MB-231 cells (5T4 overexpression)
Breast adenocarcinoma
CVCL_0062 
[581]
Half Maximal Inhibitory Concentration (IC50) 25726.05 nM
WSU-NHL cells
Diffuse large B-cell lymphoma
CVCL_1793 
Half Maximal Inhibitory Concentration (IC50) 2580 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[603]
Half Maximal Inhibitory Concentration (IC50) 2590 nM
HCT-8 cells
Ileocecal adenocarcinoma
CVCL_2478 
[604]
Half Maximal Inhibitory Concentration (IC50) 2596 nM
SK-OV-3 cells (FZD7 overexpression)
Ovarian serous cystadenocarcinoma
CVCL_0532 
[219]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 26 nM
T-47D cells
Invasive breast carcinoma
CVCL_0553 
[605]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 26 nM
T-47D cells
Invasive breast carcinoma
CVCL_0553 
[583]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 26 nM
T-47D cells
Invasive breast carcinoma
CVCL_0553 
[606]
Half Maximal Inhibitory Concentration (IC50) 26 nM
NCI-H838 cells
Lung adenocarcinoma
CVCL_1594 
[471]
Half Maximal Inhibitory Concentration (IC50) 26 nM
BGC-823 cells
Stomach adenocarcinoma
CVCL_3360 
[565]
Half Maximal Inhibitory Concentration (IC50) 26.01 nM
ARH-77 cells
Leukemia
CVCL_1072 
Half Maximal Inhibitory Concentration (IC50) 26.23 nM
IST-MEL1 cells
Melanoma
CVCL_1308 
Half Maximal Inhibitory Concentration (IC50) 26.87 nM
NB1 cells
Neuroblastoma
CVCL_8812 
Half Maximal Inhibitory Concentration (IC50) 26.88 nM
EoL-1 cells
Chronic eosinophilic leukemia
CVCL_0258 
Half Maximal Inhibitory Concentration (IC50) 26.97 nM
KY821 cells
Acute myelomonocytic leukemia
CVCL_1346 
Half Maximal Inhibitory Concentration (IC50) 260 nM
PANC-1 cells
Pancreatic ductal adenocarcinoma
CVCL_0480 
[107]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 2600 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[607]
Half Maximal Inhibitory Concentration (IC50) 2600 nM
SK-OV-3 cells (FZD7 overexpression)
Ovarian serous cystadenocarcinoma
CVCL_0532 
[215]
Half Maximal Inhibitory Concentration (IC50) 2600 nM
Hep-G2 cells
Hepatoblastoma
CVCL_0027 
[328]
Half Maximal Inhibitory Concentration (IC50) 2600 nM
PC-3 cells
Prostate carcinoma
CVCL_0035 
[474]
Half Maximal Inhibitory Concentration (IC50) 2600 nM
SK-OV-3 cells (FZD7 overexpression)
Ovarian serous cystadenocarcinoma
CVCL_0532 
[147]
Half Maximal Inhibitory Concentration (IC50) 264 nM
TOV-21G cells
Ovarian clear cell adenocarcinoma
CVCL_3613 
[490]
Half Maximal Inhibitory Concentration (IC50) 2655 nM
SK-OV-3 cells (FZD7 overexpression)
Ovarian serous cystadenocarcinoma
CVCL_0532 
[183]
Half Maximal Inhibitory Concentration (IC50) 266 nM
HCT-8 cells
Ileocecal adenocarcinoma
CVCL_2478 
[344]
Half Maximal Inhibitory Concentration (IC50) 2660 nM
Hep-G2 cells
Hepatoblastoma
CVCL_0027 
[608]
Half Maximal Inhibitory Concentration (IC50) 26653.3 nM
TUR cells
Acute monocytic leukemia
CVCL_1775 
Half Maximal Inhibitory Concentration (IC50) 267.47 nM
C2BBe1 cells
Colon adenocarcinoma
CVCL_1096 
Half Maximal Inhibitory Concentration (IC50) 2688 nM
A2780 cells
Ovarian endometrioid adenocarcinoma
CVCL_0134 
[232]
Half Maximal Inhibitory Concentration (IC50) 269.54 nM
Ramos-2G6-4C10 cells
Burkitt lymphoma
CVCL_1646 
Half Maximal Effective Concentration (EC50) 27 nM
B16 cells
Melanoma
CVCL_F936 
Half Maximal Inhibitory Concentration (IC50) 27 nM
DLD-1 cells
Colon adenocarcinoma
CVCL_0248 
[473]
Half Maximal Inhibitory Concentration (IC50) 27 nM
PC-3M cells
Bone metastasis of prostate carcinoma
CVCL_9555 
[609]
Half Maximal Inhibitory Concentration (IC50) 27 nM
MDA-MB-231 cells (5T4 overexpression)
Breast adenocarcinoma
CVCL_0062 
[610]
Half Maximal Inhibitory Concentration (IC50) 27.34 nM
CMK cells
Down syndrome
CVCL_0216 
Half Maximal Inhibitory Concentration (IC50) 27.6 nM
L1210 cells
Lymphoblastic leukemia
CVCL_0382 
[417]
Half Maximal Inhibitory Concentration (IC50) 27.68 nM
NCI-H2126 cells
Lung large cell carcinoma
CVCL_1532 
Half Maximal Inhibitory Concentration (IC50) 270 nM
SNU-387 cells
Hepatocellular carcinoma
CVCL_0250 
[611]
Half Maximal Inhibitory Concentration (IC50) 270 nM
A2780 cells
Ovarian endometrioid adenocarcinoma
CVCL_0134 
[418]
Half Maximal Inhibitory Concentration (IC50) 270.96 nM
CAS-1 cells
Glioblastoma
CVCL_1117 
Half Maximal Inhibitory Concentration (IC50) 2700 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[612]
Half Maximal Inhibitory Concentration (IC50) 2700 nM
OVCAR-3 cells (FZD7 overexpression)
Ovarian serous adenocarcinoma
CVCL_0465 
[612]
Half Maximal Inhibitory Concentration (IC50) 2700 nM
NCI-ADR-RES cells
High grade ovarian serous adenocarcinoma
CVCL_1452 
[538]
Half Maximal Inhibitory Concentration (IC50) 2700 nM
MES-SA/Dx5 cells
Uterine sarcoma
CVCL_2598 
[97]
Half Maximal Inhibitory Concentration (IC50) 2700 nM
K-562 cells
Chronic myelogenous leukemia
CVCL_0004 
[481]
Half Maximal Inhibitory Concentration (IC50) 2700 nM
Hep-G2 cells
Hepatoblastoma
CVCL_0027 
[591]
Half Maximal Inhibitory Concentration (IC50) 2700 nM
NCI-ADR-RES cells
High grade ovarian serous adenocarcinoma
CVCL_1452 
[551]
Half Maximal Inhibitory Concentration (IC50) 2700 nM
HEY cells
Ovarian carcinoma
CVCL_0297 
[530]
Half Maximal Inhibitory Concentration (IC50) 2700 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[613]
Half Maximal Inhibitory Concentration (IC50) 2700 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[614]
Half Maximal Inhibitory Concentration (IC50) 27000 nM
A549/TR cells
Lung adenocarcinoma
CVCL_C5S0 
[615]
Half Maximal Inhibitory Concentration (IC50) 27224.17 nM
RL cells
Diffuse large B-cell lymphoma
CVCL_1660 
Half Maximal Inhibitory Concentration (IC50) 273 nM
KB cells
Human papillomavirus-related endocervical adenocarcinoma
CVCL_0372 
[476]
Half Maximal Inhibitory Concentration (IC50) 2730 nM
PC-3 cells
Prostate carcinoma
CVCL_0035 
[424]
Half Maximal Inhibitory Concentration (IC50) 2730 nM
Eca-109 cells
Esophageal squamous cell carcinoma
CVCL_6898 
[593]
Half Maximal Inhibitory Concentration (IC50) 2757.12 nM
KMOE-2 cells
Erythroleukemia
CVCL_1332 
Half Maximal Inhibitory Concentration (IC50) 277 nM
MDA-MB-435 cells
Amelanotic melanoma
CVCL_0417 
[616]
Half Maximal Inhibitory Concentration (IC50) 277 nM
MDA435/LCC6 cells
Amelanotic melanoma
CVCL_IN99 
[617]
Half Maximal Inhibitory Concentration (IC50) 278.94 nM
GOTO cells
Adrenal gland neuroblastoma
CVCL_1234 
Half Maximal Effective Concentration (EC50) 28 nM
B16 cells
Melanoma
CVCL_F936 
Half Maximal Effective Concentration (EC50) 28 nM
B16 cells
Melanoma
CVCL_F936 
[618]
Half Maximal Inhibitory Concentration (IC50) 28 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[442]
Half Maximal Inhibitory Concentration (IC50) 28 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[496]
Half Maximal Inhibitory Concentration (IC50) 28 nM
Hep-G2 cells
Hepatoblastoma
CVCL_0027 
[584]
Half Maximal Inhibitory Concentration (IC50) 28 nM
A2780 cells
Ovarian endometrioid adenocarcinoma
CVCL_0134 
[619]
Half Maximal Inhibitory Concentration (IC50) 28 nM
A2780 cells
Ovarian endometrioid adenocarcinoma
CVCL_0134 
[620]
Half Maximal Inhibitory Concentration (IC50) 28 nM
A2780 cells
Ovarian endometrioid adenocarcinoma
CVCL_0134 
[621]
Half Maximal Inhibitory Concentration (IC50) 28 nM
A2780 cells
Ovarian endometrioid adenocarcinoma
CVCL_0134 
[622]
Half Maximal Inhibitory Concentration (IC50) 28 nM
B16-F0 cells
Mouse melanoma
CVCL_0604 
[85]
Half Maximal Inhibitory Concentration (IC50) 28 nM
HGC-27 cells
Gastric carcinoma
CVCL_1279 
[477]
Half Maximal Inhibitory Concentration (IC50) 28 nM
HCT-8 cells
Ileocecal adenocarcinoma
CVCL_2478 
[485]
Half Maximal Inhibitory Concentration (IC50) 28 nM
HCT-8 cells
Ileocecal adenocarcinoma
CVCL_2478 
[604]
Half Maximal Inhibitory Concentration (IC50) 28.6 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[454]
Half Maximal Inhibitory Concentration (IC50) 28.6 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[222]
Half Maximal Inhibitory Concentration (IC50) 28.91 nM
NCI-H526 cells
Lung small cell carcinoma
CVCL_1569 
Half Maximal Inhibitory Concentration (IC50) 280 nM
HT-29 cells
Colon adenocarcinoma
CVCL_0320 
[623]
Half Maximal Inhibitory Concentration (IC50) 280.57 nM
LP-1 cells
Plasma cell myeloma
CVCL_0012 
Half Maximal Inhibitory Concentration (IC50) 2800 nM
NCI-H1975 cells
Lung adenocarcinoma
CVCL_1511 
[579]
Half Maximal Inhibitory Concentration (IC50) 2800 nM
Caco-2 cells
Colon adenocarcinoma
CVCL_0025 
[501]
Half Maximal Inhibitory Concentration (IC50) 28000 nM
A549/TR cells
Lung adenocarcinoma
CVCL_C5S0 
[624]
Half Maximal Inhibitory Concentration (IC50) 28070.19 nM
EW-12 cells
Ewing sarcoma
CVCL_1210 
Half Maximal Cell Growth Inhibitory Concentration (GI50) 2820 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[346]
Half Maximal Inhibitory Concentration (IC50) 2820 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[569]
Half Maximal Inhibitory Concentration (IC50) 28286.48 nM
KG-1 cells
Adult acute myeloid leukemia
CVCL_0374 
Half Maximal Inhibitory Concentration (IC50) 28450 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[625]
Half Maximal Inhibitory Concentration (IC50) 2850 nM
PC-3 cells
Prostate carcinoma
CVCL_0035 
[593]
Half Maximal Inhibitory Concentration (IC50) 2850 nM
A2780 cells
Ovarian endometrioid adenocarcinoma
CVCL_0134 
[373]
Half Maximal Inhibitory Concentration (IC50) 2860 nM
SMMC-7721 cells
Hepatocellular carcinoma
CVCL_0534 
[593]
Half Maximal Inhibitory Concentration (IC50) 2868.05 nM
D-502MG cells
Glioblastoma
CVCL_1162 
Half Maximal Cell Growth Inhibitory Concentration (GI50) 29.04 nM
Malme-3M cells
Melanoma
CVCL_1438 
[345]
Half Maximal Inhibitory Concentration (IC50) 29.08 nM
COLO-684 cells
Endometrial adenocarcinoma
CVCL_1132 
Half Maximal Inhibitory Concentration (IC50) 29.33 nM
NCI-H747 cells
Cecum adenocarcinoma
CVCL_1587 
Half Maximal Inhibitory Concentration (IC50) 29.46 nM
JAR cells
Gestational choriocarcinoma
CVCL_0360 
Half Maximal Inhibitory Concentration (IC50) 29.5 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[626]
Half Maximal Inhibitory Concentration (IC50) 29.78 nM
MEG-01 cells
Chronic myeloid leukemia
CVCL_0425 
Half Maximal Inhibitory Concentration (IC50) 290 nM
SF-295 cells
Glioblastoma
CVCL_1690 
[414]
Half Maximal Inhibitory Concentration (IC50) 290 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[627]
Half Maximal Inhibitory Concentration (IC50) 290 nM
HT-29 cells
Colon adenocarcinoma
CVCL_0320 
[627]
Half Maximal Inhibitory Concentration (IC50) 290 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[623]
Half Maximal Inhibitory Concentration (IC50) 290 nM
K-562 cells
Chronic myelogenous leukemia
CVCL_0004 
[623]
Half Maximal Inhibitory Concentration (IC50) 2900 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[579]
Half Maximal Inhibitory Concentration (IC50) 2900 nM
Ca-Ski cells
Cervical squamous cell carcinoma
CVCL_1100 
[347]
Half Maximal Inhibitory Concentration (IC50) 2900 nM
Ca-Ski cells
Cervical squamous cell carcinoma
CVCL_1100 
[348]
Half Maximal Inhibitory Concentration (IC50) 29000 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[601]
Half Maximal Inhibitory Concentration (IC50) 29048.91 nM
P31-FUJ cells
Acute myeloid leukemia
CVCL_1632 
Half Maximal Inhibitory Concentration (IC50) 2952.45 nM
MN-60 cells
Burkitt lymphoma
CVCL_1421 
Half Maximal Inhibitory Concentration (IC50) 2980 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[593]
Half Maximal Inhibitory Concentration (IC50) 299 nM
NCI-ADR-RES cells
High grade ovarian serous adenocarcinoma
CVCL_1452 
[230]
Half Maximal Inhibitory Concentration (IC50) 299 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[225]
Half Maximal Inhibitory Concentration (IC50) 299 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[226]
Half Maximal Inhibitory Concentration (IC50) 299 nM
MCF7R cells
Breast carcinoma
CVCL_Y493 
[227]
Half Maximal Inhibitory Concentration (IC50) 299 nM
MCF7R cells
Breast carcinoma
CVCL_Y493 
[228]
Half Maximal Inhibitory Concentration (IC50) 299 nM
MCF7R cells
Breast carcinoma
CVCL_Y493 
[232]
Half Maximal Inhibitory Concentration (IC50) 299 nM
MCF7R cells
Breast carcinoma
CVCL_Y493 
[104]
Half Maximal Inhibitory Concentration (IC50) 299.79 nM
EB-3 cells
Burkitt lymphoma
CVCL_1185 
Half Maximal Cell Growth Inhibitory Concentration (GI50) 3 nM
Hs 578T cells
Invasive breast carcinoma
CVCL_0332 
[399]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 3 nM
Hs 578T cells
Invasive breast carcinoma
CVCL_0332 
[400]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 3 nM
U-251MG cells
Astrocytoma
CVCL_0021 
[141]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 3 nM
COLO 205 cells
Colon adenocarcinoma
CVCL_0218 
[400]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 3 nM
HT-29 cells
Colon adenocarcinoma
CVCL_0320 
[628]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 3 nM
HT-29 cells
Colon adenocarcinoma
CVCL_0320 
[629]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 3 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[628]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 3 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[629]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 3 nM
2008 cells
Ovarian carcinoma
CVCL_0473 
[630]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 3 nM
HCC 2998 cells
Colon adenocarcinoma
CVCL_1266 
[399]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 3 nM
HCC 2998 cells
Colon adenocarcinoma
CVCL_1266 
[400]
Half Maximal Inhibitory Concentration (IC50) 3 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[230]
Half Maximal Inhibitory Concentration (IC50) 3 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[231]
Half Maximal Inhibitory Concentration (IC50) 3 nM
CCRF-CEM cells
T acute lymphoblastic leukemia
CVCL_0207 
[395]
Half Maximal Inhibitory Concentration (IC50) 3 nM
RL cells
Diffuse large B-cell lymphoma
CVCL_1660 
[148]
Half Maximal Inhibitory Concentration (IC50) 3 nM
SK-OV-3 cells (FZD7 overexpression)
Ovarian serous cystadenocarcinoma
CVCL_0532 
[215]
Half Maximal Inhibitory Concentration (IC50) 3 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[148]
Half Maximal Inhibitory Concentration (IC50) 3 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[575]
Half Maximal Inhibitory Concentration (IC50) 3 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[631]
Half Maximal Inhibitory Concentration (IC50) 3 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[235]
Half Maximal Inhibitory Concentration (IC50) 3 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[158]
Half Maximal Inhibitory Concentration (IC50) 3 nM
CCRF-CEM cells
T acute lymphoblastic leukemia
CVCL_0207 
[189]
Half Maximal Inhibitory Concentration (IC50) 3 nM
CCRF-CEM cells
T acute lymphoblastic leukemia
CVCL_0207 
[396]
Half Maximal Inhibitory Concentration (IC50) 3 nM
COLO 205 cells
Colon adenocarcinoma
CVCL_0218 
[270]
Half Maximal Inhibitory Concentration (IC50) 3 nM
HT-29 cells
Colon adenocarcinoma
CVCL_0320 
[543]
Half Maximal Inhibitory Concentration (IC50) 3 nM
HT-29 cells
Colon adenocarcinoma
CVCL_0320 
[235]
Half Maximal Inhibitory Concentration (IC50) 3 nM
PA-1 cells
Ovarian mixed germ cell tumor
CVCL_0479 
[243]
Half Maximal Inhibitory Concentration (IC50) 3 nM
MDA-MB-231 cells (5T4 overexpression)
Breast adenocarcinoma
CVCL_0062 
[511]
Half Maximal Inhibitory Concentration (IC50) 3 nM
MDA-MB-231 cells (5T4 overexpression)
Breast adenocarcinoma
CVCL_0062 
[158]
Half Maximal Inhibitory Concentration (IC50) 3 nM
SK-OV-3 cells (FZD7 overexpression)
Ovarian serous cystadenocarcinoma
CVCL_0532 
[220]
Half Maximal Inhibitory Concentration (IC50) 3 nM
SK-OV-3 cells (FZD7 overexpression)
Ovarian serous cystadenocarcinoma
CVCL_0532 
[203]
Half Maximal Inhibitory Concentration (IC50) 3 nM
SK-OV-3 cells (FZD7 overexpression)
Ovarian serous cystadenocarcinoma
CVCL_0532 
[183]
Half Maximal Inhibitory Concentration (IC50) 3 nM
SK-OV-3 cells (FZD7 overexpression)
Ovarian serous cystadenocarcinoma
CVCL_0532 
[211]
Half Maximal Inhibitory Concentration (IC50) 3 nM
SK-OV-3 cells (FZD7 overexpression)
Ovarian serous cystadenocarcinoma
CVCL_0532 
[146]
Half Maximal Inhibitory Concentration (IC50) 3 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[632]
Half Maximal Inhibitory Concentration (IC50) 3 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[107]
Half Maximal Inhibitory Concentration (IC50) 3 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[633]
Half Maximal Inhibitory Concentration (IC50) 3 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[631]
Half Maximal Inhibitory Concentration (IC50) 3 nM
MES-SA cells
Uterine sarcoma
CVCL_1404 
[634]
Half Maximal Inhibitory Concentration (IC50) 3 nM
A2780cis cells
Ovarian carcinoma
CVCL_1942 
[275]
Half Maximal Inhibitory Concentration (IC50) 3 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[290]
Half Maximal Inhibitory Concentration (IC50) 3 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[135]
Half Maximal Inhibitory Concentration (IC50) 3 nM
MDA-MB-468 cells
Breast adenocarcinoma
CVCL_0419 
[635]
Half Maximal Inhibitory Concentration (IC50) 3 nM
K-562 cells
Chronic myelogenous leukemia
CVCL_0004 
[525]
Half Maximal Inhibitory Concentration (IC50) 3 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[163]
Half Maximal Inhibitory Concentration (IC50) 3 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[517]
Half Maximal Inhibitory Concentration (IC50) 3 nM
HCT 116 cells
Colon carcinoma
CVCL_0291 
[433]
Half Maximal Inhibitory Concentration (IC50) 3 nM
MDA-MB-231 cells (5T4 overexpression)
Breast adenocarcinoma
CVCL_0062 
[519]
Half Maximal Inhibitory Concentration (IC50) 3 nM
MDA-MB-231 cells (5T4 overexpression)
Breast adenocarcinoma
CVCL_0062 
[517]
Half Maximal Inhibitory Concentration (IC50) 3 nM
MDA-MB-231 cells (5T4 overexpression)
Breast adenocarcinoma
CVCL_0062 
[518]
Half Maximal Inhibitory Concentration (IC50) 3 nM
SK-OV-3 cells (FZD7 overexpression)
Ovarian serous cystadenocarcinoma
CVCL_0532 
[147]
Half Maximal Inhibitory Concentration (IC50) 3 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[525]
Half Maximal Inhibitory Concentration (IC50) 3 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[280]
Half Maximal Inhibitory Concentration (IC50) 3.01 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[223]
Half Maximal Inhibitory Concentration (IC50) 3.01 nM
THP-1 cells
Childhood acute monocytic leukemia
CVCL_0006 
[222]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 3.034 nM
COLO 205 cells
Colon adenocarcinoma
CVCL_0218 
[345]
Half Maximal Inhibitory Concentration (IC50) 3.04 nM
HT-29 cells
Colon adenocarcinoma
CVCL_0320 
[223]
Half Maximal Inhibitory Concentration (IC50) 3.05 nM
MDA-MB-231 cells (5T4 overexpression)
Breast adenocarcinoma
CVCL_0062 
[128]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 3.062 nM
KM12 cells
Colon adenocarcinoma
CVCL_1331 
[345]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 3.069 nM
MDA-N cells
Breast carcinoma
CVCL_1910 
[345]
Half Maximal Inhibitory Concentration (IC50) 3.08 nM
KALS-1 cells
Glioblastoma
CVCL_1323 
Half Maximal Cell Growth Inhibitory Concentration (GI50) 3.083 nM
M19-MEL cells
Melanoma
CVCL_B415 
[345]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 3.088 nM
SGC-7901 cells
Gastric carcinoma
CVCL_0520 
[186]
Half Maximal Inhibitory Concentration (IC50) 3.1 nM
CCRF-CEM cells
T acute lymphoblastic leukemia
CVCL_0207 
[171]
Half Maximal Inhibitory Concentration (IC50) 3.1 nM
CCRF-CEM cells
T acute lymphoblastic leukemia
CVCL_0207 
[188]
Half Maximal Inhibitory Concentration (IC50) 3.1 nM
C6 cells
Glioma
CVCL_0194 
[196]
Half Maximal Inhibitory Concentration (IC50) 3.1 nM
MDA-MB-435 cells
Amelanotic melanoma
CVCL_0417 
[544]
Half Maximal Inhibitory Concentration (IC50) 3.1 nM
MDA-MB-435 cells
Amelanotic melanoma
CVCL_0417 
[545]
Half Maximal Inhibitory Concentration (IC50) 3.1 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[184]
Half Maximal Inhibitory Concentration (IC50) 3.1 nM
MDA-MB-231 cells (5T4 overexpression)
Breast adenocarcinoma
CVCL_0062 
[635]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 3.126 nM
DMS-273 cells
Small cell lung carcinoma
CVCL_1176 
[345]
Half Maximal Inhibitory Concentration (IC50) 3.138 nM
BB30-HNC cells
Head and neck squamous cell carcinoma
CVCL_1076 
Half Maximal Inhibitory Concentration (IC50) 3.14 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[636]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 3.162 nM
Hs 578T cells
Invasive breast carcinoma
CVCL_0332 
[253]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 3.162 nM
COLO 205 cells
Colon adenocarcinoma
CVCL_0218 
[253]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 3.162 nM
OVCAR-3 cells (FZD7 overexpression)
Ovarian serous adenocarcinoma
CVCL_0465 
[253]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 3.162 nM
SF539 cells
Gliosarcoma
CVCL_1691 
[253]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 3.162 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[253]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 3.162 nM
KM12 cells
Colon adenocarcinoma
CVCL_1331 
[253]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 3.162 nM
NCI-H522 cells
Non-small cell lung carcinoma
CVCL_1567 
[253]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 3.2 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[637]
Half Maximal Inhibitory Concentration (IC50) 3.2 nM
HT-29 cells
Colon adenocarcinoma
CVCL_0320 
Half Maximal Inhibitory Concentration (IC50) 3.2 nM
HT-29 cells
Colon adenocarcinoma
CVCL_0320 
Half Maximal Effective Concentration (EC50) 3.2 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[638]
Half Maximal Inhibitory Concentration (IC50) 3.2 nM
HT-29 cells
Colon adenocarcinoma
CVCL_0320 
[225]
Half Maximal Inhibitory Concentration (IC50) 3.2 nM
HT-29 cells
Colon adenocarcinoma
CVCL_0320 
[227]
Half Maximal Inhibitory Concentration (IC50) 3.2 nM
SJSA-1 cells
Osteosarcoma
CVCL_1697 
[639]
Half Maximal Inhibitory Concentration (IC50) 3.2 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[534]
Half Maximal Inhibitory Concentration (IC50) 3.2 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[239]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 3.206 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[186]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 3.206 nM
OVCAR-3 cells (FZD7 overexpression)
Ovarian serous adenocarcinoma
CVCL_0465 
[345]
Half Maximal Inhibitory Concentration (IC50) 3.21 nM
HCT 116 cells
Colon carcinoma
CVCL_0291 
[201]
Half Maximal Effective Concentration (EC50) 3.23 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[213]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 3.243 nM
K-562 cells
Chronic myelogenous leukemia
CVCL_0004 
[345]
Half Maximal Inhibitory Concentration (IC50) 3.255 nM
TE-9 cells
Esophageal squamous cell carcinoma
CVCL_1767 
Half Maximal Cell Growth Inhibitory Concentration (GI50) 3.258 nM
SW620 cells
Colon adenocarcinoma
CVCL_0547 
[345]
Half Maximal Inhibitory Concentration (IC50) 3.272 nM
SIG-M5 cells
Acute myeloid leukemia
CVCL_1694 
Half Maximal Cell Growth Inhibitory Concentration (GI50) 3.273 nM
SN12K1 cells
Lung metastasis of renal carcinoma
CVCL_D106 
[345]
Half Maximal Inhibitory Concentration (IC50) 3.29 nM
BGC-823 cells
Stomach adenocarcinoma
CVCL_3360 
[640]
Half Maximal Inhibitory Concentration (IC50) 3.3 nM
COLO 205 cells
Colon adenocarcinoma
CVCL_0218 
[537]
Half Maximal Inhibitory Concentration (IC50) 3.3 nM
COLO 205 cells
Colon adenocarcinoma
CVCL_0218 
[535]
Half Maximal Inhibitory Concentration (IC50) 3.3 nM
COLO 205 cells
Colon adenocarcinoma
CVCL_0218 
[571]
Half Maximal Inhibitory Concentration (IC50) 3.3 nM
BGC-823 cells
Stomach adenocarcinoma
CVCL_3360 
[384]
Half Maximal Inhibitory Concentration (IC50) 3.3 nM
KB cells
Human papillomavirus-related endocervical adenocarcinoma
CVCL_0372 
[641]
Half Maximal Inhibitory Concentration (IC50) 3.3 nM
KB cells
Human papillomavirus-related endocervical adenocarcinoma
CVCL_0372 
[642]
Half Maximal Inhibitory Concentration (IC50) 3.3 nM
MDA-MB-435 cells
Amelanotic melanoma
CVCL_0417 
[242]
Half Maximal Inhibitory Concentration (IC50) 3.3 nM
OVCAR-3 cells (FZD7 overexpression)
Ovarian serous adenocarcinoma
CVCL_0465 
[463]
Half Maximal Inhibitory Concentration (IC50) 3.3 nM
BGC-823 cells
Stomach adenocarcinoma
CVCL_3360 
[83]
Half Maximal Inhibitory Concentration (IC50) 3.3 nM
BGC-823 cells
Stomach adenocarcinoma
CVCL_3360 
[118]
Half Maximal Inhibitory Concentration (IC50) 3.3 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[643]
Half Maximal Inhibitory Concentration (IC50) 3.3 nM
K-562 cells
Chronic myelogenous leukemia
CVCL_0004 
[643]
Half Maximal Inhibitory Concentration (IC50) 3.3 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[643]
Half Maximal Inhibitory Concentration (IC50) 3.3 nM
A2780 cells
Ovarian endometrioid adenocarcinoma
CVCL_0134 
[598]
Half Maximal Inhibitory Concentration (IC50) 3.3 nM
Capan-1 cells
Pancreatic ductal adenocarcinoma
CVCL_0237 
[120]
Half Maximal Inhibitory Concentration (IC50) 3.3 nM
OVCAR-3 cells (FZD7 overexpression)
Ovarian serous adenocarcinoma
CVCL_0465 
[94]
Half Maximal Inhibitory Concentration (IC50) 3.3 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[643]
Half Maximal Inhibitory Concentration (IC50) 3.31 nM
COLO 205 cells
Colon adenocarcinoma
CVCL_0218 
[221]
Half Maximal Inhibitory Concentration (IC50) 3.35 nM
Ramos cells
Burkitt lymphoma
CVCL_0597 
[222]
Half Maximal Inhibitory Concentration (IC50) 3.37 nM
