Payload Information

General Information of This Payload

Payload ID	PAY0PEZKN
Name	IL2 fusion toxin
Synonyms	IL2 fusion toxin Click to Show/Hide
Target(s)	Interleukin-2 receptor subunit alpha (IL2RA)	Target Info

Each Antibody-drug Conjugate Related to This Payload

Full Information of The Activity Data of The ADC(s) Related to This Payload

IL2-CCR4 immunotoxin [Investigative]

ADC Info

Revealed Based on the Cell Line Data

Click To Hide/Show 1 Activity Data Related to This Level

Experiment 1 Reporting the Activity Date of This ADC					[1]
Efficacy Data	Half Maximal Inhibitory Concentration (IC50)	1.57 pM	Positive CCR4 expression (CCR4 +++/++)
Method Description	In vitro efficacy comparison of the CCR4 IT vs IL2 fusion toxin to human CCR4+ CTCL Hut102/6TG using luminescent cell viability assay.
In Vitro Model	Cutaneous T cell lymphoma	HUT102/6TG cells		Homo sapiens

IL2-CCR4 IT [Investigative]

ADC Info

Revealed Based on the Cell Line Data

Click To Hide/Show 1 Activity Data Related to This Level

Experiment 1 Reporting the Activity Date of This ADC					[1]
Efficacy Data	Half Maximal Inhibitory Concentration (IC50)	6.30 pM	Positive CCR4 expression (CCR4 +++/++)
Method Description	In vitro efficacy comparison of the CCR4 IT vs IL2 fusion toxin to human CCR4+ CTCL Hut102/6TG using luminescent cell viability assay.
In Vitro Model	Cutaneous T cell lymphoma	HUT102/6TG cells		Homo sapiens

CCR4 IT [Investigative]

ADC Info

Revealed Based on the Cell Line Data

Click To Hide/Show 1 Activity Data Related to This Level

Experiment 1 Reporting the Activity Date of This ADC					[1]
Efficacy Data	Half Maximal Inhibitory Concentration (IC50)	15.80 pM	Positive CCR4 expression (CCR4 +++/++)
Method Description	In vitro efficacy comparison of the CCR4 IT vs IL2 fusion toxin to human CCR4+ CTCL Hut102/6TG using luminescent cell viability assay.
In Vitro Model	Cutaneous T cell lymphoma	HUT102/6TG cells		Homo sapiens

IL2 IT [Investigative]

ADC Info

Revealed Based on the Cell Line Data

Click To Hide/Show 1 Activity Data Related to This Level

Experiment 1 Reporting the Activity Date of This ADC					[1]
Efficacy Data	Half Maximal Inhibitory Concentration (IC50)	31.60 pM	Positive CCR4 expression (CCR4 +++/++)
Method Description	In vitro efficacy comparison of the CCR4 IT vs IL2 fusion toxin to human CCR4+ CTCL Hut102/6TG using luminescent cell viability assay.
In Vitro Model	Cutaneous T cell lymphoma	HUT102/6TG cells		Homo sapiens

References

Ref 1	Bispecific human IL2-CCR4 immunotoxin targets human cutaneous T-cell lymphoma. Mol Oncol. 2020 May;14(5):991-1000. doi: 10.1002/1878-0261.12653. Epub 2020 Mar 13.