Payload Information
General Information of This Payload
| Payload ID | PAY0RASIF |
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| Name | US20250025567A1, ExlL7A1, Payload |
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| Synonyms |
US20250025567A1, ExlL7A1, Payload
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| Target | Toll-like receptor 7 (TLR7); Toll-like receptor 8 (TLR8) | |||||
| Structure |
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| Formula | C23H32N6O |
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| Isosmiles | CCCCCNC1=NC(N)=NC2=C1N(C=C2)CC3=C(OC)C=C(C=C3)CNC4CC4 |
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| InChI |
InChI=1S/C23H32N6O/c1-3-4-5-11-25-22-21-19(27-23(24)28-22)10-12-29(21)15-17-7-6-16(13-20(17)30-2)14-26-18-8-9-18/h6-7,10,12-13,18,26H,3-5,8-9,11,14-15H2,1-2H3,(H3,24,25,27,28)
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| InChIKey |
ZNWGKWPURHDVPH-UHFFFAOYSA-N
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| Pharmaceutical Properties | Molecule Weight |
408.55 |
Polar area |
90.02 |
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Complexity |
967.112148 |
xlogp Value |
3.9245 |
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Heavy Count |
30 |
Rot Bonds |
11 |
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Hbond acc |
7 |
Hbond Donor |
3 |
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Each Antibody-drug Conjugate Related to This Payload
Full Information of The Activity Data of The ADC(s) Related to This Payload
US20250025567A1 ExL7A1 [Investigative]
Discovered Using Cell Line-derived Xenograft Model
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Tumor Growth lnhibition value (TGl) | > 50% | Positive CLDN6 expression (CLDN6+++/++) | ||
| Method Description |
ExL7A1 was tested in SCID mice that subcutaneously transplanted NUGC33, 3 mg/kg was administeredthrough the tail vein of the tumor-bearing mice.
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| In Vivo Model | NUGC-3 cells SCID mice model | ||||