Payload Information

General Information of This Payload
Payload ID
PAY0TJLOZ
Name
WO2024140449A1+ADC5+payload
Synonyms
WO2024140449A1+ADC5+payload
   Click to Show/Hide
Target DNA topoisomerase I (TOP1)
 Target Info 
Structure
Formula
C28H29N3O7
Isosmiles
CC[C@@]1(C(C=C2C3=NC4=CC5=C(C=C4C(CCNC6CCOCC6)=C3CN2C7=O)OCO5)=C7COC1=O)O
InChI
InChI=1S/C28H29N3O7/c1-2-28(34)20-10-22-25-18(12-31(22)26(32)19(20)13-36-27(28)33)16(3-6-29-15-4-7-35-8-5-15)17-9-23-24(38-14-37-23)11-21(17)30-25/h9-11,15,29,34H,2-8,12-14H2,1H3/t28-/m0/s1
InChIKey
NDSZNBBWCPDPNV-NDEPHWFRSA-N
Pharmaceutical Properties
Molecule Weight
519.554
Polar area
121.14
Complexity
1501.751089
xlogp Value
2.1194
Heavy Count
38
Rot Bonds
5
Hbond acc
10
Hbond Donor
2
Each Antibody-drug Conjugate Related to This Payload
Full Information of The Activity Data of The ADC(s) Related to This Payload
wO2024140449A1 ADC6 [Investigative]
 ADC Info 
Revealed Based on the Cell Line Data
Click To Hide/Show 1 Activity Data Related to This Level
Experiment 1 Reporting the Activity Date of This ADC [1]
Efficacy Data Half Maximal inhibitory Concentration (lC50)
5-50 nM
Method Description
A Cell line test on OE-33
In Vitro Model Barrett adenocarcinoma, Adenocarcinoma of the esophagus OE-33 cells CVCL_0471
wO2024140449A1 ADC10 [Investigative]
 ADC Info 
Revealed Based on the Cell Line Data
Click To Hide/Show 1 Activity Data Related to This Level
Experiment 1 Reporting the Activity Date of This ADC [1]
Efficacy Data Half Maximal inhibitory Concentration (lC50)
5-50 nM
Method Description
A Cell line test on OE-33
In Vitro Model Barrett adenocarcinoma, Adenocarcinoma of the esophagus OE-33 cells CVCL_0471
wO2024140449A1 ADC12 [Investigative]
 ADC Info 
Revealed Based on the Cell Line Data
Click To Hide/Show 1 Activity Data Related to This Level
Experiment 1 Reporting the Activity Date of This ADC [1]
Efficacy Data Half Maximal inhibitory Concentration (lC50)
5-50 nM
Method Description
A Cell line test on OE-33
In Vitro Model Barrett adenocarcinoma, Adenocarcinoma of the esophagus OE-33 cells CVCL_0471
wO2024140449A1 ADC8 [Investigative]
 ADC Info 
Revealed Based on the Cell Line Data
Click To Hide/Show 1 Activity Data Related to This Level
Experiment 1 Reporting the Activity Date of This ADC [1]
Efficacy Data Half Maximal inhibitory Concentration (lC50)
50-500 nM
Method Description
A Cell line test on OE-33
In Vitro Model Barrett adenocarcinoma, Adenocarcinoma of the esophagus OE-33 cells CVCL_0471
wO2024140449A1 ADC5 [Investigative]
 ADC Info 
Revealed Based on the Cell Line Data
Click To Hide/Show 1 Activity Data Related to This Level
Experiment 1 Reporting the Activity Date of This ADC [1]
Efficacy Data Half Maximal inhibitory Concentration (lC50) > 250 nM
Method Description
A Cell line test on OE-33
In Vitro Model Barrett adenocarcinoma, Adenocarcinoma of the esophagus OE-33 cells CVCL_0471
wO2024140449A1 ADC7 [Investigative]
 ADC Info 
Revealed Based on the Cell Line Data
Click To Hide/Show 1 Activity Data Related to This Level
Experiment 1 Reporting the Activity Date of This ADC [1]
Efficacy Data Half Maximal inhibitory Concentration (lC50) > 250 nM
Method Description
A Cell line test on OE-33
In Vitro Model Barrett adenocarcinoma, Adenocarcinoma of the esophagus OE-33 cells CVCL_0471
References
Ref 1 Antibody-drug conjugates of N-oxacycloalkyl substituted camptothecin derivatives