U-937 cells
Adult acute monocytic leukemia
CVCL_0007 
[555]
Half Maximal Inhibitory Concentration (IC50) 3.388 nM
MDA-MB-231 cells (5T4 overexpression)
Breast adenocarcinoma
CVCL_0062 
[498]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 3.4 nM
MDA-MB-435 cells
Amelanotic melanoma
CVCL_0417 
[143]
Half Maximal Inhibitory Concentration (IC50) 3.4 nM
PC-3 cells
Prostate carcinoma
CVCL_0035 
[506]
Half Maximal Inhibitory Concentration (IC50) 3.4 nM
A2780 cells
Ovarian endometrioid adenocarcinoma
CVCL_0134 
[644]
Half Maximal Inhibitory Concentration (IC50) 3.4 nM
HT-29 cells
Colon adenocarcinoma
CVCL_0320 
[645]
Half Maximal Inhibitory Concentration (IC50) 3.4 nM
Prostatic carcinoma cells
Prostatic carcinoma
Undisclosed [506]
Half Maximal Inhibitory Concentration (IC50) 3.4 nM
HL-60 cells
Adult acute myeloid leukemia
CVCL_0002 
[646]
Half Maximal Inhibitory Concentration (IC50) 3.4 nM
U2OS cells
Osteosarcoma
CVCL_0042 
[524]
Half Maximal Inhibitory Concentration (IC50) 3.4 nM
DU145 cells
Prostate carcinoma
CVCL_0105 
[239]
Half Maximal Inhibitory Concentration (IC50) 3.4 nM
GSS cells
Gastric carcinoma
CVCL_8876 
[271]
Half Maximal Inhibitory Concentration (IC50) 3.4 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[212]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 3.412 nM
HCC 2998 cells
Colon adenocarcinoma
CVCL_1266 
[345]
Half Maximal Inhibitory Concentration (IC50) 3.42 nM
MDA-MB-231 cells (5T4 overexpression)
Breast adenocarcinoma
CVCL_0062 
[222]
Half Maximal Inhibitory Concentration (IC50) 3.45 nM
MOLM-13 cells
Adult acute myeloid leukemia
CVCL_2119 
[222]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 3.483 nM
XF498 cells
Glioma
CVCL_8928 
[345]
Half Maximal Inhibitory Concentration (IC50) 3.5 nM
HCT 116 cells
Colon carcinoma
CVCL_0291 
[645]
Half Maximal Inhibitory Concentration (IC50) 3.5 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[647]
Half Maximal Inhibitory Concentration (IC50) 3.5 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[648]
Half Maximal Inhibitory Concentration (IC50) 3.5 nM
BGC-823 cells
Stomach adenocarcinoma
CVCL_3360 
[240]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 3.54 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[345]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 3.548 nM
LOX IMVI cells
Melanoma
CVCL_1381 
[345]
Half Maximal Inhibitory Concentration (IC50) 3.6 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
Half Maximal Inhibitory Concentration (IC50) 3.6 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
Half Maximal Inhibitory Concentration (IC50) 3.6 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
Half Maximal Inhibitory Concentration (IC50) 3.6 nM
HT-29 cells
Colon adenocarcinoma
CVCL_0320 
Half Maximal Inhibitory Concentration (IC50) 3.6 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[225]
Half Maximal Inhibitory Concentration (IC50) 3.6 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[226]
Half Maximal Inhibitory Concentration (IC50) 3.6 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[227]
Half Maximal Inhibitory Concentration (IC50) 3.6 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[228]
Half Maximal Inhibitory Concentration (IC50) 3.6 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[230]
Half Maximal Inhibitory Concentration (IC50) 3.6 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[154]
Half Maximal Inhibitory Concentration (IC50) 3.6 nM
HT-29 cells
Colon adenocarcinoma
CVCL_0320 
[226]
Half Maximal Inhibitory Concentration (IC50) 3.6 nM
HT-29 cells
Colon adenocarcinoma
CVCL_0320 
[172]
Half Maximal Inhibitory Concentration (IC50) 3.6 nM
HCT-8 cells
Ileocecal adenocarcinoma
CVCL_2478 
[384]
Half Maximal Inhibitory Concentration (IC50) 3.6 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[240]
Half Maximal Inhibitory Concentration (IC50) 3.6 nM
KB cells
Human papillomavirus-related endocervical adenocarcinoma
CVCL_0372 
[649]
Half Maximal Inhibitory Concentration (IC50) 3.6 nM
KB cells
Human papillomavirus-related endocervical adenocarcinoma
CVCL_0372 
[650]
Half Maximal Inhibitory Concentration (IC50) 3.618 nM
no-10 cells
Glioblastoma
CVCL_3075 
Half Maximal Cell Growth Inhibitory Concentration (GI50) 3.66 nM
SF539 cells
Gliosarcoma
CVCL_1691 
[237]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 3.7 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[651]
Half Maximal Inhibitory Concentration (IC50) 3.7 nM
PC-3 cells
Prostate carcinoma
CVCL_0035 
[175]
Half Maximal Inhibitory Concentration (IC50) 3.7 nM
KB cells
Human papillomavirus-related endocervical adenocarcinoma
CVCL_0372 
[302]
Half Maximal Inhibitory Concentration (IC50) 3.7 nM
OVCAR-8 cells
High grade ovarian serous adenocarcinoma
CVCL_1629 
[328]
Half Maximal Inhibitory Concentration (IC50) 3.71 nM
A2780-1A9 cells
Ovarian adenocarcinoma
CVCL_H619 
[652]
Half Maximal Inhibitory Concentration (IC50) 3.714 nM
EW-1 cells
Ewing sarcoma
CVCL_1208 
Half Maximal Cell Growth Inhibitory Concentration (GI50) 3.733 nM
SF539 cells
Gliosarcoma
CVCL_1691 
[345]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 3.776 nM
SNB-75 cells
Glioblastoma
CVCL_1706 
[345]
Half Maximal Inhibitory Concentration (IC50) 3.8 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[653]
Half Maximal Inhibitory Concentration (IC50) 3.8 nM
DU145 cells
Prostate carcinoma
CVCL_0105 
[561]
Half Maximal Inhibitory Concentration (IC50) 3.8 nM
HCT 116 cells
Colon carcinoma
CVCL_0291 
[212]
Half Maximal Inhibitory Concentration (IC50) 3.8 nM
HT-29 cells
Colon adenocarcinoma
CVCL_0320 
[283]
Half Maximal Inhibitory Concentration (IC50) 3.8 nM
MGC-803 cells
Gastric cancer
CVCL_5334 
[192]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 3.837 nM
U-251MG cells
Astrocytoma
CVCL_0021 
[345]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 3.86 nM
DU145 cells
Prostate carcinoma
CVCL_0105 
[654]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 3.882 nM
SK-MEL-5 cells
Cutaneous melanoma
CVCL_0527 
[345]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 3.889 nM
HT-1080 cells (FAP expression)
Fibrosarcoma
CVCL_0317 
[186]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 3.9 nM
NCI-H226 cells
Pleural epithelioid mesothelioma
CVCL_1544 
[146]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 3.9 nM
NCI-H226 cells
Pleural epithelioid mesothelioma
CVCL_1544 
[147]
Half Maximal Inhibitory Concentration (IC50) 3.9 nM
HEK293 cells
Normal
CVCL_0045 
[653]
Half Maximal Inhibitory Concentration (IC50) 3.9 nM
KB 3-1 cells
Cervical epithelial carcinoma
CVCL_2088 
[479]
Half Maximal Inhibitory Concentration (IC50) 3.9 nM
KB cells
Human papillomavirus-related endocervical adenocarcinoma
CVCL_0372 
[87]
Half Maximal Inhibitory Concentration (IC50) 3.9 nM
KB cells
Human papillomavirus-related endocervical adenocarcinoma
CVCL_0372 
[88]
Half Maximal Inhibitory Concentration (IC50) 3.9 nM
KB cells
Human papillomavirus-related endocervical adenocarcinoma
CVCL_0372 
[655]
Half Maximal Inhibitory Concentration (IC50) 3.9 nM
MDA-MB-231 cells (5T4 overexpression)
Breast adenocarcinoma
CVCL_0062 
[656]
Half Maximal Inhibitory Concentration (IC50) 3.9 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[76]
Half Maximal Inhibitory Concentration (IC50) 3.9 nM
A2780-1A9 cells
Ovarian adenocarcinoma
CVCL_H619 
[104]
Half Maximal Inhibitory Concentration (IC50) 3.94 nM
HT-29 cells
Colon adenocarcinoma
CVCL_0320 
[640]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 3.954 nM
MDA-MB-435 cells
Amelanotic melanoma
CVCL_0417 
[345]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 3.963 nM
NCI-H23 cells
Lung adenocarcinoma
CVCL_1547 
[345]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 3.981 nM
PC-3 cells
Prostate carcinoma
CVCL_0035 
[253]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 3.981 nM
MOLT-4 cells
Adult T acute lymphoblastic leukemia
CVCL_0013 
[253]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 3.981 nM
U-251MG cells
Astrocytoma
CVCL_0021 
[253]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 3.981 nM
SK-MEL-5 cells
Cutaneous melanoma
CVCL_0527 
[253]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 3.981 nM
HCC 2998 cells
Colon adenocarcinoma
CVCL_1266 
[253]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 3.981 nM
UACC-62 cells
Melanoma
CVCL_1780 
[253]
Half Maximal Inhibitory Concentration (IC50) 3.99 nM
SK-OV-3 cells (FZD7 overexpression)
Ovarian serous cystadenocarcinoma
CVCL_0532 
[530]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 30 nM
PC-3 cells
Prostate carcinoma
CVCL_0035 
[255]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 30 nM
NCI-H460 cells
Lung large cell carcinoma
CVCL_0459 
[487]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 30 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[487]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 30 nM
SiHa cells
Cervical squamous cell carcinoma
CVCL_0032 
[246]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 30 nM
Vero cells
Normal
CVCL_0059 
[141]
Half Maximal Inhibitory Concentration (IC50) 30 nM
U-251MG cells
Astrocytoma
CVCL_0021 
[151]
Half Maximal Inhibitory Concentration (IC50) 30 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[499]
Half Maximal Inhibitory Concentration (IC50) 30 nM
KB cells
Human papillomavirus-related endocervical adenocarcinoma
CVCL_0372 
[324]
Half Maximal Inhibitory Concentration (IC50) 30 nM
Fibroblast cells
Normal
Undisclosed [125]
Half Maximal Inhibitory Concentration (IC50) 30 nM
1A9/ptx-10 cells
Ovarian adenocarcinoma
CVCL_H620 
[154]
Half Maximal Inhibitory Concentration (IC50) 30 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[73]
Half Maximal Inhibitory Concentration (IC50) 30 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[74]
Half Maximal Inhibitory Concentration (IC50) 30 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[564]
Half Maximal Inhibitory Concentration (IC50) 30 nM
PC-3 cells
Prostate carcinoma
CVCL_0035 
[563]
Half Maximal Inhibitory Concentration (IC50) 30 nM
SW620 cells
Colon adenocarcinoma
CVCL_0547 
[267]
Half Maximal Inhibitory Concentration (IC50) 30 nM
SW620 cells
Colon adenocarcinoma
CVCL_0547 
[110]
Half Maximal Inhibitory Concentration (IC50) 30 nM
DU145 cells
Prostate carcinoma
CVCL_0105 
[273]
Half Maximal Inhibitory Concentration (IC50) 30 nM
A2780 cells
Ovarian endometrioid adenocarcinoma
CVCL_0134 
[161]
Half Maximal Inhibitory Concentration (IC50) 30 nM
HCT 116 cells
Colon carcinoma
CVCL_0291 
[161]
Half Maximal Inhibitory Concentration (IC50) 30 nM
NB-4 cells
Promyelocytic leukemia
CVCL_0005 
[297]
Half Maximal Inhibitory Concentration (IC50) 30 nM
NB-4 cells
Promyelocytic leukemia
CVCL_0005 
[298]
Half Maximal Inhibitory Concentration (IC50) 30 nM
NB-4 cells
Promyelocytic leukemia
CVCL_0005 
[299]
Half Maximal Inhibitory Concentration (IC50) 30 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[418]
Half Maximal Inhibitory Concentration (IC50) 30 nM
U2OS cells
Osteosarcoma
CVCL_0042 
[250]
Half Maximal Inhibitory Concentration (IC50) 30 nM
HCT 116 cells
Colon carcinoma
CVCL_0291 
[657]
Half Maximal Inhibitory Concentration (IC50) 30 nM
MDA-MB-231 cells (5T4 overexpression)
Breast adenocarcinoma
CVCL_0062 
[280]
Half Maximal Inhibitory Concentration (IC50) 30 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[610]
Half Maximal Inhibitory Concentration (IC50) 30 nM
IMR-32 cells
Neuroblastoma
CVCL_0346 
[363]
Half Maximal Inhibitory Concentration (IC50) 30.23 nM
MONO-MAC-6 cells
Acute monocytic leukemia
CVCL_1426 
Half Maximal Inhibitory Concentration (IC50) 30.42 nM
IST-SL1 cells
Lung small cell carcinoma
CVCL_1313 
Half Maximal Inhibitory Concentration (IC50) 30.79 nM
CPC-N cells
Lung small cell carcinoma
CVCL_1146 
Half Maximal Cell Growth Inhibitory Concentration (GI50) 30.8 nM
L02 cells
Cervical carcinoma
CVCL_6926 
[658]
Half Maximal Inhibitory Concentration (IC50) 30.9 nM
J774.2 cells
Mouse reticulum cell sarcoma
CVCL_0357 
Half Maximal Cell Growth Inhibitory Concentration (GI50) 300 nM
HCT 15 cells
Colon adenocarcinoma
CVCL_0292 
[140]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 300 nM
MDA-MB-231 cells (5T4 overexpression)
Breast adenocarcinoma
CVCL_0062 
[288]
Half Maximal Inhibitory Concentration (IC50) 300 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
Half Maximal Inhibitory Concentration (IC50) 300 nM
Hep-G2 cells
Hepatoblastoma
CVCL_0027 
[89]
Half Maximal Inhibitory Concentration (IC50) 300 nM
Hep-G2 cells
Hepatoblastoma
CVCL_0027 
[90]
Half Maximal Inhibitory Concentration (IC50) 300 nM
NCI-ADR-RES cells
High grade ovarian serous adenocarcinoma
CVCL_1452 
[196]
Half Maximal Inhibitory Concentration (IC50) 300 nM
NCI-ADR-RES cells
High grade ovarian serous adenocarcinoma
CVCL_1452 
[197]
Half Maximal Inhibitory Concentration (IC50) 300 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[229]
Half Maximal Inhibitory Concentration (IC50) 300 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[197]
Half Maximal Inhibitory Concentration (IC50) 300 nM
LT12 tumor cells
Rat leukemia
CVCL_D271 
[324]
Half Maximal Inhibitory Concentration (IC50) 300 nM
Hep-G2 cells
Hepatoblastoma
CVCL_0027 
[659]
Half Maximal Inhibitory Concentration (IC50) >3000 nM
DU145 cells
Prostate carcinoma
CVCL_0105 
[106]
Half Maximal Inhibitory Concentration (IC50) >3000 nM
RKO cells
Colon carcinoma
CVCL_0504 
[257]
Half Maximal Inhibitory Concentration (IC50) >3000 nM
RKO cells
Colon carcinoma
CVCL_0504 
[258]
Half Maximal Inhibitory Concentration (IC50) >3000 nM
RKO cells
Colon carcinoma
CVCL_0504 
[259]
Half Maximal Inhibitory Concentration (IC50) >3000 nM
KB 3-1 cells
Cervical epithelial carcinoma
CVCL_2088 
[660]
Half Maximal Inhibitory Concentration (IC50) >30000 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[661]
Half Maximal Inhibitory Concentration (IC50) 3019.56 nM
LU-165 cells
Lung small cell carcinoma
CVCL_1391 
Half Maximal Inhibitory Concentration (IC50) 306.2 nM
MDA435/LCC6MDR cells
Amelanotic melanoma
CVCL_IP00 
[123]
Half Maximal Inhibitory Concentration (IC50) 30700 nM
Hep-G2 cells
Hepatoblastoma
CVCL_0027 
[316]
Half Maximal Inhibitory Concentration (IC50) 30740 nM
Hep-G2 cells
Hepatoblastoma
CVCL_0027 
[317]
Half Maximal Inhibitory Concentration (IC50) 308 nM
ZR-75-1 cells
Invasive breast carcinoma
CVCL_0588 
[329]
Half Maximal Inhibitory Concentration (IC50) 31 nM
Hep 3B2.1-7 cells
Childhood hepatocellular carcinoma
CVCL_0326 
[472]
Half Maximal Inhibitory Concentration (IC50) 31 nM
786-O cells
Renal cell carcinoma
CVCL_1051 
[662]
Half Maximal Inhibitory Concentration (IC50) 31.31 nM
NCI-H1963 cells
Lung small cell carcinoma
CVCL_1510 
Half Maximal Effective Concentration (EC50) 31.5 nM
B16 cells
Melanoma
CVCL_F936 
Half Maximal Cell Growth Inhibitory Concentration (GI50) 31.62 nM
NCI-H226 cells
Pleural epithelioid mesothelioma
CVCL_1544 
[253]
Half Maximal Inhibitory Concentration (IC50) 310 nM
Caco-2 cells
Colon adenocarcinoma
CVCL_0025 
[627]
Half Maximal Inhibitory Concentration (IC50) 310 nM
MDA-MB-468 cells
Breast adenocarcinoma
CVCL_0419 
[331]
Half Maximal Inhibitory Concentration (IC50) 3100 nM
DU145 cells
Prostate carcinoma
CVCL_0105 
[579]
Half Maximal Inhibitory Concentration (IC50) 3100 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[392]
Half Maximal Inhibitory Concentration (IC50) 3100 nM
NCI-ADR-RES cells
High grade ovarian serous adenocarcinoma
CVCL_1452 
[608]
Half Maximal Inhibitory Concentration (IC50) 3110 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[593]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 3111.72 nM
NCI-ADR-RES cells
High grade ovarian serous adenocarcinoma
CVCL_1452 
[345]
Half Maximal Inhibitory Concentration (IC50) 3112 nM
A549/TR cells
Lung adenocarcinoma
CVCL_C5S0 
[663]
Half Maximal Inhibitory Concentration (IC50) 312 nM
SW480 cells
Colon adenocarcinoma
CVCL_0546 
[664]
Half Maximal Inhibitory Concentration (IC50) 31500 nM
ACHN cells
Renal adenocarcinoma
CVCL_1067 
[665]
Half Maximal Inhibitory Concentration (IC50) 31500 nM
ACHN cells
Renal adenocarcinoma
CVCL_1067 
[666]
Half Maximal Inhibitory Concentration (IC50) 31508.99 nM
NB10 cells
Neuroblastoma
CVCL_1441 
Half Maximal Inhibitory Concentration (IC50) 316.92 nM
SK-N-FI cells
Neuroblastoma
CVCL_1702 
Half Maximal Cell Growth Inhibitory Concentration (GI50) 3162.28 nM
NCI-ADR-RES cells
High grade ovarian serous adenocarcinoma
CVCL_1452 
[253]
Half Maximal Inhibitory Concentration (IC50) 3164 nM
A2780/Taxol cells
Ovarian endometrioid adenocarcinoma
CVCL_IJ13 
[667]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 32 nM
DU145 cells
Prostate carcinoma
CVCL_0105 
[252]
Half Maximal Inhibitory Concentration (IC50) 32 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[565]
Half Maximal Inhibitory Concentration (IC50) 32 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[668]
Half Maximal Inhibitory Concentration (IC50) 32 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[587]
Half Maximal Inhibitory Concentration (IC50) 32.3 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[492]
Half Maximal Inhibitory Concentration (IC50) 32.3 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[590]
Half Maximal Inhibitory Concentration (IC50) 32.47 nM
K052 cells
Adult acute myeloid leukemia
CVCL_1321 
Half Maximal Cell Growth Inhibitory Concentration (GI50) 32.66 nM
BT-549 cells
Breast ductal carcinoma
CVCL_1092 
[345]
Half Maximal Inhibitory Concentration (IC50) 32.8 nM
1A9/ptx-22 cells
Ovarian adenocarcinoma
CVCL_H621 
[104]
Half Maximal Inhibitory Concentration (IC50) 32.9 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[242]
Half Maximal Inhibitory Concentration (IC50) 320 nM
HL-60 cells
Adult acute myeloid leukemia
CVCL_0002 
[627]
Half Maximal Inhibitory Concentration (IC50) 3200 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[591]
Half Maximal Inhibitory Concentration (IC50) 3210 nM
K-562 cells
Chronic myelogenous leukemia
CVCL_0004 
[503]
Half Maximal Inhibitory Concentration (IC50) 3234.42 nM
DSH1 cells
Bladder carcinoma
CVCL_1182 
Half Maximal Inhibitory Concentration (IC50) 33.07 nM
KM-H2 cells
Hodgkin lymphoma
CVCL_1330 
Half Maximal Inhibitory Concentration (IC50) 33.09 nM
TE-12 cells
Esophageal squamous cell carcinoma
CVCL_1762 
Half Maximal Inhibitory Concentration (IC50) 33.56 nM
TK-10 cells
Renal carcinoma
CVCL_1773 
Half Maximal Cell Growth Inhibitory Concentration (GI50) 33.73 nM
786-O cells
Renal cell carcinoma
CVCL_1051 
[345]
Half Maximal Inhibitory Concentration (IC50) 33.8 nM
HCT 116 cells
Colon carcinoma
CVCL_0291 
[582]
Half Maximal Inhibitory Concentration (IC50) 330 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[627]
Half Maximal Inhibitory Concentration (IC50) 3300 nM
HCT 116 cells
Colon carcinoma
CVCL_0291 
[481]
Half Maximal Inhibitory Concentration (IC50) 3300 nM
NCI-ADR-RES cells
High grade ovarian serous adenocarcinoma
CVCL_1452 
[484]
Half Maximal Inhibitory Concentration (IC50) 3300 nM
NCI-ADR-RES cells
High grade ovarian serous adenocarcinoma
CVCL_1452 
[440]
Half Maximal Inhibitory Concentration (IC50) 33090 nM
BGC-823 cells
Stomach adenocarcinoma
CVCL_3360 
[317]
Half Maximal Inhibitory Concentration (IC50) 332.3 nM
J774.2 cells
Mouse reticulum cell sarcoma
CVCL_0357 
Half Maximal Inhibitory Concentration (IC50) 3340 nM
SGC-7901 cells
Gastric carcinoma
CVCL_0520 
[369]
Half Maximal Inhibitory Concentration (IC50) 3340 nM
SGC-7901 cells
Gastric carcinoma
CVCL_0520 
[370]
Half Maximal Inhibitory Concentration (IC50) 3340 nM
SGC-7901 cells
Gastric carcinoma
CVCL_0520 
[372]
Half Maximal Inhibitory Concentration (IC50) 3340 nM
CEM-VLB cells
Vinblastine-resistant T-cell leukemia
CVCL_4V08 
[85]
Half Maximal Inhibitory Concentration (IC50) 3340 nM
CEM-VLB cells
Vinblastine-resistant T-cell leukemia
CVCL_4V08 
[86]
Half Maximal Inhibitory Concentration (IC50) 339.13 nM
HCC2157 cells
Breast ductal carcinoma
CVCL_1261 
Half Maximal Inhibitory Concentration (IC50) 34 nM
WI-38 cells
Normal
CVCL_0579 
[669]
Half Maximal Inhibitory Concentration (IC50) 34.52 nM
NMC-G1 cells
Astrocytoma
CVCL_1608 
Half Maximal Inhibitory Concentration (IC50) 34.78 nM
no-11 cells
Glioblastoma
CVCL_3076 
Half Maximal Inhibitory Concentration (IC50) 3422 nM
A2780/Taxol cells
Ovarian endometrioid adenocarcinoma
CVCL_IJ13 
[222]
Half Maximal Inhibitory Concentration (IC50) 34300 nM
A549/TR cells
Lung adenocarcinoma
CVCL_C5S0 
[670]
Half Maximal Inhibitory Concentration (IC50) 344 nM
A2780/PTX cells
Ovarian endometrioid adenocarcinoma
CVCL_C0D6 
[576]
Half Maximal Inhibitory Concentration (IC50) 345.81 nM
SIMA cells
Adrenal gland neuroblastoma
CVCL_1695 
Half Maximal Inhibitory Concentration (IC50) 346 nM
MDA435/LCC6 cells
Amelanotic melanoma
CVCL_IN99 
[196]
Half Maximal Inhibitory Concentration (IC50) 3460 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[493]
Half Maximal Inhibitory Concentration (IC50) 35 nM
HCT 116 cells
Colon carcinoma
CVCL_0291 
[671]
Half Maximal Inhibitory Concentration (IC50) 35 nM
NCI-H1299 cells (MMAE resistant)
Lung large cell carcinoma
CVCL_0060 
[447]
Half Maximal Inhibitory Concentration (IC50) 35 nM
NCI-H1299 cells (MMAE resistant)
Lung large cell carcinoma
CVCL_0060 
[17]
Half Maximal Inhibitory Concentration (IC50) 35 nM
MX1 cells
Breast carcinoma
CVCL_4774 
[185]
Half Maximal Inhibitory Concentration (IC50) 35 nM
MX1 cells
Breast carcinoma
CVCL_4774 
[188]
Half Maximal Inhibitory Concentration (IC50) 35 nM
SK-OV-3 cells (FZD7 overexpression)
Ovarian serous cystadenocarcinoma
CVCL_0532 
[672]
Half Maximal Inhibitory Concentration (IC50) 35 nM
P388D1 cells
Lymphoma
CVCL_0477 
[85]
Half Maximal Inhibitory Concentration (IC50) 35 nM
P388D1 cells
Lymphoma
CVCL_0477 
[86]
Half Maximal Inhibitory Concentration (IC50) 35 nM
NCI-H596 cells
Lung adenosquamous carcinoma
CVCL_1571 
[515]
Half Maximal Inhibitory Concentration (IC50) 35 nM
MX1 cells
Breast carcinoma
CVCL_4774 
[189]
Half Maximal Inhibitory Concentration (IC50) 35.29 nM
NCI-H524 cells
Lung small cell carcinoma
CVCL_1568 
Half Maximal Inhibitory Concentration (IC50) 35.62 nM
MHH-CALL-2 cells
B acute lymphoblastic leukemia
CVCL_1409 
Half Maximal Inhibitory Concentration (IC50) 35.7 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[327]
Half Maximal Inhibitory Concentration (IC50) 350 nM
SAOS-2 cells
Osteosarcoma
CVCL_0548 
[627]
Half Maximal Inhibitory Concentration (IC50) 350 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[643]
Half Maximal Inhibitory Concentration (IC50) 350 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[623]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 3500 nM
A498 cells
Renal carcinoma
CVCL_1056 
[140]
Half Maximal Inhibitory Concentration (IC50) 3500 nM
SiHa cells
Cervical squamous cell carcinoma
CVCL_0032 
[398]
Half Maximal Inhibitory Concentration (IC50) 3500 nM
HT-29 cells
Colon adenocarcinoma
CVCL_0320 
[591]
Half Maximal Inhibitory Concentration (IC50) 3500 nM
PANC-1 cells
Pancreatic ductal adenocarcinoma
CVCL_0480 
[389]
Half Maximal Inhibitory Concentration (IC50) 354 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[202]
Half Maximal Inhibitory Concentration (IC50) 3543.85 nM
SK-MM-2 cells
Plasma cell myeloma
CVCL_1699 
Half Maximal Inhibitory Concentration (IC50) 3547.88 nM
LAN-6 cells
Neuroblastoma
CVCL_1363 
Half Maximal Inhibitory Concentration (IC50) 36 nM
GB-1 cells
Glioblastoma
CVCL_1227 
Half Maximal Inhibitory Concentration (IC50) 36 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[673]
Half Maximal Inhibitory Concentration (IC50) 36.73 nM
OPM-2 cells
Plasma cell myeloma
CVCL_1625 
Half Maximal Inhibitory Concentration (IC50) 36.9 nM
HCT-8 cells
Ileocecal adenocarcinoma
CVCL_2478 
[492]
Half Maximal Inhibitory Concentration (IC50) 360 nM
HEK293 cells
Normal
CVCL_0045 
[674]
Half Maximal Inhibitory Concentration (IC50) 3600 nM
HCT-8 cells
Ileocecal adenocarcinoma
CVCL_2478 
[150]
Half Maximal Inhibitory Concentration (IC50) 36400 nM
HEK-293T cells
Normal
CVCL_0063 
[588]
Half Maximal Inhibitory Concentration (IC50) 3650 nM
K-562 cells
Chronic myelogenous leukemia
CVCL_0004 
[593]
Half Maximal Inhibitory Concentration (IC50) 369.28 nM
MDA-MB-134-VI cells
Breast lobular carcinoma
CVCL_0617 
Half Maximal Cell Growth Inhibitory Concentration (GI50) 37 nM
M21 cells
Melanoma
CVCL_D031 
[675]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 37 nM
M21 cells
Melanoma
CVCL_D031 
[443]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 37 nM
M21 cells
Melanoma
CVCL_D031 
[444]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 37 nM
M21 cells
Melanoma
CVCL_D031 
[445]
Half Maximal Inhibitory Concentration (IC50) 37 nM
HCT-8 cells
Ileocecal adenocarcinoma
CVCL_2478 
[294]
Half Maximal Inhibitory Concentration (IC50) 37 nM
HCT-8 cells
Ileocecal adenocarcinoma
CVCL_2478 
[609]
Half Maximal Inhibitory Concentration (IC50) 370 nM
NCI-H1694 cells
Lung small cell carcinoma
CVCL_1489 
Half Maximal Inhibitory Concentration (IC50) 3700 nM
PC-9 cells
Lung adenocarcinoma
CVCL_B260 
[676]
Half Maximal Inhibitory Concentration (IC50) 3760 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[587]
Half Maximal Inhibitory Concentration (IC50) 3770 nM
MDA-MB-231 cells (5T4 overexpression)
Breast adenocarcinoma
CVCL_0062 
[677]
Half Maximal Inhibitory Concentration (IC50) 379 nM
MDA-MB-435 cells
Amelanotic melanoma
CVCL_0417 
[375]
Half Maximal Inhibitory Concentration (IC50) 38 nM
A10 cells
Glioma
CVCL_0130 
[575]
Half Maximal Inhibitory Concentration (IC50) 38 nM
Hep-G2 cells
Hepatoblastoma
CVCL_0027 
[344]
