Payload Information
General Information of This Payload
| Payload ID | PAY0SXCMM |
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|---|---|---|---|---|---|---|
| Name | Bifunctional immunomodulator D18 |
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| Synonyms |
Bifunctional immunomodulator D18
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| Target(s) | Toll-like receptor 7 (TLR7); Toll-like receptor 8 (TLR8) | |||||
| Structure |
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| Formula | C21H28N6 |
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| Isosmiles | CCCCNc1nc(N)nc2ccc(Cc3ccc(CN(C)C)cc3)nc12 |
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| InChI |
InChI=1S/C21H28N6/c1-4-5-12-23-20-19-18(25-21(22)26-20)11-10-17(24-19)13-15-6-8-16(9-7-15)14-27(2)3/h6-11H,4-5,12-14H2,1-3H3,(H3,22,23,25,26)
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| InChIKey |
DUCCCPVHDPRCEB-UHFFFAOYSA-N
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| Pharmaceutical Properties | Molecule Weight |
364.497 |
Polar area |
79.96 |
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Complexity |
27 |
xlogp Value |
3.4714 |
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Heavy Count |
27 |
Rot Bonds |
8 |
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Hbond acc |
6 |
Hbond Donor |
2 |
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The activity data of This Payload
| Standard Type | Value | Units | Cell line | Disease Model | Cell line ID | Reference |
|---|---|---|---|---|---|---|
| Tumor Growth Inhibition value (TGI) | ≈25 | % |
MC-38 cells
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Mouse colon adenocarcinoma
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[1] |
Each Antibody-drug Conjugate Related to This Payload
References
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