Payload Information

General Information of This Payload

Payload ID	PAY0RYATU
Name	PE15-Stx 2a
Synonyms	PE15-Stx 2a Click to Show/Hide
Target(s)	Eukaryotic elongation factor 2 (EEF2)			Target Info
Formula	C45H55F2N9O8
Isosmiles	C[C@H](NC(=O)Cc1ccncc1)C(=O)N[C@H](C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCN(C(=O)CO)[C@@H](c1cc(-c2cc(F)ccc2F)cn1Cc1ccccc1)C(C)(C)C)C(N)=O
InChI	InChI=1S/C45H55F2N9O8/c1-26(51-38(59)19-28-13-16-50-17-14-28)42(62)52-27(2)43(63)54-35(22-37(48)58)44(64)53-34(41(49)61)15-18-56(39(60)25-57)40(45(3,4)5)36-20-30(32-21-31(46)11-12-33(32)47)24-55(36)23-29-9-7-6-8-10-29/h6-14,16-17,20-21,24,26-27,34-35,40,57H,15,18-19,22-23,25H2,1-5H3,(H2,48,58)(H2,49,61)(H,51,59)(H,52,62)(H,53,64)(H,54,63)/t26-,27+,34-,35-,40-/m0/s1
Pharmaceutical Properties	Molecule Weight	887.986	Polar area	260.94
	Complexity	64	xlogp Value	1.7572
	Heavy Count	64	Rot Bonds	21
	Hbond acc	10	Hbond Donor	7

Each Antibody-drug Conjugate Related to This Payload

Full Information of The Activity Data of The ADC(s) Related to This Payload

scFv(Herceptin)-PE-STXA [Investigative]

ADC Info

Revealed Based on the Cell Line Data

Click To Hide/Show 2 Activity Data Related to This Level

Experiment 1 Reporting the Activity Date of This ADC					[1]
Efficacy Data	Half Maximal Inhibitory Concentration (IC50)	21.25 ug/mL	Positive HER2 expression (HER2 +++/++)
Method Description	The cytotoxic effect of recombinant proteins was evaluated by the MTT assay using SKBR-3 and MCF-7 cells.
In Vitro Model	Breast adenocarcinoma	SK-BR-3 cells		CVCL_0033
Experiment 2 Reporting the Activity Date of This ADC					[1]
Efficacy Data	Half Maximal Inhibitory Concentration (IC50)	100.00 ug/mL	Low HER2 expression (HER2 -)
Method Description	The cytotoxic effect of recombinant proteins was evaluated by the MTT assay using SKBR-3 and MCF-7 cells.
In Vitro Model	Invasive breast carcinoma	MCF-7 cells		CVCL_0031

References

Ref 1	Breast cancer targeted/ therapeutic with double and triple fusion Immunotoxins. J Steroid Biochem Mol Biol. 2020 Jun;200:105651. doi: 10.1016/j.jsbmb.2020.105651. Epub 2020 Mar 5.