Payload Information
General Information of This Payload
| Payload ID | PAY0VGTWQ |
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| Name | US20250025567A1, ExlL5A1, Payload |
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| Synonyms |
US20250025567A1, ExlL5A1, Payload
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| Target | Toll-like receptor 7 (TLR7); Toll-like receptor 8 (TLR8) | |||||
| Structure |
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| Formula | C25H35ClN6O2 |
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| Isosmiles | OC[C@@H]1CCCN1CC(C=C2)=CC(OC)=C2CN3C(C(NCCCCC)=NC(N)=N4)=C4C(Cl)=C3 |
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| InChI |
InChI=1S/C25H35ClN6O2/c1-3-4-5-10-28-24-23-22(29-25(27)30-24)20(26)15-32(23)14-18-9-8-17(12-21(18)34-2)13-31-11-6-7-19(31)16-33/h8-9,12,15,19,33H,3-7,10-11,13-14,16H2,1-2H3,(H3,27,28,29,30)/t19-/m0/s1
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| InChIKey |
SZDMUSJFEUOJIA-IBGZPJMESA-N
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| Pharmaceutical Properties | Molecule Weight |
487.048 |
Polar area |
101.46 |
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Complexity |
1079.101646 |
xlogp Value |
4.2826 |
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Heavy Count |
34 |
Rot Bonds |
11 |
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Hbond acc |
8 |
Hbond Donor |
3 |
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Each Antibody-drug Conjugate Related to This Payload
Full Information of The Activity Data of The ADC(s) Related to This Payload
US20250025567A1 ExL5A1 [Investigative]
Discovered Using Cell Line-derived Xenograft Model
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Tumor Growth lnhibition value (TGl) | > 50% | Positive CLDN6 expression (CLDN6+++/++) | ||
| Method Description |
ExL5A1 was tested in SCID mice that subcutaneously transplanted NUGC33, 3 mg/kg was administeredthrough the tail vein of the tumor-bearing mice.
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| In Vivo Model | NUGC-3 cells SCID mice model | ||||