Payload Information
General Information of This Payload
| Payload ID | PAY0QUDQK |
|||||
|---|---|---|---|---|---|---|
| Name | FD1 |
|||||
| Synonyms |
FD1
Click to Show/Hide
|
|||||
| Target | DNA topoisomerase I (TOP1) | |||||
| Structure |
|
|||||
| Formula | C25H24FN3O7 |
|||||
| Isosmiles | CC[C@]1(O)C(C=C2C3=NC4=CC(F)=C(C)C=C4C(CNC(OCCO)=O)=C3CN52)=C(COC1=O)C5=O |
|||||
| PubChem CID | ||||||
| InChI |
InChI=1S/C25H24FN3O7/c1-3-25(34)17-7-20-21-15(10-29(20)22(31)16(17)11-36-23(25)32)14(9-27-24(33)35-5-4-30)13-6-12(2)18(26)8-19(13)28-21/h6-8,30,34H,3-5,9-11H2,1-2H3,(H,27,33)/t25-/m0/s1
|
|||||
| InChIKey |
SJLICXIYNPAXHJ-VWLOTQADSA-N
|
|||||
| Pharmaceutical Properties | Molecule Weight |
497.479 |
Polar area |
139.98 |
||
Complexity |
1454.107326 |
xlogp Value |
1.74562 |
|||
Heavy Count |
36 |
Rot Bonds |
5 |
|||
Hbond acc |
9 |
Hbond Donor |
3 |
|||
The activity data of This Payload
Each Antibody-drug Conjugate Related to This Payload
Full Information of The Activity Data of The ADC(s) Related to This Payload
38354417 T-DL1 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) |
0.015 nM
|
High HER2 expression (HER2 +++) | ||
| Method Description |
A total of 30,000 SK-BR-3 (HER2-high) cells were seeded either as monocultures or cocultures in TC-treated 48-well microtiter plates (Greiner Bio-One, catalog no. 667180) and treated with 1.0 or 0.1 nmol/L ADCs diluted in growth medium.
|
||||
| In Vitro Model | Breast adenocarcinoma | SK-BR-3 cells | CVCL_0033 | ||
| Experiment 2 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) | > 100 nM | Negative HER2 expression (HER2-) | ||
| Method Description |
A total of 10,000 MDA-MB-468 (HER2-negative) cells were seeded either as monocultures or cocultures in TC-treated 48-well microtiter plates (Greiner Bio-One, catalog no. 667180) and treated with 1.0 or 0.1 nmol/L ADCs diluted in growth medium.
|
||||
| In Vitro Model | Breast adenocarcinoma | MDA-MB-468 cells | CVCL_0419 | ||
References