Half Maximal Inhibitory Concentration (IC50) 38 nM
A2780 cells
Ovarian endometrioid adenocarcinoma
CVCL_0134 
[118]
Half Maximal Inhibitory Concentration (IC50) 38 nM
HCT 116 cells
Colon carcinoma
CVCL_0291 
[284]
Half Maximal Inhibitory Concentration (IC50) 38.19 nM
RH-1 cells
Ewing sarcoma
CVCL_1658 
Half Maximal Inhibitory Concentration (IC50) 38.57 nM
NCI-H64 cells
Lung small cell carcinoma
CVCL_1573 
Half Maximal Cell Growth Inhibitory Concentration (GI50) 38.9 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[678]
Half Maximal Inhibitory Concentration (IC50) 380 nM
HT-29 cells
Colon adenocarcinoma
CVCL_0320 
[421]
Half Maximal Inhibitory Concentration (IC50) 380 nM
HT-29 cells
Colon adenocarcinoma
CVCL_0320 
[422]
Half Maximal Inhibitory Concentration (IC50) 380 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[569]
Half Maximal Inhibitory Concentration (IC50) 380 nM
HT-29 cells
Colon adenocarcinoma
CVCL_0320 
[423]
Half Maximal Inhibitory Concentration (IC50) 380 nM
K-562 cells
Chronic myelogenous leukemia
CVCL_0004 
[504]
Half Maximal Inhibitory Concentration (IC50) 380 nM
OVCAR-3 cells (FZD7 overexpression)
Ovarian serous adenocarcinoma
CVCL_0465 
[679]
Half Maximal Inhibitory Concentration (IC50) 3800 nM
HL-60 cells
Adult acute myeloid leukemia
CVCL_0002 
[579]
Half Maximal Inhibitory Concentration (IC50) 3800 nM
K-562 cells
Chronic myelogenous leukemia
CVCL_0004 
[579]
Half Maximal Inhibitory Concentration (IC50) 3800 nM
KB cells
Human papillomavirus-related endocervical adenocarcinoma
CVCL_0372 
[591]
Half Maximal Inhibitory Concentration (IC50) 3800 nM
KB cells
Human papillomavirus-related endocervical adenocarcinoma
CVCL_0372 
[322]
Half Maximal Inhibitory Concentration (IC50) 3800 nM
MGC-803 cells
Gastric cancer
CVCL_5334 
[680]
Half Maximal Inhibitory Concentration (IC50) 38000 nM
MCF-10A cells
Normal
CVCL_0598 
[603]
Half Maximal Inhibitory Concentration (IC50) 384.1 nM
PANC-1 cells
Pancreatic ductal adenocarcinoma
CVCL_0480 
[182]
Half Maximal Inhibitory Concentration (IC50) 3870 nM
MDA-MB-468 cells
Breast adenocarcinoma
CVCL_0419 
[581]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 39 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[678]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 39 nM
786-O cells
Renal cell carcinoma
CVCL_1051 
[146]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 39 nM
786-O cells
Renal cell carcinoma
CVCL_1051 
[147]
Half Maximal Inhibitory Concentration (IC50) 39 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[599]
Half Maximal Inhibitory Concentration (IC50) 39 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[352]
Half Maximal Inhibitory Concentration (IC50) 39.23 nM
EVSA-T cells
Breast carcinoma
CVCL_1207 
Half Maximal Inhibitory Concentration (IC50) 39.8 nM
Karpas-299 cells/Karpas BVR cells
ALK-positive anaplastic large cell lymphoma
CVCL_1324 
Half Maximal Inhibitory Concentration (IC50) 390 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[467]
Half Maximal Inhibitory Concentration (IC50) 390 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[135]
Half Maximal Inhibitory Concentration (IC50) 390.85 nM
EHEB cells
Normal
CVCL_1194 
Half Maximal Inhibitory Concentration (IC50) 3900 nM
Hep-G2 cells
Hepatoblastoma
CVCL_0027 
[681]
Half Maximal Inhibitory Concentration (IC50) 3900 nM
NCI-H1975 cells
Lung adenocarcinoma
CVCL_1511 
[676]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 398 nM
ACHN cells
Renal adenocarcinoma
CVCL_1067 
[399]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 398 nM
ACHN cells
Renal adenocarcinoma
CVCL_1067 
[400]
Half Maximal Inhibitory Concentration (IC50) 398.46 nM
U266B1 cells
Plasma cell myeloma
CVCL_0566 
Half Maximal Inhibitory Concentration (IC50) 3990 nM
PC-3 cells
Prostate carcinoma
CVCL_0035 
[440]
Half Maximal Inhibitory Concentration (IC50) 3990 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[581]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 4 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[399]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 4 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[400]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 4 nM
NCI-H1993 cells
Lung adenocarcinoma
CVCL_1512 
[319]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 4 nM
PC-3 cells
Prostate carcinoma
CVCL_0035 
[628]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 4 nM
PC-3 cells
Prostate carcinoma
CVCL_0035 
[400]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 4 nM
SW620 cells
Colon adenocarcinoma
CVCL_0547 
[146]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 4 nM
SW620 cells
Colon adenocarcinoma
CVCL_0547 
[147]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 4 nM
K-562 cells
Chronic myelogenous leukemia
CVCL_0004 
[628]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 4 nM
HCT 116 cells
Colon carcinoma
CVCL_0291 
[146]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 4 nM
HCT 116 cells
Colon carcinoma
CVCL_0291 
[147]
Half Maximal Inhibitory Concentration (IC50) 4 nM
HCT 116 cells
Colon carcinoma
CVCL_0291 
Half Maximal Inhibitory Concentration (IC50) 4 nM
HCT 116 cells
Colon carcinoma
CVCL_0291 
Half Maximal Inhibitory Concentration (IC50) 4 nM
HCT 116 cells
Colon carcinoma
CVCL_0291 
Half Maximal Cell Growth Inhibitory Concentration (GI50) 4 nM
MDA-MB-435 cells
Amelanotic melanoma
CVCL_0417 
[682]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 4 nM
MDA-MB-435 cells
Amelanotic melanoma
CVCL_0417 
[146]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 4 nM
MDA-MB-435 cells
Amelanotic melanoma
CVCL_0417 
[147]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 4 nM
OVCAR-3 cells (FZD7 overexpression)
Ovarian serous adenocarcinoma
CVCL_0465 
[146]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 4 nM
OVCAR-3 cells (FZD7 overexpression)
Ovarian serous adenocarcinoma
CVCL_0465 
[147]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 4 nM
SNB-75 cells
Glioblastoma
CVCL_1706 
[399]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 4 nM
SNB-75 cells
Glioblastoma
CVCL_1706 
[400]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 4 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[146]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 4 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[147]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 4 nM
BT-549 cells
Breast ductal carcinoma
CVCL_1092 
[146]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 4 nM
BT-549 cells
Breast ductal carcinoma
CVCL_1092 
[147]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 4 nM
KM12 cells
Colon adenocarcinoma
CVCL_1331 
[399]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 4 nM
KM12 cells
Colon adenocarcinoma
CVCL_1331 
[400]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 4 nM
MES-SA cells
Uterine sarcoma
CVCL_1404 
[630]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 4 nM
HL-60(TB) cells
Adult acute myeloid leukemia
CVCL_A794 
[146]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 4 nM
HL-60(TB) cells
Adult acute myeloid leukemia
CVCL_A794 
[147]
Half Maximal Inhibitory Concentration (IC50) 4 nM
HCT 116 cells
Colon carcinoma
CVCL_0291 
[683]
Half Maximal Inhibitory Concentration (IC50) 4 nM
HCT 116 cells
Colon carcinoma
CVCL_0291 
[684]
Half Maximal Inhibitory Concentration (IC50) 4 nM
MDA-MB-435 cells
Amelanotic melanoma
CVCL_0417 
[375]
Half Maximal Inhibitory Concentration (IC50) 4 nM
T-47D cells
Invasive breast carcinoma
CVCL_0553 
[148]
Half Maximal Inhibitory Concentration (IC50) 4 nM
NCI-ADR-RES cells
High grade ovarian serous adenocarcinoma
CVCL_1452 
[125]
Half Maximal Inhibitory Concentration (IC50) 4 nM
WRL68 cells
Embryonic hepatoma
CVCL_0581 
[685]
Half Maximal Inhibitory Concentration (IC50) 4 nM
MDA435/LCC6 cells
Amelanotic melanoma
CVCL_IN99 
[616]
Half Maximal Inhibitory Concentration (IC50) 4 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[470]
Half Maximal Inhibitory Concentration (IC50) 4 nM
MKN45 cells
Gastric adenocarcinoma
CVCL_0434 
[271]
Half Maximal Inhibitory Concentration (IC50) 4 nM
PC-3 cells
Prostate carcinoma
CVCL_0035 
[272]
Half Maximal Inhibitory Concentration (IC50) 4 nM
K-562 cells
Chronic myelogenous leukemia
CVCL_0004 
[270]
Half Maximal Inhibitory Concentration (IC50) 4 nM
DU145 cells
Prostate carcinoma
CVCL_0105 
[648]
Half Maximal Inhibitory Concentration (IC50) 4 nM
A2780 cells
Ovarian endometrioid adenocarcinoma
CVCL_0134 
[344]
Half Maximal Inhibitory Concentration (IC50) 4 nM
HCT 116 cells
Colon carcinoma
CVCL_0291 
[484]
Half Maximal Inhibitory Concentration (IC50) 4 nM
HCT 116 cells
Colon carcinoma
CVCL_0291 
[686]
Half Maximal Inhibitory Concentration (IC50) 4 nM
MDA-MB-435 cells
Amelanotic melanoma
CVCL_0417 
[617]
Half Maximal Inhibitory Concentration (IC50) 4 nM
NCI-H460 cells
Lung large cell carcinoma
CVCL_0459 
[351]
Half Maximal Inhibitory Concentration (IC50) 4 nM
NCI-H460 cells
Lung large cell carcinoma
CVCL_0459 
[284]
Half Maximal Inhibitory Concentration (IC50) 4 nM
786-O cells
Renal cell carcinoma
CVCL_1051 
[662]
Half Maximal Inhibitory Concentration (IC50) 4 nM
MDA-MB-231 cells (5T4 overexpression)
Breast adenocarcinoma
CVCL_0062 
[470]
Half Maximal Inhibitory Concentration (IC50) 4 nM
SH-SY5Y cells
Bone marrow neuroblastoma
CVCL_0019 
[632]
Half Maximal Inhibitory Concentration (IC50) 4 nM
WRL68 cells
Embryonic hepatoma
CVCL_0581 
[687]
Half Maximal Inhibitory Concentration (IC50) 4 nM
MES-SA cells
Uterine sarcoma
CVCL_1404 
[688]
Half Maximal Inhibitory Concentration (IC50) 4 nM
MES-SA cells
Uterine sarcoma
CVCL_1404 
[689]
Half Maximal Inhibitory Concentration (IC50) 4 nM
MES-SA cells
Uterine sarcoma
CVCL_1404 
[484]
Half Maximal Inhibitory Concentration (IC50) 4 nM
MES-SA cells
Uterine sarcoma
CVCL_1404 
[440]
Half Maximal Inhibitory Concentration (IC50) 4 nM
MES-SA cells
Uterine sarcoma
CVCL_1404 
[328]
Half Maximal Inhibitory Concentration (IC50) 4 nM
PC-3 cells
Prostate carcinoma
CVCL_0035 
[433]
Half Maximal Inhibitory Concentration (IC50) 4 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[519]
Half Maximal Inhibitory Concentration (IC50) 4 nM
DU145 cells
Prostate carcinoma
CVCL_0105 
[305]
Half Maximal Inhibitory Concentration (IC50) 4 nM
CCRF-CEM cells
T acute lymphoblastic leukemia
CVCL_0207 
[277]
Half Maximal Inhibitory Concentration (IC50) 4 nM
Kasumi-1 cells
Myeloid leukemia with maturation
CVCL_0589 
[307]
Half Maximal Inhibitory Concentration (IC50) 4 nM
OVCAR-8 cells
High grade ovarian serous adenocarcinoma
CVCL_1629 
[608]
Half Maximal Inhibitory Concentration (IC50) 4 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[382]
Half Maximal Inhibitory Concentration (IC50) 4 nM
BGC-823 cells
Stomach adenocarcinoma
CVCL_3360 
[163]
Half Maximal Inhibitory Concentration (IC50) 4.006 nM
SK-LMS-1 cells
Vulvar leiomyosarcoma
CVCL_0628 
Half Maximal Cell Growth Inhibitory Concentration (GI50) 4.1 nM
KB cells
Human papillomavirus-related endocervical adenocarcinoma
CVCL_0372 
[532]
Half Maximal Inhibitory Concentration (IC50) 4.1 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[690]
Half Maximal Inhibitory Concentration (IC50) 4.1 nM
HCT 116 cells
Colon carcinoma
CVCL_0291 
[243]
Half Maximal Inhibitory Concentration (IC50) 4.1 nM
HCT 116 cells
Colon carcinoma
CVCL_0291 
[568]
Half Maximal Inhibitory Concentration (IC50) 4.1 nM
KB cells
Human papillomavirus-related endocervical adenocarcinoma
CVCL_0372 
[691]
Half Maximal Inhibitory Concentration (IC50) 4.1 nM
NALM-6 cells
B acute lymphoblastic leukemia
CVCL_0092 
[692]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 4.12 nM
KB cells
Human papillomavirus-related endocervical adenocarcinoma
CVCL_0372 
[654]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 4.188 nM
UACC-62 cells
Melanoma
CVCL_1780 
[345]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 4.2 nM
SW1573 cells
Lung carcinoma
CVCL_1720 
[208]
Half Maximal Inhibitory Concentration (IC50) 4.2 nM
KB cells
Human papillomavirus-related endocervical adenocarcinoma
CVCL_0372 
[693]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 4.266 nM
HL-60 cells
Adult acute myeloid leukemia
CVCL_0002 
[345]
Half Maximal Inhibitory Concentration (IC50) 4.3 nM
NSCLC cells
Non-small cell lung carcinoma
Undisclosed
Half Maximal Inhibitory Concentration (IC50) 4.3 nM
WI-38 VA13 cells
Normal
CVCL_2759 
[669]
Half Maximal Inhibitory Concentration (IC50) 4.3 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[526]
Half Maximal Inhibitory Concentration (IC50) 4.339 nM
GT3TKB cells
Lung squamous cell carcinoma
CVCL_1237 
Half Maximal Cell Growth Inhibitory Concentration (GI50) 4.38 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[523]
Half Maximal Inhibitory Concentration (IC50) 4.4 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[653]
Half Maximal Inhibitory Concentration (IC50) 4.4 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[182]
Half Maximal Inhibitory Concentration (IC50) 4.4 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[566]
Half Maximal Inhibitory Concentration (IC50) 4.4 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[239]
Half Maximal Inhibitory Concentration (IC50) 4.4 nM
Hep-G2 cells
Hepatoblastoma
CVCL_0027 
[640]
Half Maximal Inhibitory Concentration (IC50) 4.4 nM
Hep-G2 cells
Hepatoblastoma
CVCL_0027 
[83]
Half Maximal Inhibitory Concentration (IC50) 4.4 nM
PC-14 cells
Lung adenocarcinoma
CVCL_1640 
[271]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 4.426 nM
MOLT-4 cells
Adult T acute lymphoblastic leukemia
CVCL_0013 
[345]
Half Maximal Inhibitory Concentration (IC50) 4.494 nM
ES4 cells
Ewing sarcoma
CVCL_1200 
Half Maximal Inhibitory Concentration (IC50) 4.496 nM
IMR-5 cells
Neuroblastoma
CVCL_1306 
Half Maximal Inhibitory Concentration (IC50) 4.5 nM
MDA-MB-231 cells (5T4 overexpression)
Breast adenocarcinoma
CVCL_0062 
[17]
Half Maximal Inhibitory Concentration (IC50) 4.5 nM
MDA-MB-231 cells (5T4 overexpression)
Breast adenocarcinoma
CVCL_0062 
[597]
Half Maximal Inhibitory Concentration (IC50) 4.5 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[649]
Half Maximal Inhibitory Concentration (IC50) 4.5 nM
Jurkat cells
T acute lymphoblastic leukemia
CVCL_0065 
[692]
Half Maximal Inhibitory Concentration (IC50) 4.5 nM
KB cells
Human papillomavirus-related endocervical adenocarcinoma
CVCL_0372 
[388]
Half Maximal Inhibitory Concentration (IC50) 4.5 nM
MDA-MB-435 cells
Amelanotic melanoma
CVCL_0417 
[550]
Half Maximal Inhibitory Concentration (IC50) 4.5 nM
MDA-MB-435 cells
Amelanotic melanoma
CVCL_0417 
[391]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 4.539 nM
OVCAR-8 cells
High grade ovarian serous adenocarcinoma
CVCL_1629 
[345]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 4.6 nM
KB cells
Human papillomavirus-related endocervical adenocarcinoma
CVCL_0372 
[115]
Half Maximal Inhibitory Concentration (IC50) 4.6 nM
A2780 cells
Ovarian endometrioid adenocarcinoma
CVCL_0134 
[232]
Half Maximal Inhibitory Concentration (IC50) 4.6 nM
Hep-G2 cells
Hepatoblastoma
CVCL_0027 
[364]
Half Maximal Inhibitory Concentration (IC50) 4.6 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[412]
Half Maximal Inhibitory Concentration (IC50) 4.6 nM
A375 cells
Amelanotic melanoma
CVCL_0132 
[182]
Half Maximal Inhibitory Concentration (IC50) 4.687 nM
NCI-H1648 cells
Lung adenocarcinoma
CVCL_1482 
Half Maximal Cell Growth Inhibitory Concentration (GI50) 4.7 nM
SK-OV-3 cells (FZD7 overexpression)
Ovarian serous cystadenocarcinoma
CVCL_0532 
[694]
Half Maximal Inhibitory Concentration (IC50) 4.7 nM
NFF Fibroblast cells
Normal
Undisclosed [653]
Half Maximal Inhibitory Concentration (IC50) 4.7 nM
SK-OV-3 cells (FZD7 overexpression)
Ovarian serous cystadenocarcinoma
CVCL_0532 
[695]
Half Maximal Inhibitory Concentration (IC50) 4.7 nM
A2058 cells
Melanoma
CVCL_1059 
[379]
Half Maximal Inhibitory Concentration (IC50) 4.7 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[283]
Half Maximal Inhibitory Concentration (IC50) 4.747 nM
MV4-11 cells
Childhood acute monocytic leukemia
CVCL_0064 
Half Maximal Inhibitory Concentration (IC50) 4.8 nM
A2780-1A9 cells
Ovarian adenocarcinoma
CVCL_H619 
[446]
Half Maximal Inhibitory Concentration (IC50) 4.803 nM
SK-UT-1 cells
Uterine corpus leiomyosarcoma
CVCL_0533 
Half Maximal Cell Growth Inhibitory Concentration (GI50) 4.808 nM
SN12C cells
Renal cell carcinoma
CVCL_1705 
[345]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 4.85 nM
K-562 cells
Chronic myelogenous leukemia
CVCL_0004 
[548]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 4.87 nM
KB cells
Human papillomavirus-related endocervical adenocarcinoma
CVCL_0372 
[696]
Half Maximal Inhibitory Concentration (IC50) 4.88 nM
DU145 cells
Prostate carcinoma
CVCL_0105 
[302]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 4.89 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[541]
Half Maximal Inhibitory Concentration (IC50) 4.89 nM
DU145 cells
Prostate carcinoma
CVCL_0105 
[77]
Half Maximal Inhibitory Concentration (IC50) 4.9 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
Half Maximal Inhibitory Concentration (IC50) 4.9 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[241]
Half Maximal Inhibitory Concentration (IC50) 4.9 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[574]
Half Maximal Inhibitory Concentration (IC50) 4.9 nM
NCI-H460 cells
Lung large cell carcinoma
CVCL_0459 
[197]
Half Maximal Inhibitory Concentration (IC50) 4.9 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[17]
Half Maximal Inhibitory Concentration (IC50) 4.9 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[597]
Half Maximal Inhibitory Concentration (IC50) 4.9 nM
K-562 cells
Chronic myelogenous leukemia
CVCL_0004 
[240]
Half Maximal Inhibitory Concentration (IC50) 4.9 nM
HCT 116 cells
Colon carcinoma
CVCL_0291 
[234]
Half Maximal Inhibitory Concentration (IC50) 4.9 nM
A375 cells
Amelanotic melanoma
CVCL_0132 
[640]
Half Maximal Inhibitory Concentration (IC50) >4.9 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[573]
Half Maximal Inhibitory Concentration (IC50) 4.912 nM
NB13 cells
Neuroblastoma
CVCL_1443 
Half Maximal Inhibitory Concentration (IC50) 4.97 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[222]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 40 nM
NCI-ADR-RES cells
High grade ovarian serous adenocarcinoma
CVCL_1452 
[141]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 40 nM
UACC-257 cells
Melanoma
CVCL_1779 
[399]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 40 nM
UACC-257 cells
Melanoma
CVCL_1779 
[400]
Half Maximal Inhibitory Concentration (IC50) 40 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[334]
Half Maximal Inhibitory Concentration (IC50) 40 nM
WI-38 cells
Normal
CVCL_0579 
[491]
Half Maximal Inhibitory Concentration (IC50) 40 nM
WI-38 cells
Normal
CVCL_0579 
[697]
Half Maximal Inhibitory Concentration (IC50) 40 nM
WI-38 cells
Normal
CVCL_0579 
[698]
Half Maximal Inhibitory Concentration (IC50) 40 nM
WI-38 cells
Normal
CVCL_0579 
[699]
Half Maximal Inhibitory Concentration (IC50) 40 nM
BGC-823 cells
Stomach adenocarcinoma
CVCL_3360 
[150]
Half Maximal Inhibitory Concentration (IC50) 40 nM
P388 cells
Lymphoma
CVCL_7222 
[258]
Half Maximal Inhibitory Concentration (IC50) 40 nM
P388 cells
Lymphoma
CVCL_7222 
[259]
Half Maximal Inhibitory Concentration (IC50) 40 nM
B16 cells
Melanoma
CVCL_F936 
[151]
Half Maximal Inhibitory Concentration (IC50) 40 nM
P388/ADR cells
Lymphoma
CVCL_IZ75 
[257]
Half Maximal Inhibitory Concentration (IC50) 40 nM
PC-3 cells
Prostate carcinoma
CVCL_0035 
[648]
Half Maximal Inhibitory Concentration (IC50) 40 nM
DU145 cells
Prostate carcinoma
CVCL_0105 
[560]
Half Maximal Inhibitory Concentration (IC50) 40 nM
SW480 cells
Colon adenocarcinoma
CVCL_0546 
[437]
Half Maximal Inhibitory Concentration (IC50) 40 nM
SW480 cells
Colon adenocarcinoma
CVCL_0546 
[295]
Half Maximal Inhibitory Concentration (IC50) 40 nM
HEK293 cells
Normal
CVCL_0045 
[674]
Half Maximal Inhibitory Concentration (IC50) 40 nM
P388 cells
Lymphoma
CVCL_7222 
[269]
Half Maximal Inhibitory Concentration (IC50) 40 nM
QGY-7701 cells
Endocervical adenocarcinoma
CVCL_6859 
[394]
Half Maximal Inhibitory Concentration (IC50) 40 nM
PANC-1 cells
Pancreatic ductal adenocarcinoma
CVCL_0480 
[700]
Half Maximal Inhibitory Concentration (IC50) 40 nM
PC-3 cells
Prostate carcinoma
CVCL_0035 
[657]
Half Maximal Inhibitory Concentration (IC50) 40 nM
MDA-MB-231 cells (5T4 overexpression)
Breast adenocarcinoma
CVCL_0062 
[610]
Half Maximal Inhibitory Concentration (IC50) 40.4 nM
MZ7-mel cells
Melanoma
CVCL_1436 
Half Maximal Inhibitory Concentration (IC50) 40.5 nM
MDA-MB-231 cells (5T4 overexpression)
Breast adenocarcinoma
CVCL_0062 
[414]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 400 nM
SK-MEL-2 cells (MEK inhibitor-resistant)
Melanoma
CVCL_0069 
[146]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 400 nM
SK-MEL-2 cells (MEK inhibitor-resistant)
Melanoma
CVCL_0069 
[147]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 400 nM
SK-MEL-28 cells (BRAF inhibitor resistant)
Cutaneous melanoma
CVCL_0526 
[146]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 400 nM
SK-MEL-28 cells (BRAF inhibitor resistant)
Cutaneous melanoma
CVCL_0526 
[147]
Half Maximal Inhibitory Concentration (IC50) 400 nM
OE19 cells
Esophageal adenocarcinoma
CVCL_1622 
[89]
Half Maximal Inhibitory Concentration (IC50) 400 nM
CCRF-CEM cells
T acute lymphoblastic leukemia
CVCL_0207 
[173]
Half Maximal Inhibitory Concentration (IC50) 400 nM
Multi-drug resistant cells
Normal
Undisclosed [258]
Half Maximal Inhibitory Concentration (IC50) 400 nM
LT12 tumor cells
Rat leukemia
CVCL_D271 
[257]
Half Maximal Inhibitory Concentration (IC50) 400 nM
HuO9-L12 cells
Osteosarcoma
CVCL_WL12 
[259]
Half Maximal Inhibitory Concentration (IC50) 400 nM
SK-OV-3 cells (FZD7 overexpression)
Ovarian serous cystadenocarcinoma
CVCL_0532 
[361]
Half Maximal Inhibitory Concentration (IC50) 400 nM
LT12 tumor cells
Rat leukemia
CVCL_D271 
[269]
Half Maximal Inhibitory Concentration (IC50) 400 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[501]
Half Maximal Inhibitory Concentration (IC50) >400 nM
MES-SA/Dx5 cells
Uterine sarcoma
CVCL_2598 
[238]
Half Maximal Inhibitory Concentration (IC50) 40000 nM
WI-38 cells
Normal
CVCL_0579 
[701]
Half Maximal Inhibitory Concentration (IC50) 40370 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[702]
Half Maximal Inhibitory Concentration (IC50) 41 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[382]
Half Maximal Inhibitory Concentration (IC50) 41.05 nM
LB373-MEL-D cells
Melanoma
CVCL_1367 
Half Maximal Inhibitory Concentration (IC50) 41.4 nM
HEL cells
Erythroleukemia
CVCL_0001 
Half Maximal Inhibitory Concentration (IC50) 410 nM
NCI-ADR-RES cells
High grade ovarian serous adenocarcinoma
CVCL_1452 
[509]
Half Maximal Inhibitory Concentration (IC50) 410 nM
K-562 cells
Chronic myelogenous leukemia
CVCL_0004 
[493]
Half Maximal Inhibitory Concentration (IC50) 410 nM
K-562 cells
Chronic myelogenous leukemia
CVCL_0004 
[494]
Half Maximal Inhibitory Concentration (IC50) 410 nM
K-562 cells
Chronic myelogenous leukemia
CVCL_0004 
[495]
Half Maximal Inhibitory Concentration (IC50) 410 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[270]
Half Maximal Inhibitory Concentration (IC50) 410 nM
A2780 cells
Ovarian endometrioid adenocarcinoma
CVCL_0134 
[679]
Half Maximal Inhibitory Concentration (IC50) 4100 nM
SK-MEL cells
Melanoma
Undisclosed [559]
Half Maximal Inhibitory Concentration (IC50) 4140 nM
K-562 cells
Chronic myelogenous leukemia
CVCL_0004 
[510]
Half Maximal Inhibitory Concentration (IC50) 415 nM
A2780 ADR cells
Ovarian endometrioid adenocarcinoma
CVCL_1941 
[549]
Half Maximal Inhibitory Concentration (IC50) 4150 nM
Hep-G2 cells
Hepatoblastoma
CVCL_0027 
[510]
Half Maximal Inhibitory Concentration (IC50) 4185.73 nM
NCI-H1838 cells
Lung adenocarcinoma
CVCL_1499 
Half Maximal Inhibitory Concentration (IC50) 4186.73 nM
U-87MG ATCC cells
Glioblastoma
CVCL_0022 
Half Maximal Inhibitory Concentration (IC50) 42.1 nM
SW872 cells
Liposarcoma
CVCL_1730 
Half Maximal Inhibitory Concentration (IC50) 42.44 nM
DU-4475 cells
Breast adenocarcinoma
CVCL_1183 
Half Maximal Inhibitory Concentration (IC50) 42.75 nM
IST-SL2 cells
Lung small cell carcinoma
CVCL_1314 
Half Maximal Inhibitory Concentration (IC50) 420 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[93]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 4200 nM
SW1573 cells
Lung carcinoma
CVCL_1720 
[458]
Half Maximal Inhibitory Concentration (IC50) 4200 nM
NIH3T3 cells
Normal
CVCL_0594 
[74]
Half Maximal Inhibitory Concentration (IC50) 427000 nM
MCF-10A cells
Normal
CVCL_0598 
[703]
Half Maximal Inhibitory Concentration (IC50) 4287 nM
NCI-H460 cells
Lung large cell carcinoma
CVCL_0459 
[133]
Half Maximal Inhibitory Concentration (IC50) 429 nM
CCRF-CEM cells
T acute lymphoblastic leukemia
CVCL_0207 
[171]
Half Maximal Inhibitory Concentration (IC50) 429 nM
CCRF-CEM cells
T acute lymphoblastic leukemia
CVCL_0207 
[185]
Half Maximal Inhibitory Concentration (IC50) 429 nM
CCRF-CEM cells
T acute lymphoblastic leukemia
CVCL_0207 
[188]
Half Maximal Inhibitory Concentration (IC50) 43 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[442]
Half Maximal Inhibitory Concentration (IC50) 43.07 nM
NCI-H82 cells
Lung small cell carcinoma
CVCL_1591 
Half Maximal Inhibitory Concentration (IC50) 43.51 nM
LC4-1 cells
B acute lymphoblastic leukemia
CVCL_1374 
Half Maximal Inhibitory Concentration (IC50) 43.92 nM
