Payload Information

General Information of This Payload

Payload ID	PAY0UFRFU
Name	Duocarmycin 405
Synonyms	Duocarmycin 405 Click to Show/Hide
Target(s)	Human Deoxyribonucleic acid (hDNA)	Target Info

Each Antibody-drug Conjugate Related to This Payload

Full Information of The Activity Data of The ADC(s) Related to This Payload

Alpha-HER2-Duo 405 [Investigative]

ADC Info

Revealed Based on the Cell Line Data

Click To Hide/Show 2 Activity Data Related to This Level

Experiment 1 Reporting the Activity Date of This ADC					[1]
Efficacy Data	Half Maximal Inhibitory Concentration (IC50)	0.08 nM	Positive HER2 expression (HER2 +++/++)
Method Description	The cells wereincubated with serial dilutions of Duocarmycin-405 conjugated to anti-HER2 or a non-targetingantibody, Duocarmycin free drug and naked ant-HER2 controls for 6 days.
In Vitro Model	Breast adenocarcinoma	SK-BR-3 cells		CVCL_0033
Experiment 2 Reporting the Activity Date of This ADC					[1]
Efficacy Data	Half Maximal Inhibitory Concentration (IC50)	> 100 nM	Negative HER2 expression (HER2 -)
Method Description	The cells wereincubated with serial dilutions of Duocarmycin-405 conjugated to anti-HER2 or a non-targetingantibody, Duocarmycin free drug and naked ant-HER2 controls for 6 days.
In Vitro Model	Breast adenocarcinoma	MDA-MB-468 cells		CVCL_0419

References

Ref 1	Phosphate based linkers for intracellular delivery of drug conjugates; 2015-10-08.

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