Payload Information

General Information of This Payload
Payload ID
PAY0RXSLX
Name
WO2025015586A1, ADC34, Payload
Synonyms
compound 7
   Click to Show/Hide
Target Toll-like receptor 7 (TLR7); Toll-like receptor 8 (TLR8)
 Target Info 
Structure
Formula
C26H36N7O4P
Isosmiles
CCCCC(N1OCCCCNC2=C(NCCN)C(C2=O)=O)=NC3=C1C4=CC=C(P(C)(C)=O)C=C4N=C3N
InChI
InChI=1S/C26H36N7O4P/c1-4-5-8-19-32-22-23(17-10-9-16(38(2,3)36)15-18(17)31-26(22)28)33(19)37-14-7-6-12-29-20-21(30-13-11-27)25(35)24(20)34/h9-10,15,29-30H,4-8,11-14,27H2,1-3H3,(H2,28,31)
InChIKey
JAQQIQNPZKJNFY-UHFFFAOYSA-N
Pharmaceutical Properties
Molecule Weight
541.593
Polar area
167.25
Complexity
1516.626857
xlogp Value
2.0448
Heavy Count
38
Rot Bonds
14
Hbond acc
11
Hbond Donor
4
The activity data of This Payload
Standard Type Value Units Cell line Disease Model Cell line ID Reference
The minimum effective concentration (MEC) 0.0457 uM
peripheral blood mononuclear cells (PBMCs)
Normal
CVCL_0140 
[1]
The minimum effective concentration (MEC) 0.0457 uM
peripheral blood mononuclear cells (PBMCs)
Normal
CVCL_0140 
[1]
The minimum effective concentration (MEC) 1.23 uM
peripheral blood mononuclear cells (PBMCs)
Normal
CVCL_0140 
[1]
The minimum effective concentration (MEC) 1.23 uM
peripheral blood mononuclear cells (PBMCs)
Normal
CVCL_0140 
[1]
Each Antibody-drug Conjugate Related to This Payload
Full Information of The Activity Data of The ADC(s) Related to This Payload
wO2023232144A1ADC38 [Investigative]
 ADC Info 
Discovered Using Cell Line-derived Xenograft Model
Click To Hide/Show 1 Activity Data Related to This Level
Experiment 1 Reporting the Activity Date of This ADC [1]
Efficacy Data Max Tumor Growth lnhibition value (TGl) (d)
20-50 %
Positive TLR expression (TLR+++/++)
Method Description
ADC38 was tested in mouse M38 CRC model in C57BL/6 mice, 2.5 mg/kg, QWx3, IV
In Vivo Model Mouse MC38 CRC Model in C57BL/6 Mice
wO2023232144A1ADC40 [Investigative]
 ADC Info 
Discovered Using Cell Line-derived Xenograft Model
Click To Hide/Show 1 Activity Data Related to This Level
Experiment 1 Reporting the Activity Date of This ADC [1]
Efficacy Data Max Tumor Growth lnhibition value (TGl) (d) > 50% Positive TLR expression (TLR+++/++)
Method Description
ADC40 was tested in mouse M38 CRC model in C57BL/6 mice, 2.5 mg/kg, QWx3, IV
In Vivo Model Mouse MC38 CRC Model in C57BL/6 Mice
wO2023232144A1ADC42 [Investigative]
 ADC Info 
Discovered Using Cell Line-derived Xenograft Model
Click To Hide/Show 1 Activity Data Related to This Level
Experiment 1 Reporting the Activity Date of This ADC [1]
Efficacy Data Max Tumor Growth lnhibition value (TGl) (d) > 50% Positive TLR expression (TLR+++/++)
Method Description
ADC42 was tested in mouse M38 CRC model in C57BL/6 mice, 2.5 mg/kg, QWx2, IV
In Vivo Model Mouse MC38 CRC Model in C57BL/6 Mice
isumab01-C7 [Investigative]
 ADC Info 
Revealed Based on the Cell Line Data
Click To Hide/Show 1 Activity Data Related to This Level
Experiment 1 Reporting the Activity Date of This ADC [2]
Efficacy Data Half Maximal inhibitory Concentration (lC50)
4800 pM
High FRa expression (FRa +++)
Method Description
A Cell line test on Jeg3
In Vitro Model Gestational choriocarcinoma Jeg3 cells CVCL_0363
References
Ref 1 Drug conjugates of imidazoquinoline amine derivatives, compositions and methods thereof
Ref 2 Antibody-drug conjugate compounds, and methods of use and treatment