HDLM-2 cells
Hodgkin lymphoma
CVCL_0009 
Half Maximal Inhibitory Concentration (IC50) 430 nM
CCRF-CEM cells
T acute lymphoblastic leukemia
CVCL_0207 
[395]
Half Maximal Inhibitory Concentration (IC50) 430 nM
CCRF-CEM cells
T acute lymphoblastic leukemia
CVCL_0207 
[189]
Half Maximal Inhibitory Concentration (IC50) 430 nM
CCRF-CEM cells
T acute lymphoblastic leukemia
CVCL_0207 
[396]
Half Maximal Inhibitory Concentration (IC50) 430 nM
CCRF-CEM cells
T acute lymphoblastic leukemia
CVCL_0207 
[181]
Half Maximal Inhibitory Concentration (IC50) 430 nM
CaES-17 cells
Endocervical adenocarcinoma
CVCL_UY83 
[493]
Half Maximal Inhibitory Concentration (IC50) 430 nM
CaES-17 cells
Endocervical adenocarcinoma
CVCL_UY83 
[494]
Half Maximal Inhibitory Concentration (IC50) 430 nM
CaES-17 cells
Endocervical adenocarcinoma
CVCL_UY83 
[495]
Half Maximal Inhibitory Concentration (IC50) 430 nM
SK-OV-3 cells (FZD7 overexpression)
Ovarian serous cystadenocarcinoma
CVCL_0532 
[679]
Half Maximal Inhibitory Concentration (IC50) 43000 nM
HEK293 cells
Normal
CVCL_0045 
[704]
Half Maximal Inhibitory Concentration (IC50) 437.65 nM
LC-1F cells
Lung squamous cell carcinoma
CVCL_1372 
Half Maximal Inhibitory Concentration (IC50) 4370 nM
HCT 116 cells
Colon carcinoma
CVCL_0291 
[368]
Half Maximal Inhibitory Concentration (IC50) 4370 nM
HCT 116 cells
Colon carcinoma
CVCL_0291 
[369]
Half Maximal Inhibitory Concentration (IC50) 4370 nM
HCT 116 cells
Colon carcinoma
CVCL_0291 
[370]
Half Maximal Inhibitory Concentration (IC50) 4370 nM
HCT 116 cells
Colon carcinoma
CVCL_0291 
[372]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 44.77 nM
DLD-1 cells
Colon adenocarcinoma
CVCL_0248 
[345]
Half Maximal Inhibitory Concentration (IC50) 44.9 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[640]
Half Maximal Inhibitory Concentration (IC50) 4400 nM
A2780/Taxol cells
Ovarian endometrioid adenocarcinoma
CVCL_IJ13 
[631]
Half Maximal Inhibitory Concentration (IC50) 4403.76 nM
NB7 cells
Neuroblastoma
CVCL_8824 
Half Maximal Inhibitory Concentration (IC50) 4420000 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[705]
Half Maximal Inhibitory Concentration (IC50) 4498 nM
A2780 cells
Ovarian endometrioid adenocarcinoma
CVCL_0134 
[232]
Half Maximal Inhibitory Concentration (IC50) 45 nM
Hep-G2 cells
Hepatoblastoma
CVCL_0027 
[668]
Half Maximal Inhibitory Concentration (IC50) 45 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[397]
Half Maximal Inhibitory Concentration (IC50) 45.22 nM
MGC-803 cells
Gastric cancer
CVCL_5334 
[706]
Half Maximal Inhibitory Concentration (IC50) 450 nM
HT-29 cells
Colon adenocarcinoma
CVCL_0320 
[273]
Half Maximal Inhibitory Concentration (IC50) 457 nM
MDA-MB-231 cells (5T4 overexpression)
Breast adenocarcinoma
CVCL_0062 
[707]
Half Maximal Inhibitory Concentration (IC50) 4570 nM
PC-3 cells
Prostate carcinoma
CVCL_0035 
[426]
Half Maximal Inhibitory Concentration (IC50) 45780 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[702]
Half Maximal Effective Concentration (EC50) 46 nM
Col2 cells
Colon carcinoma
CVCL_D645 
[102]
Half Maximal Inhibitory Concentration (IC50) 46 nM
MX1 cells
Breast carcinoma
CVCL_4774 
[171]
Half Maximal Inhibitory Concentration (IC50) 46 nM
MX1 cells
Breast carcinoma
CVCL_4774 
[173]
Half Maximal Inhibitory Concentration (IC50) 46 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[477]
Half Maximal Inhibitory Concentration (IC50) 46.39 nM
L-540 cells
Hodgkin lymphoma
CVCL_1362 
Half Maximal Inhibitory Concentration (IC50) 46.8 nM
Hep-G2 cells
Hepatoblastoma
CVCL_0027 
[359]
Half Maximal Inhibitory Concentration (IC50) 46.8 nM
WI-38 cells
Normal
CVCL_0579 
[708]
Half Maximal Inhibitory Concentration (IC50) 465 nM
MDA-MB-435 cells
Amelanotic melanoma
CVCL_0417 
[106]
Half Maximal Inhibitory Concentration (IC50) 4670 nM
U-87MG ATCC cells
Glioblastoma
CVCL_0022 
[500]
Half Maximal Inhibitory Concentration (IC50) 47 nM
CFPAC-1 cells
Pancreatic ductal adenocarcinoma
CVCL_1119 
[509]
Half Maximal Inhibitory Concentration (IC50) 47.1 nM
MDA-MB-231 cells (5T4 overexpression)
Breast adenocarcinoma
CVCL_0062 
[599]
Half Maximal Inhibitory Concentration (IC50) 47.42 nM
MZ2-MEL cells
Melanoma
CVCL_1435 
Half Maximal Inhibitory Concentration (IC50) 47.73 nM
LU-134-A cells
Lung small cell carcinoma
CVCL_1387 
Half Maximal Inhibitory Concentration (IC50) 47.8 nM
A375 cells
Amelanotic melanoma
CVCL_0132 
[709]
Half Maximal Inhibitory Concentration (IC50) 470 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[398]
Half Maximal Inhibitory Concentration (IC50) 470 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[343]
Half Maximal Inhibitory Concentration (IC50) 4730 nM
SK-MEL-24 cells
Melanoma
CVCL_0599 
[410]
Half Maximal Inhibitory Concentration (IC50) 4770 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[493]
Half Maximal Inhibitory Concentration (IC50) 478.55 nM
SHP-77 cells
Small cell lung carcinoma
CVCL_1693 
Half Maximal Inhibitory Concentration (IC50) 480 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[474]
Half Maximal Inhibitory Concentration (IC50) 484.3 nM
CCRF-CEM cells
T acute lymphoblastic leukemia
CVCL_0207 
[169]
Half Maximal Inhibitory Concentration (IC50) 4840 nM
DU145 cells
Prostate carcinoma
CVCL_0105 
[710]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 486.41 nM
OVCAR-4 cells
Ovarian adenocarcinoma
CVCL_1627 
[345]
Half Maximal Inhibitory Concentration (IC50) 4863 nM
A549/TR cells
Lung adenocarcinoma
CVCL_C5S0 
[222]
Half Maximal Inhibitory Concentration (IC50) 4875 nM
SK-OV-3 cells (FZD7 overexpression)
Ovarian serous cystadenocarcinoma
CVCL_0532 
[198]
Half Maximal Inhibitory Concentration (IC50) 4875 nM
SK-OV-3 cells (FZD7 overexpression)
Ovarian serous cystadenocarcinoma
CVCL_0532 
[203]
Half Maximal Inhibitory Concentration (IC50) 4875 nM
NIH3T3 cells
Normal
CVCL_0594 
[598]
Half Maximal Inhibitory Concentration (IC50) 49.53 nM
NCI-H1581 cells
Lung large cell carcinoma
CVCL_1479 
Half Maximal Inhibitory Concentration (IC50) 49.79 nM
NB17 cells
Neuroblastoma
CVCL_1445 
Half Maximal Inhibitory Concentration (IC50) 490 nM
MDA-MB-435 cells
Amelanotic melanoma
CVCL_0417 
[126]
Half Maximal Inhibitory Concentration (IC50) 4900 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[603]
Half Maximal Inhibitory Concentration (IC50) 4900 nM
PC-3 cells
Prostate carcinoma
CVCL_0035 
[328]
Half Maximal Inhibitory Concentration (IC50) 493.07 nM
LS-513 cells
Cecum adenocarcinoma
CVCL_1386 
Half Maximal Inhibitory Concentration (IC50) 4946.17 nM
BB49-HNC cells
Floor of mouth squamous cell carcinoma
CVCL_1077 
Half Maximal Cell Growth Inhibitory Concentration (GI50) 5 nM
Hs 578T cells
Invasive breast carcinoma
CVCL_0332 
[146]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 5 nM
Hs 578T cells
Invasive breast carcinoma
CVCL_0332 
[147]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 5 nM
SW620 cells
Colon adenocarcinoma
CVCL_0547 
[536]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 5 nM
MOLT-4 cells
Adult T acute lymphoblastic leukemia
CVCL_0013 
[146]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 5 nM
MOLT-4 cells
Adult T acute lymphoblastic leukemia
CVCL_0013 
[147]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 5 nM
DU145 cells
Prostate carcinoma
CVCL_0105 
[399]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 5 nM
DU145 cells
Prostate carcinoma
CVCL_0105 
[400]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 5 nM
CCRF-CEM cells
T acute lymphoblastic leukemia
CVCL_0207 
[146]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 5 nM
CCRF-CEM cells
T acute lymphoblastic leukemia
CVCL_0207 
[147]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 5 nM
HCT 116 cells
Colon carcinoma
CVCL_0291 
[536]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 5 nM
HT-29 cells
Colon adenocarcinoma
CVCL_0320 
[146]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 5 nM
HT-29 cells
Colon adenocarcinoma
CVCL_0320 
[147]
Half Maximal Effective Concentration (EC50) 5 nM
LNCaP cells
Prostate carcinoma
CVCL_0395 
[102]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 5 nM
SK-MEL-5 cells
Cutaneous melanoma
CVCL_0527 
[146]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 5 nM
SF539 cells
Gliosarcoma
CVCL_1691 
[146]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 5 nM
SF539 cells
Gliosarcoma
CVCL_1691 
[147]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 5 nM
SF268 cells
Astrocytoma
CVCL_1689 
[146]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 5 nM
SF268 cells
Astrocytoma
CVCL_1689 
[147]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 5 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[141]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 5 nM
KM12 cells
Colon adenocarcinoma
CVCL_1331 
[146]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 5 nM
KM12 cells
Colon adenocarcinoma
CVCL_1331 
[147]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 5 nM
LOX IMVI cells
Melanoma
CVCL_1381 
[146]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 5 nM
LOX IMVI cells
Melanoma
CVCL_1381 
[147]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 5 nM
M14 cells
Melanoma
CVCL_1395 
[146]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 5 nM
M14 cells
Melanoma
CVCL_1395 
[147]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 5 nM
SW1573 cells
Lung carcinoma
CVCL_1720 
[75]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 5 nM
UACC-62 cells
Melanoma
CVCL_1780 
[146]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 5 nM
UACC-62 cells
Melanoma
CVCL_1780 
[147]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 5 nM
SK-MEL-25 cells
Melanoma
CVCL_6028 
[147]
Half Maximal Inhibitory Concentration (IC50) 5 nM
HL-60 cells
Adult acute myeloid leukemia
CVCL_0002 
[262]
Half Maximal Inhibitory Concentration (IC50) 5 nM
HL-60 cells
Adult acute myeloid leukemia
CVCL_0002 
[263]
Half Maximal Inhibitory Concentration (IC50) 5 nM
DU145 cells
Prostate carcinoma
CVCL_0105 
[262]
Half Maximal Inhibitory Concentration (IC50) 5 nM
DU145 cells
Prostate carcinoma
CVCL_0105 
[263]
Half Maximal Inhibitory Concentration (IC50) 5 nM
MDA-MB-435 cells
Amelanotic melanoma
CVCL_0417 
[262]
Half Maximal Inhibitory Concentration (IC50) 5 nM
MDA-MB-435 cells
Amelanotic melanoma
CVCL_0417 
[263]
Half Maximal Inhibitory Concentration (IC50) 5 nM
SK-OV-3 cells (FZD7 overexpression)
Ovarian serous cystadenocarcinoma
CVCL_0532 
[241]
Half Maximal Inhibitory Concentration (IC50) 5 nM
MES-SA cells
Uterine sarcoma
CVCL_1404 
[262]
Half Maximal Inhibitory Concentration (IC50) 5 nM
MES-SA cells
Uterine sarcoma
CVCL_1404 
[263]
Half Maximal Inhibitory Concentration (IC50) 5 nM
WI-38 VA13 cells
Normal
CVCL_2759 
[491]
Half Maximal Inhibitory Concentration (IC50) 5 nM
WI-38 VA13 cells
Normal
CVCL_2759 
[697]
Half Maximal Inhibitory Concentration (IC50) 5 nM
WI-38 VA13 cells
Normal
CVCL_2759 
[698]
Half Maximal Inhibitory Concentration (IC50) 5 nM
PT-45 cells
Pancreatic carcinoma
CVCL_8407 
[90]
Half Maximal Inhibitory Concentration (IC50) 5 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[584]
Half Maximal Inhibitory Concentration (IC50) 5 nM
MDA-MB-468 cells
Breast adenocarcinoma
CVCL_0419 
[328]
Half Maximal Inhibitory Concentration (IC50) 5 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[484]
Half Maximal Inhibitory Concentration (IC50) 5 nM
DU145 cells
Prostate carcinoma
CVCL_0105 
[321]
Half Maximal Inhibitory Concentration (IC50) 5 nM
A2780 cells
Ovarian endometrioid adenocarcinoma
CVCL_0134 
[381]
Half Maximal Inhibitory Concentration (IC50) 5 nM
COLO 205 cells
Colon adenocarcinoma
CVCL_0218 
[351]
Half Maximal Inhibitory Concentration (IC50) 5 nM
MDA-MB-435 cells
Amelanotic melanoma
CVCL_0417 
[321]
Half Maximal Inhibitory Concentration (IC50) 5 nM
MDA-MB-435 cells
Amelanotic melanoma
CVCL_0417 
[707]
Half Maximal Inhibitory Concentration (IC50) 5 nM
OVCAR-8 cells
High grade ovarian serous adenocarcinoma
CVCL_1629 
[484]
Half Maximal Inhibitory Concentration (IC50) 5 nM
OVCAR-8 cells
High grade ovarian serous adenocarcinoma
CVCL_1629 
[440]
Half Maximal Inhibitory Concentration (IC50) 5 nM
SK-OV-3 cells (FZD7 overexpression)
Ovarian serous cystadenocarcinoma
CVCL_0532 
[550]
Half Maximal Inhibitory Concentration (IC50) 5 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[687]
Half Maximal Inhibitory Concentration (IC50) 5 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[240]
Half Maximal Inhibitory Concentration (IC50) 5 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[711]
Half Maximal Inhibitory Concentration (IC50) 5 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[712]
Half Maximal Inhibitory Concentration (IC50) 5 nM
MES-SA cells
Uterine sarcoma
CVCL_1404 
[321]
Half Maximal Inhibitory Concentration (IC50) 5 nM
HCT-8 cells
Ileocecal adenocarcinoma
CVCL_2478 
[344]
Half Maximal Inhibitory Concentration (IC50) 5 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[519]
Half Maximal Inhibitory Concentration (IC50) 5 nM
HCT 116 cells
Colon carcinoma
CVCL_0291 
[518]
Half Maximal Inhibitory Concentration (IC50) 5 nM
Huh-7 cells
Adult hepatocellular carcinoma
CVCL_0336 
[519]
Half Maximal Inhibitory Concentration (IC50) 5 nM
NCI-H460 cells
Lung large cell carcinoma
CVCL_0459 
[163]
Half Maximal Inhibitory Concentration (IC50) 5 nM
OVCAR-3 cells (FZD7 overexpression)
Ovarian serous adenocarcinoma
CVCL_0465 
[105]
Half Maximal Inhibitory Concentration (IC50) 5 nM
NCI-H1299 cells (MMAE resistant)
Lung large cell carcinoma
CVCL_0060 
[132]
Half Maximal Inhibitory Concentration (IC50) 5 nM
SK-OV-3 cells (FZD7 overexpression)
Ovarian serous cystadenocarcinoma
CVCL_0532 
[552]
Half Maximal Inhibitory Concentration (IC50) 5 nM
SK-OV-3 cells (FZD7 overexpression)
Ovarian serous cystadenocarcinoma
CVCL_0532 
[390]
Half Maximal Inhibitory Concentration (IC50) 5 nM
SK-OV-3 cells (FZD7 overexpression)
Ovarian serous cystadenocarcinoma
CVCL_0532 
[391]
Half Maximal Inhibitory Concentration (IC50) 5 nM
Human umbilical vein endothelial cells(HUVEC)
Normal
Undisclosed [279]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 5.012 nM
HL-60 cells
Adult acute myeloid leukemia
CVCL_0002 
[253]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 5.012 nM
SK-MEL-2 cells (MEK inhibitor-resistant)
Melanoma
CVCL_0069 
[253]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 5.012 nM
OVCAR-8 cells
High grade ovarian serous adenocarcinoma
CVCL_1629 
[253]
Half Maximal Inhibitory Concentration (IC50) 5.1 nM
K-562 cells
Chronic myelogenous leukemia
CVCL_0004 
[528]
Half Maximal Inhibitory Concentration (IC50) 5.1 nM
KB cells
Human papillomavirus-related endocervical adenocarcinoma
CVCL_0372 
[713]
Half Maximal Inhibitory Concentration (IC50) 5.1 nM
KB cells
Human papillomavirus-related endocervical adenocarcinoma
CVCL_0372 
[714]
Half Maximal Inhibitory Concentration (IC50) 5.1 nM
SGC-7901 cells
Gastric carcinoma
CVCL_0520 
[239]
Half Maximal Inhibitory Concentration (IC50) 5.1 nM
OVCAR-3 cells (FZD7 overexpression)
Ovarian serous adenocarcinoma
CVCL_0465 
[95]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 5.12 nM
KB cells
Human papillomavirus-related endocervical adenocarcinoma
CVCL_0372 
[254]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 5.16 nM
KB cells
Human papillomavirus-related endocervical adenocarcinoma
CVCL_0372 
[308]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 5.2 nM
MDA-MB-231 cells (5T4 overexpression)
Breast adenocarcinoma
CVCL_0062 
[532]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 5.2 nM
A2780-1A9 cells
Ovarian adenocarcinoma
CVCL_H619 
[715]
Half Maximal Inhibitory Concentration (IC50) 5.2 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[609]
Half Maximal Inhibitory Concentration (IC50) 5.2 nM
MDA-MB-435 cells
Amelanotic melanoma
CVCL_0417 
[342]
Half Maximal Inhibitory Concentration (IC50) 5.2 nM
PANC-1 cells
Pancreatic ductal adenocarcinoma
CVCL_0480 
[524]
Half Maximal Inhibitory Concentration (IC50) 5.2 nM
K-562 cells
Chronic myelogenous leukemia
CVCL_0004 
[239]
Half Maximal Inhibitory Concentration (IC50) 5.2 nM
LU-99A cells
Lung giant cell carcinoma
CVCL_1393 
[271]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 5.23 nM
DU145 cells
Prostate carcinoma
CVCL_0105 
[308]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 5.3 nM
HT-29 cells
Colon adenocarcinoma
CVCL_0320 
[716]
Half Maximal Inhibitory Concentration (IC50) 5.3 nM
A2780 cells
Ovarian endometrioid adenocarcinoma
CVCL_0134 
[232]
Half Maximal Inhibitory Concentration (IC50) 5.3 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[274]
Half Maximal Inhibitory Concentration (IC50) 5.3 nM
KU812 cells
Chronic myeloid leukemia
CVCL_0379 
[528]
Half Maximal Inhibitory Concentration (IC50) 5.3 nM
OVCAR-8 cells
High grade ovarian serous adenocarcinoma
CVCL_1629 
[717]
Half Maximal Inhibitory Concentration (IC50) 5.301 nM
DJM-1 cells
Skin squamous cell carcinoma
CVCL_1172 
Half Maximal Inhibitory Concentration (IC50) 5.38 nM
ES8 cells
Ewing sarcoma
CVCL_1204 
Half Maximal Inhibitory Concentration (IC50) 5.4 nM
Hep 3B2.1-7 cells
Childhood hepatocellular carcinoma
CVCL_0326 
[98]
Half Maximal Inhibitory Concentration (IC50) 5.4 nM
MDA-MB-468 cells
Breast adenocarcinoma
CVCL_0419 
[243]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 5.46 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[654]
Half Maximal Inhibitory Concentration (IC50) 5.5 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[377]
Half Maximal Inhibitory Concentration (IC50) 5.5 nM
K-562 cells
Chronic myelogenous leukemia
CVCL_0004 
[692]
Half Maximal Inhibitory Concentration (IC50) 5.5 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[608]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 5.55 nM
DU145 cells
Prostate carcinoma
CVCL_0105 
[696]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 5.568 nM
DU145 cells
Prostate carcinoma
CVCL_0105 
[186]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 5.58 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[696]
Half Maximal Inhibitory Concentration (IC50) 5.59 nM
MX1 cells
Breast carcinoma
CVCL_4774 
[417]
Half Maximal Inhibitory Concentration (IC50) 5.6 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[386]
Half Maximal Inhibitory Concentration (IC50) 5.6 nM
MDA-MB-231 cells (5T4 overexpression)
Breast adenocarcinoma
CVCL_0062 
[718]
Half Maximal Inhibitory Concentration (IC50) 5.62 nM
A2780S cells
Ovarian endometrioid adenocarcinoma
CVCL_4863 
[222]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 5.689 nM
P388 cells
Lymphoma
CVCL_7222 
[345]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 5.7 nM
DU145 cells
Prostate carcinoma
CVCL_0105 
[719]
Half Maximal Inhibitory Concentration (IC50) 5.7 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[655]
Half Maximal Inhibitory Concentration (IC50) 5.7 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[720]
Half Maximal Inhibitory Concentration (IC50) 5.7 nM
A549-Taxol cells
Lung adenocarcinoma
CVCL_W218 
[721]
Half Maximal Inhibitory Concentration (IC50) 5.703 nM
TE-6 cells
Esophageal squamous cell carcinoma
CVCL_1765 
Half Maximal Cell Growth Inhibitory Concentration (GI50) 5.77 nM
NCI-H1975 cells
Lung adenocarcinoma
CVCL_1511 
[523]
Half Maximal Inhibitory Concentration (IC50) 5.79 nM
KB cells
Human papillomavirus-related endocervical adenocarcinoma
CVCL_0372 
[720]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 5.8 nM
PC-3 cells
Prostate carcinoma
CVCL_0035 
[651]
Half Maximal Inhibitory Concentration (IC50) 5.8 nM
HL-60 cells
Adult acute myeloid leukemia
CVCL_0002 
[528]
Half Maximal Inhibitory Concentration (IC50) 5.8 nM
MCF-10A cells
Normal
CVCL_0598 
[722]
Half Maximal Inhibitory Concentration (IC50) 5.816 nM
KS-1 cells
Glioblastoma
CVCL_1343 
Half Maximal Inhibitory Concentration (IC50) 5.9 nM
Hep-G2 cells
Hepatoblastoma
CVCL_0027 
[436]
Half Maximal Inhibitory Concentration (IC50) 5.9 nM
WI-38 VA13 cells
Normal
CVCL_2759 
[708]
Half Maximal Inhibitory Concentration (IC50) 5.9 nM
U-937/GTB cells
Histiocytic lymphoma
CVCL_U631 
[665]
Half Maximal Inhibitory Concentration (IC50) 5.9 nM
U-937/GTB cells
Histiocytic lymphoma
CVCL_U631 
[666]
Half Maximal Inhibitory Concentration (IC50) 5.9 nM
NCI-N87 cells
Gastric tubular adenocarcinoma
CVCL_1603 
[182]
Half Maximal Inhibitory Concentration (IC50) 5.9 nM
KB cells
Human papillomavirus-related endocervical adenocarcinoma
CVCL_0372 
[358]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 5.97 nM
Hs 578T cells
Invasive breast carcinoma
CVCL_0332 
[345]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 50 nM
NCI-H322M cells
Minimally invasive lung adenocarcinoma
CVCL_1557 
[252]
Half Maximal Inhibitory Concentration (IC50) <50 nM
Human umbilical vein endothelial cells(HUVEC)
Normal
Undisclosed [327]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 50 nM
Malme-3M cells
Melanoma
CVCL_1438 
[146]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 50 nM
Malme-3M cells
Melanoma
CVCL_1438 
[147]
Half Maximal Inhibitory Concentration (IC50) 50 nM
HT-29 cells
Colon adenocarcinoma
CVCL_0320 
[90]
Half Maximal Inhibitory Concentration (IC50) 50 nM
SK-OV-3 cells (FZD7 overexpression)
Ovarian serous cystadenocarcinoma
CVCL_0532 
[324]
Half Maximal Inhibitory Concentration (IC50) 50 nM
SF268 cells
Astrocytoma
CVCL_1689 
[324]
Half Maximal Inhibitory Concentration (IC50) 50 nM
Human umbilical vein endothelial cells(HUVEC)
Normal
Undisclosed [293]
Half Maximal Inhibitory Concentration (IC50) 50 nM
P388 cells
Lymphoma
CVCL_7222 
[324]
Half Maximal Inhibitory Concentration (IC50) 50 nM
RXF 944 cells
Renal carcinoma
CVCL_D127 
[334]
Half Maximal Inhibitory Concentration (IC50) 50 nM
LT12 tumor cells
Rat leukemia
CVCL_D271 
[324]
Half Maximal Inhibitory Concentration (IC50) 50 nM
Hep-G2 cells
Hepatoblastoma
CVCL_0027 
[394]
Half Maximal Inhibitory Concentration (IC50) 50 nM
A2780 cells
Ovarian endometrioid adenocarcinoma
CVCL_0134 
[275]
Half Maximal Inhibitory Concentration (IC50) 50 nM
DLD-1 cells
Colon adenocarcinoma
CVCL_0248 
[351]
Half Maximal Inhibitory Concentration (IC50) 50 nM
HCT 116 cells
Colon carcinoma
CVCL_0291 
[361]
Half Maximal Inhibitory Concentration (IC50) 50 nM
WI-38 cells
Normal
CVCL_0579 
[560]
Half Maximal Inhibitory Concentration (IC50) 50 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[723]
Half Maximal Inhibitory Concentration (IC50) 50 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[723]
Half Maximal Inhibitory Concentration (IC50) 50 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[438]
Half Maximal Inhibitory Concentration (IC50) 50 nM
KETR3 cells
Renal carcinoma
CVCL_H579 
[163]
Half Maximal Inhibitory Concentration (IC50) >50 nM
MDA-MB-231/PacR cells
Breast adenocarcinoma
CVCL_4Z64 
[123]
Half Maximal Inhibitory Concentration (IC50) 50.42 nM
SBC-1 cells
Lung small cell carcinoma
CVCL_1676 
Half Maximal Inhibitory Concentration (IC50) 50.45 nM
TALL-1 cells
T acute lymphoblastic leukemia
CVCL_1736 
Half Maximal Cell Growth Inhibitory Concentration (GI50) 50.7 nM
SK-MEL-2 cells (MEK inhibitor-resistant)
Melanoma
CVCL_0069 
[345]
Half Maximal Inhibitory Concentration (IC50) 500 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[460]
Half Maximal Inhibitory Concentration (IC50) >500 nM
A2780/Taxol cells
Ovarian endometrioid adenocarcinoma
CVCL_IJ13 
[517]
Half Maximal Inhibitory Concentration (IC50) >500 nM
A2780/PTX cells
Ovarian endometrioid adenocarcinoma
CVCL_C0D6 
[518]
Half Maximal Inhibitory Concentration (IC50) 5000 nM
HL-60 cells
Adult acute myeloid leukemia
CVCL_0002 
[262]
Half Maximal Inhibitory Concentration (IC50) 5000 nM
HL-60 cells
Adult acute myeloid leukemia
CVCL_0002 
[263]
Half Maximal Inhibitory Concentration (IC50) 5000 nM
MES-SA/Dx5 cells
Uterine sarcoma
CVCL_2598 
[262]
Half Maximal Inhibitory Concentration (IC50) 5000 nM
MES-SA/Dx5 cells
Uterine sarcoma
CVCL_2598 
[263]
Half Maximal Inhibitory Concentration (IC50) 5000 nM
WI-38 VA13 cells
Normal
CVCL_2759 
[701]
Half Maximal Inhibitory Concentration (IC50) 5000 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[461]
Half Maximal Inhibitory Concentration (IC50) 5000 nM
NCI-ADR-RES cells
High grade ovarian serous adenocarcinoma
CVCL_1452 
[274]
Half Maximal Inhibitory Concentration (IC50) 5000 nM
OVCAR-8 cells
High grade ovarian serous adenocarcinoma
CVCL_1629 
[475]
Half Maximal Inhibitory Concentration (IC50) 5000 nM
MDA-MB-231 cells (5T4 overexpression)
Breast adenocarcinoma
CVCL_0062 
[107]
Half Maximal Inhibitory Concentration (IC50) 5000 nM
Peripheral blood mononuclear cells
Normal
Undisclosed [321]
Half Maximal Inhibitory Concentration (IC50) 5000 nM
MES-SA cells
Uterine sarcoma
CVCL_1404 
[321]
Half Maximal Inhibitory Concentration (IC50) 5000 nM
CCD-39Sk cells
Normal
CVCL_2395 
[321]
Half Maximal Inhibitory Concentration (IC50) >5000 nM
L1210 cells
Lymphoblastic leukemia
CVCL_0382 
[257]
Half Maximal Inhibitory Concentration (IC50) >5000 nM
L1210 cells
Lymphoblastic leukemia
CVCL_0382 
[258]
Half Maximal Inhibitory Concentration (IC50) >5000 nM
L1210 cells
Lymphoblastic leukemia
CVCL_0382 
[259]
Half Maximal Inhibitory Concentration (IC50) >5000 nM
L1210 cells
Lymphoblastic leukemia
CVCL_0382 
[260]
Half Maximal Inhibitory Concentration (IC50) >5000 nM
L1210 cells
Lymphoblastic leukemia
CVCL_0382 
[269]
Half Maximal Inhibitory Concentration (IC50) >5000 nM
RAW264.7 cells
Monocytic-macrophage leukemia
CVCL_0493 
[272]
Half Maximal Inhibitory Concentration (IC50) >5000 nM
P388 cells
Lymphoma
CVCL_7222 
[258]
