Payload Information

General Information of This Payload

Payload ID	PAY0QWAHL
Name	Oxaliplatin
Synonyms	Oxaliplatin; DTXSID0036760; Oxalato(trans-l-1,2-cyclohexanediamine)platinum(II); cis-oxalato-trans-l-1,2-diaminocyclohexaneplatinum(II); DTXCID8016760; CAS-61825-94-3; NCGC00167798-01; SCHEMBL19511; HMS3269F19; Tox21_112585; Tox21_112629; AKOS005766023; AKOS015855804; CS-0992; BP-25383; HY-17371; [(1S,2S)-2-azanidylcyclohexyl]azanide; oxalate; platinum(4+) Click to Show/Hide
Target(s)	Human Deoxyribonucleic acid (hDNA)			Target Info
Structure
Structure	3D MOL		2D MOL
Formula	C8H14N2O4Pt
Isosmiles	C1CC[C@H]([C@@H](C1)[NH-])[NH-].C(=O)(C(=O)O)O.[Pt+2]
PubChem CID	9887053
InChI	InChI=1S/C6H12N2.C2H2O4.Pt/c7-5-3-1-2-4-6(5)8;3-1(4)2(5)6;/h5-8H,1-4H2;(H,3,4)(H,5,6);/q-2;;+2/t5-,6-;;/m1../s1
InChIKey	DRMCATBEKSVAPL-BNTLRKBRSA-N
IUPAC Name	[(1R,2R)-2-azanidylcyclohexyl]azanide;oxalic acid;platinum(2+)
Pharmaceutical Properties	Molecule Weight	397.29	Polar area	76.6
	Complexity	191	xlogp Value	.
	Heavy Count	15	Rot Bonds	0
	Hbond acc	6	Hbond Donor	4

Each Antibody-drug Conjugate Related to This Payload

Full Information of The Activity Data of The ADC(s) Related to This Payload

Anti-c-Met IgG-OXA [Investigative]

ADC Info

Discovered Using Cell Line-derived Xenograft Model

Click To Hide/Show 1 Activity Data Related to This Level

Experiment 1 Reporting the Activity Date of This ADC					[1]
Efficacy Data	Tumor Growth Inhibition value (TGI)	≈ 83.40% (Day 28)	Positive MET expression (MET+++/++)
Method Description	The mice were randomly assigned to groups: those treated with oxaliplatin , anti-c-Met IgG-OXA (10 mg/kg), and vehicle 5% sterile glucose solution. Different drugs were injected intravenously.
In Vivo Model	HepG2 CDX model
In Vitro Model	Hepatoblastoma	Hep-G2 cells		CVCL_0027

References

Ref 1	High-Affinity Human Anti-c-Met IgG Conjugated to Oxaliplatin as Targeted Chemotherapy for Hepatocellular Carcinoma. Front Oncol. 2019 Aug 2;9:717. doi: 10.3389/fonc.2019.00717. eCollection 2019.