Target Information

General Information of This Target
Target ID
PATR0OQNFE
Target Name
Interleukin-2 receptor subunit alpha (IL2RA)
Gene Name
IL2RA
Gene ID
3559
Synonym
TAC antigenp55CD_antigen=CD25
Sequence
MDSYLLMWGLLTFIMVPGCQAELCDDDPPEIPHATFKAMAYKEGTMLNCECKRGFRRIKS
GSLYMLCTGNSSHSSWDNQCQCTSSATRNTTKQVTPQPEEQKERKTTEMQSPMQPVDQAS
LPGHCREPPPWENEATERIYHFVVGQMVYYQCVQGYRALHRGPAESVCKMTHGKTRWTQP
QLICTGEMETSQFPGEEKPQASPEGRPESETSCLVTTTDFQIQTEMAATMETSIFTTEYQ
VAVAGCVFLLISVLLLSGLTWQRRQRKSRRTI

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Function
Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells.

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Uniprot Entry
IL2RA_HUMAN
HGNC ID
HGNC:6008
KEGG ID
hsa:3559
Full List of The ADC Related to This Target
Investigative
Click To Hide/Show 4 ADC Related to This Stage
ADC Name Antibody Antigen Payload Linker ADC Info
IL2-CCR4 IT [1]
DT390
C-C chemokine receptor type 4 (CCR4)
IL2 fusion toxin
Undisclosed
ADC Info
IL2-CCR4 immunotoxin [1]
DT390
C-C chemokine receptor type 4 (CCR4)
IL2 fusion toxin
Undisclosed
ADC Info
IL2 IT [1]
Undisclosed
C-C chemokine receptor type 4 (CCR4)
IL2 fusion toxin
Undisclosed
ADC Info
CCR4 IT [1]
Undisclosed
C-C chemokine receptor type 4 (CCR4)
IL2 fusion toxin
Undisclosed
ADC Info
References
Ref 1 Bispecific human IL2-CCR4 immunotoxin targets human cutaneous T-cell lymphoma. Mol Oncol. 2020 May;14(5):991-1000. doi: 10.1002/1878-0261.12653. Epub 2020 Mar 13.