Half Maximal Inhibitory Concentration (IC50) >5000 nM
P388 cells
Lymphoma
CVCL_7222 
[259]
Half Maximal Inhibitory Concentration (IC50) >5000 nM
P388 cells
Lymphoma
CVCL_7222 
[260]
Half Maximal Inhibitory Concentration (IC50) >5000 nM
P388 cells
Lymphoma
CVCL_7222 
[269]
Half Maximal Inhibitory Concentration (IC50) >5000 nM
P388/ADR cells
Lymphoma
CVCL_IZ75 
[257]
Half Maximal Inhibitory Concentration (IC50) >50000 nM
PC-3 cells
Prostate carcinoma
CVCL_0035 
[151]
Half Maximal Cell Growth Inhibitory Concentration (GI50) >50000 nM
NCI-ADR-RES cells
High grade ovarian serous adenocarcinoma
CVCL_1452 
[167]
Half Maximal Inhibitory Concentration (IC50) >50000 nM
MDA-MB-231 cells (5T4 overexpression)
Breast adenocarcinoma
CVCL_0062 
[151]
Half Maximal Inhibitory Concentration (IC50) >50000 nM
SMMC-7721 cells
Hepatocellular carcinoma
CVCL_0534 
[151]
Half Maximal Inhibitory Concentration (IC50) 5003.45 nM
NCI-H1395 cells
Lung adenocarcinoma
CVCL_1467 
Half Maximal Inhibitory Concentration (IC50) 5062.71 nM
RCC10RGB cells
Renal cell carcinoma
CVCL_1647 
Half Maximal Inhibitory Concentration (IC50) 5083.13 nM
COLO-824 cells
Breast carcinoma
CVCL_1136 
Half Maximal Cell Growth Inhibitory Concentration (GI50) 51 nM
1A9/ptx-22 cells
Ovarian adenocarcinoma
CVCL_H621 
[124]
Half Maximal Inhibitory Concentration (IC50) 51 nM
HCT-8 cells
Ileocecal adenocarcinoma
CVCL_2478 
[136]
Half Maximal Inhibitory Concentration (IC50) 51 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[477]
Half Maximal Inhibitory Concentration (IC50) 51 nM
HCT-8 cells
Ileocecal adenocarcinoma
CVCL_2478 
[137]
Half Maximal Inhibitory Concentration (IC50) 51 nM
HCT-8 cells
Ileocecal adenocarcinoma
CVCL_2478 
[138]
Half Maximal Inhibitory Concentration (IC50) 51 nM
HCT-8 cells
Ileocecal adenocarcinoma
CVCL_2478 
[139]
Half Maximal Inhibitory Concentration (IC50) 51.8 nM
L02 cells
Cervical carcinoma
CVCL_6926 
[602]
Half Maximal Inhibitory Concentration (IC50) 5100 nM
MES-SA/Dx5 cells
Uterine sarcoma
CVCL_2598 
[707]
Half Maximal Inhibitory Concentration (IC50) 5100 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[333]
Half Maximal Inhibitory Concentration (IC50) 5140 nM
Human umbilical vein endothelial cells(HUVEC)
Normal
Undisclosed [471]
Half Maximal Inhibitory Concentration (IC50) 5186 nM
NCI-H322M cells
Minimally invasive lung adenocarcinoma
CVCL_1557 
Half Maximal Inhibitory Concentration (IC50) 5190 nM
OV-90 cells
Ovarian adenocarcinoma
CVCL_3768 
[250]
Half Maximal Inhibitory Concentration (IC50) 52 nM
MDA-MB-231 cells (5T4 overexpression)
Breast adenocarcinoma
CVCL_0062 
[724]
Half Maximal Inhibitory Concentration (IC50) 52.08 nM
NCI-H1304 cells
Lung small cell carcinoma
CVCL_1462 
Half Maximal Inhibitory Concentration (IC50) 52.86 nM
NEC8 cells
Testicular embryonal carcinoma
CVCL_1604 
Half Maximal Inhibitory Concentration (IC50) 520 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[527]
Half Maximal Inhibitory Concentration (IC50) 520 nM
CHO-TAX 5-6 cells
Normal
CVCL_U346 
[85]
Half Maximal Inhibitory Concentration (IC50) 520 nM
CHO-TAX 5-6 cells
Normal
CVCL_U346 
[86]
Half Maximal Inhibitory Concentration (IC50) 523 nM
MRC5 cells
Normal
CVCL_0440 
[119]
Half Maximal Inhibitory Concentration (IC50) 5232.88 nM
SW684 cells
Fibrosarcoma
CVCL_1726 
Half Maximal Inhibitory Concentration (IC50) 524.79 nM
TE-441-T cells
Rhabdomyosarcoma
CVCL_1754 
Half Maximal Cell Growth Inhibitory Concentration (GI50) 528.45 nM
LXFL 529 cells
Non-small cell lung carcinoma
CVCL_D085 
[345]
Half Maximal Inhibitory Concentration (IC50) 53 nM
AGS cells
Gastric adenocarcinoma
CVCL_0139 
[192]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 53.95 nM
T-47D cells
Invasive breast carcinoma
CVCL_0553 
[345]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 53.95 nM
MDA-MB-231 cells (5T4 overexpression)
Breast adenocarcinoma
CVCL_0062 
[345]
Half Maximal Inhibitory Concentration (IC50) 530 nM
SK-OV-3 cells (FZD7 overexpression)
Ovarian serous cystadenocarcinoma
CVCL_0532 
[559]
Half Maximal Inhibitory Concentration (IC50) 530 nM
B16-F10 cells
Mouse melanoma
CVCL_0159 
[470]
Half Maximal Inhibitory Concentration (IC50) 530 nM
B16-F10 cells
Mouse melanoma
CVCL_0159 
[307]
Half Maximal Inhibitory Concentration (IC50) 5300 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[475]
Half Maximal Inhibitory Concentration (IC50) 5300 nM
SPC-A1 cells
Endocervical adenocarcinoma
CVCL_6955 
[273]
Half Maximal Inhibitory Concentration (IC50) 53000 nM
AGS cells
Gastric adenocarcinoma
CVCL_0139 
[680]
Half Maximal Inhibitory Concentration (IC50) 532.95 nM
1A9/ptx-10 cells
Ovarian adenocarcinoma
CVCL_H620 
[196]
Half Maximal Inhibitory Concentration (IC50) 532.95 nM
1A9/ptx-10 cells
Ovarian adenocarcinoma
CVCL_H620 
[197]
Half Maximal Inhibitory Concentration (IC50) 532.95 nM
1A9/ptx-10 cells
Ovarian adenocarcinoma
CVCL_H620 
[199]
Half Maximal Inhibitory Concentration (IC50) 5340 nM
MDA-MB-231 cells (5T4 overexpression)
Breast adenocarcinoma
CVCL_0062 
[725]
Half Maximal Inhibitory Concentration (IC50) 535 nM
A2780 ADR cells
Ovarian endometrioid adenocarcinoma
CVCL_1941 
[31]
Half Maximal Inhibitory Concentration (IC50) 5350.52 nM
P30-OHK cells
B acute lymphoblastic leukemia
CVCL_1631 
Half Maximal Inhibitory Concentration (IC50) 53900 nM
NIH-3T3-G185 cells
Nornal
CVCL_L991 
[726]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 54 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[675]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 54 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[443]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 54 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[444]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 54 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[445]
Half Maximal Inhibitory Concentration (IC50) 54 nM
Hep-G2 cells
Hepatoblastoma
CVCL_0027 
[724]
Half Maximal Inhibitory Concentration (IC50) 54.39 nM
CAL-148 cells
Breast carcinoma
CVCL_1106 
Half Maximal Inhibitory Concentration (IC50) 54.49 nM
CGTH-W-1 cells
Thyroid gland squamous cell carcinoma
CVCL_1120 
Half Maximal Inhibitory Concentration (IC50) 540 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[343]
Half Maximal Inhibitory Concentration (IC50) 540 nM
L02 cells
Cervical carcinoma
CVCL_6926 
[301]
Half Maximal Inhibitory Concentration (IC50) 5400 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[333]
Half Maximal Inhibitory Concentration (IC50) 54000 nM
NIH-3T3-G185 cells
Nornal
CVCL_L991 
[726]
Half Maximal Inhibitory Concentration (IC50) 54800 nM
MCF7/PTX cells
Invasive ductal carcinoma
CVCL_C5RS 
[373]
Half Maximal Inhibitory Concentration (IC50) 5498.84 nM
COLO-829 cells
Cutaneous melanoma
CVCL_1137 
Half Maximal Effective Concentration (EC50) 55.5 nM
PC-3 cells
Prostate carcinoma
CVCL_0035 
[149]
Half Maximal Inhibitory Concentration (IC50) 55.7 nM
WI-38 cells
Normal
CVCL_0579 
[417]
Half Maximal Inhibitory Concentration (IC50) 55.92 nM
NCI-H889 cells
Lung small cell carcinoma
CVCL_1598 
Half Maximal Inhibitory Concentration (IC50) 550 nM
MCF7R cells
Breast carcinoma
CVCL_Y493 
[233]
Half Maximal Inhibitory Concentration (IC50) 5500 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[481]
Half Maximal Inhibitory Concentration (IC50) 5560 nM
143B cells
Osteosarcoma
CVCL_2270 
[431]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 56 nM
MIA PaCa-2 cells (MSLN expression)
Pancreatic ductal adenocarcinoma
CVCL_0428 
[594]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 56 nM
MIA PaCa-2 cells (MSLN expression)
Pancreatic ductal adenocarcinoma
CVCL_0428 
[595]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 56 nM
MIA PaCa-2 cells (MSLN expression)
Pancreatic ductal adenocarcinoma
CVCL_0428 
[596]
Half Maximal Inhibitory Concentration (IC50) 56 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[724]
Half Maximal Inhibitory Concentration (IC50) 56 nM
SF-295 cells
Glioblastoma
CVCL_1690 
[272]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 56.1 nM
MIA PaCa-2 cells (MSLN expression)
Pancreatic ductal adenocarcinoma
CVCL_0428 
[596]
Half Maximal Inhibitory Concentration (IC50) 56.21 nM
GR-ST cells
B acute lymphoblastic leukemia
CVCL_1236 
Half Maximal Inhibitory Concentration (IC50) 56.5 nM
Karpas-422 cells
Diffuse large B-cell lymphoma
CVCL_1325 
Half Maximal Inhibitory Concentration (IC50) 560 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[93]
Half Maximal Inhibitory Concentration (IC50) 5600 nM
L02 cells
Cervical carcinoma
CVCL_6926 
[615]
Half Maximal Inhibitory Concentration (IC50) 56000 nM
B16 cells
Melanoma
CVCL_F936 
[727]
Half Maximal Inhibitory Concentration (IC50) 56120 nM
MDA-MB-231 cells (5T4 overexpression)
Breast adenocarcinoma
CVCL_0062 
[587]
Half Maximal Inhibitory Concentration (IC50) 5630 nM
K-562 cells
Chronic myelogenous leukemia
CVCL_0004 
[368]
Half Maximal Inhibitory Concentration (IC50) 5630 nM
K-562 cells
Chronic myelogenous leukemia
CVCL_0004 
[372]
Half Maximal Inhibitory Concentration (IC50) 56600 nM
A2780/Taxol cells
Ovarian endometrioid adenocarcinoma
CVCL_IJ13 
[492]
Half Maximal Inhibitory Concentration (IC50) 5680 nM
A2780/Taxol cells
Ovarian endometrioid adenocarcinoma
CVCL_IJ13 
[381]
Half Maximal Inhibitory Concentration (IC50) 57.12 nM
RPMI-8866 cells
Chronic myelogenous leukemia
CVCL_1668 
Half Maximal Inhibitory Concentration (IC50) 570 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[93]
Half Maximal Inhibitory Concentration (IC50) 57200 nM
PC-3 cells
Prostate carcinoma
CVCL_0035 
[316]
Half Maximal Inhibitory Concentration (IC50) 5731.85 nM
HAL-01 cells
B acute lymphoblastic leukemia
CVCL_1242 
Half Maximal Inhibitory Concentration (IC50) 578.2 nM
Bel-7402 cells
Hepatoma
CVCL_5492 
[182]
Half Maximal Inhibitory Concentration (IC50) 58 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[234]
Half Maximal Inhibitory Concentration (IC50) 58 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[352]
Half Maximal Inhibitory Concentration (IC50) 58.1 nM
A2780S cells
Ovarian endometrioid adenocarcinoma
CVCL_4863 
[492]
Half Maximal Inhibitory Concentration (IC50) 58.5 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[120]
Half Maximal Inhibitory Concentration (IC50) 58.84 nM
SCLC-21H cells
Lung small cell carcinoma
CVCL_0024 
Half Maximal Inhibitory Concentration (IC50) 580 nM
BEAS-2B cells
Normal
CVCL_0168 
[728]
Half Maximal Inhibitory Concentration (IC50) 580 nM
BEAS-2B cells
Normal
CVCL_0168 
[729]
Half Maximal Inhibitory Concentration (IC50) 580 nM
NIH3T3 cells
Normal
CVCL_0594 
[631]
Half Maximal Inhibitory Concentration (IC50) 5800 nM
K-562 cells
Chronic myelogenous leukemia
CVCL_0004 
[373]
Half Maximal Inhibitory Concentration (IC50) 5800 nM
HEK293 cells
Normal
CVCL_0045 
[474]
Half Maximal Inhibitory Concentration (IC50) 5820 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[725]
Half Maximal Inhibitory Concentration (IC50) 585 nM
MCF7-DOX cells
Breast carcinoma
Undisclosed [116]
Half Maximal Inhibitory Concentration (IC50) 58700 nM
NCI-ADR-RES cells
High grade ovarian serous adenocarcinoma
CVCL_1452 
[730]
Half Maximal Inhibitory Concentration (IC50) 58855 nM
A2780/Taxol cells
Ovarian endometrioid adenocarcinoma
CVCL_IJ13 
[590]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 59 nM
Hep-G2 cells
Hepatoblastoma
CVCL_0027 
[731]
Half Maximal Inhibitory Concentration (IC50) 59 nM
MDA-MB-231 cells (5T4 overexpression)
Breast adenocarcinoma
CVCL_0062 
[722]
Half Maximal Inhibitory Concentration (IC50) 59.27 nM
COR-L88 cells
Lung small cell carcinoma
CVCL_1141 
Half Maximal Cell Growth Inhibitory Concentration (GI50) 5900 nM
Farage cells
Normal
CVCL_0214 
[376]
Half Maximal Inhibitory Concentration (IC50) 5900 nM
KB cells
Human papillomavirus-related endocervical adenocarcinoma
CVCL_0372 
[367]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 5943 nM
NCI-ADR-RES cells
High grade ovarian serous adenocarcinoma
CVCL_1452 
[488]
Half Maximal Inhibitory Concentration (IC50) 599.24 nM
D-247MG cells
Gliosarcoma
CVCL_1153 
Half Maximal Cell Growth Inhibitory Concentration (GI50) 6 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[715]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 6 nM
DU145 cells
Prostate carcinoma
CVCL_0105 
[732]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 6 nM
DU145 cells
Prostate carcinoma
CVCL_0105 
[733]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 6 nM
DU145 cells
Prostate carcinoma
CVCL_0105 
[734]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 6 nM
DU145 cells
Prostate carcinoma
CVCL_0105 
[735]
Half Maximal Inhibitory Concentration (IC50) 6 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[89]
Half Maximal Inhibitory Concentration (IC50) 6 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[90]
Half Maximal Inhibitory Concentration (IC50) 6 nM
KB cells
Human papillomavirus-related endocervical adenocarcinoma
CVCL_0372 
[736]
Half Maximal Inhibitory Concentration (IC50) 6 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[685]
Half Maximal Inhibitory Concentration (IC50) 6 nM
KB 3-1 cells
Cervical epithelial carcinoma
CVCL_2088 
[660]
Half Maximal Inhibitory Concentration (IC50) 6 nM
LT12 tumor cells
Rat leukemia
CVCL_D271 
[257]
Half Maximal Inhibitory Concentration (IC50) 6 nM
LT12 tumor cells
Rat leukemia
CVCL_D271 
[258]
Half Maximal Inhibitory Concentration (IC50) 6 nM
LT12 tumor cells
Rat leukemia
CVCL_D271 
[260]
Half Maximal Inhibitory Concentration (IC50) 6 nM
HuO9-L12 cells
Osteosarcoma
CVCL_WL12 
[259]
Half Maximal Inhibitory Concentration (IC50) 6 nM
HSmC-78 cells
Squamous cell carcinoma of salivary glands
CVCL_M122 
[575]
Half Maximal Inhibitory Concentration (IC50) 6 nM
NPC-TW01 cells
Nasopharyngeal carcinoma
CVCL_6008 
[471]
Half Maximal Inhibitory Concentration (IC50) 6 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[686]
Half Maximal Inhibitory Concentration (IC50) 6 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[631]
Half Maximal Inhibitory Concentration (IC50) 6 nM
U-937 cells
Adult acute monocytic leukemia
CVCL_0007 
[108]
Half Maximal Inhibitory Concentration (IC50) 6 nM
Hep-G2 cells
Hepatoblastoma
CVCL_0027 
[380]
Half Maximal Inhibitory Concentration (IC50) 6 nM
Hep-G2 cells
Hepatoblastoma
CVCL_0027 
[564]
Half Maximal Inhibitory Concentration (IC50) 6 nM
A2780 cells
Ovarian endometrioid adenocarcinoma
CVCL_0134 
[631]
Half Maximal Inhibitory Concentration (IC50) 6 nM
HT-29 cells
Colon adenocarcinoma
CVCL_0320 
[737]
Half Maximal Inhibitory Concentration (IC50) 6 nM
MIA PaCa-2 cells (MSLN expression)
Pancreatic ductal adenocarcinoma
CVCL_0428 
[712]
Half Maximal Inhibitory Concentration (IC50) 6 nM
NCI-H292 cells
Lung mucoepidermoid carcinoma
CVCL_0455 
[738]
Half Maximal Inhibitory Concentration (IC50) 6 nM
NCI-H460 cells
Lung large cell carcinoma
CVCL_0459 
[432]
Half Maximal Inhibitory Concentration (IC50) 6 nM
SK-OV-3 cells (FZD7 overexpression)
Ovarian serous cystadenocarcinoma
CVCL_0532 
[351]
Half Maximal Inhibitory Concentration (IC50) 6 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[739]
Half Maximal Inhibitory Concentration (IC50) 6 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[740]
Half Maximal Inhibitory Concentration (IC50) 6 nM
BT-549 cells
Breast ductal carcinoma
CVCL_1092 
[351]
Half Maximal Inhibitory Concentration (IC50) 6 nM
UACC-62 cells
Melanoma
CVCL_1780 
[272]
Half Maximal Inhibitory Concentration (IC50) 6 nM
Bel-7402 cells
Hepatoma
CVCL_5492 
[137]
Half Maximal Inhibitory Concentration (IC50) 6 nM
Bel-7402 cells
Hepatoma
CVCL_5492 
[138]
Half Maximal Inhibitory Concentration (IC50) 6 nM
Bel-7402 cells
Hepatoma
CVCL_5492 
[139]
Half Maximal Inhibitory Concentration (IC50) 6 nM
LT12 tumor cells
Rat leukemia
CVCL_D271 
[269]
Half Maximal Inhibitory Concentration (IC50) 6 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[453]
Half Maximal Inhibitory Concentration (IC50) 6 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[518]
Half Maximal Inhibitory Concentration (IC50) 6 nM
HCT 116 cells
Colon carcinoma
CVCL_0291 
[519]
Half Maximal Inhibitory Concentration (IC50) 6.01 nM
NCI-H460 cells
Lung large cell carcinoma
CVCL_0459 
[222]
Half Maximal Inhibitory Concentration (IC50) 6.059 nM
TF-1 cells
Esophageal squamous cell carcinoma
CVCL_1759 
Half Maximal Inhibitory Concentration (IC50) 6.09 nM
ATN-1 cells
T acute lymphoblastic leukemia
CVCL_1073 
Half Maximal Inhibitory Concentration (IC50) 6.1 nM
A121 cells
Ovarian carcinoma
CVCL_G294 
Half Maximal Inhibitory Concentration (IC50) 6.1 nM
A121 cells
Ovarian carcinoma
CVCL_G294 
Half Maximal Inhibitory Concentration (IC50) 6.1 nM
A121 cells
Ovarian carcinoma
CVCL_G294 
[225]
Half Maximal Inhibitory Concentration (IC50) 6.1 nM
A121 cells
Ovarian carcinoma
CVCL_G294 
[227]
Half Maximal Inhibitory Concentration (IC50) 6.1 nM
A121 cells
Ovarian carcinoma
CVCL_G294 
[228]
Half Maximal Inhibitory Concentration (IC50) 6.1 nM
MDA-MB-468 cells
Breast adenocarcinoma
CVCL_0419 
[722]
Half Maximal Inhibitory Concentration (IC50) 6.1 nM
HCT 116 cells
Colon carcinoma
CVCL_0291 
[271]
Half Maximal Inhibitory Concentration (IC50) 6.1 nM
HT-29 cells
Colon adenocarcinoma
CVCL_0320 
[434]
Half Maximal Inhibitory Concentration (IC50) 6.1 nM
MIA PaCa-2 cells (MSLN expression)
Pancreatic ductal adenocarcinoma
CVCL_0428 
[271]
Half Maximal Inhibitory Concentration (IC50) 6.1 nM
KB cells
Human papillomavirus-related endocervical adenocarcinoma
CVCL_0372 
[356]
Half Maximal Inhibitory Concentration (IC50) 6.1 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[452]
Half Maximal Inhibitory Concentration (IC50) 6.109 nM
A4-Fuk cells
B acute lymphoblastic leukemia
CVCL_1064 
Half Maximal Inhibitory Concentration (IC50) 6.13 nM
HCT 116 cells
Colon carcinoma
CVCL_0291 
[244]
Half Maximal Inhibitory Concentration (IC50) 6.2 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[286]
Half Maximal Inhibitory Concentration (IC50) 6.2 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[357]
Half Maximal Inhibitory Concentration (IC50) 6.2 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[741]
Half Maximal Inhibitory Concentration (IC50) 6.2 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[239]
Half Maximal Inhibitory Concentration (IC50) 6.2 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[356]
Half Maximal Inhibitory Concentration (IC50) <6.25 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[626]
Half Maximal Inhibitory Concentration (IC50) 6.27 nM
KB cells
Human papillomavirus-related endocervical adenocarcinoma
CVCL_0372 
[286]
Half Maximal Inhibitory Concentration (IC50) 6.298 nM
ALL-PO cells
B acute lymphoblastic leukemia
CVCL_1069 
Half Maximal Cell Growth Inhibitory Concentration (GI50) 6.3 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[146]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 6.3 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[147]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 6.3 nM
PC-3 cells
Prostate carcinoma
CVCL_0035 
[146]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 6.3 nM
PC-3 cells
Prostate carcinoma
CVCL_0035 
[147]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 6.3 nM
SN12C cells
Renal cell carcinoma
CVCL_1705 
[146]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 6.3 nM
SN12C cells
Renal cell carcinoma
CVCL_1705 
[147]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 6.3 nM
K-562 cells
Chronic myelogenous leukemia
CVCL_0004 
[146]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 6.3 nM
K-562 cells
Chronic myelogenous leukemia
CVCL_0004 
[147]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 6.3 nM
U-251MG cells
Astrocytoma
CVCL_0021 
[146]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 6.3 nM
U-251MG cells
Astrocytoma
CVCL_0021 
[147]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 6.3 nM
DU145 cells
Prostate carcinoma
CVCL_0105 
[146]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 6.3 nM
DU145 cells
Prostate carcinoma
CVCL_0105 
[147]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 6.3 nM
NCI-H460 cells
Lung large cell carcinoma
CVCL_0459 
[146]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 6.3 nM
NCI-H460 cells
Lung large cell carcinoma
CVCL_0459 
[147]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 6.3 nM
IGROV-1 cells
Ovarian endometrioid adenocarcinoma
CVCL_1304 
[146]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 6.3 nM
IGROV-1 cells
Ovarian endometrioid adenocarcinoma
CVCL_1304 
[147]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 6.3 nM
NCI-H23 cells
Lung adenocarcinoma
CVCL_1547 
[146]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 6.3 nM
NCI-H23 cells
Lung adenocarcinoma
CVCL_1547 
[147]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 6.3 nM
SK-OV-3 cells (FZD7 overexpression)
Ovarian serous cystadenocarcinoma
CVCL_0532 
[146]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 6.3 nM
SK-OV-3 cells (FZD7 overexpression)
Ovarian serous cystadenocarcinoma
CVCL_0532 
[147]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 6.3 nM
SR cells
Leukemia
CVCL_1711 
[146]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 6.3 nM
SR cells
Leukemia
CVCL_1711 
[147]
Half Maximal Inhibitory Concentration (IC50) 6.3 nM
A121 cells
Ovarian carcinoma
CVCL_G294 
Half Maximal Inhibitory Concentration (IC50) 6.3 nM
A2780 cells
Ovarian endometrioid adenocarcinoma
CVCL_0134 
[294]
Half Maximal Inhibitory Concentration (IC50) 6.3 nM
A121 cells
Ovarian carcinoma
CVCL_G294 
[226]
Half Maximal Inhibitory Concentration (IC50) 6.3 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[133]
Half Maximal Inhibitory Concentration (IC50) 6.3 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[355]
Half Maximal Inhibitory Concentration (IC50) 6.3 nM
Hep-G2 cells
Hepatoblastoma
CVCL_0027 
[129]
Half Maximal Inhibitory Concentration (IC50) 6.3 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[339]
Half Maximal Inhibitory Concentration (IC50) 6.3 nM
KB cells
Human papillomavirus-related endocervical adenocarcinoma
CVCL_0372 
[741]
Half Maximal Inhibitory Concentration (IC50) 6.3 nM
SK-OV-3 cells (FZD7 overexpression)
Ovarian serous cystadenocarcinoma
CVCL_0532 
[242]
Half Maximal Inhibitory Concentration (IC50) 6.3 nM
HCT-116/VP35 cells
Colon carcinoma
CVCL_N509 
[243]
Half Maximal Inhibitory Concentration (IC50) 6.3 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[287]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 6.31 nM
BT-549 cells
Breast ductal carcinoma
CVCL_1092 
[253]
Half Maximal Inhibitory Concentration (IC50) 6.363 nM
BE-13 cells
T acute lymphoblastic leukemia
CVCL_1081 
Half Maximal Inhibitory Concentration (IC50) 6.373 nM
KM12 cells
Colon adenocarcinoma
CVCL_1331 
Half Maximal Cell Growth Inhibitory Concentration (GI50) 6.4 nM
KB cells
Human papillomavirus-related endocervical adenocarcinoma
CVCL_0372 
[732]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 6.4 nM
KB cells
Human papillomavirus-related endocervical adenocarcinoma
CVCL_0372 
[734]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 6.4 nM
KB cells
Human papillomavirus-related endocervical adenocarcinoma
CVCL_0372 
[719]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 6.4 nM
KB cells
Human papillomavirus-related endocervical adenocarcinoma
CVCL_0372 
[735]
Half Maximal Inhibitory Concentration (IC50) 6.4 nM
Hep-G2 cells
Hepatoblastoma
CVCL_0027 
[602]
Half Maximal Inhibitory Concentration (IC50) 6.4 nM
MGC-803 cells
Gastric cancer
CVCL_5334 
[73]
Half Maximal Inhibitory Concentration (IC50) 6.4 nM
MGC-803 cells
Gastric cancer
CVCL_5334 
[74]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 6.486 nM
RXF 393 cells
Renal carcinoma
CVCL_1673 
[345]
Half Maximal Inhibitory Concentration (IC50) 6.496 nM
NOS-1 cells
Osteosarcoma
CVCL_1610 
Half Maximal Cell Growth Inhibitory Concentration (GI50) 6.5 nM
DU145 cells
Prostate carcinoma
CVCL_0105 
[742]
Half Maximal Inhibitory Concentration (IC50) 6.5 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[534]
Half Maximal Inhibitory Concentration (IC50) 6.5 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[413]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 6.577 nM
SF268 cells
Astrocytoma
CVCL_1689 
[345]
Half Maximal Inhibitory Concentration (IC50) 6.6 nM
KB cells
Human papillomavirus-related endocervical adenocarcinoma
CVCL_0372 
[357]
Half Maximal Inhibitory Concentration (IC50) 6.6 nM
MDA-MB-231 cells (5T4 overexpression)
Breast adenocarcinoma
CVCL_0062 
[655]
Half Maximal Inhibitory Concentration (IC50) 6.6 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[454]
Half Maximal Inhibitory Concentration (IC50) 6.617 nM
OCUB-M cells
Breast carcinoma
CVCL_1621 
Half Maximal Inhibitory Concentration (IC50) 6.623 nM
SW 962 cells
Vulva lymphoid carcinoma
CVCL_1733 
Half Maximal Inhibitory Concentration (IC50) 6.652 nM
NCI-H510A cells
Lung small cell carcinoma
CVCL_1565 
Half Maximal Inhibitory Concentration (IC50) 6.69 nM
KB cells
Human papillomavirus-related endocervical adenocarcinoma
CVCL_0372 
[265]
Half Maximal Inhibitory Concentration (IC50) 6.7 nM
HEK-293T cells
Normal
CVCL_0063 
[635]
Half Maximal Inhibitory Concentration (IC50) 6.8 nM
NCI-H226 cells
Pleural epithelioid mesothelioma
CVCL_1544 
[98]
Half Maximal Inhibitory Concentration (IC50) 6.8 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[511]
Half Maximal Inhibitory Concentration (IC50) 6.8 nM
KB cells
Human papillomavirus-related endocervical adenocarcinoma
CVCL_0372 
[355]
Half Maximal Inhibitory Concentration (IC50) 6.85 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[358]
