Payload Information
General Information of This Payload
| Payload ID | PAY0OUVCV |
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|---|---|---|---|---|---|---|
| Name | DMTub |
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| Synonyms |
DMTub
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| Target(s) | Microtubule (MT) | |||||
| Structure |
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| Formula | C37H55N5O7S |
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| Isosmiles | CCC(C)C(NC(=O)C1CCCCN1)C(=O)N(C)C(CC(OC(C)=O)c1nc(C(=O)NC(Cc2ccccc2)CC(C)C(=O)O)cs1)C(C)C |
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| InChI |
InChI=1S/C37H55N5O7S/c1-8-23(4)32(41-33(44)28-16-12-13-17-38-28)36(46)42(7)30(22(2)3)20-31(49-25(6)43)35-40-29(21-50-35)34(45)39-27(18-24(5)37(47)48)19-26-14-10-9-11-15-26/h9-11,14-15,21-24,27-28,30-32,38H,8,12-13,16-20H2,1-7H3,(H,39,45)(H,41,44)(H,47,48)
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| InChIKey |
WHGCQQXCXRCXJW-UHFFFAOYSA-N
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| Pharmaceutical Properties | Molecule Weight |
713.942 |
Polar area |
167.03 |
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Complexity |
50 |
xlogp Value |
4.7453 |
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Heavy Count |
50 |
Rot Bonds |
18 |
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Hbond acc |
9 |
Hbond Donor |
4 |
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The activity data of This Payload
| Standard Type | Value | Units | Cell line | Disease Model | Cell line ID | Reference |
|---|---|---|---|---|---|---|
| Half Maximal Inhibitory Concentration (IC50) | >100 | nmol/L |
786-O cells
|
Renal cell carcinoma
|
[1] | |
| Half Maximal Inhibitory Concentration (IC50) | 15 | nmol/L |
L-428 cells
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Hodgkin lymphoma
|
[1] | |
| Half Maximal Inhibitory Concentration (IC50) | 3.5 | nmol/L |
Ramos cells
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Burkitt lymphoma
|
[1] | |
| Half Maximal Inhibitory Concentration (IC50) | 7.7 | nmol/L |
Karpas-299 cells
|
ALK-positive anaplastic large cell lymphoma
|
[1] | |
| Half Maximal Inhibitory Concentration (IC50) | 8.7 | nmol/L |
L540cy cells
|
Hodgkin's disease
|
Undisclosed | [1] |
Each Antibody-drug Conjugate Related to This Payload
References
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