Half Maximal Inhibitory Concentration (IC50) 6.937 nM
EW-16 cells
Ewing sarcoma
CVCL_1212 
Half Maximal Cell Growth Inhibitory Concentration (GI50) 60 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[487]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 60 nM
HCT 116 cells
Colon carcinoma
CVCL_0291 
[605]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 60 nM
HCT 116 cells
Colon carcinoma
CVCL_0291 
[606]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 60 nM
MIA PaCa-2 cells (MSLN expression)
Pancreatic ductal adenocarcinoma
CVCL_0428 
[678]
Half Maximal Inhibitory Concentration (IC50) 60 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[89]
Half Maximal Inhibitory Concentration (IC50) 60 nM
IGROV-1 cells
Ovarian endometrioid adenocarcinoma
CVCL_1304 
[743]
Half Maximal Inhibitory Concentration (IC50) 60 nM
Human umbilical vein endothelial cells(HUVEC)
Normal
Undisclosed [398]
Half Maximal Inhibitory Concentration (IC50) 60 nM
L1210 cells
Lymphoblastic leukemia
CVCL_0382 
[257]
Half Maximal Inhibitory Concentration (IC50) 60 nM
L1210 cells
Lymphoblastic leukemia
CVCL_0382 
[258]
Half Maximal Inhibitory Concentration (IC50) 60 nM
L1210 cells
Lymphoblastic leukemia
CVCL_0382 
[259]
Half Maximal Inhibitory Concentration (IC50) 60 nM
L1210 cells
Lymphoblastic leukemia
CVCL_0382 
[324]
Half Maximal Inhibitory Concentration (IC50) 60 nM
L1210 cells
Lymphoblastic leukemia
CVCL_0382 
[260]
Half Maximal Inhibitory Concentration (IC50) 60 nM
Bel-7402 cells
Hepatoma
CVCL_5492 
[136]
Half Maximal Inhibitory Concentration (IC50) 60 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[564]
Half Maximal Inhibitory Concentration (IC50) 60 nM
L1210 cells
Lymphoblastic leukemia
CVCL_0382 
[269]
Half Maximal Inhibitory Concentration (IC50) 60 nM
Hep-G2 cells
Hepatoblastoma
CVCL_0027 
[723]
Half Maximal Inhibitory Concentration (IC50) 60 nM
MDA-MB-231 cells (5T4 overexpression)
Breast adenocarcinoma
CVCL_0062 
[134]
Half Maximal Inhibitory Concentration (IC50) 60 nM
OVCAR cells
Ovarian adenocarcinoma
Undisclosed [363]
Half Maximal Inhibitory Concentration (IC50) 60 nM
RCC4/VHL cells
Clear cell renal cell carcinoma
CVCL_2706 
[250]
Half Maximal Inhibitory Concentration (IC50) 60.4 nM
A2780S cells
Ovarian endometrioid adenocarcinoma
CVCL_4863 
[590]
Half Maximal Inhibitory Concentration (IC50) 600 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[264]
Half Maximal Inhibitory Concentration (IC50) >600 nM
KB 3-1 cells
Cervical epithelial carcinoma
CVCL_2088 
[522]
Half Maximal Inhibitory Concentration (IC50) 6000 nM
L1210 cells
Lymphoblastic leukemia
CVCL_0382 
Half Maximal Inhibitory Concentration (IC50) 6000 nM
P388 cells
Lymphoma
CVCL_7222 
Half Maximal Inhibitory Concentration (IC50) 6000 nM
NCI-ADR-RES cells
High grade ovarian serous adenocarcinoma
CVCL_1452 
[328]
Half Maximal Inhibitory Concentration (IC50) >6000 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[377]
Half Maximal Inhibitory Concentration (IC50) >600000 nM
OVCAR-4 cells
Ovarian adenocarcinoma
CVCL_1627 
[464]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 605.34 nM
P388/ADR cells
Lymphoma
CVCL_IZ75 
[345]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 61 nM
SNU-398 cells
Hepatocellular carcinoma
CVCL_0077 
[605]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 61 nM
SNU-398 cells
Hepatocellular carcinoma
CVCL_0077 
[606]
Half Maximal Inhibitory Concentration (IC50) 61 nM
Lewis lung carcinoma cells
Lung carcinoma
CVCL_4358 
Half Maximal Inhibitory Concentration (IC50) 61 nM
HCT 116 cells
Colon carcinoma
CVCL_0291 
[471]
Half Maximal Inhibitory Concentration (IC50) 61 nM
A498 cells
Renal carcinoma
CVCL_1056 
[98]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 6100 nM
SK-BR-3 cells
Breast adenocarcinoma
CVCL_0033 
[744]
Half Maximal Inhibitory Concentration (IC50) 6100 nM
L02 cells
Cervical carcinoma
CVCL_6926 
[670]
Half Maximal Inhibitory Concentration (IC50) 612 nM
MDA-MB-435 cells
Amelanotic melanoma
CVCL_0417 
[126]
Half Maximal Inhibitory Concentration (IC50) 6125 nM
CHO cells
Normal
CVCL_0213 
[483]
Half Maximal Inhibitory Concentration (IC50) 618.87 nM
SNU-C1 cells
Colon adenocarcinoma
CVCL_1708 
Half Maximal Inhibitory Concentration (IC50) 6180 nM
HCT 116 cells
Colon carcinoma
CVCL_0291 
[424]
Half Maximal Inhibitory Concentration (IC50) 61800 nM
Hep-G2 cells
Hepatoblastoma
CVCL_0027 
[625]
Half Maximal Inhibitory Concentration (IC50) 6195 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[365]
Half Maximal Inhibitory Concentration (IC50) 62.01 nM
OVCAR-3 cells (FZD7 overexpression)
Ovarian serous adenocarcinoma
CVCL_0465 
[121]
Half Maximal Inhibitory Concentration (IC50) 620 nM
Hep-G2 cells
Hepatoblastoma
CVCL_0027 
[424]
Half Maximal Inhibitory Concentration (IC50) 6200 nM
NCI-ADR-RES cells
High grade ovarian serous adenocarcinoma
CVCL_1452 
[631]
Half Maximal Inhibitory Concentration (IC50) 6200 nM
MDA-MB-231 cells (5T4 overexpression)
Breast adenocarcinoma
CVCL_0062 
[745]
Half Maximal Inhibitory Concentration (IC50) 6200 nM
SK-OV-3 cells (FZD7 overexpression)
Ovarian serous cystadenocarcinoma
CVCL_0532 
[648]
Half Maximal Inhibitory Concentration (IC50) 6200 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[326]
Half Maximal Inhibitory Concentration (IC50) 626 nM
KB cells
Human papillomavirus-related endocervical adenocarcinoma
CVCL_0372 
[554]
Half Maximal Inhibitory Concentration (IC50) 6263 nM
NCI-ADR-RES cells
High grade ovarian serous adenocarcinoma
CVCL_1452 
[746]
Half Maximal Inhibitory Concentration (IC50) 628.9 nM
SU-DHL-1 cells
Anaplastic large cell lymphoma
CVCL_0538 
Half Maximal Inhibitory Concentration (IC50) 6290 nM
SK-OV-3 cells (FZD7 overexpression)
Ovarian serous cystadenocarcinoma
CVCL_0532 
[373]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 63 nM
MES-SA/Dx5 cells
Uterine sarcoma
CVCL_2598 
[330]
Half Maximal Inhibitory Concentration (IC50) 63.3 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[720]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 630 nM
NCI-ADR-RES cells
High grade ovarian serous adenocarcinoma
CVCL_1452 
[146]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 630 nM
NCI-ADR-RES cells
High grade ovarian serous adenocarcinoma
CVCL_1452 
[147]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 630 nM
OVCAR-4 cells
Ovarian adenocarcinoma
CVCL_1627 
[146]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 630 nM
OVCAR-4 cells
Ovarian adenocarcinoma
CVCL_1627 
[147]
Half Maximal Inhibitory Concentration (IC50) 630 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[439]
Half Maximal Inhibitory Concentration (IC50) 630 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[93]
Half Maximal Inhibitory Concentration (IC50) 6300 nM
Bel-7402 cells
Hepatoma
CVCL_5492 
[150]
Half Maximal Inhibitory Concentration (IC50) 6320 nM
LNCaP cells
Prostate carcinoma
CVCL_0395 
[710]
Half Maximal Inhibitory Concentration (IC50) 6344.89 nM
LNCaP-Clone-FGC cells
Prostate carcinoma
CVCL_1379 
Half Maximal Cell Growth Inhibitory Concentration (GI50) 64 nM
1A9/ptx-10 cells
Ovarian adenocarcinoma
CVCL_H620 
[124]
Half Maximal Inhibitory Concentration (IC50) 64.24 nM
NCI-H1882 cells
Lung small cell carcinoma
CVCL_1504 
Half Maximal Inhibitory Concentration (IC50) 64.83 nM
EW-24 cells
Ewing sarcoma
CVCL_1215 
Half Maximal Inhibitory Concentration (IC50) 640 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[301]
Half Maximal Inhibitory Concentration (IC50) >6400 nM
NCI-ADR-RES cells
High grade ovarian serous adenocarcinoma
CVCL_1452 
[221]
Half Maximal Inhibitory Concentration (IC50) 6420 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[426]
Half Maximal Inhibitory Concentration (IC50) 65.6 nM
J774 cells
Mouse reticulum cell sarcoma
CVCL_4692 
Half Maximal Inhibitory Concentration (IC50) 65.8 nM
SK-OV-3 cells (FZD7 overexpression)
Ovarian serous cystadenocarcinoma
CVCL_0532 
[599]
Half Maximal Inhibitory Concentration (IC50) 650 nM
A2780 cells
Ovarian endometrioid adenocarcinoma
CVCL_0134 
[489]
Half Maximal Inhibitory Concentration (IC50) 650 nM
Vero cells
Normal
CVCL_0059 
[108]
Half Maximal Inhibitory Concentration (IC50) 6587 nM
KB cells
Human papillomavirus-related endocervical adenocarcinoma
CVCL_0372 
[365]
Half Maximal Inhibitory Concentration (IC50) 66 nM
ACHN cells
Renal adenocarcinoma
CVCL_1067 
[272]
Half Maximal Inhibitory Concentration (IC50) 66 nM
HCT-8 cells
Ileocecal adenocarcinoma
CVCL_2478 
[631]
Half Maximal Inhibitory Concentration (IC50) 660 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[273]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 660.69 nM
ACHN cells
Renal adenocarcinoma
CVCL_1067 
[345]
Half Maximal Inhibitory Concentration (IC50) 6600 nM
KB cells
Human papillomavirus-related endocervical adenocarcinoma
CVCL_0372 
[326]
Half Maximal Inhibitory Concentration (IC50) 6620 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[335]
Half Maximal Inhibitory Concentration (IC50) 6684 nM
KB cells
Human papillomavirus-related endocervical adenocarcinoma
CVCL_0372 
[747]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 6690000 nM
HCT 116 cells
Colon carcinoma
CVCL_0291 
[748]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 67.1 nM
HOP-62 cells
Non-small cell lung carcinoma
CVCL_1285 
[237]
Half Maximal Inhibitory Concentration (IC50) 67.27 nM
HCT 116 cells
Colon carcinoma
CVCL_0291 
[577]
Half Maximal Inhibitory Concentration (IC50) 67.5 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[721]
Half Maximal Inhibitory Concentration (IC50) 670 nM
HCT-8 cells
Ileocecal adenocarcinoma
CVCL_2478 
[489]
Half Maximal Inhibitory Concentration (IC50) 670 nM
PC-3 cells
Prostate carcinoma
CVCL_0035 
[362]
Half Maximal Inhibitory Concentration (IC50) 6700 nM
Hep-G2 cells
Hepatoblastoma
CVCL_0027 
[481]
Half Maximal Inhibitory Concentration (IC50) 6708.96 nM
SK-MEL-1 cells
Metastatic melanoma
CVCL_0068 
Half Maximal Inhibitory Concentration (IC50) 6725.83 nM
THP-1 cells
Childhood acute monocytic leukemia
CVCL_0006 
Half Maximal Inhibitory Concentration (IC50) 6750 nM
Huh-7 cells
Adult hepatocellular carcinoma
CVCL_0336 
[503]
Half Maximal Inhibitory Concentration (IC50) 68 nM
NCI-H1650 cells
Lung adenocarcinoma
CVCL_1483 
[118]
Half Maximal Inhibitory Concentration (IC50) 68.1 nM
CP67-MEL cells
Melanoma
CVCL_1145 
Half Maximal Inhibitory Concentration (IC50) 68.99 nM
DG-75 cells
Burkitt lymphoma
CVCL_0244 
Half Maximal Inhibitory Concentration (IC50) 680 nM
A375 cells
Amelanotic melanoma
CVCL_0132 
[501]
Half Maximal Inhibitory Concentration (IC50) 6800 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[367]
Half Maximal Inhibitory Concentration (IC50) 69 nM
HCT 116 cells
Colon carcinoma
CVCL_0291 
[397]
Half Maximal Inhibitory Concentration (IC50) 690 nM
Jurkat cells
T acute lymphoblastic leukemia
CVCL_0065 
[331]
Half Maximal Inhibitory Concentration (IC50) 6900 nM
Hep-G2 cells
Hepatoblastoma
CVCL_0027 
[669]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 7 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[167]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 7 nM
NCI-H460 cells
Lung large cell carcinoma
CVCL_0459 
[140]
Half Maximal Inhibitory Concentration (IC50) 7 nM
NCI-H460 cells
Lung large cell carcinoma
CVCL_0459 
Half Maximal Cell Growth Inhibitory Concentration (GI50) 7 nM
MES-SA cells
Uterine sarcoma
CVCL_1404 
[749]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 7 nM
MES-SA cells
Uterine sarcoma
CVCL_1404 
[750]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 7 nM
MES-SA cells
Uterine sarcoma
CVCL_1404 
[318]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 7 nM
MES-SA cells
Uterine sarcoma
CVCL_1404 
[319]
Half Maximal Inhibitory Concentration (IC50) 7 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[359]
Half Maximal Inhibitory Concentration (IC50) 7 nM
PANC-1 cells
Pancreatic ductal adenocarcinoma
CVCL_0480 
[313]
Half Maximal Inhibitory Concentration (IC50) 7 nM
CCRF-CEM cells
T acute lymphoblastic leukemia
CVCL_0207 
[665]
Half Maximal Inhibitory Concentration (IC50) 7 nM
CCRF-CEM cells
T acute lymphoblastic leukemia
CVCL_0207 
[666]
Half Maximal Inhibitory Concentration (IC50) 7 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[89]
Half Maximal Inhibitory Concentration (IC50) 7 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[90]
Half Maximal Inhibitory Concentration (IC50) 7 nM
Human umbilical vein endothelial cells(HUVEC)
Normal
Undisclosed [575]
Half Maximal Inhibitory Concentration (IC50) 7 nM
BGC-823 cells
Stomach adenocarcinoma
CVCL_3360 
[294]
Half Maximal Inhibitory Concentration (IC50) 7 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[484]
Half Maximal Inhibitory Concentration (IC50) 7 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[328]
Half Maximal Inhibitory Concentration (IC50) 7 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[663]
Half Maximal Inhibitory Concentration (IC50) 7 nM
PC-3 cells
Prostate carcinoma
CVCL_0035 
[712]
Half Maximal Inhibitory Concentration (IC50) 7 nM
K-562 cells
Chronic myelogenous leukemia
CVCL_0004 
[528]
Half Maximal Inhibitory Concentration (IC50) 7 nM
Hep-G2 cells
Hepatoblastoma
CVCL_0027 
[632]
Half Maximal Inhibitory Concentration (IC50) 7 nM
A-431 cells
Skin squamous cell carcinoma
CVCL_0037 
[270]
Half Maximal Inhibitory Concentration (IC50) 7 nM
HT-29 cells
Colon adenocarcinoma
CVCL_0320 
[739]
Half Maximal Inhibitory Concentration (IC50) 7 nM
HT-29 cells
Colon adenocarcinoma
CVCL_0320 
[271]
Half Maximal Inhibitory Concentration (IC50) 7 nM
NCI-H460 cells
Lung large cell carcinoma
CVCL_0459 
[432]
Half Maximal Inhibitory Concentration (IC50) 7 nM
SW480 cells
Colon adenocarcinoma
CVCL_0546 
[584]
Half Maximal Inhibitory Concentration (IC50) 7 nM
MDA-MB-231 cells (5T4 overexpression)
Breast adenocarcinoma
CVCL_0062 
[328]
Half Maximal Inhibitory Concentration (IC50) 7 nM
MDA-MB-231 cells (5T4 overexpression)
Breast adenocarcinoma
CVCL_0062 
[649]
Half Maximal Inhibitory Concentration (IC50) 7 nM
Human umbilical vein endothelial cells(HUVEC)
Normal
Undisclosed [633]
Half Maximal Inhibitory Concentration (IC50) 7 nM
M14 cells
Melanoma
CVCL_1395 
[272]
Half Maximal Inhibitory Concentration (IC50) 7 nM
MDA-MB-231 cells (5T4 overexpression)
Breast adenocarcinoma
CVCL_0062 
[352]
Half Maximal Inhibitory Concentration (IC50) 7 nM
BEAS-2B cells
Normal
CVCL_0168 
[700]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 7.014 nM
K-562 cells
Chronic myelogenous leukemia
CVCL_0004 
[186]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 7.03 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[254]
Half Maximal Inhibitory Concentration (IC50) 7.05 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[751]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 7.079 nM
IGROV-1 cells
Ovarian endometrioid adenocarcinoma
CVCL_1304 
[345]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 7.1 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[719]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 7.1 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[115]
Half Maximal Inhibitory Concentration (IC50) 7.1 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[568]
Half Maximal Inhibitory Concentration (IC50) 7.124 nM
KGN cells
Ovarian granulosa cell tumor
CVCL_0375 
Half Maximal Inhibitory Concentration (IC50) 7.166 nM
LS-411N cells
Cecum adenocarcinoma
CVCL_1385 
Half Maximal Inhibitory Concentration (IC50) 7.17 nM
MDA-MB-468 cells
Breast adenocarcinoma
CVCL_0419 
[752]
Half Maximal Inhibitory Concentration (IC50) 7.17 nM
K-562 cells
Chronic myelogenous leukemia
CVCL_0004 
[223]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 7.2 nM
PC-3 cells
Prostate carcinoma
CVCL_0035 
[716]
Half Maximal Inhibitory Concentration (IC50) 7.2 nM
SK-MEL-2 cells (MEK inhibitor-resistant)
Melanoma
CVCL_0069 
[241]
Half Maximal Inhibitory Concentration (IC50) 7.2 nM
A2780 cells
Ovarian endometrioid adenocarcinoma
CVCL_0134 
[197]
Half Maximal Inhibitory Concentration (IC50) 7.2 nM
A2780 cells
Ovarian endometrioid adenocarcinoma
CVCL_0134 
[224]
Half Maximal Inhibitory Concentration (IC50) 7.2 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[753]
Half Maximal Inhibitory Concentration (IC50) 7.2 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[754]
Half Maximal Inhibitory Concentration (IC50) 7.2 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[755]
Half Maximal Inhibitory Concentration (IC50) 7.2 nM
K-562 cells
Chronic myelogenous leukemia
CVCL_0004 
[235]
Half Maximal Inhibitory Concentration (IC50) 7.2 nM
MIA PaCa-2 cells (MSLN expression)
Pancreatic ductal adenocarcinoma
CVCL_0428 
[524]
Half Maximal Inhibitory Concentration (IC50) 7.213 nM
HC-1 cells
Hairy cell leukemia
CVCL_1243 
Half Maximal Inhibitory Concentration (IC50) 7.3 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[235]
Half Maximal Inhibitory Concentration (IC50) 7.32 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[223]
Half Maximal Inhibitory Concentration (IC50) 7.35 nM
Huh-7 cells
Adult hepatocellular carcinoma
CVCL_0336 
[222]
Half Maximal Inhibitory Concentration (IC50) 7.374 nM
CESS cells
Adult acute myeloid leukemia
CVCL_0209 
Half Maximal Cell Growth Inhibitory Concentration (GI50) 7.4 nM
MDA-MB-231 cells (5T4 overexpression)
Breast adenocarcinoma
CVCL_0062 
[115]
Half Maximal Inhibitory Concentration (IC50) 7.4 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[656]
Half Maximal Inhibitory Concentration (IC50) 7.4 nM
KB cells
Human papillomavirus-related endocervical adenocarcinoma
CVCL_0372 
[287]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 7.41 nM
Huh-7 cells
Adult hepatocellular carcinoma
CVCL_0336 
[548]
Half Maximal Inhibitory Concentration (IC50) 7.47 nM
HT-29 cells
Colon adenocarcinoma
CVCL_0320 
[222]
Half Maximal Inhibitory Concentration (IC50) 7.478 nM
KURAMOCHI cells
Ovarian serous adenocarcinoma
CVCL_1345 
Half Maximal Inhibitory Concentration (IC50) 7.48 nM
HCT 116 cells
Colon carcinoma
CVCL_0291 
[222]
Half Maximal Inhibitory Concentration (IC50) 7.5 nM
OVCAR-3 cells (FZD7 overexpression)
Ovarian serous adenocarcinoma
CVCL_0465 
[544]
Half Maximal Inhibitory Concentration (IC50) 7.5 nM
OVCAR-3 cells (FZD7 overexpression)
Ovarian serous adenocarcinoma
CVCL_0465 
[545]
Half Maximal Inhibitory Concentration (IC50) 7.5 nM
A2780S cells
Ovarian endometrioid adenocarcinoma
CVCL_4863 
[667]
Half Maximal Inhibitory Concentration (IC50) 7.52 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[265]
Half Maximal Inhibitory Concentration (IC50) 7.52 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[383]
Half Maximal Inhibitory Concentration (IC50) 7.523 nM
TGBC24TKB cells
Gallbladder carcinoma
CVCL_1770 
Half Maximal Cell Growth Inhibitory Concentration (GI50) 7.53 nM
A2780 cells
Ovarian endometrioid adenocarcinoma
CVCL_0134 
[756]
Half Maximal Inhibitory Concentration (IC50) 7.53 nM
NCI-N87 cells
Gastric tubular adenocarcinoma
CVCL_1603 
[752]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 7.6 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[308]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 7.6 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[732]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 7.6 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[733]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 7.6 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[734]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 7.6 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[735]
Half Maximal Inhibitory Concentration (IC50) 7.6 nM
Hep-G2 cells
Hepatoblastoma
CVCL_0027 
[91]
Half Maximal Inhibitory Concentration (IC50) 7.66 nM
SW982 cells
Biphasic synovial sarcoma
CVCL_1734 
Half Maximal Inhibitory Concentration (IC50) 7.671 nM
HCE-4 cells
Esophageal squamous cell carcinoma
CVCL_1271 
Half Maximal Inhibitory Concentration (IC50) 7.7 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[215]
Half Maximal Inhibitory Concentration (IC50) 7.7 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[220]
Half Maximal Inhibitory Concentration (IC50) 7.7 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[104]
Half Maximal Inhibitory Concentration (IC50) 7.7 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[146]
Half Maximal Inhibitory Concentration (IC50) 7.7 nM
NCI-H1975 cells
Lung adenocarcinoma
CVCL_1511 
[239]
Half Maximal Inhibitory Concentration (IC50) 7.7 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[147]
Half Maximal Inhibitory Concentration (IC50) 7.7 nM
KB cells
Human papillomavirus-related endocervical adenocarcinoma
CVCL_0372 
[413]
Half Maximal Inhibitory Concentration (IC50) 7.75 nM
LOUCY cells
Adult T acute lymphoblastic leukemia
CVCL_1380 
Half Maximal Cell Growth Inhibitory Concentration (GI50) 7.77 nM
KB cells
Human papillomavirus-related endocervical adenocarcinoma
CVCL_0372 
[742]
Half Maximal Inhibitory Concentration (IC50) >7.8 nM
MDA-MB-231 cells (5T4 overexpression)
Breast adenocarcinoma
CVCL_0062 
[302]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 7.9 nM
COLO 205 cells
Colon adenocarcinoma
CVCL_0218 
[146]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 7.9 nM
COLO 205 cells
Colon adenocarcinoma
CVCL_0218 
[147]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 7.9 nM
OVCAR-5 cells
Ovarian serous adenocarcinoma
CVCL_1628 
[146]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 7.9 nM
OVCAR-5 cells
Ovarian serous adenocarcinoma
CVCL_1628 
[147]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 7.9 nM
OVCAR-8 cells
High grade ovarian serous adenocarcinoma
CVCL_1629 
[146]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 7.9 nM
OVCAR-8 cells
High grade ovarian serous adenocarcinoma
CVCL_1629 
[147]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 7.9 nM
SNB-75 cells
Glioblastoma
CVCL_1706 
[146]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 7.9 nM
SNB-75 cells
Glioblastoma
CVCL_1706 
[147]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 7.9 nM
SU-DHL-6 cells
Diffuse large B-cell lymphoma
CVCL_2206 
[757]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 7.9 nM
A498 cells
Renal carcinoma
CVCL_1056 
[146]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 7.9 nM
A498 cells
Renal carcinoma
CVCL_1056 
[147]
Half Maximal Inhibitory Concentration (IC50) 7.9 nM
YOSHIDA cells
Rat sarcoma
CVCL_G359 
Half Maximal Inhibitory Concentration (IC50) 7.9 nM
A2780 cells
Ovarian endometrioid adenocarcinoma
CVCL_0134 
[384]
Half Maximal Inhibitory Concentration (IC50) 7.9 nM
KB cells
Human papillomavirus-related endocervical adenocarcinoma
CVCL_0372 
[476]
Half Maximal Inhibitory Concentration (IC50) 7.9 nM
HL-60 cells
Adult acute myeloid leukemia
CVCL_0002 
[271]
Half Maximal Inhibitory Concentration (IC50) 7.9 nM
NCI-H358 cells
Minimally invasive lung adenocarcinoma
CVCL_1559 
[271]
Half Maximal Inhibitory Concentration (IC50) 7.9 nM
GES1 cells
Normal
CVCL_EQ22 
[192]
Half Maximal Inhibitory Concentration (IC50) 7.94 nM
NCI-H1975 cells
Lung adenocarcinoma
CVCL_1511 
[752]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 7.943 nM
SF268 cells
Astrocytoma
CVCL_1689 
[253]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 7.943 nM
RXF 393 cells
Renal carcinoma
CVCL_1673 
[253]
Half Maximal Inhibitory Concentration (IC50) 7.958 nM
8-MG-BA cells
Glioblastoma
CVCL_1052 
Half Maximal Inhibitory Concentration (IC50) 70 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[151]
Half Maximal Inhibitory Concentration (IC50) 70 nM
SK-MEL-2 cells (MEK inhibitor-resistant)
Melanoma
CVCL_0069 
[72]
Half Maximal Inhibitory Concentration (IC50) 70 nM
NCI-H460 cells
Lung large cell carcinoma
CVCL_0459 
[324]
Half Maximal Inhibitory Concentration (IC50) 70 nM
L1210 cells
Lymphoblastic leukemia
CVCL_0382 
[324]
Half Maximal Inhibitory Concentration (IC50) 70 nM
P388 cells
Lymphoma
CVCL_7222 
[324]
Half Maximal Inhibitory Concentration (IC50) 70 nM
NCI-H1650 cells
Lung adenocarcinoma
CVCL_1483 
[161]
Half Maximal Inhibitory Concentration (IC50) 70 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[418]
Half Maximal Inhibitory Concentration (IC50) 70 nM
HT-29 cells
Colon adenocarcinoma
CVCL_0320 
[164]
Half Maximal Inhibitory Concentration (IC50) 70 nM
SMMC-7721 cells
Hepatocellular carcinoma
CVCL_0534 
[723]
Half Maximal Inhibitory Concentration (IC50) 70 nM
RT-112 cells
Bladder carcinoma
CVCL_1670 
[657]
Half Maximal Inhibitory Concentration (IC50) 70.28 nM
LOX IMVI cells
Melanoma
CVCL_1381 
Half Maximal Inhibitory Concentration (IC50) 70.3 nM
MDA-MB-231 cells (5T4 overexpression)
Breast adenocarcinoma
CVCL_0062 
[359]
Half Maximal Inhibitory Concentration (IC50) 700 nM
UACC-812 cells
Invasive breast carcinoma of no special type
CVCL_1781 
[148]
Half Maximal Inhibitory Concentration (IC50) 700 nM
A375 cells
Amelanotic melanoma
CVCL_0132 
[600]
Half Maximal Inhibitory Concentration (IC50) 700 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[615]
Half Maximal Inhibitory Concentration (IC50) 700 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[322]
Half Maximal Inhibitory Concentration (IC50) 700 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[657]
Half Maximal Inhibitory Concentration (IC50) 7000 nM
PC-3 cells
Prostate carcinoma
CVCL_0035 
[758]
Half Maximal Inhibitory Concentration (IC50) 7000 nM
PEO1 cells
Metastasis of ovarian carcinoma
CVCL_2686 
[759]
Half Maximal Inhibitory Concentration (IC50) 70200 nM
NIH-3T3-G185 cells
Nornal
CVCL_L991 
[726]
Half Maximal Inhibitory Concentration (IC50) 7036.75 nM
EW-18 cells
Ewing sarcoma
CVCL_1213 
Half Maximal Inhibitory Concentration (IC50) 71 nM
Human umbilical vein endothelial cells(HUVEC)
Normal
Undisclosed [135]
Half Maximal Inhibitory Concentration (IC50) 71.57 nM
HH cells
T-cell non-Hodgkin lymphoma
CVCL_1280 
Half Maximal Inhibitory Concentration (IC50) 7100 nM
769-P cells
Renal cell carcinom
CVCL_1050 
[459]
Half Maximal Inhibitory Concentration (IC50) 7100 nM
769-P cells
Renal cell carcinom
CVCL_1050 
[421]
Half Maximal Inhibitory Concentration (IC50) 7100 nM
769-P cells
Renal cell carcinom
CVCL_1050 
[422]
Half Maximal Inhibitory Concentration (IC50) 7100 nM
769-P cells
Renal cell carcinom
CVCL_1050 
[423]
Half Maximal Inhibitory Concentration (IC50) 71000 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[93]
Half Maximal Inhibitory Concentration (IC50) 7168.65 nM
EKVX cells
Non-small cell lung carcinoma
CVCL_1195 
Half Maximal Inhibitory Concentration (IC50) 72.26 nM
K5 cells
Thyroid gland papillary carcinoma
CVCL_1322 
Half Maximal Inhibitory Concentration (IC50) 72.57 nM
EC-GI-10 cells
Esophageal squamous cell carcinoma
CVCL_1187 
Half Maximal Inhibitory Concentration (IC50) 720 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[107]
Half Maximal Inhibitory Concentration (IC50) 7260 nM
Hep 3B2.1-7 cells
Childhood hepatocellular carcinoma
CVCL_0326 
[471]
Half Maximal Inhibitory Concentration (IC50) 72967.46 nM
A2780/Taxol cells
Ovarian endometrioid adenocarcinoma
CVCL_IJ13 
[486]
Half Maximal Inhibitory Concentration (IC50) 73.07 nM
SK-N-DZ cells
Neuroblastoma
CVCL_1701 
Half Maximal Inhibitory Concentration (IC50) 73.51 nM
A3-KAW cells
Diffuse large B-cell lymphoma
CVCL_1062 
Half Maximal Cell Growth Inhibitory Concentration (GI50) 73.79 nM
HOP-92 cells
Non-small cell lung carcinoma
CVCL_1286 
[345]
Half Maximal Inhibitory Concentration (IC50) 730 nM
Hep 3B2.1-7 cells
Childhood hepatocellular carcinoma
CVCL_0326 
[659]
Half Maximal Inhibitory Concentration (IC50) 74.65 nM
MLMA cells
Hairy cell leukemia
CVCL_1419 
Half Maximal Inhibitory Concentration (IC50) 740 nM
T98G cells
Glioblastoma
CVCL_0556 
[500]
Half Maximal Inhibitory Concentration (IC50) 740 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[331]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 75 nM
IMR-32 cells
Neuroblastoma
CVCL_0346 
[594]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 75 nM
IMR-32 cells
Neuroblastoma
CVCL_0346 
[595]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 75 nM
IMR-32 cells
Neuroblastoma
CVCL_0346 
[596]
Half Maximal Inhibitory Concentration (IC50) 75 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[754]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 75.16 nM
IMR-32 cells
Neuroblastoma
CVCL_0346 
[596]
Half Maximal Inhibitory Concentration (IC50) 75.2 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[753]
Half Maximal Inhibitory Concentration (IC50) 75.2 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[755]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 750 nM
MES-SA/Dx5 cells
Uterine sarcoma
CVCL_2598 
[630]
Half Maximal Inhibitory Concentration (IC50) 750 nM
MES-SA/Dx5 cells
Uterine sarcoma
CVCL_2598 
[688]
Half Maximal Inhibitory Concentration (IC50) 750 nM
MV4-11 cells
Childhood acute monocytic leukemia
CVCL_0064 
[331]
Half Maximal Inhibitory Concentration (IC50) 7520 nM
KB cells
Human papillomavirus-related endocervical adenocarcinoma
CVCL_0372 
[725]
Half Maximal Inhibitory Concentration (IC50) 75200 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[703]
Half Maximal Inhibitory Concentration (IC50) 7538 nM
MES-SA/Dx5 cells
Uterine sarcoma
CVCL_2598 
[760]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 7540 nM
MES-SA/Dx5 cells
Uterine sarcoma
CVCL_2598 
[760]
Half Maximal Inhibitory Concentration (IC50) 759.39 nM
A549/TR cells
Lung adenocarcinoma
CVCL_C5S0 
[486]
Half Maximal Inhibitory Concentration (IC50) 77 nM
PC-3 cells
Prostate carcinoma
CVCL_0035 
[17]
Half Maximal Inhibitory Concentration (IC50) 77 nM
PC-3 cells
Prostate carcinoma
CVCL_0035 
[597]
Half Maximal Inhibitory Concentration (IC50) 77.07 nM
LB996-RCC cells
Renal cell carcinoma
CVCL_1371 
Half Maximal Inhibitory Concentration (IC50) 77.48 nM
OS-RC-2 cells
Clear cell renal cell carcinoma
CVCL_1626 
Half Maximal Inhibitory Concentration (IC50) 7700 nM
HCT 116 cells
Colon carcinoma
CVCL_0291 
[761]
Half Maximal Inhibitory Concentration (IC50) 77200 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[625]
Half Maximal Inhibitory Concentration (IC50) 777.8 nM
HGC-27 cells
Gastric carcinoma
CVCL_1279 
[386]
Half Maximal Inhibitory Concentration (IC50) 78.1 nM
CTB-1 cells
Diffuse large B-cell lymphoma
CVCL_1149 
Half Maximal Cell Growth Inhibitory Concentration (GI50) 78.34 nM
OVCAR-5 cells
Ovarian serous adenocarcinoma
CVCL_1628 
[345]
Half Maximal Inhibitory Concentration (IC50) 7800 nM
Breast carcinoma cells
Breast carcinoma
Undisclosed [762]
Half Maximal Inhibitory Concentration (IC50) 7813.9 nM
NB14 cells
Neuroblastoma
CVCL_1444 
Half Maximal Inhibitory Concentration (IC50) 7830 nM
NCI-H1299 cells (MMAE resistant)
Lung large cell carcinoma
CVCL_0060 
[426]
Half Maximal Inhibitory Concentration (IC50) 7866.62 nM
ES5 cells
Ewing sarcoma
CVCL_1201 
Half Maximal Cell Growth Inhibitory Concentration (GI50) 79 nM
EKVX cells
Non-small cell lung carcinoma
CVCL_1195 
[146]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 79 nM
EKVX cells
Non-small cell lung carcinoma
CVCL_1195 
[147]
Half Maximal Inhibitory Concentration (IC50) 79.12 nM
IST-MES1 cells
Pleural epithelioid mesothelioma
CVCL_1311 
Half Maximal Inhibitory Concentration (IC50) 79.4 nM
HCT 15 cells
Colon adenocarcinoma
CVCL_0292 
[218]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 79.43 nM
A498 cells
Renal carcinoma
CVCL_1056 
[253]
Half Maximal Inhibitory Concentration (IC50) 79670 nM
L02 cells
Cervical carcinoma
CVCL_6926 
[587]
Half Maximal Inhibitory Concentration (IC50) <8 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[266]
Half Maximal Inhibitory Concentration (IC50) <8 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[763]
Half Maximal Inhibitory Concentration (IC50) <8 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[455]
Half Maximal Inhibitory Concentration (IC50) <8 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[764]
Half Maximal Inhibitory Concentration (IC50) <8 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[728]
Half Maximal Inhibitory Concentration (IC50) <8 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[765]
Half Maximal Inhibitory Concentration (IC50) <8 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[766]
Half Maximal Inhibitory Concentration (IC50) <8 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[456]
Half Maximal Inhibitory Concentration (IC50) <8 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[767]
Half Maximal Inhibitory Concentration (IC50) <8 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[768]
Half Maximal Inhibitory Concentration (IC50) <8 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[729]
Half Maximal Inhibitory Concentration (IC50) <8 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[769]
Half Maximal Inhibitory Concentration (IC50) <8 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[770]
Half Maximal Inhibitory Concentration (IC50) <8 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[771]
Half Maximal Inhibitory Concentration (IC50) <8 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[772]
Half Maximal Inhibitory Concentration (IC50) <8 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[773]
Half Maximal Inhibitory Concentration (IC50) <8 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[774]
Half Maximal Inhibitory Concentration (IC50) <8 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[775]
Half Maximal Inhibitory Concentration (IC50) <8 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[776]
Half Maximal Inhibitory Concentration (IC50) <8 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[777]
Half Maximal Inhibitory Concentration (IC50) <8 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[778]
Half Maximal Inhibitory Concentration (IC50) <8 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[779]
Half Maximal Inhibitory Concentration (IC50) <8 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[441]
Half Maximal Inhibitory Concentration (IC50) <8 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[780]
Half Maximal Inhibitory Concentration (IC50) <8 nM
HL-60 cells
Adult acute myeloid leukemia
CVCL_0002 
[360]
Half Maximal Inhibitory Concentration (IC50) <8 nM
HL-60 cells
Adult acute myeloid leukemia
CVCL_0002 
[763]
Half Maximal Inhibitory Concentration (IC50) <8 nM
HL-60 cells
Adult acute myeloid leukemia
CVCL_0002 
[455]
Half Maximal Inhibitory Concentration (IC50) <8 nM
HL-60 cells
Adult acute myeloid leukemia
CVCL_0002 
[437]
Half Maximal Inhibitory Concentration (IC50) <8 nM
HL-60 cells
Adult acute myeloid leukemia
CVCL_0002 
[295]
Half Maximal Inhibitory Concentration (IC50) <8 nM
HL-60 cells
Adult acute myeloid leukemia
CVCL_0002 
[764]
Half Maximal Inhibitory Concentration (IC50) <8 nM
HL-60 cells
Adult acute myeloid leukemia
CVCL_0002 
[728]
Half Maximal Inhibitory Concentration (IC50) <8 nM
HL-60 cells
Adult acute myeloid leukemia
CVCL_0002 
[765]
Half Maximal Inhibitory Concentration (IC50) <8 nM
HL-60 cells
Adult acute myeloid leukemia
CVCL_0002 
[766]
Half Maximal Inhibitory Concentration (IC50) <8 nM
HL-60 cells
Adult acute myeloid leukemia
CVCL_0002 
[456]
Half Maximal Inhibitory Concentration (IC50) <8 nM
HL-60 cells
Adult acute myeloid leukemia
CVCL_0002 
[767]
Half Maximal Inhibitory Concentration (IC50) <8 nM
HL-60 cells
Adult acute myeloid leukemia
CVCL_0002 
[768]
Half Maximal Inhibitory Concentration (IC50) <8 nM
HL-60 cells
Adult acute myeloid leukemia
CVCL_0002 
[729]
Half Maximal Inhibitory Concentration (IC50) <8 nM
HL-60 cells
Adult acute myeloid leukemia
CVCL_0002 
[769]
Half Maximal Inhibitory Concentration (IC50) <8 nM
HL-60 cells
Adult acute myeloid leukemia
CVCL_0002 
[770]
Half Maximal Inhibitory Concentration (IC50) <8 nM
HL-60 cells
Adult acute myeloid leukemia
CVCL_0002 
[771]
Half Maximal Inhibitory Concentration (IC50) <8 nM
HL-60 cells
Adult acute myeloid leukemia
CVCL_0002 
[772]
Half Maximal Inhibitory Concentration (IC50) <8 nM
HL-60 cells
Adult acute myeloid leukemia
CVCL_0002 
[773]
Half Maximal Inhibitory Concentration (IC50) <8 nM
HL-60 cells
Adult acute myeloid leukemia
CVCL_0002 
[774]
Half Maximal Inhibitory Concentration (IC50) <8 nM
HL-60 cells
Adult acute myeloid leukemia
CVCL_0002 
[775]
Half Maximal Inhibitory Concentration (IC50) <8 nM
HL-60 cells
Adult acute myeloid leukemia
CVCL_0002 
[781]
Half Maximal Inhibitory Concentration (IC50) <8 nM
HL-60 cells
Adult acute myeloid leukemia
CVCL_0002 
[776]
Half Maximal Inhibitory Concentration (IC50) <8 nM
HL-60 cells
Adult acute myeloid leukemia
CVCL_0002 
[778]
Half Maximal Inhibitory Concentration (IC50) <8 nM
HL-60 cells
Adult acute myeloid leukemia
CVCL_0002 
[779]
Half Maximal Inhibitory Concentration (IC50) <8 nM
HL-60 cells
Adult acute myeloid leukemia
CVCL_0002 
[441]
Half Maximal Inhibitory Concentration (IC50) <8 nM
PANC-1 cells
Pancreatic ductal adenocarcinoma
CVCL_0480 
[360]
Half Maximal Inhibitory Concentration (IC50) <8 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[769]
Half Maximal Inhibitory Concentration (IC50) <8 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[777]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 8 nM
KB cells
Human papillomavirus-related endocervical adenocarcinoma
CVCL_0372 
[733]
Half Maximal Inhibitory Concentration (IC50) <8 nM
SW480 cells
Colon adenocarcinoma
CVCL_0546 
[266]
Half Maximal Inhibitory Concentration (IC50) <8 nM
SW480 cells
Colon adenocarcinoma
CVCL_0546 
[763]
Half Maximal Inhibitory Concentration (IC50) <8 nM
SW480 cells
Colon adenocarcinoma
CVCL_0546 
[764]
Half Maximal Inhibitory Concentration (IC50) <8 nM
SW480 cells
Colon adenocarcinoma
CVCL_0546 
[728]
Half Maximal Inhibitory Concentration (IC50) <8 nM
SW480 cells
Colon adenocarcinoma
CVCL_0546 
[766]
Half Maximal Inhibitory Concentration (IC50) <8 nM
SW480 cells
Colon adenocarcinoma
CVCL_0546 
[767]
Half Maximal Inhibitory Concentration (IC50) <8 nM
SW480 cells
Colon adenocarcinoma
CVCL_0546 
[768]
Half Maximal Inhibitory Concentration (IC50) <8 nM
SW480 cells
Colon adenocarcinoma
CVCL_0546 
[729]
Half Maximal Inhibitory Concentration (IC50) <8 nM
SW480 cells
Colon adenocarcinoma
CVCL_0546 
[769]
Half Maximal Inhibitory Concentration (IC50) <8 nM
SW480 cells
Colon adenocarcinoma
CVCL_0546 
[770]
Half Maximal Inhibitory Concentration (IC50) <8 nM
SW480 cells
Colon adenocarcinoma
CVCL_0546 
[771]
Half Maximal Inhibitory Concentration (IC50) <8 nM
SW480 cells
Colon adenocarcinoma
CVCL_0546 
[772]
Half Maximal Inhibitory Concentration (IC50) <8 nM
SW480 cells
Colon adenocarcinoma
CVCL_0546 
[773]
Half Maximal Inhibitory Concentration (IC50) <8 nM
SW480 cells
Colon adenocarcinoma
CVCL_0546 
[774]
Half Maximal Inhibitory Concentration (IC50) <8 nM
SW480 cells
Colon adenocarcinoma
CVCL_0546 
[775]
Half Maximal Inhibitory Concentration (IC50) <8 nM
SW480 cells
Colon adenocarcinoma
CVCL_0546 
[776]
Half Maximal Inhibitory Concentration (IC50) <8 nM
SW480 cells
Colon adenocarcinoma
CVCL_0546 
[778]
Half Maximal Inhibitory Concentration (IC50) <8 nM
SW480 cells
Colon adenocarcinoma
CVCL_0546 
[779]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 8 nM
SK-OV-3 cells (FZD7 overexpression)
Ovarian serous cystadenocarcinoma
CVCL_0532 
[399]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 8 nM
SK-OV-3 cells (FZD7 overexpression)
Ovarian serous cystadenocarcinoma
CVCL_0532 
[400]
Half Maximal Inhibitory Concentration (IC50) <8 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[266]
Half Maximal Inhibitory Concentration (IC50) <8 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[763]
Half Maximal Inhibitory Concentration (IC50) <8 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[455]
Half Maximal Inhibitory Concentration (IC50) <8 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[437]
Half Maximal Inhibitory Concentration (IC50) <8 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[295]
Half Maximal Inhibitory Concentration (IC50) <8 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[764]
Half Maximal Inhibitory Concentration (IC50) <8 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[728]
Half Maximal Inhibitory Concentration (IC50) <8 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[765]
Half Maximal Inhibitory Concentration (IC50) <8 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[766]
Half Maximal Inhibitory Concentration (IC50) <8 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[456]
Half Maximal Inhibitory Concentration (IC50) <8 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[767]
Half Maximal Inhibitory Concentration (IC50) <8 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[768]
Half Maximal Inhibitory Concentration (IC50) <8 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[729]
Half Maximal Inhibitory Concentration (IC50) <8 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[769]
Half Maximal Inhibitory Concentration (IC50) <8 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[770]
Half Maximal Inhibitory Concentration (IC50) <8 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[771]
Half Maximal Inhibitory Concentration (IC50) <8 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[772]
Half Maximal Inhibitory Concentration (IC50) <8 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[773]
Half Maximal Inhibitory Concentration (IC50) <8 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[774]
Half Maximal Inhibitory Concentration (IC50) <8 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[775]
Half Maximal Inhibitory Concentration (IC50) <8 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[781]
Half Maximal Inhibitory Concentration (IC50) <8 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[776]
Half Maximal Inhibitory Concentration (IC50) <8 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[777]
Half Maximal Inhibitory Concentration (IC50) <8 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[778]
Half Maximal Inhibitory Concentration (IC50) <8 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[779]
Half Maximal Inhibitory Concentration (IC50) <8 nM
NCM460 cells
Normal
CVCL_0460 
[777]
Half Maximal Inhibitory Concentration (IC50) <8 nM
NCM460 cells
Normal
CVCL_0460 
[778]
Half Maximal Inhibitory Concentration (IC50) <8 nM
SMMC-7721 cells
Hepatocellular carcinoma
CVCL_0534 
[266]
Half Maximal Inhibitory Concentration (IC50) <8 nM
SMMC-7721 cells
Hepatocellular carcinoma
CVCL_0534 
[763]
Half Maximal Inhibitory Concentration (IC50) <8 nM
SMMC-7721 cells
Hepatocellular carcinoma
CVCL_0534 
[455]
Half Maximal Inhibitory Concentration (IC50) <8 nM
SMMC-7721 cells
Hepatocellular carcinoma
CVCL_0534 
[437]
Half Maximal Inhibitory Concentration (IC50) <8 nM
SMMC-7721 cells
Hepatocellular carcinoma
CVCL_0534 
[295]
Half Maximal Inhibitory Concentration (IC50) <8 nM
SMMC-7721 cells
Hepatocellular carcinoma
CVCL_0534 
[764]
Half Maximal Inhibitory Concentration (IC50) <8 nM
SMMC-7721 cells
Hepatocellular carcinoma
CVCL_0534 
[728]
Half Maximal Inhibitory Concentration (IC50) <8 nM
SMMC-7721 cells
Hepatocellular carcinoma
CVCL_0534 
[765]
Half Maximal Inhibitory Concentration (IC50) <8 nM
SMMC-7721 cells
Hepatocellular carcinoma
CVCL_0534 
[766]
Half Maximal Inhibitory Concentration (IC50) <8 nM
SMMC-7721 cells
Hepatocellular carcinoma
CVCL_0534 
[456]
Half Maximal Inhibitory Concentration (IC50) <8 nM
SMMC-7721 cells
Hepatocellular carcinoma
CVCL_0534 
[767]
Half Maximal Inhibitory Concentration (IC50) <8 nM
SMMC-7721 cells
Hepatocellular carcinoma
CVCL_0534 
[768]
Half Maximal Inhibitory Concentration (IC50) <8 nM
SMMC-7721 cells
Hepatocellular carcinoma
CVCL_0534 
[729]
Half Maximal Inhibitory Concentration (IC50) <8 nM
SMMC-7721 cells
Hepatocellular carcinoma
CVCL_0534 
[769]
Half Maximal Inhibitory Concentration (IC50) <8 nM
SMMC-7721 cells
Hepatocellular carcinoma
CVCL_0534 
[770]
Half Maximal Inhibitory Concentration (IC50) <8 nM
SMMC-7721 cells
Hepatocellular carcinoma
CVCL_0534 
[771]
Half Maximal Inhibitory Concentration (IC50) <8 nM
SMMC-7721 cells
Hepatocellular carcinoma
CVCL_0534 
[772]
Half Maximal Inhibitory Concentration (IC50) <8 nM
SMMC-7721 cells
Hepatocellular carcinoma
CVCL_0534 
[773]
Half Maximal Inhibitory Concentration (IC50) <8 nM
SMMC-7721 cells
Hepatocellular carcinoma
CVCL_0534 
[774]
Half Maximal Inhibitory Concentration (IC50) <8 nM
SMMC-7721 cells
Hepatocellular carcinoma
CVCL_0534 
[775]
Half Maximal Inhibitory Concentration (IC50) <8 nM
SMMC-7721 cells
Hepatocellular carcinoma
CVCL_0534 
[776]
Half Maximal Inhibitory Concentration (IC50) <8 nM
SMMC-7721 cells
Hepatocellular carcinoma
CVCL_0534 
[778]
Half Maximal Inhibitory Concentration (IC50) 8 nM
B16 cells
Melanoma
CVCL_F936 
Half Maximal Inhibitory Concentration (IC50) 8 nM
Caco-2 cells
Colon adenocarcinoma
CVCL_0025 
[685]
Half Maximal Inhibitory Concentration (IC50) 8 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[89]
Half Maximal Inhibitory Concentration (IC50) 8 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[90]
Half Maximal Inhibitory Concentration (IC50) 8 nM
Huh-7 cells
Adult hepatocellular carcinoma
CVCL_0336 
[125]
Half Maximal Inhibitory Concentration (IC50) 8 nM
MES-SA cells
Uterine sarcoma
CVCL_1404 
[471]
Half Maximal Inhibitory Concentration (IC50) 8 nM
Caco-2 cells
Colon adenocarcinoma
CVCL_0025 
[687]
Half Maximal Inhibitory Concentration (IC50) 8 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[686]
Half Maximal Inhibitory Concentration (IC50) 8 nM
SUP-B15 cells
B-lymphoblastic leukemia
CVCL_0103 
[528]
Half Maximal Inhibitory Concentration (IC50) 8 nM
HT-29 cells
Colon adenocarcinoma
CVCL_0320 
[484]
Half Maximal Inhibitory Concentration (IC50) 8 nM
NCI-H460 cells
Lung large cell carcinoma
CVCL_0459 
[632]
Half Maximal Inhibitory Concentration (IC50) 8 nM
PA-1 cells
Ovarian mixed germ cell tumor
CVCL_0479 
[687]
Half Maximal Inhibitory Concentration (IC50) 8 nM
AGS cells
Gastric adenocarcinoma
CVCL_0139 
[344]
Half Maximal Inhibitory Concentration (IC50) 8 nM
MDA-MB-436 cells
Metastasis of ductal carcinoma
CVCL_0623 
[328]
Half Maximal Inhibitory Concentration (IC50) 8 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[451]
Half Maximal Inhibitory Concentration (IC50) 8 nM
HT-29 cells
Colon adenocarcinoma
CVCL_0320 
[700]
Half Maximal Inhibitory Concentration (IC50) 8 nM
KB cells
Human papillomavirus-related endocervical adenocarcinoma
CVCL_0372 
[453]
Half Maximal Inhibitory Concentration (IC50) 8 nM
HCC1806 cells
Breast squamous cell carcinoma
CVCL_1258 
[610]
Half Maximal Inhibitory Concentration (IC50) 8 nM
MDA-MB-231 cells (5T4 overexpression)
Breast adenocarcinoma
CVCL_0062 
[453]
Half Maximal Inhibitory Concentration (IC50) 8 nM
U-87MG ATCC cells
Glioblastoma
CVCL_0022 
[279]
Half Maximal Inhibitory Concentration (IC50) 8 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[451]
Half Maximal Inhibitory Concentration (IC50) 8 nM
BEAS-2B cells
Normal
CVCL_0168 
[610]
Half Maximal Inhibitory Concentration (IC50) 8.003 nM
HT-144 cells
Melanoma
CVCL_0318 
Half Maximal Cell Growth Inhibitory Concentration (GI50) 8.08 nM
SNB-75 cells
Glioblastoma
CVCL_1706 
[237]
Half Maximal Inhibitory Concentration (IC50) 8.1 nM
MDA-MB-231 cells (5T4 overexpression)
Breast adenocarcinoma
CVCL_0062 
[355]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 8.18 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[742]
Half Maximal Inhibitory Concentration (IC50) 8.184 nM
LXF-289 cells
Lung adenocarcinoma
CVCL_1394 
Half Maximal Inhibitory Concentration (IC50) 8.2 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[339]
Half Maximal Inhibitory Concentration (IC50) 8.2 nM
NCI-H520 cells
Lung squamous cell carcinoma
CVCL_1566 
[243]
Half Maximal Inhibitory Concentration (IC50) 8.2 nM
MDA-MB-231 cells (5T4 overexpression)
Breast adenocarcinoma
CVCL_0062 
[364]
Half Maximal Inhibitory Concentration (IC50) 8.21 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[466]
Half Maximal Inhibitory Concentration (IC50) 8.21 nM
KB cells
Human papillomavirus-related endocervical adenocarcinoma
CVCL_0372 
[265]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 8.3 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[532]
Half Maximal Inhibitory Concentration (IC50) 8.357 nM
RS4
11 cells
Adult B acute lymphoblastic leukemia
CVCL_0093 
Half Maximal Inhibitory Concentration (IC50) 8.36 nM
BT474-M1 cells
Invasive breast carcinoma
CVCL_0179 
[752]
Half Maximal Inhibitory Concentration (IC50) 8.4 nM
Rhabdomyosarcoma cells
Rhabdomyosarcoma
Undisclosed [782]
Half Maximal Inhibitory Concentration (IC50) 8.4 nM
HGC-27 cells
Gastric carcinoma
CVCL_1279 
[192]
Half Maximal Inhibitory Concentration (IC50) 8.449 nM
DEL/BVR cells
Anaplastic large cell lymphoma
CVCL_1170 
Half Maximal Inhibitory Concentration (IC50) 8.51 nM
MDA-MB-231 cells (5T4 overexpression)
Breast adenocarcinoma
CVCL_0062 
[265]
Half Maximal Inhibitory Concentration (IC50) 8.521 nM
OCI-AML-2 cells
Adult acute myeloid leukemia
CVCL_1619 
Half Maximal Inhibitory Concentration (IC50) 8.54 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[265]
Half Maximal Inhibitory Concentration (IC50) 8.6 nM
HT-29 cells
Colon adenocarcinoma
CVCL_0320 
[454]
Half Maximal Inhibitory Concentration (IC50) 8.6 nM
MDA-MB-231 cells (5T4 overexpression)
Breast adenocarcinoma
CVCL_0062 
[413]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 8.67 nM
MDA-MB-231 cells (5T4 overexpression)
Breast adenocarcinoma
CVCL_0062 
[523]
Half Maximal Inhibitory Concentration (IC50) 8.708 nM
CCRF-CEM cells
T acute lymphoblastic leukemia
CVCL_0207 
Half Maximal Inhibitory Concentration (IC50) 8.738 nM
A388 cells
Skin squamous cell carcinoma
CVCL_1063 
Half Maximal Inhibitory Concentration (IC50) 8.76 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[265]
Half Maximal Inhibitory Concentration (IC50) 8.8 nM
MDA-MB-231 cells (5T4 overexpression)
Breast adenocarcinoma
CVCL_0062 
[741]
Half Maximal Inhibitory Concentration (IC50) 8.8 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[722]
Half Maximal Inhibitory Concentration (IC50) 8.8 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[649]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 8.81 nM
SK-OV-3 cells (FZD7 overexpression)
Ovarian serous cystadenocarcinoma
CVCL_0532 
[345]
Half Maximal Inhibitory Concentration (IC50) 8.82 nM
MDA-MB-231 cells (5T4 overexpression)
Breast adenocarcinoma
CVCL_0062 
[286]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 8.851 nM
NCI-H322M cells
Minimally invasive lung adenocarcinoma
CVCL_1557 
[345]
Half Maximal Effective Concentration (EC50) 8.87 nM
PC-3 cells
Prostate carcinoma
CVCL_0035 
[303]
Half Maximal Inhibitory Concentration (IC50) 8.9 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[653]
Half Maximal Inhibitory Concentration (IC50) 8.9 nM
KM20 cells
Colon adenocarcinoma
CVCL_L095 
[479]
Half Maximal Inhibitory Concentration (IC50) 8.9 nM
A375 cells
Amelanotic melanoma
CVCL_0132 
[73]
Half Maximal Inhibitory Concentration (IC50) 8.9 nM
A375 cells
Amelanotic melanoma
CVCL_0132 
[74]
Half Maximal Inhibitory Concentration (IC50) 8.907 nM
KNS-42 cells
Glioblastoma
CVCL_0378 
Half Maximal Inhibitory Concentration (IC50) <80 nM
Hep-G2 cells
Hepatoblastoma
CVCL_0027 
[421]
Half Maximal Inhibitory Concentration (IC50) <80 nM
Hep-G2 cells
Hepatoblastoma
CVCL_0027 
[422]
Half Maximal Inhibitory Concentration (IC50) <80 nM
Hep-G2 cells
Hepatoblastoma
CVCL_0027 
[423]
Half Maximal Inhibitory Concentration (IC50) <80 nM
786-O cells
Renal cell carcinoma
CVCL_1051 
[459]
Half Maximal Inhibitory Concentration (IC50) <80 nM
786-O cells
Renal cell carcinoma
CVCL_1051 
[421]
Half Maximal Inhibitory Concentration (IC50) <80 nM
786-O cells
Renal cell carcinoma
CVCL_1051 
[422]
Half Maximal Inhibitory Concentration (IC50) <80 nM
786-O cells
Renal cell carcinoma
CVCL_1051 
[423]
Half Maximal Inhibitory Concentration (IC50) <80 nM
OS-RC-2 cells
Clear cell renal cell carcinoma
CVCL_1626 
[421]
Half Maximal Inhibitory Concentration (IC50) <80 nM
OS-RC-2 cells
Clear cell renal cell carcinoma
CVCL_1626 
[422]
Half Maximal Inhibitory Concentration (IC50) <80 nM
OS-RC-2 cells
Clear cell renal cell carcinoma
CVCL_1626 
[423]
Half Maximal Inhibitory Concentration (IC50) 80 nM
KB cells
Human papillomavirus-related endocervical adenocarcinoma
CVCL_0372 
[660]
Half Maximal Inhibitory Concentration (IC50) 80 nM
KB cells
Human papillomavirus-related endocervical adenocarcinoma
CVCL_0372 
[459]
Half Maximal Inhibitory Concentration (IC50) 80 nM
KB cells
Human papillomavirus-related endocervical adenocarcinoma
CVCL_0372 
[421]
Half Maximal Inhibitory Concentration (IC50) 80 nM
KB cells
Human papillomavirus-related endocervical adenocarcinoma
CVCL_0372 
[422]
Half Maximal Inhibitory Concentration (IC50) 80 nM
22RV1 cells
Prostate carcinoma
CVCL_1045 
[421]
Half Maximal Inhibitory Concentration (IC50) 80 nM
U-87MG ATCC cells
Glioblastoma
CVCL_0022 
[398]
Half Maximal Inhibitory Concentration (IC50) 80 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[783]
Half Maximal Inhibitory Concentration (IC50) 80 nM
NCI-H295R cells
Adrenal cortex carcinoma
CVCL_0458 
[89]
Half Maximal Inhibitory Concentration (IC50) 80 nM
NCI-H295R cells
Adrenal cortex carcinoma
CVCL_0458 
[90]
Half Maximal Inhibitory Concentration (IC50) 80 nM
B16 cells
Melanoma
CVCL_F936 
[398]
Half Maximal Inhibitory Concentration (IC50) 80 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[563]
Half Maximal Inhibitory Concentration (IC50) 80 nM
KB cells
Human papillomavirus-related endocervical adenocarcinoma
CVCL_0372 
[423]
Half Maximal Inhibitory Concentration (IC50) 80 nM
22RV1 cells
Prostate carcinoma
CVCL_1045 
[423]
Half Maximal Inhibitory Concentration (IC50) 80 nM
MDA-MB-231 cells (5T4 overexpression)
Breast adenocarcinoma
CVCL_0062 
[784]
Half Maximal Inhibitory Concentration (IC50) 80 nM
MRC5 cells
Normal
CVCL_0440 
[271]
Half Maximal Inhibitory Concentration (IC50) 80 nM
HL-60 cells
Adult acute myeloid leukemia
CVCL_0002 
[785]
Half Maximal Inhibitory Concentration (IC50) 80.35 nM
LS1034 cells
Cecum adenocarcinoma
CVCL_1382 
Half Maximal Inhibitory Concentration (IC50) 80.86 nM
HT cells
Diffuse large B-cell lymphoma
CVCL_1290 
Half Maximal Inhibitory Concentration (IC50) 800 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[480]
Half Maximal Inhibitory Concentration (IC50) 800 nM
NCI-ADR-RES cells
High grade ovarian serous adenocarcinoma
CVCL_1452 
[717]
Half Maximal Inhibitory Concentration (IC50) 800 nM
4T1 cells
Mammary carcinoma
CVCL_0125 
[786]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 8000 nM
NCI-ADR-RES cells
High grade ovarian serous adenocarcinoma
CVCL_1452 
[140]
Half Maximal Inhibitory Concentration (IC50) 8000 nM
KB-V1 cells
Cervical carcinoma
CVCL_2089 
[510]
Half Maximal Inhibitory Concentration (IC50) 8000 nM
A375 cells
Amelanotic melanoma
CVCL_0132 
[603]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 80000 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[748]
Half Maximal Inhibitory Concentration (IC50) 80000 nM
ACHN cells
Renal adenocarcinoma
CVCL_1067 
[464]
Half Maximal Inhibitory Concentration (IC50) 802 nM
A549/TR cells
Lung adenocarcinoma
CVCL_C5S0 
[590]
Half Maximal Inhibitory Concentration (IC50) 81 nM
NCI-H2141 cells
Lung small cell carcinoma
CVCL_1534 
Half Maximal Inhibitory Concentration (IC50) >81.1 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[626]
Half Maximal Inhibitory Concentration (IC50) 81.41 nM
LB2518-MEL cells
Melanoma
CVCL_1366 
Half Maximal Inhibitory Concentration (IC50) 810 nM
A375 cells
Amelanotic melanoma
CVCL_0132 
[459]
Half Maximal Inhibitory Concentration (IC50) 810 nM
A375 cells
Amelanotic melanoma
CVCL_0132 
[421]
Half Maximal Inhibitory Concentration (IC50) 810 nM
A375 cells
Amelanotic melanoma
CVCL_0132 
[422]
Half Maximal Inhibitory Concentration (IC50) 810 nM
A375 cells
Amelanotic melanoma
CVCL_0132 
[423]
Half Maximal Inhibitory Concentration (IC50) 8100 nM
Hep-G2 cells
Hepatoblastoma
CVCL_0027 
[491]
Half Maximal Inhibitory Concentration (IC50) 8100 nM
Hep-G2 cells
Hepatoblastoma
CVCL_0027 
[697]
Half Maximal Inhibitory Concentration (IC50) 8100 nM
Hep-G2 cells
Hepatoblastoma
CVCL_0027 
[698]
Half Maximal Inhibitory Concentration (IC50) 8100 nM
Hep-G2 cells
Hepatoblastoma
CVCL_0027 
[699]
Half Maximal Inhibitory Concentration (IC50) 8100 nM
U-87MG ATCC cells
Glioblastoma
CVCL_0022 
[107]
Half Maximal Inhibitory Concentration (IC50) 8100000 nM
Hep-G2 cells
Hepatoblastoma
CVCL_0027 
[701]
Half Maximal Inhibitory Concentration (IC50) 82 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[711]
Half Maximal Inhibitory Concentration (IC50) 820 nM
Hep-G2 cells
Hepatoblastoma
CVCL_0027 
[366]
Half Maximal Inhibitory Concentration (IC50) 820 nM
BEL-7404 tumor cells
Endocervical adenocarcinoma
CVCL_6568 
[394]
Half Maximal Inhibitory Concentration (IC50) 8200 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[787]
Half Maximal Inhibitory Concentration (IC50) 8250 nM
A2780 cells
Ovarian endometrioid adenocarcinoma
CVCL_0134 
[273]
Half Maximal Inhibitory Concentration (IC50) 828.72 nM
DB cells
Diffuse large B-cell lymphoma
CVCL_1168 
Half Maximal Cell Growth Inhibitory Concentration (GI50) 830 nM
HCT 15 cells
Colon adenocarcinoma
CVCL_0292 
[71]
Half Maximal Inhibitory Concentration (IC50) 830 nM
MGC-803 cells
Gastric cancer
CVCL_5334 
[504]
Half Maximal Inhibitory Concentration (IC50) 8350 nM
MCF7/PTX cells
Invasive ductal carcinoma
CVCL_C5RS 
[352]
Half Maximal Inhibitory Concentration (IC50) 84 nM
Hep-G2 cells
Hepatoblastoma
CVCL_0027 
[397]
Half Maximal Inhibitory Concentration (IC50) 84 nM
H22 cells
Hepatoma
CVCL_H613 
[788]
Half Maximal Inhibitory Concentration (IC50) 84.52 nM
GI-ME-N cells
Neuroblastoma
CVCL_1232 
Half Maximal Inhibitory Concentration (IC50) 8400 nM
Hep-G2 cells
Hepatoblastoma
CVCL_0027 
[333]
Half Maximal Inhibitory Concentration (IC50) 8459.76 nM
SK-MEL-2 cells (MEK inhibitor-resistant)
Melanoma
CVCL_0069 
Half Maximal Inhibitory Concentration (IC50) 850 nM
MGC-803 cells
Gastric cancer
CVCL_5334 
[493]
Half Maximal Inhibitory Concentration (IC50) 850 nM
MGC-803 cells
Gastric cancer
CVCL_5334 
[494]
Half Maximal Inhibitory Concentration (IC50) 850 nM
MGC-803 cells
Gastric cancer
CVCL_5334 
[495]
Half Maximal Inhibitory Concentration (IC50) 850 nM
NCI-H1688 cells
Normal
CVCL_1487 
[341]
Half Maximal Inhibitory Concentration (IC50) 854000 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[789]
Half Maximal Inhibitory Concentration (IC50) 8560 nM
SH-SY5Y cells
Bone marrow neuroblastoma
CVCL_0019 
[335]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 86 nM
IMR-32 cells
Neuroblastoma
CVCL_0346 
[678]
Half Maximal Inhibitory Concentration (IC50) 86 nM
HCT-8 cells
Ileocecal adenocarcinoma
CVCL_2478 
[135]
Half Maximal Inhibitory Concentration (IC50) 86.07 nM
TGW cells
Adrenal gland neuroblastoma
CVCL_1771 
Half Maximal Inhibitory Concentration (IC50) 86.41 nM
SK-NEP-1 cells
Ewing sarcoma
CVCL_0631 
Half Maximal Inhibitory Concentration (IC50) 860 nM
MDA-MB-435 cells
Amelanotic melanoma
CVCL_0417 
[790]
Half Maximal Inhibitory Concentration (IC50) 860 nM
MCF7R cells
Breast carcinoma
CVCL_Y493 
[790]
Half Maximal Inhibitory Concentration (IC50) 8626 nM
DU145 cells
Prostate carcinoma
CVCL_0105 
[747]
Half Maximal Inhibitory Concentration (IC50) 8700 nM
T98G cells
Glioblastoma
CVCL_0556 
[526]
Half Maximal Inhibitory Concentration (IC50) 8700 nM
HCT-8 cells
Ileocecal adenocarcinoma
CVCL_2478 
[322]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 87000 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[748]
Half Maximal Inhibitory Concentration (IC50) 87000 nM
MDA-MB-231 cells (5T4 overexpression)
Breast adenocarcinoma
CVCL_0062 
[703]
Half Maximal Inhibitory Concentration (IC50) 880 nM
SMMC-7721 cells
Hepatocellular carcinoma
CVCL_0534 
[394]
Half Maximal Inhibitory Concentration (IC50) 8810 nM
A498 cells
Renal carcinoma
CVCL_1056 
[471]
Half Maximal Inhibitory Concentration (IC50) 89 nM
AsPC-1 cells
Pancreatic ductal adenocarcinoma
CVCL_0152 
[420]
Half Maximal Inhibitory Concentration (IC50) 890 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[493]
Half Maximal Inhibitory Concentration (IC50) 89060 nM
MKN45 cells
Gastric adenocarcinoma
CVCL_0434 
[471]
Half Maximal Inhibitory Concentration (IC50) 9 nM
Hep-G2 cells
Hepatoblastoma
CVCL_0027 
[685]
Half Maximal Inhibitory Concentration (IC50) 9 nM
EMT6 cells
Mammary gland malignant neoplasms
CVCL_1923 
[448]
Half Maximal Inhibitory Concentration (IC50) 9 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[381]
Half Maximal Inhibitory Concentration (IC50) 9 nM
Hep-G2 cells
Hepatoblastoma
CVCL_0027 
[631]
Half Maximal Inhibitory Concentration (IC50) 9 nM
SK-MEL-2 cells (MEK inhibitor-resistant)
Melanoma
CVCL_0069 
[272]
Half Maximal Inhibitory Concentration (IC50) 9 nM
A2780 cells
Ovarian endometrioid adenocarcinoma
CVCL_0134 
[275]
Half Maximal Inhibitory Concentration (IC50) 9 nM
HT-29 cells
Colon adenocarcinoma
CVCL_0320 
[403]
Half Maximal Inhibitory Concentration (IC50) 9 nM
MDA-MB-231 cells (5T4 overexpression)
Breast adenocarcinoma
CVCL_0062 
[109]
Half Maximal Inhibitory Concentration (IC50) 9 nM
MDA-MB-435S cells
Amelanotic melanoma
CVCL_0622 
[270]
Half Maximal Inhibitory Concentration (IC50) 9 nM
Hep-G2 cells
Hepatoblastoma
CVCL_0027 
[700]
Half Maximal Inhibitory Concentration (IC50) 9 nM
Hep-G2 cells
Hepatoblastoma
CVCL_0027 
[190]
Half Maximal Inhibitory Concentration (IC50) 9 nM
HCC1806 cells
Breast squamous cell carcinoma
CVCL_1258 
[610]
Half Maximal Inhibitory Concentration (IC50) 9 nM
NCI-H1299 cells (MMAE resistant)
Lung large cell carcinoma
CVCL_0060 
[135]
Half Maximal Inhibitory Concentration (IC50) 9.041 nM
OVCAR-4 cells
Ovarian adenocarcinoma
CVCL_1627 
Half Maximal Inhibitory Concentration (IC50) 9.05 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[198]
Half Maximal Inhibitory Concentration (IC50) 9.1 nM
KB cells
Human papillomavirus-related endocervical adenocarcinoma
CVCL_0372 
[377]
Half Maximal Inhibitory Concentration (IC50) 9.1 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[203]
Half Maximal Inhibitory Concentration (IC50) 9.1 nM
MDA-MB-231 cells (5T4 overexpression)
Breast adenocarcinoma
CVCL_0062 
[85]
Half Maximal Inhibitory Concentration (IC50) 9.1 nM
MDA-MB-231 cells (5T4 overexpression)
Breast adenocarcinoma
CVCL_0062 
[86]
Half Maximal Inhibitory Concentration (IC50) 9.1 nM
MDA-MB-231 cells (5T4 overexpression)
Breast adenocarcinoma
CVCL_0062 
[356]
Half Maximal Inhibitory Concentration (IC50) 9.138 nM
NCI-H1355 cells
Lung adenocarcinoma
CVCL_1464 
Half Maximal Inhibitory Concentration (IC50) 9.17 nM
MDA-MB-231 cells (5T4 overexpression)
Breast adenocarcinoma
CVCL_0062 
[720]
Half Maximal Inhibitory Concentration (IC50) 9.2 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[219]
Half Maximal Inhibitory Concentration (IC50) 9.2 nM
A-431 cells
Skin squamous cell carcinoma
CVCL_0037 
[434]
Half Maximal Inhibitory Concentration (IC50) 9.2 nM
A375 cells
Amelanotic melanoma
CVCL_0132 
[107]
Half Maximal Inhibitory Concentration (IC50) 9.2 nM
NCM460 cells
Normal
CVCL_0460 
[454]
Half Maximal Inhibitory Concentration (IC50) 9.303 nM
BL-70 cells
Burkitt lymphoma
CVCL_1088 
Half Maximal Inhibitory Concentration (IC50) 9.345 nM
BL-41 cells
Burkitt lymphoma
CVCL_1087 
Half Maximal Inhibitory Concentration (IC50) 9.4 nM
MDA-MB-231 cells (5T4 overexpression)
Breast adenocarcinoma
CVCL_0062 
[357]
Half Maximal Inhibitory Concentration (IC50) 9.5 nM
NCI-H460 cells
Lung large cell carcinoma
CVCL_0459 
[353]
Half Maximal Inhibitory Concentration (IC50) 9.5 nM
NCI-H460 cells
Lung large cell carcinoma
CVCL_0459 
[354]
Half Maximal Inhibitory Concentration (IC50) 9.5 nM
LS174T cells
Colon adenocarcinoma
CVCL_1384 
[243]
Half Maximal Inhibitory Concentration (IC50) 9.598 nM
A101D cells
Melanoma
CVCL_1057 
Half Maximal Inhibitory Concentration (IC50) 9.6 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[285]
Half Maximal Inhibitory Concentration (IC50) 9.63 nM
MDA-MB-231 cells (5T4 overexpression)
Breast adenocarcinoma
CVCL_0062 
[358]
Half Maximal Inhibitory Concentration (IC50) 9.656 nM
HL-60 cells
Adult acute myeloid leukemia
CVCL_0002 
Half Maximal Inhibitory Concentration (IC50) 9.74 nM
MDA-MB-231 cells (5T4 overexpression)
Breast adenocarcinoma
CVCL_0062 
[383]
Half Maximal Inhibitory Concentration (IC50) 9.8 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[123]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 9.817 nM
SNB-78 cells
Glioblastoma
CVCL_B321 
[345]
Half Maximal Inhibitory Concentration (IC50) 9.9 nM
PANC-1 cells
Pancreatic ductal adenocarcinoma
CVCL_0480 
[420]
Half Maximal Inhibitory Concentration (IC50) 9.99 nM
COR-L279 cells
Lung small cell carcinoma
CVCL_1140 
Half Maximal Inhibitory Concentration (IC50) 90 nM
DLD-1 cells
Colon adenocarcinoma
CVCL_0248 
[398]
Half Maximal Inhibitory Concentration (IC50) 90 nM
LoVo cells
Colon adenocarcinoma
CVCL_0399 
[17]
Half Maximal Inhibitory Concentration (IC50) 90 nM
BxPC-3 CDX model cells
Pancreatic ductal adenocarcinoma
CVCL_0186 
[107]
Half Maximal Inhibitory Concentration (IC50) 90 nM
HCT 15 cells
Colon adenocarcinoma
CVCL_0292 
[484]
Half Maximal Inhibitory Concentration (IC50) 90 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[163]
Half Maximal Inhibitory Concentration (IC50) 900 nM
A2780 cells
Ovarian endometrioid adenocarcinoma
CVCL_0134 
[150]
Half Maximal Inhibitory Concentration (IC50) 900 nM
A2780 ADR cells
Ovarian endometrioid adenocarcinoma
CVCL_1941 
[154]
Half Maximal Inhibitory Concentration (IC50) 900 nM
K-562 cells
Chronic myelogenous leukemia
CVCL_0004 
[791]
Half Maximal Inhibitory Concentration (IC50) 900 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[361]
Half Maximal Inhibitory Concentration (IC50) 900 nM
MDA-MB-231 cells (5T4 overexpression)
Breast adenocarcinoma
CVCL_0062 
[792]
Half Maximal Inhibitory Concentration (IC50) 90000 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[93]
Half Maximal Inhibitory Concentration (IC50) >9000000 nM
NCI-ADR-RES cells
High grade ovarian serous adenocarcinoma
CVCL_1452 
[464]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 91 nM
MDA-MB-231 cells (5T4 overexpression)
Breast adenocarcinoma
CVCL_0062 
[594]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 91 nM
MDA-MB-231 cells (5T4 overexpression)
Breast adenocarcinoma
CVCL_0062 
[595]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 91 nM
MDA-MB-231 cells (5T4 overexpression)
Breast adenocarcinoma
CVCL_0062 
[596]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 91.2 nM
MDA-MB-231 cells (5T4 overexpression)
Breast adenocarcinoma
CVCL_0062 
[596]
Half Maximal Inhibitory Concentration (IC50) 9153 nM
NCI-ADR-RES cells
High grade ovarian serous adenocarcinoma
CVCL_1452 
[492]
Half Maximal Inhibitory Concentration (IC50) 9198.35 nM
EB2 cells
Burkitt lymphoma
CVCL_1186 
Half Maximal Cell Growth Inhibitory Concentration (GI50) 92 nM
MDA-MB-231 cells (5T4 overexpression)
Breast adenocarcinoma
CVCL_0062 
[678]
Half Maximal Inhibitory Concentration (IC50) 92 nM
S1 cells
Colon adenocarcinoma
CVCL_0H88 
[479]
Half Maximal Inhibitory Concentration (IC50) 92.3 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[647]
Half Maximal Inhibitory Concentration (IC50) 92.75 nM
NOMO-1 cells
Acute monocytic leukemia
CVCL_1609 
Half Maximal Inhibitory Concentration (IC50) 920 nM
A2780 ADR cells
Ovarian endometrioid adenocarcinoma
CVCL_1941 
[216]
Half Maximal Inhibitory Concentration (IC50) 9240 nM
BGC-823 cells
Stomach adenocarcinoma
CVCL_3360 
[335]
Half Maximal Inhibitory Concentration (IC50) 9260 nM
BGC-823 cells
Stomach adenocarcinoma
CVCL_3360 
[338]
Half Maximal Inhibitory Concentration (IC50) 9260 nM
BGC-1 cells
Normal
CVCL_6572 
[336]
Half Maximal Inhibitory Concentration (IC50) 9260 nM
BGC-1 cells
Normal
CVCL_6572 
[337]
Half Maximal Inhibitory Concentration (IC50) 9265 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[747]
Half Maximal Inhibitory Concentration (IC50) 930 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[793]
Half Maximal Inhibitory Concentration (IC50) 930 nM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[794]
Half Maximal Inhibitory Concentration (IC50) 930 nM
HL-60 cells
Adult acute myeloid leukemia
CVCL_0002 
[793]
Half Maximal Inhibitory Concentration (IC50) 930 nM
HL-60 cells
Adult acute myeloid leukemia
CVCL_0002 
[794]
Half Maximal Inhibitory Concentration (IC50) 930 nM
Bel-7402 cells
Hepatoma
CVCL_5492 
[793]
Half Maximal Inhibitory Concentration (IC50) 930 nM
Bel-7402 cells
Hepatoma
CVCL_5492 
[794]
Half Maximal Inhibitory Concentration (IC50) 930 nM
P388 cells
Lymphoma
CVCL_7222 
[793]
Half Maximal Inhibitory Concentration (IC50) 930 nM
P388 cells
Lymphoma
CVCL_7222 
[794]
Half Maximal Inhibitory Concentration (IC50) 9306.65 nM
ES3 cells
Ewing sarcoma
CVCL_1199 
Half Maximal Inhibitory Concentration (IC50) 9335 nM
NCI-ADR-RES cells
High grade ovarian serous adenocarcinoma
CVCL_1452 
[590]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 935.3 nM
A549-Taxol cells
Lung adenocarcinoma
CVCL_W218 
[658]
Half Maximal Inhibitory Concentration (IC50) 9384 nM
MDA-MB-231 cells (5T4 overexpression)
Breast adenocarcinoma
CVCL_0062 
[365]
Half Maximal Inhibitory Concentration (IC50) 9390 nM
Human umbilical vein endothelial cells(HUVEC)
Normal
Undisclosed [373]
Half Maximal Inhibitory Concentration (IC50) 9394.59 nM
SKM-1 cells
Acute myeloid leukemia
CVCL_0098 
Half Maximal Inhibitory Concentration (IC50) 94 nM
4T1 cells
Mammary carcinoma
CVCL_0125 
[470]
Half Maximal Inhibitory Concentration (IC50) 94 nM
4T1 cells
Mammary carcinoma
CVCL_0125 
[307]
Half Maximal Inhibitory Concentration (IC50) 940 nM
PC-3 cells
Prostate carcinoma
CVCL_0035 
[341]
Half Maximal Inhibitory Concentration (IC50) 940 nM
Eca-109 cells
Esophageal squamous cell carcinoma
CVCL_6898 
[673]
Half Maximal Inhibitory Concentration (IC50) 9400 nM
NCI-H460 cells
Lung large cell carcinoma
CVCL_0459 
[572]
Half Maximal Inhibitory Concentration (IC50) 9400 nM
MDA-MB-231 cells (5T4 overexpression)
Breast adenocarcinoma
CVCL_0062 
[326]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 948000 nM
KB cells
Human papillomavirus-related endocervical adenocarcinoma
CVCL_0372 
[607]
Half Maximal Inhibitory Concentration (IC50) 949 nM
A2780 ADR cells
Ovarian endometrioid adenocarcinoma
CVCL_1941 
[131]
Half Maximal Inhibitory Concentration (IC50) 9490 nM
Hep-G2 cells
Hepatoblastoma
CVCL_0027 
[708]
Half Maximal Inhibitory Concentration (IC50) 95 nM
Bel-7402 cells
Hepatoma
CVCL_5492 
[609]
Half Maximal Inhibitory Concentration (IC50) 95.89 nM
ES6 cells
Ewing sarcoma
CVCL_1202 
Half Maximal Inhibitory Concentration (IC50) 9501.27 nM
MFM-223 cells
Breast carcinoma
CVCL_1408 
Half Maximal Inhibitory Concentration (IC50) 951.98 nM
CP66-MEL cells
Melanoma
CVCL_1144 
Half Maximal Inhibitory Concentration (IC50) 9600 nM
MDA-MB-231 cells (5T4 overexpression)
Breast adenocarcinoma
CVCL_0062 
[367]
Half Maximal Inhibitory Concentration (IC50) 9660 nM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[331]
Half Maximal Inhibitory Concentration (IC50) 97.86 nM
NCI-H209 cells
Lung small cell carcinoma
CVCL_1525 
Half Maximal Inhibitory Concentration (IC50) 980 nM
A2780 cells
Ovarian endometrioid adenocarcinoma
CVCL_0134 
[187]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 9800 nM
MES-SA/Dx5 cells
Uterine sarcoma
CVCL_2598 
[749]
Half Maximal Cell Growth Inhibitory Concentration (GI50) 9800 nM
MES-SA/Dx5 cells
Uterine sarcoma
CVCL_2598 
[750]
Half Maximal Inhibitory Concentration (IC50) 9800 nM
SGC-7901 cells
Gastric carcinoma
CVCL_0520 
[579]
Half Maximal Inhibitory Concentration (IC50) 9800 nM
KB-V1 cells
Cervical carcinoma
CVCL_2089 
[165]
Half Maximal Inhibitory Concentration (IC50) 99 nM
HeLa cells
Endocervical adenocarcinoma
CVCL_0030 
[108]
Half Maximal Inhibitory Concentration (IC50) 990 nM
Hep-G2 cells
Hepatoblastoma
CVCL_0027 
[270]
Half Maximal Effective Concentration (EC50) 0.0006 uM
HT-29 cells
Colon adenocarcinoma
CVCL_0320 
[795]
Half Maximal Effective Concentration (EC50) 0.001 uM
HT-29 cells
Colon adenocarcinoma
CVCL_0320 
[796]
Half Maximal Effective Concentration (EC50) 0.003 uM
DU145 cells
Prostate carcinoma
CVCL_0105 
[797]
Half Maximal Effective Concentration (EC50) 0.006 uM
HT-29 cells
Colon adenocarcinoma
CVCL_0320 
[798]
Half Maximal Effective Concentration (EC50) 0.007 uM
KB cells
Human papillomavirus-related endocervical adenocarcinoma
CVCL_0372 
[797]
Half Maximal Effective Concentration (EC50) 0.008 uM
A-549 cells
Lung adenocarcinoma
CVCL_0023 
[797]
Half Maximal Effective Concentration (EC50) 0.015 uM
NCI-H460 cells
Lung large cell carcinoma
CVCL_0459 
[799]
Half Maximal Effective Concentration (EC50) 0.016 uM
J774.2 cells
Mouse reticulum cell sarcoma
CVCL_0357 
Half Maximal Effective Concentration (EC50) 0.023 uM
KB cells
Human papillomavirus-related endocervical adenocarcinoma
CVCL_0372 
[68]
Half Maximal Effective Concentration (EC50) 0.09 uM
J774.2 cells
Mouse reticulum cell sarcoma
CVCL_0357 
[800]
Half Maximal Effective Concentration (EC50) 0.09 uM
J774 cells
Mouse reticulum cell sarcoma
CVCL_4692 
Half Maximal Effective Concentration (EC50) 0.09 uM
J774 cells
Mouse reticulum cell sarcoma
CVCL_4692 
[801]
Half Maximal Effective Concentration (EC50) 0.35 uM
CHO cells
Normal
CVCL_0213 
[800]
Half Maximal Effective Concentration (EC50) 0.54 uM
HCT 15 cells
Colon adenocarcinoma
CVCL_0292 
[799]
Half Maximal Effective Concentration (EC50) 0.7 uM
B16 cells
Melanoma
CVCL_F936 
Half Maximal Effective Concentration (EC50) 1 uM
B16 cells
Melanoma
CVCL_F936 
Half Maximal Effective Concentration (EC50) 1.5 uM
NCI-ADR-RES cells
High grade ovarian serous adenocarcinoma
CVCL_1452 
[638]
Half Maximal Effective Concentration (EC50) >10 uM
LNCaP cells
Prostate carcinoma
CVCL_0395 
[802]
Half Maximal Effective Concentration (EC50) >10 uM
MCF7-F (fulvestrant resistant) cells
Invasive breast carcinoma
CVCL_0031 
[802]
Half Maximal Effective Concentration (EC50) >10 uM
Lu1 cells
Lung carcinoma
Undisclosed [802]
Half Maximal Effective Concentration (EC50) 2 uM
NCI-ADR-RES cells
High grade ovarian serous adenocarcinoma
CVCL_1452 
[521]
Half Maximal Effective Concentration (EC50) 23 uM
CCD-112CoN cells
Normal
CVCL_6382 
[796]
Each Antibody-drug Conjugate Related to This Payload
Full Information of The Activity Data of The ADC(s) Related to This Payload
AB-160 [Phase 1]
Identified from the Human Clinical Data
Click To Hide/Show 1 Activity Data Related to This Level
Experiment 1 Reporting the Activity Date of This ADC [803]
Efficacy Data Progression Free Survival
5.3 months
Patients Enrolled
Eligibility criteria: Adults (≥18) with specific advanced cancers (melanoma/gynecologic) meeting measurable disease requirements, adequate organ function, and prior therapy specifications. Key exclusions: active brain metastases, uncontrolled comorbidities, recent anticancer therapy, pregnancy/nursing, other active malignancies, or significant cardiac/CNS history. Cohort-specific requirements apply for platinum resistance and prior treatments.

   Click to Show/Hide
Administration Dosage
Patients receive nab-paclitaxel/bevacizumab-complex IV over 30-60 minutes on days 1, 8, and 15. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity. Patient may receive paclitaxel if supply of nab-paclitaxel is exhausted.
Related Clinical Trial
NCT Number NCT02020707  Phase Status PHASE1
Clinical Description
Targeted Complex Therapy for Advanced Melanoma, Gynecologic Cancers, and Other Malignancies: Nab-Paclitaxel (Abraxane)/Bevacizumab Complex (AB-Complex)
Primary Endpoint
The primary objectives are to determine the maximum tolerated dose (MTD) within 28 days and assess tumor response (complete/partial per RECIST v1.1) over 12 months in patients with advanced cancers.
Other Endpoint
Secondary endpoints include progression-free survival (PFS), overall survival (OS) up to 12 months, and comprehensive safety monitoring (CTCAE v4.0-graded AEs) throughout the study period.
Trastuzumab/nab-paclitaxel [Investigative]
Revealed Based on the Cell Line Data
Click To Hide/Show 1 Activity Data Related to This Level
Experiment 1 Reporting the Activity Date of This ADC [804]
Efficacy Data Half Maximal Inhibitory Concentration (IC50)
0.24 ug/mL
Positive HER2 expression (HER2 +++/++)
Method Description
Paclitaxel, nab-paclitaxel and trastuzumab/nab-paclitaxel, respectively, at a concentration of 0.24 ug/ml paclitaxel equivalent for 48 h.
In Vitro Model Gastric tubular adenocarcinoma NCI-N87 cells CVCL_1603
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